Gene Gene information from NCBI Gene database.
Entrez ID 10955
Gene name Serine incorporator 3
Gene symbol SERINC3
Synonyms (NCBI Gene)
AIGP1DIFF33SBBI99TDETDE1TMS-1
Chromosome 20
Chromosome location 20q13.12
miRNA miRNA information provided by mirtarbase database.
776
miRTarBase ID miRNA Experiments Reference
MIRT005842 hsa-miR-204-5p Luciferase reporter assayMicroarrayqRT-PCR 21282569
MIRT020296 hsa-miR-130b-3p Sequencing 20371350
MIRT024221 hsa-miR-218-5p Sequencing 20371350
MIRT031259 hsa-miR-19b-3p Sequencing 20371350
MIRT039739 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
20
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0002376 Process Immune system process IEA
GO:0005515 Function Protein binding IPI 32814053
GO:0005737 Component Cytoplasm IEA
GO:0005794 Component Golgi apparatus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607165 11699 ENSG00000132824
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13530
Protein name Serine incorporator 3 (Tumor differentially expressed protein 1)
Protein function Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP
PDB 7RU6 , 7RUG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03348 Serinc 16 471 Serine incorporator (Serinc) Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues. {ECO:0000269|PubMed:10559794}.
Sequence
Sequence length 473
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Viral life cycle - HIV-1   Serine biosynthesis