Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10965
Gene name	Acyl-CoA thioesterase 2
Gene symbol	ACOT2
Synonyms (NCBI Gene)	CTE-IACTE1AMTE1PTE2PTE2AZAP128
Chromosome	14
Chromosome location	14q24.3
Summary	This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

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Show/Hide all (189)

miRTarBase ID	miRNA	Experiments	Reference
MIRT050818	hsa-miR-17-5p	CLASH	23622248
MIRT715995	hsa-miR-5088-5p	HITS-CLIP	19536157
MIRT715994	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT715993	hsa-miR-7113-5p	HITS-CLIP	19536157
MIRT715992	hsa-miR-4685-5p	HITS-CLIP	19536157
MIRT715991	hsa-miR-6837-5p	HITS-CLIP	19536157
MIRT715990	hsa-miR-1304-3p	HITS-CLIP	19536157
MIRT715989	hsa-miR-4772-3p	HITS-CLIP	19536157
MIRT715988	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT715987	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT715986	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT715985	hsa-miR-4437	HITS-CLIP	19536157
MIRT715984	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT715983	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT689869	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT683457	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683456	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683455	hsa-miR-940	HITS-CLIP	23313552
MIRT683454	hsa-miR-3929	HITS-CLIP	23313552
MIRT683453	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683452	hsa-miR-4478	HITS-CLIP	23313552
MIRT683451	hsa-miR-6767-3p	HITS-CLIP	23313552
MIRT683450	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT689868	hsa-miR-4459	HITS-CLIP	23313552
MIRT683445	hsa-miR-665	HITS-CLIP	23313552
MIRT689867	hsa-miR-6840-3p	HITS-CLIP	23313552
MIRT683449	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT683448	hsa-miR-1827	HITS-CLIP	23313552
MIRT689866	hsa-miR-6087	HITS-CLIP	23313552
MIRT689865	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT689864	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT683447	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT683446	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT683457	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683456	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683455	hsa-miR-940	HITS-CLIP	23313552
MIRT683454	hsa-miR-3929	HITS-CLIP	23313552
MIRT683453	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683452	hsa-miR-4478	HITS-CLIP	23313552
MIRT683451	hsa-miR-6767-3p	HITS-CLIP	23313552
MIRT683450	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT683449	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT683448	hsa-miR-1827	HITS-CLIP	23313552
MIRT683447	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT683446	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT683445	hsa-miR-665	HITS-CLIP	23313552
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609363	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609360	hsa-miR-4672	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609363	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT661416	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609360	hsa-miR-4672	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT636882	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT636881	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT636880	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT636879	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT636878	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT636877	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT636876	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT636875	hsa-miR-4435	HITS-CLIP	23824327
MIRT636874	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609363	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609360	hsa-miR-4672	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609363	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609360	hsa-miR-4672	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609363	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609360	hsa-miR-4672	HITS-CLIP	23824327
MIRT715995	hsa-miR-5088-5p	HITS-CLIP	19536157
MIRT715994	hsa-miR-6890-3p	HITS-CLIP	19536157
MIRT715993	hsa-miR-7113-5p	HITS-CLIP	19536157
MIRT715992	hsa-miR-4685-5p	HITS-CLIP	19536157
MIRT715991	hsa-miR-6837-5p	HITS-CLIP	19536157
MIRT715990	hsa-miR-1304-3p	HITS-CLIP	19536157
MIRT715989	hsa-miR-4772-3p	HITS-CLIP	19536157
MIRT715988	hsa-miR-6778-3p	HITS-CLIP	19536157
MIRT715987	hsa-miR-6791-3p	HITS-CLIP	19536157
MIRT715986	hsa-miR-6829-3p	HITS-CLIP	19536157
MIRT715985	hsa-miR-4437	HITS-CLIP	19536157
MIRT715984	hsa-miR-5001-3p	HITS-CLIP	19536157
MIRT715983	hsa-miR-6836-3p	HITS-CLIP	19536157
MIRT689869	hsa-miR-4695-5p	HITS-CLIP	23313552
MIRT683457	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683456	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683455	hsa-miR-940	HITS-CLIP	23313552
MIRT683454	hsa-miR-3929	HITS-CLIP	23313552
MIRT683453	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683452	hsa-miR-4478	HITS-CLIP	23313552
MIRT683451	hsa-miR-6767-3p	HITS-CLIP	23313552
MIRT683450	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT689868	hsa-miR-4459	HITS-CLIP	23313552
MIRT683445	hsa-miR-665	HITS-CLIP	23313552
MIRT689867	hsa-miR-6840-3p	HITS-CLIP	23313552
MIRT683449	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT683448	hsa-miR-1827	HITS-CLIP	23313552
MIRT689866	hsa-miR-6087	HITS-CLIP	23313552
MIRT689865	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT689864	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT683447	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT683446	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT683457	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT683456	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT683455	hsa-miR-940	HITS-CLIP	23313552
MIRT683454	hsa-miR-3929	HITS-CLIP	23313552
MIRT683453	hsa-miR-4419b	HITS-CLIP	23313552
MIRT683452	hsa-miR-4478	HITS-CLIP	23313552
MIRT683451	hsa-miR-6767-3p	HITS-CLIP	23313552
MIRT683450	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT683449	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT683448	hsa-miR-1827	HITS-CLIP	23313552
MIRT683447	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT683446	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT683445	hsa-miR-665	HITS-CLIP	23313552
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609363	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609360	hsa-miR-4672	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609363	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT661416	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609360	hsa-miR-4672	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT636882	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT636881	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT636880	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT636879	hsa-miR-3190-5p	HITS-CLIP	23824327
MIRT636878	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT636877	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT636876	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT636875	hsa-miR-4435	HITS-CLIP	23824327
MIRT636874	hsa-miR-3677-5p	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609363	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609360	hsa-miR-4672	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609363	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609360	hsa-miR-4672	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609364	hsa-miR-8485	HITS-CLIP	23824327
MIRT609363	hsa-miR-6768-5p	HITS-CLIP	23824327
MIRT609362	hsa-miR-499a-3p	HITS-CLIP	23824327
MIRT609361	hsa-miR-499b-3p	HITS-CLIP	23824327
MIRT609360	hsa-miR-4672	HITS-CLIP	23824327
MIRT2166107	hsa-miR-185	CLIP-seq
MIRT2166108	hsa-miR-3180-5p	CLIP-seq
MIRT2166109	hsa-miR-4306	CLIP-seq
MIRT2166110	hsa-miR-4644	CLIP-seq
MIRT2166111	hsa-miR-4717-5p	CLIP-seq
MIRT2166112	hsa-miR-4766-3p	CLIP-seq

Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000038	Process	Very long-chain fatty acid metabolic process	IDA	16940157
GO:0001676	Process	Long-chain fatty acid metabolic process	IDA	16940157
GO:0005515	Function	Protein binding	IPI	25464930
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	16940157
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005782	Component	Peroxisomal matrix	TAS
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IBA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006637	Process	Acyl-CoA metabolic process	IBA
GO:0006637	Process	Acyl-CoA metabolic process	IDA	10944470, 16940157
GO:0006637	Process	Acyl-CoA metabolic process	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016790	Function	Thiolester hydrolase activity	IEA
GO:0032787	Process	Monocarboxylic acid metabolic process	IEA
GO:0047617	Function	Fatty acyl-CoA hydrolase activity	IBA
GO:0047617	Function	Fatty acyl-CoA hydrolase activity	IDA	10944470, 16940157
GO:0047617	Function	Fatty acyl-CoA hydrolase activity	IEA
GO:0052689	Function	Carboxylic ester hydrolase activity	IEA

MIM	HGNC	e!Ensembl
609972	18431	ENSG00000119673

P49753

Protein name

Acyl-coenzyme A thioesterase 2, mitochondrial (Acyl-CoA thioesterase 2) (EC 3.1.2.2) (Acyl-coenzyme A thioester hydrolase 2a) (CTE-Ia) (Long-chain acyl-CoA thioesterase 2) (ZAP128)

Protein function

Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:10944470, PubMed:16940157). Displays higher activity toward long chain acyl CoAs (C14-C20) (PubMed:10944

PDB

3HLK

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF04775	Bile_Hydr_Trans	78 → 203	Acyl-CoA thioester hydrolase/BAAT N-terminal region	Family
PF08840	BAAT_C	265 → 474	BAAT / Acyl-CoA thioester hydrolase C terminal	Domain

Tissue specificity

TISSUE SPECIFICITY: Strongest expression in heart, liver, muscle and kidney. Weak in placenta and pancreas. {ECO:0000269|PubMed:16940157}.

Sequence

MSNKLLSPHPHSVVLRSEFKMASSPAVLRASRLYQWSLKSSAQFLGSPQLRQVGQIIRVP
ARMAATLILEPAGRCCWDEPVRIAVRGLAPEQPVTLRASLRDEKGALFQAHARYRADTLG
ELDLERAPALGGSFAGLEPMGLLWALEPEKPLVRLVKRDVRTPLAVELEVLDGHDPDPGR
LLCQTRHERYFLPPGVRREPVRVGRVRGTLFLPPEPGPFPGIVDMFGTGGGLLEYRASLL
AGKGFAVMALAYYNYEDLPKTMETLHLEYFEEAMNYLLSHPEVKGPGVGLLGISKGGELC
LSMASFLKGITAAVVINGSVANVGGTLHYKGETLPPVGVNRNRIKVTKDGYADIVDVLNS
PLEGPDQKSFIPVERAESTFLFLVGQDDHNWKSEFYANEACKRLQAHGRRKPQIICYPET
GHYIEPPYFPLCRASLHALVGSPIIWGGEPRAHAMAQVDAWKQLQTFFHKHLGGHEGTIP
SKV

Sequence length

483

Interactions

View interactions

	KEGG		Reactome
	Fatty acid elongation Biosynthesis of unsaturated fatty acids Metabolic pathways Ovarian steroidogenesis		Mitochondrial Fatty Acid Beta-Oxidation Peroxisomal protein import

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
MYOCARDIAL ISCHEMIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Asthma	Associate	38375886	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemangioblastoma	Associate	33446752	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	36193167	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver Cirrhosis	Associate	37486962	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	32907841	★★★★★ ★☆☆☆☆ Found in Text Mining only
Severe Acute Respiratory Syndrome	Associate	38375886	★★★★★ ★☆☆☆☆ Found in Text Mining only

ACOT2 (acyl-CoA thioesterase 2)