Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10955
Gene name Gene Name - the full gene name approved by the HGNC.
Serine incorporator 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SERINC3
Synonyms (NCBI Gene) Gene synonyms aliases
AIGP1, DIFF33, SBBI99, TDE, TDE1, TMS-1
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q13.12
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005842 hsa-miR-204-5p Luciferase reporter assay, Microarray, qRT-PCR 21282569
MIRT020296 hsa-miR-130b-3p Sequencing 20371350
MIRT024221 hsa-miR-218-5p Sequencing 20371350
MIRT031259 hsa-miR-19b-3p Sequencing 20371350
MIRT039739 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0005515 Function Protein binding IPI 32814053
GO:0005886 Component Plasma membrane TAS
GO:0006564 Process L-serine biosynthetic process TAS
GO:0006658 Process Phosphatidylserine metabolic process IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607165 11699 ENSG00000132824
Protein
UniProt ID Q13530
Protein name Serine incorporator 3 (Tumor differentially expressed protein 1)
Protein function Restriction factor required to restrict infectivity of lentiviruses, such as HIV-1: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm (PubMed:26416733, PubMed:26416734). Non-ATP
PDB 7RU6 , 7RUG
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03348 Serinc 16 471 Serine incorporator (Serinc) Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Expression levels were increased fourfold to tenfold in lung tumor tissues compared with normal pulmonary tissues. {ECO:0000269|PubMed:10559794}.
Sequence
Sequence length 473
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Viral life cycle - HIV-1   Serine biosynthesis
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Malignant neoplasm of prostate rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 17013881
Associations from Text Mining
Disease Name Relationship Type References
Colitis Ulcerative Associate 37345922
HIV Infections Associate 26416733, 40200291
Inflammatory Bowel Diseases Associate 37345922
Neoplasms Associate 37952080
Ovarian Neoplasms Associate 16928264