Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID	10963
Gene name	Stress induced phosphoprotein 1
Gene symbol	STIP1
Synonyms (NCBI Gene)	HEL-S-94nHOPIEF-SSP-3521P60STI1STI1L
Chromosome	11
Chromosome location	11q13.1
Summary	STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substra

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miRTarBase ID	miRNA	Experiments	Reference
MIRT032016	hsa-miR-16-5p	Proteomics	18668040
MIRT051957	hsa-let-7b-5p	CLASH	23622248
MIRT047040	hsa-miR-183-5p	CLASH	23622248
MIRT044894	hsa-miR-193a-3p	CLASH	23622248
MIRT041679	hsa-miR-484	CLASH	23622248
MIRT035915	hsa-miR-1180-3p	CLASH	23622248
MIRT439523	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439523	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1397117	hsa-miR-1270	CLIP-seq
MIRT1397118	hsa-miR-1827	CLIP-seq
MIRT1397119	hsa-miR-1909	CLIP-seq
MIRT1397120	hsa-miR-3616-3p	CLIP-seq
MIRT1397121	hsa-miR-3960	CLIP-seq
MIRT1397122	hsa-miR-410	CLIP-seq
MIRT1397123	hsa-miR-4434	CLIP-seq
MIRT1397124	hsa-miR-4436b-3p	CLIP-seq
MIRT1397125	hsa-miR-4516	CLIP-seq
MIRT1397126	hsa-miR-4531	CLIP-seq
MIRT1397127	hsa-miR-620	CLIP-seq
MIRT1397128	hsa-miR-885-3p	CLIP-seq
MIRT1397129	hsa-miR-892b	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT1397117	hsa-miR-1270	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2118880	hsa-miR-3154	CLIP-seq
MIRT2118881	hsa-miR-3179	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2118883	hsa-miR-3191	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT1397123	hsa-miR-4434	CLIP-seq
MIRT1397125	hsa-miR-4516	CLIP-seq
MIRT1397126	hsa-miR-4531	CLIP-seq
MIRT2118888	hsa-miR-4640-3p	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2118893	hsa-miR-568	CLIP-seq
MIRT1397127	hsa-miR-620	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT1397118	hsa-miR-1827	CLIP-seq
MIRT1397119	hsa-miR-1909	CLIP-seq
MIRT2341250	hsa-miR-2278	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2341251	hsa-miR-3120-3p	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2341252	hsa-miR-3192	CLIP-seq
MIRT1397120	hsa-miR-3616-3p	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2341253	hsa-miR-3689a-3p	CLIP-seq
MIRT2341254	hsa-miR-3689c	CLIP-seq
MIRT2341255	hsa-miR-3924	CLIP-seq
MIRT1397121	hsa-miR-3960	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT1397124	hsa-miR-4436b-3p	CLIP-seq
MIRT2341256	hsa-miR-4532	CLIP-seq
MIRT2118888	hsa-miR-4640-3p	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2341257	hsa-miR-4707-5p	CLIP-seq
MIRT2341258	hsa-miR-4709-3p	CLIP-seq
MIRT2341259	hsa-miR-4711-3p	CLIP-seq
MIRT2341260	hsa-miR-4728-5p	CLIP-seq
MIRT2341261	hsa-miR-4731-5p	CLIP-seq
MIRT2341262	hsa-miR-4786-5p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2341263	hsa-miR-548aa	CLIP-seq
MIRT2341264	hsa-miR-548ac	CLIP-seq
MIRT2341265	hsa-miR-548b-3p	CLIP-seq
MIRT2341266	hsa-miR-548d-3p	CLIP-seq
MIRT2341267	hsa-miR-548z	CLIP-seq
MIRT2118893	hsa-miR-568	CLIP-seq
MIRT2341268	hsa-miR-591	CLIP-seq
MIRT2341269	hsa-miR-593	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT1397128	hsa-miR-885-3p	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2341265	hsa-miR-548b-3p	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT1397118	hsa-miR-1827	CLIP-seq
MIRT1397119	hsa-miR-1909	CLIP-seq
MIRT2341250	hsa-miR-2278	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2341251	hsa-miR-3120-3p	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2635141	hsa-miR-3189-5p	CLIP-seq
MIRT2341252	hsa-miR-3192	CLIP-seq
MIRT1397120	hsa-miR-3616-3p	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2341253	hsa-miR-3689a-3p	CLIP-seq
MIRT2341254	hsa-miR-3689c	CLIP-seq
MIRT1397121	hsa-miR-3960	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT1397124	hsa-miR-4436b-3p	CLIP-seq
MIRT2118888	hsa-miR-4640-3p	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2341258	hsa-miR-4709-3p	CLIP-seq
MIRT2341260	hsa-miR-4728-5p	CLIP-seq
MIRT2341261	hsa-miR-4731-5p	CLIP-seq
MIRT2635142	hsa-miR-4758-3p	CLIP-seq
MIRT2341262	hsa-miR-4786-5p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2341263	hsa-miR-548aa	CLIP-seq
MIRT2341264	hsa-miR-548ac	CLIP-seq
MIRT2341265	hsa-miR-548b-3p	CLIP-seq
MIRT2341266	hsa-miR-548d-3p	CLIP-seq
MIRT2341267	hsa-miR-548z	CLIP-seq
MIRT2341268	hsa-miR-591	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT1397128	hsa-miR-885-3p	CLIP-seq
MIRT2118878	hsa-miR-1207-3p	CLIP-seq
MIRT1397118	hsa-miR-1827	CLIP-seq
MIRT1397119	hsa-miR-1909	CLIP-seq
MIRT2341250	hsa-miR-2278	CLIP-seq
MIRT2118879	hsa-miR-2467-5p	CLIP-seq
MIRT2341251	hsa-miR-3120-3p	CLIP-seq
MIRT2118882	hsa-miR-3188	CLIP-seq
MIRT2635141	hsa-miR-3189-5p	CLIP-seq
MIRT2341252	hsa-miR-3192	CLIP-seq
MIRT1397120	hsa-miR-3616-3p	CLIP-seq
MIRT2118884	hsa-miR-3649	CLIP-seq
MIRT2118885	hsa-miR-3652	CLIP-seq
MIRT2341253	hsa-miR-3689a-3p	CLIP-seq
MIRT2341254	hsa-miR-3689c	CLIP-seq
MIRT1397121	hsa-miR-3960	CLIP-seq
MIRT2118886	hsa-miR-3975	CLIP-seq
MIRT2118887	hsa-miR-4430	CLIP-seq
MIRT1397124	hsa-miR-4436b-3p	CLIP-seq
MIRT2118888	hsa-miR-4640-3p	CLIP-seq
MIRT2118889	hsa-miR-4649-3p	CLIP-seq
MIRT2341258	hsa-miR-4709-3p	CLIP-seq
MIRT2341260	hsa-miR-4728-5p	CLIP-seq
MIRT2341261	hsa-miR-4731-5p	CLIP-seq
MIRT2635142	hsa-miR-4758-3p	CLIP-seq
MIRT2341262	hsa-miR-4786-5p	CLIP-seq
MIRT2118890	hsa-miR-485-5p	CLIP-seq
MIRT2118891	hsa-miR-492	CLIP-seq
MIRT2118892	hsa-miR-544b	CLIP-seq
MIRT2341263	hsa-miR-548aa	CLIP-seq
MIRT2341264	hsa-miR-548ac	CLIP-seq
MIRT2341265	hsa-miR-548b-3p	CLIP-seq
MIRT2341266	hsa-miR-548d-3p	CLIP-seq
MIRT2341267	hsa-miR-548z	CLIP-seq
MIRT2341268	hsa-miR-591	CLIP-seq
MIRT2118894	hsa-miR-7	CLIP-seq
MIRT1397128	hsa-miR-885-3p	CLIP-seq

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Transcription factor	Regulation	Reference
HSF1	Unknown	20692357;22669480

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GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	20029029, 21044950, 21170051, 21360678, 23349634, 23431407, 24880080, 25036637, 27353360, 28330616, 28514442, 31980649, 32814053, 33961781, 35140242, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	1569099, 16130169
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	TAS	1569099
GO:0005829	Component	Cytosol	TAS
GO:0032991	Component	Protein-containing complex	IDA	23349634
GO:0051879	Function	Hsp90 protein binding	IBA
GO:0051879	Function	Hsp90 protein binding	IPI	29127155
GO:0098761	Process	Cellular response to interleukin-7	IEA
GO:0101031	Component	Protein folding chaperone complex	IDA	29127155
GO:0120293	Component	Dynein axonemal particle	IEA
GO:0120293	Component	Dynein axonemal particle	ISS

MIM	HGNC	e!Ensembl
605063	11387	ENSG00000168439

P31948

Protein name

Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)

Protein function

Acts as a co-chaperone for HSP90AA1 (PubMed:27353360). Mediates the association of the molecular chaperones HSPA8/HSC70 and HSP90 (By similarity).

PDB

1ELR , 1ELW , 2LNI , 2NC9 , 3ESK , 3FWV , 7KW7

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17830	STI1	130 → 184	STI1 domain	Domain
PF13181	TPR_8	261 → 291	Tetratricopeptide repeat	Repeat
PF00515	TPR_1	300 → 332	Tetratricopeptide repeat	Repeat
PF00515	TPR_1	360 → 393	Tetratricopeptide repeat	Repeat
PF00515	TPR_1	394 → 427	Tetratricopeptide repeat	Repeat
PF17830	STI1	482 → 536	STI1 domain	Domain

Sequence

MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYED
GCKTVDLKPDWGKGYSRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLA
ERKFMNPFNMPNLYQKLESDPRTRTLLSDPTYRELIEQLRNKPSDLGTKLQDPRIMTTLS
VLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQALKEKELGNDAYKKKD
FDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIA
KAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLA
LEEKNKGNECFQKGDYPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEEC
IQLEPTFIKGYTRKAAALEAMKDYTKAMDVYQKALDLDSSCKEAADGYQRCMMAQYNRHD
SPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNPVIAQKIQKLMDVGLI
AIR

Sequence length

543

Interactions

View interactions

	KEGG		Reactome
	Prion disease		HSP90 chaperone cycle for steroid hormone receptors (SHR)

STIP1 (stress induced phosphoprotein 1)