MLLT11 (MLLT11 transcription factor 7 cofactor)

Gene

• Entrez ID: 10962
• Gene name: MLLT11 transcription factor 7 cofactor
• Gene symbol: MLLT11
• Synonyms (NCBI Gene): AF1Q
• Chromosome: 1
• Chromosome location: 1q21.3
• Summary: The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005154	hsa-miR-30a-5p	pSILAC	18668040
MIRT001441	hsa-miR-16-5p	pSILAC	18668040
MIRT016055	hsa-miR-374b-5p	Sequencing	20371350
MIRT005154	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT001441	hsa-miR-16-5p	Proteomics;Other	18668040
MIRT445958	hsa-miR-6873-5p	PAR-CLIP	22100165
MIRT445957	hsa-miR-4476	PAR-CLIP	22100165
MIRT445956	hsa-miR-6876-5p	PAR-CLIP	22100165
MIRT445955	hsa-miR-6085	PAR-CLIP	22100165
MIRT445954	hsa-miR-6813-5p	PAR-CLIP	22100165
MIRT445953	hsa-miR-3179	PAR-CLIP	22100165
MIRT445952	hsa-miR-3202	PAR-CLIP	22100165
MIRT445950	hsa-miR-3978	PAR-CLIP	22100165
MIRT445951	hsa-miR-6124	PAR-CLIP	22100165
MIRT445949	hsa-miR-6780a-5p	PAR-CLIP	22100165
MIRT445958	hsa-miR-6873-5p	PAR-CLIP	22100165
MIRT445957	hsa-miR-4476	PAR-CLIP	22100165
MIRT445956	hsa-miR-6876-5p	PAR-CLIP	22100165
MIRT445955	hsa-miR-6085	PAR-CLIP	22100165
MIRT445954	hsa-miR-6813-5p	PAR-CLIP	22100165
MIRT445953	hsa-miR-3179	PAR-CLIP	22100165
MIRT445952	hsa-miR-3202	PAR-CLIP	22100165
MIRT445950	hsa-miR-3978	PAR-CLIP	22100165
MIRT445951	hsa-miR-6124	PAR-CLIP	22100165
MIRT445949	hsa-miR-6780a-5p	PAR-CLIP	22100165
MIRT1152063	hsa-miR-1182	CLIP-seq
MIRT1152064	hsa-miR-1206	CLIP-seq
MIRT1152065	hsa-miR-186	CLIP-seq
MIRT1152066	hsa-miR-3127-5p	CLIP-seq
MIRT1152067	hsa-miR-3148	CLIP-seq
MIRT1152068	hsa-miR-3915	CLIP-seq
MIRT1152069	hsa-miR-3921	CLIP-seq
MIRT1152070	hsa-miR-3928	CLIP-seq
MIRT1152071	hsa-miR-4649-3p	CLIP-seq
MIRT1152072	hsa-miR-4653-5p	CLIP-seq
MIRT1152073	hsa-miR-579	CLIP-seq
MIRT2043292	hsa-miR-105	CLIP-seq
MIRT2043293	hsa-miR-25	CLIP-seq
MIRT2043294	hsa-miR-32	CLIP-seq
MIRT2043295	hsa-miR-363	CLIP-seq
MIRT2043296	hsa-miR-367	CLIP-seq
MIRT2043297	hsa-miR-518a-5p	CLIP-seq
MIRT2043298	hsa-miR-527	CLIP-seq
MIRT2043299	hsa-miR-92a	CLIP-seq
MIRT2043300	hsa-miR-92b	CLIP-seq
MIRT2272692	hsa-miR-29a	CLIP-seq
MIRT2272693	hsa-miR-29b	CLIP-seq
MIRT2272694	hsa-miR-29c	CLIP-seq
MIRT2272695	hsa-miR-3065-3p	CLIP-seq
MIRT2454195	hsa-miR-3119	CLIP-seq
MIRT2454196	hsa-miR-3140-3p	CLIP-seq
MIRT2454197	hsa-miR-411	CLIP-seq
MIRT2454198	hsa-miR-4694-3p	CLIP-seq
MIRT2454199	hsa-miR-539	CLIP-seq
MIRT2571564	hsa-miR-106a	CLIP-seq
MIRT2571565	hsa-miR-106b	CLIP-seq
MIRT2571566	hsa-miR-1258	CLIP-seq
MIRT2571567	hsa-miR-1273e	CLIP-seq
MIRT2571568	hsa-miR-127-5p	CLIP-seq
MIRT2571569	hsa-miR-1305	CLIP-seq
MIRT2571570	hsa-miR-134	CLIP-seq
MIRT2571571	hsa-miR-136	CLIP-seq
MIRT2571572	hsa-miR-146b-3p	CLIP-seq
MIRT2571573	hsa-miR-17	CLIP-seq
MIRT2571574	hsa-miR-200b	CLIP-seq
MIRT2571575	hsa-miR-200c	CLIP-seq
MIRT2571576	hsa-miR-20a	CLIP-seq
MIRT2571577	hsa-miR-20b	CLIP-seq
MIRT2571578	hsa-miR-216b	CLIP-seq
MIRT2571579	hsa-miR-28-5p	CLIP-seq
MIRT2571580	hsa-miR-3118	CLIP-seq
MIRT2454195	hsa-miR-3119	CLIP-seq
MIRT2571581	hsa-miR-3130-5p	CLIP-seq
MIRT2571582	hsa-miR-3139	CLIP-seq
MIRT2454196	hsa-miR-3140-3p	CLIP-seq
MIRT2571583	hsa-miR-3145-5p	CLIP-seq
MIRT2571584	hsa-miR-3150a-5p	CLIP-seq
MIRT2571585	hsa-miR-3150b-5p	CLIP-seq
MIRT2571586	hsa-miR-3154	CLIP-seq
MIRT2571587	hsa-miR-3158-3p	CLIP-seq
MIRT2571588	hsa-miR-3161	CLIP-seq
MIRT2571589	hsa-miR-3164	CLIP-seq
MIRT2571590	hsa-miR-3173-5p	CLIP-seq
MIRT2571591	hsa-miR-3174	CLIP-seq
MIRT2571592	hsa-miR-3185	CLIP-seq
MIRT2571593	hsa-miR-34c-3p	CLIP-seq
MIRT2571594	hsa-miR-3609	CLIP-seq
MIRT2571595	hsa-miR-3611	CLIP-seq
MIRT2571596	hsa-miR-3614-3p	CLIP-seq
MIRT2571597	hsa-miR-3616-3p	CLIP-seq
MIRT2571598	hsa-miR-382	CLIP-seq
MIRT1152069	hsa-miR-3921	CLIP-seq
MIRT2454197	hsa-miR-411	CLIP-seq
MIRT2571599	hsa-miR-4254	CLIP-seq
MIRT2571600	hsa-miR-4266	CLIP-seq
MIRT2571601	hsa-miR-429	CLIP-seq
MIRT2571602	hsa-miR-4308	CLIP-seq
MIRT2571603	hsa-miR-4475	CLIP-seq
MIRT2571604	hsa-miR-4477b	CLIP-seq
MIRT2571605	hsa-miR-4482	CLIP-seq
MIRT2571606	hsa-miR-452	CLIP-seq
MIRT2571607	hsa-miR-4635	CLIP-seq
MIRT1152072	hsa-miR-4653-5p	CLIP-seq
MIRT2571608	hsa-miR-4676-3p	CLIP-seq
MIRT2454198	hsa-miR-4694-3p	CLIP-seq
MIRT2571609	hsa-miR-4699-3p	CLIP-seq
MIRT2571610	hsa-miR-4709-3p	CLIP-seq
MIRT2571611	hsa-miR-4712-5p	CLIP-seq
MIRT2571612	hsa-miR-4721	CLIP-seq
MIRT2571613	hsa-miR-4780	CLIP-seq
MIRT2571614	hsa-miR-4796-3p	CLIP-seq
MIRT2571615	hsa-miR-487a	CLIP-seq
MIRT2571616	hsa-miR-508-5p	CLIP-seq
MIRT2571617	hsa-miR-519d	CLIP-seq
MIRT2454199	hsa-miR-539	CLIP-seq
MIRT2571618	hsa-miR-548a-3p	CLIP-seq
MIRT2571619	hsa-miR-548ac	CLIP-seq
MIRT2571620	hsa-miR-548ae	CLIP-seq
MIRT2571621	hsa-miR-548ah	CLIP-seq
MIRT2571622	hsa-miR-548aj	CLIP-seq
MIRT2571623	hsa-miR-548am	CLIP-seq
MIRT2571624	hsa-miR-548d-3p	CLIP-seq
MIRT2571625	hsa-miR-548e	CLIP-seq
MIRT2571626	hsa-miR-548f	CLIP-seq
MIRT2571627	hsa-miR-548x	CLIP-seq
MIRT2571628	hsa-miR-548z	CLIP-seq
MIRT2571629	hsa-miR-599	CLIP-seq
MIRT2571630	hsa-miR-633	CLIP-seq
MIRT2571631	hsa-miR-708	CLIP-seq
MIRT2571632	hsa-miR-758	CLIP-seq
MIRT2571633	hsa-miR-770-5p	CLIP-seq
MIRT2571634	hsa-miR-874	CLIP-seq
MIRT2571635	hsa-miR-93	CLIP-seq
MIRT2571564	hsa-miR-106a	CLIP-seq
MIRT2571565	hsa-miR-106b	CLIP-seq
MIRT2571566	hsa-miR-1258	CLIP-seq
MIRT2571567	hsa-miR-1273e	CLIP-seq
MIRT2571569	hsa-miR-1305	CLIP-seq
MIRT2685066	hsa-miR-1321	CLIP-seq
MIRT2571570	hsa-miR-134	CLIP-seq
MIRT2571571	hsa-miR-136	CLIP-seq
MIRT2571572	hsa-miR-146b-3p	CLIP-seq
MIRT2571573	hsa-miR-17	CLIP-seq
MIRT2571574	hsa-miR-200b	CLIP-seq
MIRT2571575	hsa-miR-200c	CLIP-seq
MIRT2571576	hsa-miR-20a	CLIP-seq
MIRT2571577	hsa-miR-20b	CLIP-seq
MIRT2571578	hsa-miR-216b	CLIP-seq
MIRT2571579	hsa-miR-28-5p	CLIP-seq
MIRT2272692	hsa-miR-29a	CLIP-seq
MIRT2272693	hsa-miR-29b	CLIP-seq
MIRT2272694	hsa-miR-29c	CLIP-seq
MIRT2272695	hsa-miR-3065-3p	CLIP-seq
MIRT2571580	hsa-miR-3118	CLIP-seq
MIRT2454195	hsa-miR-3119	CLIP-seq
MIRT2685067	hsa-miR-3128	CLIP-seq
MIRT2571581	hsa-miR-3130-5p	CLIP-seq
MIRT2571582	hsa-miR-3139	CLIP-seq
MIRT2454196	hsa-miR-3140-3p	CLIP-seq
MIRT2571583	hsa-miR-3145-5p	CLIP-seq
MIRT2571584	hsa-miR-3150a-5p	CLIP-seq
MIRT2571585	hsa-miR-3150b-5p	CLIP-seq
MIRT2571586	hsa-miR-3154	CLIP-seq
MIRT2571587	hsa-miR-3158-3p	CLIP-seq
MIRT2571588	hsa-miR-3161	CLIP-seq
MIRT2685068	hsa-miR-3162-5p	CLIP-seq
MIRT2571589	hsa-miR-3164	CLIP-seq
MIRT2571590	hsa-miR-3173-5p	CLIP-seq
MIRT2571591	hsa-miR-3174	CLIP-seq
MIRT2571592	hsa-miR-3185	CLIP-seq
MIRT2571593	hsa-miR-34c-3p	CLIP-seq
MIRT2571594	hsa-miR-3609	CLIP-seq
MIRT2571595	hsa-miR-3611	CLIP-seq
MIRT2571596	hsa-miR-3614-3p	CLIP-seq
MIRT2571597	hsa-miR-3616-3p	CLIP-seq
MIRT2685069	hsa-miR-376c	CLIP-seq
MIRT2571598	hsa-miR-382	CLIP-seq
MIRT1152069	hsa-miR-3921	CLIP-seq
MIRT2454197	hsa-miR-411	CLIP-seq
MIRT2571599	hsa-miR-4254	CLIP-seq
MIRT2571600	hsa-miR-4266	CLIP-seq
MIRT2571601	hsa-miR-429	CLIP-seq
MIRT2571602	hsa-miR-4308	CLIP-seq
MIRT2571603	hsa-miR-4475	CLIP-seq
MIRT2571604	hsa-miR-4477b	CLIP-seq
MIRT2571605	hsa-miR-4482	CLIP-seq
MIRT2571606	hsa-miR-452	CLIP-seq
MIRT2571607	hsa-miR-4635	CLIP-seq
MIRT1152072	hsa-miR-4653-5p	CLIP-seq
MIRT2571608	hsa-miR-4676-3p	CLIP-seq
MIRT2454198	hsa-miR-4694-3p	CLIP-seq
MIRT2571609	hsa-miR-4699-3p	CLIP-seq
MIRT2571610	hsa-miR-4709-3p	CLIP-seq
MIRT2571611	hsa-miR-4712-5p	CLIP-seq
MIRT2685070	hsa-miR-4720-5p	CLIP-seq
MIRT2571612	hsa-miR-4721	CLIP-seq
MIRT2685071	hsa-miR-4739	CLIP-seq
MIRT2685072	hsa-miR-4756-5p	CLIP-seq
MIRT2571613	hsa-miR-4780	CLIP-seq
MIRT2571614	hsa-miR-4796-3p	CLIP-seq
MIRT2685073	hsa-miR-4799-3p	CLIP-seq
MIRT2571615	hsa-miR-487a	CLIP-seq
MIRT2571616	hsa-miR-508-5p	CLIP-seq
MIRT2571617	hsa-miR-519d	CLIP-seq
MIRT2454199	hsa-miR-539	CLIP-seq
MIRT2571618	hsa-miR-548a-3p	CLIP-seq
MIRT2571619	hsa-miR-548ac	CLIP-seq
MIRT2571620	hsa-miR-548ae	CLIP-seq
MIRT2571621	hsa-miR-548ah	CLIP-seq
MIRT2571622	hsa-miR-548aj	CLIP-seq
MIRT2571623	hsa-miR-548am	CLIP-seq
MIRT2571624	hsa-miR-548d-3p	CLIP-seq
MIRT2571625	hsa-miR-548e	CLIP-seq
MIRT2571626	hsa-miR-548f	CLIP-seq
MIRT2571627	hsa-miR-548x	CLIP-seq
MIRT2571628	hsa-miR-548z	CLIP-seq
MIRT2685074	hsa-miR-577	CLIP-seq
MIRT2571629	hsa-miR-599	CLIP-seq
MIRT2571630	hsa-miR-633	CLIP-seq
MIRT2571631	hsa-miR-708	CLIP-seq
MIRT2571632	hsa-miR-758	CLIP-seq
MIRT2571633	hsa-miR-770-5p	CLIP-seq
MIRT2571634	hsa-miR-874	CLIP-seq
MIRT2571635	hsa-miR-93	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	26079538, 28514442, 33961781, 35253622
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IMP	18852119
GO:0045893	Process	Positive regulation of DNA-templated transcription	IBA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	18852119
GO:0051901	Process	Positive regulation of mitochondrial depolarization	IBA
GO:0051901	Process	Positive regulation of mitochondrial depolarization	IDA	18852119
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IBA
GO:0090200	Process	Positive regulation of release of cytochrome c from mitochondria	IDA	18852119
GO:0097190	Process	Apoptotic signaling pathway	IEA
GO:0097191	Process	Extrinsic apoptotic signaling pathway	IDA	18852119
GO:0097193	Process	Intrinsic apoptotic signaling pathway	IDA	18852119

Other IDs

• MIM: 604684
• HGNC: 16997
• e!Ensembl: ENSG00000213190

Protein

• UniProt ID: Q13015
• Protein name: Protein AF1q
• Protein function: Cofactor for the transcription factor TCF7 (PubMed:26079538). Involved in regulation of lymphoid development by driving multipotent hematopoietic progenitor cells towards a T cell fate (PubMed:21715312). {ECO:0000269|PubMed:21715312, ECO:0000269
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15017	WRNPLPNID	7 → 79	Putative WW-binding domain and destruction box	Disordered

• Tissue specificity: TISSUE SPECIFICITY: Expressed in myoepithelial cells of normal breast tissue (at protein level) (PubMed:26079538). Highly expressed in thymus (PubMed:7833468). Expressed in colon, small intestine, prostate and ovary. Not detected in peripheral blood lymph
• Sequence:

  MRDPVSSQYSSFLFWRMPIPELDLSELEGLGLSDTATYKVKDSSVGKMIGQATAADQEKN
  PEGDGLLEYSTFNFWRAPIASIHSFELDLL

• Sequence length: 90

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BURKITT LYMPHOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Breast Neoplasms	Associate	38075552	★☆☆☆☆ Found in Text Mining only
Carcinoma Adenoid Cystic	Associate	31273546	★☆☆☆☆ Found in Text Mining only
Endometriosis	Inhibit	38203610	★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Associate	31671695	★☆☆☆☆ Found in Text Mining only
Hematologic Neoplasms	Associate	31671695	★☆☆☆☆ Found in Text Mining only
Leukemia	Associate	15217837, 7833468	★☆☆☆☆ Found in Text Mining only
Leukemia Myelogenous Chronic BCR ABL Positive	Stimulate	30154435	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	15217837, 19396856, 22846743	★☆☆☆☆ Found in Text Mining only
Leukemia Myelomonocytic Acute	Associate	7833468	★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Stimulate	31273546	★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Associate	15638856, 19396856, 21496004	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	28423573, 31273546, 31671695, 38203610	★☆☆☆☆ Found in Text Mining only
Oncogene Addiction	Associate	17167184	★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	28423573	★☆☆☆☆ Found in Text Mining only
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	21496004, 28423573	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Associate	36686485	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms Castration Resistant	Associate	36686485	★☆☆☆☆ Found in Text Mining only
Testicular Germ Cell Tumor	Associate	17167184	★☆☆☆☆ Found in Text Mining only