Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10924
Gene name Gene Name - the full gene name approved by the HGNC.	Sphingomyelin phosphodiesterase acid like 3A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SMPDL3A
Synonyms (NCBI Gene) Gene synonyms aliases	ASM3A, ASML3a, yR36GH4.1
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q22.31

Show/Hide all(10)

miRTarBase ID	miRNA	Experiments	Reference
MIRT018214	hsa-miR-335-5p	Microarray	18185580
MIRT022831	hsa-miR-124-3p	Microarray	18668037
MIRT029820	hsa-miR-26b-5p	Microarray	19088304
MIRT439579	hsa-miR-376a-5p	HITS-CLIP	24374217
MIRT439579	hsa-miR-376a-5p	HITS-CLIP	24374217
MIRT1373899	hsa-miR-380	CLIP-seq
MIRT1373900	hsa-miR-3924	CLIP-seq
MIRT1373901	hsa-miR-4495	CLIP-seq
MIRT1373902	hsa-miR-4797-3p	CLIP-seq
MIRT1373903	hsa-miR-495	CLIP-seq

Show/Hide all(22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004767	Function	Sphingomyelin phosphodiesterase activity	IDA	26783088
GO:0005515	Function	Protein binding	IPI	12442002
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IDA	28104755
GO:0005615	Component	Extracellular space	IDA	25288789
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	IMP	37890481
GO:0005615	Component	Extracellular space	IMP	26783088
GO:0006685	Process	Sphingomyelin catabolic process	IDA	26783088
GO:0008081	Function	Phosphoric diester hydrolase activity	IBA
GO:0008081	Function	Phosphoric diester hydrolase activity	IDA	26783088, 28104755
GO:0008081	Function	Phosphoric diester hydrolase activity	IMP	37890481
GO:0008270	Function	Zinc ion binding	IDA	26783088
GO:0009143	Process	Nucleoside triphosphate catabolic process	IDA	26783088
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0017111	Function	Ribonucleoside triphosphate phosphatase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0160049	Process	Negative regulation of cGAS/STING signaling pathway	IEA
GO:0160049	Process	Negative regulation of cGAS/STING signaling pathway	IMP	37890481

MIM	HGNC	e!Ensembl
610728	17389	ENSG00000172594

Protein

UniProt ID

Q92484

Protein name

Cyclic GMP-AMP phosphodiesterase SMPDL3A (2',3'-cGAMP phosphodiesterase SMPDL3A) (EC 3.1.4.-) (Acid sphingomyelinase-like phosphodiesterase 3a) (ASM-like phosphodiesterase 3a) (EC 3.6.1.15)

Protein function

Cyclic-nucleotide phosphodiesterase that acts as a negative regulator of innate immunity by mediating degradation of 2',3'-cGAMP, thereby inhibiting the cGAS-STING signaling (PubMed:37890481). Specifically linearizes 2',3'-cGAMP into 2'5'-bond p

PDB

5EBB , 5EBE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00149	Metallophos	38 → 297	Calcineurin-like phosphoesterase	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in blood serum. Detected in macrophages (at protein level). {ECO:0000269|PubMed:25288789}.

Sequence

MALVRALVCCLLTAWHCRSGLGLPVAPAGGRNPPPAIGQFWHVTDLHLDPTYHITDDHTK
VCASSKGANASNPGPFGDVLCDSPYQLILSAFDFIKNSGQEASFMIWTGDSPPHVPVPEL
STDTVINVITNMTTTIQSLFPNLQVFPALGNHDYWPQDQLPVVTSKVYNAVANLWKPWLD
EEAISTLRKGGFYSQKVTTNPNLRIISLNTNLYYGPNIMTLNKTDPANQFEWLESTLNNS
QQNKEKVYIIAHVPVGYLPSSQNITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIM
VLSDKKGSPVNSLFVAPAVTPVKSVLEKQTNNPGIRLFQYDPRDYKLLDMLQYYLNLTEA
NLKGESIWKLEYILTQTYDIEDLQPESLYGLAKQFTILDSKQFIKYYNYFFVSYDSSVTC
DKTCKAFQICAIMNLDNISYADCLKQLYIKHNY

Sequence length

453

Interactions

View interactions

SMPDL3A (sphingomyelin phosphodiesterase acid like 3A)