STARD3 (StAR related lipid transfer domain containing 3)

Gene

• Entrez ID: 10948
• Gene name: StAR related lipid transfer domain containing 3
• Gene symbol: STARD3
• Synonyms (NCBI Gene): CAB1, MLN64, es64
• Chromosome: 17
• Chromosome location: 17q12
• Summary: This gene encodes a member of a subfamily of lipid trafficking proteins that are characterized by a C-terminal steroidogenic acute regulatory domain and an N-terminal metastatic lymph node 64 domain. The encoded protein localizes to the membranes of late

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT489075	hsa-miR-3714	PAR-CLIP	23592263
MIRT489074	hsa-miR-4476	PAR-CLIP	23592263
MIRT489073	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT489071	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT489072	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT489070	hsa-miR-940	PAR-CLIP	23592263
MIRT489069	hsa-miR-1321	PAR-CLIP	23592263
MIRT489068	hsa-miR-4739	PAR-CLIP	23592263
MIRT489067	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT489066	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT489065	hsa-miR-4419a	PAR-CLIP	23592263
MIRT489064	hsa-miR-4510	PAR-CLIP	23592263
MIRT489063	hsa-miR-6127	PAR-CLIP	23592263
MIRT489062	hsa-miR-6129	PAR-CLIP	23592263
MIRT489061	hsa-miR-6130	PAR-CLIP	23592263
MIRT489059	hsa-miR-6133	PAR-CLIP	23592263
MIRT489060	hsa-miR-3194-5p	PAR-CLIP	23592263
MIRT489058	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT489057	hsa-miR-765	PAR-CLIP	23592263
MIRT489056	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT489055	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT489054	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT489053	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT489052	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT489051	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT489050	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT489075	hsa-miR-3714	PAR-CLIP	23592263
MIRT489074	hsa-miR-4476	PAR-CLIP	23592263
MIRT489073	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT489071	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT489072	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT489070	hsa-miR-940	PAR-CLIP	23592263
MIRT489069	hsa-miR-1321	PAR-CLIP	23592263
MIRT489068	hsa-miR-4739	PAR-CLIP	23592263
MIRT489067	hsa-miR-4756-5p	PAR-CLIP	23592263
MIRT489066	hsa-miR-605-3p	PAR-CLIP	23592263
MIRT489065	hsa-miR-4419a	PAR-CLIP	23592263
MIRT489064	hsa-miR-4510	PAR-CLIP	23592263
MIRT489063	hsa-miR-6127	PAR-CLIP	23592263
MIRT489062	hsa-miR-6129	PAR-CLIP	23592263
MIRT489061	hsa-miR-6130	PAR-CLIP	23592263
MIRT489059	hsa-miR-6133	PAR-CLIP	23592263
MIRT489060	hsa-miR-3194-5p	PAR-CLIP	23592263
MIRT489058	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT489057	hsa-miR-765	PAR-CLIP	23592263
MIRT489056	hsa-miR-1249-5p	PAR-CLIP	23592263
MIRT489055	hsa-miR-6797-5p	PAR-CLIP	23592263
MIRT489054	hsa-miR-7106-5p	PAR-CLIP	23592263
MIRT489053	hsa-miR-149-3p	PAR-CLIP	23592263
MIRT489052	hsa-miR-4728-5p	PAR-CLIP	23592263
MIRT489051	hsa-miR-6785-5p	PAR-CLIP	23592263
MIRT489050	hsa-miR-6883-5p	PAR-CLIP	23592263
MIRT1395289	hsa-miR-1291	CLIP-seq
MIRT1395290	hsa-miR-1827	CLIP-seq
MIRT1395291	hsa-miR-3192	CLIP-seq
MIRT1395292	hsa-miR-361-3p	CLIP-seq
MIRT1395293	hsa-miR-3689a-3p	CLIP-seq
MIRT1395294	hsa-miR-3689c	CLIP-seq
MIRT1395295	hsa-miR-374c	CLIP-seq
MIRT1395296	hsa-miR-4292	CLIP-seq
MIRT1395297	hsa-miR-4307	CLIP-seq
MIRT1395298	hsa-miR-4459	CLIP-seq
MIRT1395299	hsa-miR-4695-5p	CLIP-seq
MIRT1395300	hsa-miR-4716-3p	CLIP-seq
MIRT1395301	hsa-miR-4756-3p	CLIP-seq
MIRT1395302	hsa-miR-4760-3p	CLIP-seq
MIRT1395303	hsa-miR-4779	CLIP-seq
MIRT1395304	hsa-miR-520d-5p	CLIP-seq
MIRT1395305	hsa-miR-524-5p	CLIP-seq
MIRT1395306	hsa-miR-655	CLIP-seq
MIRT1395307	hsa-miR-661	CLIP-seq
MIRT1395308	hsa-miR-665	CLIP-seq
MIRT2118566	hsa-miR-4645-5p	CLIP-seq
MIRT2118567	hsa-miR-4673	CLIP-seq
MIRT2340691	hsa-let-7a	CLIP-seq
MIRT2340692	hsa-let-7b	CLIP-seq
MIRT2340693	hsa-let-7c	CLIP-seq
MIRT2340694	hsa-let-7d	CLIP-seq
MIRT2340695	hsa-let-7e	CLIP-seq
MIRT2340696	hsa-let-7f	CLIP-seq
MIRT2340697	hsa-let-7g	CLIP-seq
MIRT2340698	hsa-let-7i	CLIP-seq
MIRT2340699	hsa-miR-106a	CLIP-seq
MIRT2340700	hsa-miR-106b	CLIP-seq
MIRT2340701	hsa-miR-10a	CLIP-seq
MIRT2340702	hsa-miR-10b	CLIP-seq
MIRT2340703	hsa-miR-1207-5p	CLIP-seq
MIRT2340704	hsa-miR-1224-3p	CLIP-seq
MIRT2340705	hsa-miR-1225-3p	CLIP-seq
MIRT2340706	hsa-miR-1228	CLIP-seq
MIRT2340707	hsa-miR-1245b-3p	CLIP-seq
MIRT2340708	hsa-miR-1273	CLIP-seq
MIRT2340709	hsa-miR-1286	CLIP-seq
MIRT2340710	hsa-miR-1289	CLIP-seq
MIRT1395289	hsa-miR-1291	CLIP-seq
MIRT2340711	hsa-miR-1299	CLIP-seq
MIRT2340712	hsa-miR-142-5p	CLIP-seq
MIRT2340713	hsa-miR-146b-3p	CLIP-seq
MIRT2340714	hsa-miR-149	CLIP-seq
MIRT2340715	hsa-miR-1538	CLIP-seq
MIRT2340716	hsa-miR-17	CLIP-seq
MIRT2340717	hsa-miR-1825	CLIP-seq
MIRT1395290	hsa-miR-1827	CLIP-seq
MIRT2340718	hsa-miR-1908	CLIP-seq
MIRT2340719	hsa-miR-1909	CLIP-seq
MIRT2340720	hsa-miR-1910	CLIP-seq
MIRT2340721	hsa-miR-1915	CLIP-seq
MIRT2340722	hsa-miR-1972	CLIP-seq
MIRT2340723	hsa-miR-199a-5p	CLIP-seq
MIRT2340724	hsa-miR-199b-5p	CLIP-seq
MIRT2340725	hsa-miR-205	CLIP-seq
MIRT2340726	hsa-miR-20a	CLIP-seq
MIRT2340727	hsa-miR-20b	CLIP-seq
MIRT2340728	hsa-miR-216a	CLIP-seq
MIRT2340729	hsa-miR-216b	CLIP-seq
MIRT2340730	hsa-miR-2277-3p	CLIP-seq
MIRT2340731	hsa-miR-2355-5p	CLIP-seq
MIRT2340732	hsa-miR-2682	CLIP-seq
MIRT2340733	hsa-miR-296-5p	CLIP-seq
MIRT2340734	hsa-miR-298	CLIP-seq
MIRT2340735	hsa-miR-299-3p	CLIP-seq
MIRT2340736	hsa-miR-3064-5p	CLIP-seq
MIRT2340737	hsa-miR-30a	CLIP-seq
MIRT2340738	hsa-miR-30b	CLIP-seq
MIRT2340739	hsa-miR-30c	CLIP-seq
MIRT2340740	hsa-miR-30d	CLIP-seq
MIRT2340741	hsa-miR-30e	CLIP-seq
MIRT2340742	hsa-miR-31	CLIP-seq
MIRT2340743	hsa-miR-3127-3p	CLIP-seq
MIRT2340744	hsa-miR-3128	CLIP-seq
MIRT2340745	hsa-miR-3151	CLIP-seq
MIRT2340746	hsa-miR-3173-5p	CLIP-seq
MIRT2340747	hsa-miR-3180	CLIP-seq
MIRT2340748	hsa-miR-3180-3p	CLIP-seq
MIRT2340749	hsa-miR-3189-5p	CLIP-seq
MIRT1395291	hsa-miR-3192	CLIP-seq
MIRT2340750	hsa-miR-3196	CLIP-seq
MIRT2340751	hsa-miR-329	CLIP-seq
MIRT2340752	hsa-miR-34a	CLIP-seq
MIRT2340753	hsa-miR-34c-5p	CLIP-seq
MIRT2340754	hsa-miR-3609	CLIP-seq
MIRT2340755	hsa-miR-3612	CLIP-seq
MIRT2340756	hsa-miR-362-3p	CLIP-seq
MIRT2340757	hsa-miR-3663-5p	CLIP-seq
MIRT1395293	hsa-miR-3689a-3p	CLIP-seq
MIRT1395294	hsa-miR-3689c	CLIP-seq
MIRT2340758	hsa-miR-3691-3p	CLIP-seq
MIRT2340759	hsa-miR-377	CLIP-seq
MIRT2340760	hsa-miR-3913-3p	CLIP-seq
MIRT2340761	hsa-miR-3918	CLIP-seq
MIRT2340762	hsa-miR-3922-5p	CLIP-seq
MIRT2340763	hsa-miR-3925-3p	CLIP-seq
MIRT2340764	hsa-miR-3927	CLIP-seq
MIRT2340765	hsa-miR-412	CLIP-seq
MIRT2340766	hsa-miR-421	CLIP-seq
MIRT2340767	hsa-miR-423-3p	CLIP-seq
MIRT2340768	hsa-miR-4253	CLIP-seq
MIRT2340769	hsa-miR-4256	CLIP-seq
MIRT2340770	hsa-miR-4265	CLIP-seq
MIRT2340771	hsa-miR-4269	CLIP-seq
MIRT2340772	hsa-miR-4286	CLIP-seq
MIRT1395296	hsa-miR-4292	CLIP-seq
MIRT2340773	hsa-miR-4296	CLIP-seq
MIRT2340774	hsa-miR-4322	CLIP-seq
MIRT2340775	hsa-miR-4417	CLIP-seq
MIRT2340776	hsa-miR-4435	CLIP-seq
MIRT2340777	hsa-miR-4438	CLIP-seq
MIRT2340778	hsa-miR-4458	CLIP-seq
MIRT1395298	hsa-miR-4459	CLIP-seq
MIRT2340779	hsa-miR-4480	CLIP-seq
MIRT2340780	hsa-miR-4488	CLIP-seq
MIRT2340781	hsa-miR-4495	CLIP-seq
MIRT2340782	hsa-miR-449a	CLIP-seq
MIRT2340783	hsa-miR-449b	CLIP-seq
MIRT2340784	hsa-miR-449c	CLIP-seq
MIRT2340785	hsa-miR-4500	CLIP-seq
MIRT2340786	hsa-miR-4504	CLIP-seq
MIRT2340787	hsa-miR-4514	CLIP-seq
MIRT2340788	hsa-miR-4520a-5p	CLIP-seq
MIRT2340789	hsa-miR-4520b-5p	CLIP-seq
MIRT2340790	hsa-miR-4530	CLIP-seq
MIRT2340791	hsa-miR-455-3p	CLIP-seq
MIRT2340792	hsa-miR-4640-5p	CLIP-seq
MIRT2118566	hsa-miR-4645-5p	CLIP-seq
MIRT2118567	hsa-miR-4673	CLIP-seq
MIRT2340793	hsa-miR-4676-5p	CLIP-seq
MIRT2340794	hsa-miR-4685-5p	CLIP-seq
MIRT2340795	hsa-miR-4686	CLIP-seq
MIRT2340796	hsa-miR-4690-3p	CLIP-seq
MIRT2340797	hsa-miR-4691-5p	CLIP-seq
MIRT2340798	hsa-miR-4692	CLIP-seq
MIRT1395299	hsa-miR-4695-5p	CLIP-seq
MIRT2340799	hsa-miR-4697-5p	CLIP-seq
MIRT2340800	hsa-miR-4700-3p	CLIP-seq
MIRT2340801	hsa-miR-4704-3p	CLIP-seq
MIRT2340802	hsa-miR-4709-3p	CLIP-seq
MIRT2340803	hsa-miR-4709-5p	CLIP-seq
MIRT2340804	hsa-miR-4715-3p	CLIP-seq
MIRT1395300	hsa-miR-4716-3p	CLIP-seq
MIRT2340805	hsa-miR-4717-5p	CLIP-seq
MIRT2340806	hsa-miR-4722-3p	CLIP-seq
MIRT2340807	hsa-miR-4725-5p	CLIP-seq
MIRT2340808	hsa-miR-4726-5p	CLIP-seq
MIRT2340809	hsa-miR-4736	CLIP-seq
MIRT2340810	hsa-miR-4745-3p	CLIP-seq
MIRT2340811	hsa-miR-4747-5p	CLIP-seq
MIRT1395301	hsa-miR-4756-3p	CLIP-seq
MIRT2340812	hsa-miR-4761-5p	CLIP-seq
MIRT2340813	hsa-miR-4762-3p	CLIP-seq
MIRT2340814	hsa-miR-4763-3p	CLIP-seq
MIRT1395303	hsa-miR-4779	CLIP-seq
MIRT2340815	hsa-miR-4794	CLIP-seq
MIRT2340816	hsa-miR-4795-5p	CLIP-seq
MIRT2340817	hsa-miR-4796-3p	CLIP-seq
MIRT2340818	hsa-miR-486-3p	CLIP-seq
MIRT2340819	hsa-miR-489	CLIP-seq
MIRT2340820	hsa-miR-504	CLIP-seq
MIRT2340821	hsa-miR-508-5p	CLIP-seq
MIRT2340822	hsa-miR-519d	CLIP-seq
MIRT2340823	hsa-miR-542-3p	CLIP-seq
MIRT2340824	hsa-miR-548ac	CLIP-seq
MIRT2340825	hsa-miR-548ah	CLIP-seq
MIRT2340826	hsa-miR-548d-3p	CLIP-seq
MIRT2340827	hsa-miR-548z	CLIP-seq
MIRT2340828	hsa-miR-575	CLIP-seq
MIRT2340829	hsa-miR-602	CLIP-seq
MIRT2340830	hsa-miR-625	CLIP-seq
MIRT2340831	hsa-miR-650	CLIP-seq
MIRT1395307	hsa-miR-661	CLIP-seq
MIRT2340832	hsa-miR-663	CLIP-seq
MIRT1395308	hsa-miR-665	CLIP-seq
MIRT2340833	hsa-miR-744	CLIP-seq
MIRT2340834	hsa-miR-760	CLIP-seq
MIRT2340835	hsa-miR-764	CLIP-seq
MIRT2340836	hsa-miR-766	CLIP-seq
MIRT2340837	hsa-miR-767-3p	CLIP-seq
MIRT2340838	hsa-miR-874	CLIP-seq
MIRT2340839	hsa-miR-875-3p	CLIP-seq
MIRT2340840	hsa-miR-93	CLIP-seq
MIRT2340841	hsa-miR-98	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SP1	Activation	12802284

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15718238, 24105263, 25416956, 28377464, 28514442, 29858488, 32296183, 33124732, 33961781, 35512704
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	TAS	9139840
GO:0005739	Component	Mitochondrion	IEA
GO:0005765	Component	Lysosomal membrane	HDA	17897319
GO:0005768	Component	Endosome	IDA	29858488
GO:0005768	Component	Endosome	IEA
GO:0005770	Component	Late endosome	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IBA
GO:0005789	Component	Endoplasmic reticulum membrane	IDA	24105263, 28377464
GO:0005829	Component	Cytosol	TAS
GO:0006629	Process	Lipid metabolic process	TAS	7490069
GO:0006701	Process	Progesterone biosynthetic process	IEA
GO:0006839	Process	Mitochondrial transport	TAS	9270027
GO:0006869	Process	Lipid transport	IEA
GO:0008202	Process	Steroid metabolic process	IEA
GO:0008202	Process	Steroid metabolic process	TAS	9139840
GO:0008203	Process	Cholesterol metabolic process	TAS	9270027
GO:0008289	Function	Lipid binding	IEA
GO:0015485	Function	Cholesterol binding	IBA
GO:0015485	Function	Cholesterol binding	IDA	12011453, 15718238, 28377464
GO:0015485	Function	Cholesterol binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0030301	Process	Cholesterol transport	IBA
GO:0030301	Process	Cholesterol transport	IDA	28377464, 33124732
GO:0031902	Component	Late endosome membrane	IBA
GO:0031902	Component	Late endosome membrane	IDA	24105263, 28377464
GO:0031902	Component	Late endosome membrane	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	15718238
GO:0044232	Component	Organelle membrane contact site	IDA	24105263, 28377464, 29858488
GO:0044281	Process	Small molecule metabolic process	IEA
GO:0099044	Process	Vesicle tethering to endoplasmic reticulum	IBA
GO:0099044	Process	Vesicle tethering to endoplasmic reticulum	IDA	24105263, 28377464
GO:0120020	Function	Cholesterol transfer activity	IEA
GO:0140284	Component	Endoplasmic reticulum-endosome membrane contact site	IBA
GO:0140284	Component	Endoplasmic reticulum-endosome membrane contact site	IDA	24105263

Other IDs

• MIM: 607048
• HGNC: 17579
• e!Ensembl: ENSG00000131748

Protein

• UniProt ID: Q14849
• Protein name: StAR-related lipid transfer protein 3 (Metastatic lymph node gene 64 protein) (MLN 64) (Protein CAB1) (START domain-containing protein 3) (StARD3)
• Protein function: Sterol-binding protein that mediates cholesterol transport from the endoplasmic reticulum to endosomes (PubMed:11053434, PubMed:15930133, PubMed:22514632, PubMed:28377464, PubMed:33124732). The sterol transport mechanism is triggered by phosphor
• PDB: 1EM2, 5I9J, 6TQR, 6TQU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10457	MENTAL	47 → 213	Cholesterol-capturing domain	Domain
  PF01852	START	239 → 444	START domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in retina. {ECO:0000269|PubMed:21322544}.
• Sequence:

  MSKLPRELTRDLERSLPAVASLGSSLSHSQSLSSHLLPPPEKRRAISDVRRTFCLFVTFD
  LLFISLLWIIELNTNTGIRKNLEQEIIQYNFKTSFFDIFVLAFFRFSGLLLGYAVLRLRH
  WWVIAVTTLVSSAFLIVKVILSELLSKGAFGYLLPIVSFVLAWLETWFLDFKVLPQEAEE
  ERWYLAAQVAVARGPLLFSGALSEGQFYSPPESFAGSDNESDEEVAGKKSFSAQEREYIR
  QGKEATAVVDQILAQEENWKFEKNNEYGDTVYTIEVPFHGKTFILKTFLPCPAELVYQEV
  ILQPERMVLWNKTVTACQILQRVEDNTLISYDVSAGAAGGVVSPRDFVNVRRIERRRDRY
  LSSGIATSHSAKPPTHKYVRGENGPGGFIVLKSASNPRVCTFVWILNTDLKGRLPRYLIH
  QSLAATMFEFAFHLRQRISELGARA

• Sequence length: 445

Pathways

KEGG:

Cholesterol metabolism

Reactome:

Pregnenolone biosynthesis