Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10959
Gene name Gene Name - the full gene name approved by the HGNC.
Transmembrane p24 trafficking protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TMED2
Synonyms (NCBI Gene) Gene synonyms aliases
P24A, RNP24, p24, p24b1, p24beta1
Chromosome Chromosome number
12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
12q24.31
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005187 hsa-miR-30a-5p pSILAC 18668040
MIRT016541 hsa-miR-193b-3p Proteomics 21512034
MIRT005187 hsa-miR-30a-5p Proteomics;Other 18668040
MIRT047764 hsa-miR-7-5p CLASH 23622248
MIRT039998 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane TAS
GO:0001701 Process In utero embryonic development IEA
GO:0001756 Process Somitogenesis IEA
GO:0001843 Process Neural tube closure IEA
GO:0001892 Process Embryonic placenta development IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
619642 16996 ENSG00000086598
Protein
UniProt ID Q15363
Protein name Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1)
Protein function Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesic
PDB 5AZW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01105 EMP24_GP25L 20 196 emp24/gp25L/p24 family/GOLD Domain
Sequence
Sequence length 201
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Pre-NOTCH Processing in Golgi
COPII-mediated vesicle transport
Cargo concentration in the ER
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Breast Cancer Postmenopausal breast cancer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acquired Immunodeficiency Syndrome Associate 17878955
Adenocarcinoma of Lung Associate 35135563
Anti Neutrophil Cytoplasmic Antibody Associated Vasculitis Associate 25060059
Arthritis Rheumatoid Associate 2774054
Autoimmune Diseases Associate 25060059
Breast Neoplasms Associate 2372491
Carcinogenesis Associate 40519935
Carcinoma Giant Cell Associate 11689650
Carcinoma Hepatocellular Associate 33210454
Colorectal Neoplasms Associate 35924107