Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10963
Gene name Gene Name - the full gene name approved by the HGNC.	Stress induced phosphoprotein 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	STIP1
Synonyms (NCBI Gene) Gene synonyms aliases	HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L
Chromosome Chromosome number	11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	11q13.1
Summary Summary of gene provided in NCBI Entrez Gene.	STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substra

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miRTarBase ID	miRNA	Experiments	Reference
MIRT032016	hsa-miR-16-5p	Proteomics	18668040
MIRT051957	hsa-let-7b-5p	CLASH	23622248
MIRT047040	hsa-miR-183-5p	CLASH	23622248
MIRT044894	hsa-miR-193a-3p	CLASH	23622248
MIRT041679	hsa-miR-484	CLASH	23622248
MIRT035915	hsa-miR-1180-3p	CLASH	23622248
MIRT439523	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439523	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1397117	hsa-miR-1270	CLIP-seq
MIRT1397118	hsa-miR-1827	CLIP-seq
MIRT1397119	hsa-miR-1909	CLIP-seq
MIRT1397120	hsa-miR-3616-3p	CLIP-seq
MIRT1397121	hsa-miR-3960	CLIP-seq
MIRT1397122	hsa-miR-410	CLIP-seq
MIRT1397123	hsa-miR-4434	CLIP-seq
MIRT1397124	hsa-miR-4436b-3p	CLIP-seq
MIRT1397125	hsa-miR-4516	CLIP-seq
MIRT1397126	hsa-miR-4531	CLIP-seq
MIRT1397127	hsa-miR-620	CLIP-seq
MIRT1397128	hsa-miR-885-3p	CLIP-seq
MIRT1397129	hsa-miR-892b	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT1397117	hsa-miR-1270	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2118880	hsa-miR-3154	CLIP-seq
MIRT2118881	hsa-miR-3179	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2118883	hsa-miR-3191	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT1397123	hsa-miR-4434	CLIP-seq
MIRT1397125	hsa-miR-4516	CLIP-seq
MIRT1397126	hsa-miR-4531	CLIP-seq
MIRT2118888	hsa-miR-4640-3p	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2118893	hsa-miR-568	CLIP-seq
MIRT1397127	hsa-miR-620	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT1397118	hsa-miR-1827	CLIP-seq
MIRT1397119	hsa-miR-1909	CLIP-seq
MIRT2341250	hsa-miR-2278	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2341251	hsa-miR-3120-3p	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2341252	hsa-miR-3192	CLIP-seq
MIRT1397120	hsa-miR-3616-3p	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2341253	hsa-miR-3689a-3p	CLIP-seq
MIRT2341254	hsa-miR-3689c	CLIP-seq
MIRT2341255	hsa-miR-3924	CLIP-seq
MIRT1397121	hsa-miR-3960	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT1397124	hsa-miR-4436b-3p	CLIP-seq
MIRT2341256	hsa-miR-4532	CLIP-seq
MIRT2118888	hsa-miR-4640-3p	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2341257	hsa-miR-4707-5p	CLIP-seq
MIRT2341258	hsa-miR-4709-3p	CLIP-seq
MIRT2341259	hsa-miR-4711-3p	CLIP-seq
MIRT2341260	hsa-miR-4728-5p	CLIP-seq
MIRT2341261	hsa-miR-4731-5p	CLIP-seq
MIRT2341262	hsa-miR-4786-5p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2341263	hsa-miR-548aa	CLIP-seq
MIRT2341264	hsa-miR-548ac	CLIP-seq
MIRT2341265	hsa-miR-548b-3p	CLIP-seq
MIRT2341266	hsa-miR-548d-3p	CLIP-seq
MIRT2341267	hsa-miR-548z	CLIP-seq
MIRT2118893	hsa-miR-568	CLIP-seq
MIRT2341268	hsa-miR-591	CLIP-seq
MIRT2341269	hsa-miR-593	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT1397128	hsa-miR-885-3p	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2341265	hsa-miR-548b-3p	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT1397118	hsa-miR-1827	CLIP-seq
MIRT1397119	hsa-miR-1909	CLIP-seq
MIRT2341250	hsa-miR-2278	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2341251	hsa-miR-3120-3p	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2635141	hsa-miR-3189-5p	CLIP-seq
MIRT2341252	hsa-miR-3192	CLIP-seq
MIRT1397120	hsa-miR-3616-3p	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2341253	hsa-miR-3689a-3p	CLIP-seq
MIRT2341254	hsa-miR-3689c	CLIP-seq
MIRT1397121	hsa-miR-3960	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT1397124	hsa-miR-4436b-3p	CLIP-seq
MIRT2118888	hsa-miR-4640-3p	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2341258	hsa-miR-4709-3p	CLIP-seq
MIRT2341260	hsa-miR-4728-5p	CLIP-seq
MIRT2341261	hsa-miR-4731-5p	CLIP-seq
MIRT2635142	hsa-miR-4758-3p	CLIP-seq
MIRT2341262	hsa-miR-4786-5p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2341263	hsa-miR-548aa	CLIP-seq
MIRT2341264	hsa-miR-548ac	CLIP-seq
MIRT2341265	hsa-miR-548b-3p	CLIP-seq
MIRT2341266	hsa-miR-548d-3p	CLIP-seq
MIRT2341267	hsa-miR-548z	CLIP-seq
MIRT2341268	hsa-miR-591	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT1397128	hsa-miR-885-3p	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT1397118	hsa-miR-1827	CLIP-seq
MIRT1397119	hsa-miR-1909	CLIP-seq
MIRT2341250	hsa-miR-2278	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2341251	hsa-miR-3120-3p	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2635141	hsa-miR-3189-5p	CLIP-seq
MIRT2341252	hsa-miR-3192	CLIP-seq
MIRT1397120	hsa-miR-3616-3p	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2341253	hsa-miR-3689a-3p	CLIP-seq
MIRT2341254	hsa-miR-3689c	CLIP-seq
MIRT1397121	hsa-miR-3960	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT1397124	hsa-miR-4436b-3p	CLIP-seq
MIRT2118888	hsa-miR-4640-3p	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2341258	hsa-miR-4709-3p	CLIP-seq
MIRT2341260	hsa-miR-4728-5p	CLIP-seq
MIRT2341261	hsa-miR-4731-5p	CLIP-seq
MIRT2635142	hsa-miR-4758-3p	CLIP-seq
MIRT2341262	hsa-miR-4786-5p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2341263	hsa-miR-548aa	CLIP-seq
MIRT2341264	hsa-miR-548ac	CLIP-seq
MIRT2341265	hsa-miR-548b-3p	CLIP-seq
MIRT2341266	hsa-miR-548d-3p	CLIP-seq
MIRT2341267	hsa-miR-548z	CLIP-seq
MIRT2341268	hsa-miR-591	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT1397128	hsa-miR-885-3p	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
HSF1	Unknown	20692357;22669480

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	20029029, 21044950, 21170051, 21360678, 23349634, 23431407, 24880080, 25036637, 27353360, 28330616, 28514442, 31980649, 32814053, 33961781, 35140242, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	1569099, 16130169
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	TAS	1569099
GO:0005829	Component	Cytosol	TAS
GO:0032991	Component	Protein-containing complex	IDA	23349634
GO:0051879	Function	Hsp90 protein binding	IBA
GO:0051879	Function	Hsp90 protein binding	IPI	29127155
GO:0098761	Process	Cellular response to interleukin-7	IEA
GO:0101031	Component	Protein folding chaperone complex	IDA	29127155
GO:0120293	Component	Dynein axonemal particle	IEA
GO:0120293	Component	Dynein axonemal particle	ISS

MIM	HGNC	e!Ensembl
605063	11387	ENSG00000168439

Protein

UniProt ID

P31948

Protein name

Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)

Protein function

Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).

PDB

1ELR , 1ELW , 2LNI , 2NC9 , 3ESK , 3FWV , 7KW7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17830	STI1	130 → 184	STI1 domain	Domain
PF13181	TPR_8	261 → 291	Tetratricopeptide repeat	Repeat
PF00515	TPR_1	300 → 332	Tetratricopeptide repeat	Repeat
PF00515	TPR_1	360 → 393	Tetratricopeptide repeat	Repeat
PF00515	TPR_1	394 → 427	Tetratricopeptide repeat	Repeat
PF17830	STI1	482 → 536	STI1 domain	Domain

Sequence

MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYED
GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLA
ERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLS
VLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKD
FDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIA
KAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLA
LEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEEC
IQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHD
SPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLI
AIR

Sequence length

543

Interactions

View interactions

	KEGG		Reactome
	Prion disease		HSP90 chaperone cycle for steroid hormone receptors (SHR)

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Attention Deficit Hyperactivity Disorder	Attention deficit hyperactivity disorder	N/A	N/A	GWAS
Schizophrenia	Schizophrenia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (32)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Adenomyosis	Associate	29304094, 29673672
Amyloid Neuropathies	Associate	24828240
Asthma	Associate	33208131
Attention Deficit Disorder with Hyperactivity	Associate	21784300
Breast Neoplasms	Associate	27026610
Carcinoma Hepatocellular	Associate	30138346
Carcinoma Renal Cell	Associate	28199984
Carcinoma Squamous Cell	Associate	28186972
Cholangiocarcinoma	Associate	25034945
Chronobiology Disorders	Associate	21784300
Colonic Neoplasms	Associate	20617406
Colorectal Neoplasms	Associate	22669480, 34890713
Diabetes Mellitus	Associate	35855056
Endometrial Neoplasms	Associate	29673672
Endometriosis	Associate	29304094, 29673672
Genital Neoplasms Female	Associate	29304094
Glaucoma	Associate	21850170
Glaucoma Open Angle	Associate	21850170
Leukemia Myeloid Chronic Phase	Associate	28117336
Low Tension Glaucoma	Associate	21850170
Lymphatic Metastasis	Stimulate	24163084
Melanoma	Associate	31103826
Myelodysplastic Syndromes	Inhibit	12411319
Neoplasm Metastasis	Associate	28199984, 31103826
Neoplasms	Associate	20501939, 20617406, 22669480, 27026610, 28186972, 29843139, 31103826, 35269562
Ovarian Neoplasms	Associate	20501939, 23468915, 24654750
Spinocerebellar Ataxias	Associate	35398354
Squamous Cell Carcinoma of Head and Neck	Associate	20497865
Status Asthmaticus	Associate	19254810
Stomach Neoplasms	Associate	29843139
Thyroid Cancer Papillary	Associate	24163084
Urinary Bladder Neoplasms	Associate	31250373

STIP1 (stress induced phosphoprotein 1)