Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10920
Gene name	COP9 signalosome subunit 8
Gene symbol	COPS8
Synonyms (NCBI Gene)	COP9CSN8SGN8
Chromosome	2
Chromosome location	2q37.3
Summary	The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to tha

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024114	hsa-let-7i-5p	Western blot	21530537
MIRT032086	hsa-let-7f-5p	Western blot	21530537
MIRT032094	hsa-let-7e-3p	Western blot	21530537
MIRT032190	hsa-let-7c-5p	Western blot	21530537
MIRT053496	hsa-miR-146a-5p	In situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	22992343
MIRT053496	hsa-miR-146a-5p	In situ hybridizationLuciferase reporter assayqRT-PCRWestern blot	22992343
MIRT717902	hsa-miR-3123	HITS-CLIP	19536157
MIRT717901	hsa-miR-3919	HITS-CLIP	19536157
MIRT717900	hsa-miR-4756-3p	HITS-CLIP	19536157
MIRT717899	hsa-miR-1250-3p	HITS-CLIP	19536157
MIRT717898	hsa-miR-153-5p	HITS-CLIP	19536157
MIRT717897	hsa-miR-7703	HITS-CLIP	19536157
MIRT717896	hsa-miR-3942-3p	HITS-CLIP	19536157
MIRT717895	hsa-miR-30a-3p	HITS-CLIP	19536157
MIRT717894	hsa-miR-30d-3p	HITS-CLIP	19536157
MIRT717893	hsa-miR-30e-3p	HITS-CLIP	19536157
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT504347	hsa-miR-4643	HITS-CLIP	21572407
MIRT516896	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT504346	hsa-miR-466	HITS-CLIP	21572407
MIRT504345	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT516894	hsa-miR-448	HITS-CLIP	21572407
MIRT516893	hsa-miR-202-5p	HITS-CLIP	21572407
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT504347	hsa-miR-4643	HITS-CLIP	21572407
MIRT504348	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT504346	hsa-miR-466	HITS-CLIP	21572407
MIRT504345	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT504344	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT504347	hsa-miR-4643	HITS-CLIP	23313552
MIRT504346	hsa-miR-466	HITS-CLIP	23313552
MIRT504345	hsa-miR-4789-5p	HITS-CLIP	23313552
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT504347	hsa-miR-4643	HITS-CLIP	23313552
MIRT504346	hsa-miR-466	HITS-CLIP	23313552
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT646704	hsa-miR-556-3p	HITS-CLIP	23824327
MIRT646703	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT646702	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT504347	hsa-miR-4643	PAR-CLIP	21572407
MIRT516897	hsa-miR-3163	PAR-CLIP	21572407
MIRT516896	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT504346	hsa-miR-466	PAR-CLIP	21572407
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT516893	hsa-miR-202-5p	PAR-CLIP	21572407
MIRT516898	hsa-miR-4282	PAR-CLIP	23446348
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504347	hsa-miR-4643	PAR-CLIP	23446348
MIRT516897	hsa-miR-3163	PAR-CLIP	23446348
MIRT516896	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT516895	hsa-miR-586	PAR-CLIP	23446348
MIRT504346	hsa-miR-466	PAR-CLIP	23446348
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT516894	hsa-miR-448	PAR-CLIP	23446348
MIRT516893	hsa-miR-202-5p	PAR-CLIP	23446348
MIRT509361	hsa-miR-3646	PAR-CLIP	23446348
MIRT509360	hsa-miR-1252-3p	PAR-CLIP	23446348
MIRT509359	hsa-miR-7-1-3p	PAR-CLIP	23446348
MIRT509358	hsa-miR-7-2-3p	PAR-CLIP	23446348
MIRT509357	hsa-miR-105-5p	PAR-CLIP	23446348
MIRT509356	hsa-miR-7853-5p	PAR-CLIP	23446348
MIRT509355	hsa-miR-2467-3p	PAR-CLIP	23446348
MIRT509354	hsa-miR-7158-3p	PAR-CLIP	23446348
MIRT509353	hsa-miR-3678-3p	PAR-CLIP	23446348
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504347	hsa-miR-4643	PAR-CLIP	23446348
MIRT504348	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504346	hsa-miR-466	PAR-CLIP	23446348
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT504344	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504347	hsa-miR-4643	PAR-CLIP	23446348
MIRT504348	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504346	hsa-miR-466	PAR-CLIP	23446348
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT504344	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT717902	hsa-miR-3123	HITS-CLIP	19536157
MIRT717901	hsa-miR-3919	HITS-CLIP	19536157
MIRT717900	hsa-miR-4756-3p	HITS-CLIP	19536157
MIRT717899	hsa-miR-1250-3p	HITS-CLIP	19536157
MIRT717898	hsa-miR-153-5p	HITS-CLIP	19536157
MIRT717897	hsa-miR-7703	HITS-CLIP	19536157
MIRT717896	hsa-miR-3942-3p	HITS-CLIP	19536157
MIRT717895	hsa-miR-30a-3p	HITS-CLIP	19536157
MIRT717894	hsa-miR-30d-3p	HITS-CLIP	19536157
MIRT717893	hsa-miR-30e-3p	HITS-CLIP	19536157
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT504347	hsa-miR-4643	HITS-CLIP	21572407
MIRT516896	hsa-miR-410-3p	HITS-CLIP	21572407
MIRT504346	hsa-miR-466	HITS-CLIP	21572407
MIRT504345	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT516894	hsa-miR-448	HITS-CLIP	21572407
MIRT516893	hsa-miR-202-5p	HITS-CLIP	21572407
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	21572407
MIRT504347	hsa-miR-4643	HITS-CLIP	21572407
MIRT504348	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT504346	hsa-miR-466	HITS-CLIP	21572407
MIRT504345	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT504344	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT504347	hsa-miR-4643	HITS-CLIP	23313552
MIRT504346	hsa-miR-466	HITS-CLIP	23313552
MIRT504345	hsa-miR-4789-5p	HITS-CLIP	23313552
MIRT504349	hsa-miR-4789-3p	HITS-CLIP	23313552
MIRT504347	hsa-miR-4643	HITS-CLIP	23313552
MIRT504346	hsa-miR-466	HITS-CLIP	23313552
MIRT504343	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT646704	hsa-miR-556-3p	HITS-CLIP	23824327
MIRT646703	hsa-miR-6807-5p	HITS-CLIP	23824327
MIRT646702	hsa-miR-4701-5p	HITS-CLIP	23824327
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	21572407
MIRT504347	hsa-miR-4643	PAR-CLIP	21572407
MIRT516897	hsa-miR-3163	PAR-CLIP	21572407
MIRT516896	hsa-miR-410-3p	PAR-CLIP	21572407
MIRT504346	hsa-miR-466	PAR-CLIP	21572407
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT516893	hsa-miR-202-5p	PAR-CLIP	21572407
MIRT516898	hsa-miR-4282	PAR-CLIP	23446348
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504347	hsa-miR-4643	PAR-CLIP	23446348
MIRT516897	hsa-miR-3163	PAR-CLIP	23446348
MIRT516896	hsa-miR-410-3p	PAR-CLIP	23446348
MIRT516895	hsa-miR-586	PAR-CLIP	23446348
MIRT504346	hsa-miR-466	PAR-CLIP	23446348
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT516894	hsa-miR-448	PAR-CLIP	23446348
MIRT516893	hsa-miR-202-5p	PAR-CLIP	23446348
MIRT509361	hsa-miR-3646	PAR-CLIP	23446348
MIRT509360	hsa-miR-1252-3p	PAR-CLIP	23446348
MIRT509359	hsa-miR-7-1-3p	PAR-CLIP	23446348
MIRT509358	hsa-miR-7-2-3p	PAR-CLIP	23446348
MIRT509357	hsa-miR-105-5p	PAR-CLIP	23446348
MIRT509356	hsa-miR-7853-5p	PAR-CLIP	23446348
MIRT509355	hsa-miR-2467-3p	PAR-CLIP	23446348
MIRT509354	hsa-miR-7158-3p	PAR-CLIP	23446348
MIRT509353	hsa-miR-3678-3p	PAR-CLIP	23446348
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504347	hsa-miR-4643	PAR-CLIP	23446348
MIRT504348	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504346	hsa-miR-466	PAR-CLIP	23446348
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT504344	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT504349	hsa-miR-4789-3p	PAR-CLIP	23446348
MIRT504347	hsa-miR-4643	PAR-CLIP	23446348
MIRT504348	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT504346	hsa-miR-466	PAR-CLIP	23446348
MIRT504345	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT504344	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT504343	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT904221	hsa-miR-1283	CLIP-seq
MIRT904222	hsa-miR-1305	CLIP-seq
MIRT904223	hsa-miR-146a	CLIP-seq
MIRT904224	hsa-miR-146b-5p	CLIP-seq
MIRT904225	hsa-miR-200b	CLIP-seq
MIRT904226	hsa-miR-200c	CLIP-seq
MIRT904227	hsa-miR-2054	CLIP-seq
MIRT904228	hsa-miR-2117	CLIP-seq
MIRT904229	hsa-miR-2355-5p	CLIP-seq
MIRT904230	hsa-miR-3065-5p	CLIP-seq
MIRT904231	hsa-miR-3155	CLIP-seq
MIRT904232	hsa-miR-3155b	CLIP-seq
MIRT904233	hsa-miR-3201	CLIP-seq
MIRT904234	hsa-miR-342-3p	CLIP-seq
MIRT904235	hsa-miR-3660	CLIP-seq
MIRT904236	hsa-miR-3662	CLIP-seq
MIRT904237	hsa-miR-3680	CLIP-seq
MIRT904238	hsa-miR-3908	CLIP-seq
MIRT904239	hsa-miR-421	CLIP-seq
MIRT904240	hsa-miR-4273	CLIP-seq
MIRT904241	hsa-miR-429	CLIP-seq
MIRT904242	hsa-miR-4311	CLIP-seq
MIRT904243	hsa-miR-4438	CLIP-seq
MIRT904244	hsa-miR-4477a	CLIP-seq
MIRT904245	hsa-miR-452	CLIP-seq
MIRT904246	hsa-miR-4526	CLIP-seq
MIRT904247	hsa-miR-4637	CLIP-seq
MIRT904248	hsa-miR-4676-3p	CLIP-seq
MIRT904249	hsa-miR-4698	CLIP-seq
MIRT904250	hsa-miR-4791	CLIP-seq
MIRT904251	hsa-miR-4798-3p	CLIP-seq
MIRT904252	hsa-miR-484	CLIP-seq
MIRT904253	hsa-miR-494	CLIP-seq
MIRT904254	hsa-miR-515-5p	CLIP-seq
MIRT904255	hsa-miR-583	CLIP-seq
MIRT904256	hsa-miR-589	CLIP-seq
MIRT904257	hsa-miR-105	CLIP-seq
MIRT904221	hsa-miR-1283	CLIP-seq
MIRT904222	hsa-miR-1305	CLIP-seq
MIRT904223	hsa-miR-146a	CLIP-seq
MIRT904224	hsa-miR-146b-5p	CLIP-seq
MIRT904230	hsa-miR-3065-5p	CLIP-seq
MIRT904236	hsa-miR-3662	CLIP-seq
MIRT904239	hsa-miR-421	CLIP-seq
MIRT904258	hsa-miR-4291	CLIP-seq
MIRT904259	hsa-miR-4310	CLIP-seq
MIRT904245	hsa-miR-452	CLIP-seq
MIRT904248	hsa-miR-4676-3p	CLIP-seq
MIRT904249	hsa-miR-4698	CLIP-seq
MIRT904256	hsa-miR-589	CLIP-seq
MIRT1968108	hsa-miR-1178	CLIP-seq
MIRT1968109	hsa-miR-1266	CLIP-seq
MIRT904222	hsa-miR-1305	CLIP-seq
MIRT904223	hsa-miR-146a	CLIP-seq
MIRT904224	hsa-miR-146b-5p	CLIP-seq
MIRT1968110	hsa-miR-2681	CLIP-seq
MIRT904230	hsa-miR-3065-5p	CLIP-seq
MIRT904231	hsa-miR-3155	CLIP-seq
MIRT904232	hsa-miR-3155b	CLIP-seq
MIRT1968111	hsa-miR-323-3p	CLIP-seq
MIRT1968112	hsa-miR-3613-5p	CLIP-seq
MIRT904235	hsa-miR-3660	CLIP-seq
MIRT904236	hsa-miR-3662	CLIP-seq
MIRT1968113	hsa-miR-3664-3p	CLIP-seq
MIRT1968114	hsa-miR-3677-5p	CLIP-seq
MIRT1968115	hsa-miR-3686	CLIP-seq
MIRT1968116	hsa-miR-3689d	CLIP-seq
MIRT1968117	hsa-miR-377	CLIP-seq
MIRT904239	hsa-miR-421	CLIP-seq
MIRT1968118	hsa-miR-4307	CLIP-seq
MIRT904242	hsa-miR-4311	CLIP-seq
MIRT1968119	hsa-miR-4318	CLIP-seq
MIRT1968120	hsa-miR-4433	CLIP-seq
MIRT904243	hsa-miR-4438	CLIP-seq
MIRT1968121	hsa-miR-4447	CLIP-seq
MIRT1968122	hsa-miR-4459	CLIP-seq
MIRT1968123	hsa-miR-4460	CLIP-seq
MIRT1968124	hsa-miR-4472	CLIP-seq
MIRT1968125	hsa-miR-4518	CLIP-seq
MIRT904245	hsa-miR-452	CLIP-seq
MIRT904246	hsa-miR-4526	CLIP-seq
MIRT1968126	hsa-miR-4652-3p	CLIP-seq
MIRT1968127	hsa-miR-4675	CLIP-seq
MIRT904248	hsa-miR-4676-3p	CLIP-seq
MIRT1968128	hsa-miR-4693-5p	CLIP-seq
MIRT904249	hsa-miR-4698	CLIP-seq
MIRT1968129	hsa-miR-4727-3p	CLIP-seq
MIRT1968130	hsa-miR-4741	CLIP-seq
MIRT1968131	hsa-miR-4742-3p	CLIP-seq
MIRT1968132	hsa-miR-4768-3p	CLIP-seq
MIRT1968133	hsa-miR-4797-3p	CLIP-seq
MIRT904252	hsa-miR-484	CLIP-seq
MIRT1968134	hsa-miR-520d-5p	CLIP-seq
MIRT1968135	hsa-miR-520g	CLIP-seq
MIRT1968136	hsa-miR-520h	CLIP-seq
MIRT1968137	hsa-miR-524-5p	CLIP-seq
MIRT1968138	hsa-miR-548u	CLIP-seq
MIRT904256	hsa-miR-589	CLIP-seq
MIRT1968139	hsa-miR-600	CLIP-seq
MIRT1968140	hsa-miR-760	CLIP-seq
MIRT1968141	hsa-miR-892a	CLIP-seq
MIRT1968108	hsa-miR-1178	CLIP-seq
MIRT904230	hsa-miR-3065-5p	CLIP-seq
MIRT2204005	hsa-miR-374a	CLIP-seq
MIRT2204006	hsa-miR-374b	CLIP-seq
MIRT1968117	hsa-miR-377	CLIP-seq
MIRT2204007	hsa-miR-4446-3p	CLIP-seq
MIRT2204008	hsa-miR-4528	CLIP-seq
MIRT1968127	hsa-miR-4675	CLIP-seq
MIRT2204009	hsa-miR-4721	CLIP-seq
MIRT1968130	hsa-miR-4741	CLIP-seq
MIRT1968133	hsa-miR-4797-3p	CLIP-seq
MIRT1968138	hsa-miR-548u	CLIP-seq
MIRT2204010	hsa-miR-944	CLIP-seq
MIRT2507200	hsa-miR-103b	CLIP-seq
MIRT1968108	hsa-miR-1178	CLIP-seq
MIRT2507201	hsa-miR-1205	CLIP-seq
MIRT1968109	hsa-miR-1266	CLIP-seq
MIRT904221	hsa-miR-1283	CLIP-seq
MIRT2507202	hsa-miR-1286	CLIP-seq
MIRT904222	hsa-miR-1305	CLIP-seq
MIRT904223	hsa-miR-146a	CLIP-seq
MIRT904224	hsa-miR-146b-5p	CLIP-seq
MIRT2507203	hsa-miR-1587	CLIP-seq
MIRT904225	hsa-miR-200b	CLIP-seq
MIRT904226	hsa-miR-200c	CLIP-seq
MIRT904227	hsa-miR-2054	CLIP-seq
MIRT904228	hsa-miR-2117	CLIP-seq
MIRT1968110	hsa-miR-2681	CLIP-seq
MIRT2507204	hsa-miR-299-5p	CLIP-seq
MIRT904230	hsa-miR-3065-5p	CLIP-seq
MIRT2507205	hsa-miR-3148	CLIP-seq
MIRT904231	hsa-miR-3155	CLIP-seq
MIRT904232	hsa-miR-3155b	CLIP-seq
MIRT1968111	hsa-miR-323-3p	CLIP-seq
MIRT2507206	hsa-miR-323b-3p	CLIP-seq
MIRT1968112	hsa-miR-3613-5p	CLIP-seq
MIRT2507207	hsa-miR-3647-3p	CLIP-seq
MIRT904235	hsa-miR-3660	CLIP-seq
MIRT904236	hsa-miR-3662	CLIP-seq
MIRT1968113	hsa-miR-3664-3p	CLIP-seq
MIRT1968114	hsa-miR-3677-5p	CLIP-seq
MIRT1968115	hsa-miR-3686	CLIP-seq
MIRT2507208	hsa-miR-3688-3p	CLIP-seq
MIRT1968116	hsa-miR-3689d	CLIP-seq
MIRT2507209	hsa-miR-375	CLIP-seq
MIRT2507210	hsa-miR-376a	CLIP-seq
MIRT2507211	hsa-miR-376b	CLIP-seq
MIRT1968117	hsa-miR-377	CLIP-seq
MIRT2507212	hsa-miR-3924	CLIP-seq
MIRT2507213	hsa-miR-3978	CLIP-seq
MIRT904239	hsa-miR-421	CLIP-seq
MIRT904240	hsa-miR-4273	CLIP-seq
MIRT904241	hsa-miR-429	CLIP-seq
MIRT904258	hsa-miR-4291	CLIP-seq
MIRT1968118	hsa-miR-4307	CLIP-seq
MIRT904259	hsa-miR-4310	CLIP-seq
MIRT904242	hsa-miR-4311	CLIP-seq
MIRT2507214	hsa-miR-4326	CLIP-seq
MIRT1968120	hsa-miR-4433	CLIP-seq
MIRT2507215	hsa-miR-4436b-3p	CLIP-seq
MIRT904243	hsa-miR-4438	CLIP-seq
MIRT1968121	hsa-miR-4447	CLIP-seq
MIRT1968122	hsa-miR-4459	CLIP-seq
MIRT1968123	hsa-miR-4460	CLIP-seq
MIRT1968124	hsa-miR-4472	CLIP-seq
MIRT904244	hsa-miR-4477a	CLIP-seq
MIRT2507216	hsa-miR-4492	CLIP-seq
MIRT2507217	hsa-miR-4498	CLIP-seq
MIRT2507218	hsa-miR-4509	CLIP-seq
MIRT1968125	hsa-miR-4518	CLIP-seq
MIRT904245	hsa-miR-452	CLIP-seq
MIRT904246	hsa-miR-4526	CLIP-seq
MIRT904247	hsa-miR-4637	CLIP-seq
MIRT2507219	hsa-miR-4641	CLIP-seq
MIRT1968126	hsa-miR-4652-3p	CLIP-seq
MIRT2507220	hsa-miR-4656	CLIP-seq
MIRT2507221	hsa-miR-4663	CLIP-seq
MIRT1968127	hsa-miR-4675	CLIP-seq
MIRT904248	hsa-miR-4676-3p	CLIP-seq
MIRT904249	hsa-miR-4698	CLIP-seq
MIRT2507222	hsa-miR-4720-3p	CLIP-seq
MIRT2507223	hsa-miR-4722-5p	CLIP-seq
MIRT1968129	hsa-miR-4727-3p	CLIP-seq
MIRT2507224	hsa-miR-4728-3p	CLIP-seq
MIRT1968130	hsa-miR-4741	CLIP-seq
MIRT1968131	hsa-miR-4742-3p	CLIP-seq
MIRT2507225	hsa-miR-4744	CLIP-seq
MIRT1968132	hsa-miR-4768-3p	CLIP-seq
MIRT1968133	hsa-miR-4797-3p	CLIP-seq
MIRT2507226	hsa-miR-4804-3p	CLIP-seq
MIRT904252	hsa-miR-484	CLIP-seq
MIRT904253	hsa-miR-494	CLIP-seq
MIRT2507227	hsa-miR-495	CLIP-seq
MIRT904254	hsa-miR-515-5p	CLIP-seq
MIRT1968134	hsa-miR-520d-5p	CLIP-seq
MIRT1968135	hsa-miR-520g	CLIP-seq
MIRT1968136	hsa-miR-520h	CLIP-seq
MIRT2507228	hsa-miR-522	CLIP-seq
MIRT1968137	hsa-miR-524-5p	CLIP-seq
MIRT2507229	hsa-miR-548c-3p	CLIP-seq
MIRT1968138	hsa-miR-548u	CLIP-seq
MIRT2507230	hsa-miR-561	CLIP-seq
MIRT2507231	hsa-miR-582-3p	CLIP-seq
MIRT904255	hsa-miR-583	CLIP-seq
MIRT904256	hsa-miR-589	CLIP-seq
MIRT1968139	hsa-miR-600	CLIP-seq
MIRT2507232	hsa-miR-601	CLIP-seq
MIRT1968140	hsa-miR-760	CLIP-seq
MIRT2507233	hsa-miR-762	CLIP-seq
MIRT2507200	hsa-miR-103b	CLIP-seq
MIRT1968108	hsa-miR-1178	CLIP-seq
MIRT2678463	hsa-miR-1202	CLIP-seq
MIRT2507201	hsa-miR-1205	CLIP-seq
MIRT1968109	hsa-miR-1266	CLIP-seq
MIRT904221	hsa-miR-1283	CLIP-seq
MIRT2507202	hsa-miR-1286	CLIP-seq
MIRT904222	hsa-miR-1305	CLIP-seq
MIRT904223	hsa-miR-146a	CLIP-seq
MIRT904224	hsa-miR-146b-5p	CLIP-seq
MIRT2507203	hsa-miR-1587	CLIP-seq
MIRT904225	hsa-miR-200b	CLIP-seq
MIRT904226	hsa-miR-200c	CLIP-seq
MIRT904227	hsa-miR-2054	CLIP-seq
MIRT904228	hsa-miR-2117	CLIP-seq
MIRT1968110	hsa-miR-2681	CLIP-seq
MIRT2507204	hsa-miR-299-5p	CLIP-seq
MIRT904230	hsa-miR-3065-5p	CLIP-seq
MIRT2507205	hsa-miR-3148	CLIP-seq
MIRT904231	hsa-miR-3155	CLIP-seq
MIRT904232	hsa-miR-3155b	CLIP-seq
MIRT2678464	hsa-miR-3194-5p	CLIP-seq
MIRT904233	hsa-miR-3201	CLIP-seq
MIRT1968111	hsa-miR-323-3p	CLIP-seq
MIRT904234	hsa-miR-342-3p	CLIP-seq
MIRT1968112	hsa-miR-3613-5p	CLIP-seq
MIRT904235	hsa-miR-3660	CLIP-seq
MIRT904236	hsa-miR-3662	CLIP-seq
MIRT1968113	hsa-miR-3664-3p	CLIP-seq
MIRT1968114	hsa-miR-3677-5p	CLIP-seq
MIRT904237	hsa-miR-3680	CLIP-seq
MIRT1968115	hsa-miR-3686	CLIP-seq
MIRT2507208	hsa-miR-3688-3p	CLIP-seq
MIRT1968116	hsa-miR-3689d	CLIP-seq
MIRT2507209	hsa-miR-375	CLIP-seq
MIRT2507210	hsa-miR-376a	CLIP-seq
MIRT2507211	hsa-miR-376b	CLIP-seq
MIRT1968117	hsa-miR-377	CLIP-seq
MIRT904238	hsa-miR-3908	CLIP-seq
MIRT2507212	hsa-miR-3924	CLIP-seq
MIRT2678465	hsa-miR-3972	CLIP-seq
MIRT2507213	hsa-miR-3978	CLIP-seq
MIRT904239	hsa-miR-421	CLIP-seq
MIRT904240	hsa-miR-4273	CLIP-seq
MIRT904241	hsa-miR-429	CLIP-seq
MIRT904258	hsa-miR-4291	CLIP-seq
MIRT2678466	hsa-miR-4304	CLIP-seq
MIRT1968118	hsa-miR-4307	CLIP-seq
MIRT904259	hsa-miR-4310	CLIP-seq
MIRT904242	hsa-miR-4311	CLIP-seq
MIRT2507214	hsa-miR-4326	CLIP-seq
MIRT1968120	hsa-miR-4433	CLIP-seq
MIRT2507215	hsa-miR-4436b-3p	CLIP-seq
MIRT904243	hsa-miR-4438	CLIP-seq
MIRT1968121	hsa-miR-4447	CLIP-seq
MIRT1968122	hsa-miR-4459	CLIP-seq
MIRT1968123	hsa-miR-4460	CLIP-seq
MIRT1968124	hsa-miR-4472	CLIP-seq
MIRT904244	hsa-miR-4477a	CLIP-seq
MIRT2507216	hsa-miR-4492	CLIP-seq
MIRT2507217	hsa-miR-4498	CLIP-seq
MIRT2507218	hsa-miR-4509	CLIP-seq
MIRT1968125	hsa-miR-4518	CLIP-seq
MIRT904245	hsa-miR-452	CLIP-seq
MIRT904246	hsa-miR-4526	CLIP-seq
MIRT904247	hsa-miR-4637	CLIP-seq
MIRT2507219	hsa-miR-4641	CLIP-seq
MIRT1968126	hsa-miR-4652-3p	CLIP-seq
MIRT2507220	hsa-miR-4656	CLIP-seq
MIRT2507221	hsa-miR-4663	CLIP-seq
MIRT1968127	hsa-miR-4675	CLIP-seq
MIRT904248	hsa-miR-4676-3p	CLIP-seq
MIRT904249	hsa-miR-4698	CLIP-seq
MIRT2507222	hsa-miR-4720-3p	CLIP-seq
MIRT2507223	hsa-miR-4722-5p	CLIP-seq
MIRT1968129	hsa-miR-4727-3p	CLIP-seq
MIRT2507224	hsa-miR-4728-3p	CLIP-seq
MIRT1968130	hsa-miR-4741	CLIP-seq
MIRT1968131	hsa-miR-4742-3p	CLIP-seq
MIRT2507225	hsa-miR-4744	CLIP-seq
MIRT1968132	hsa-miR-4768-3p	CLIP-seq
MIRT904250	hsa-miR-4791	CLIP-seq
MIRT1968133	hsa-miR-4797-3p	CLIP-seq
MIRT904251	hsa-miR-4798-3p	CLIP-seq
MIRT2507226	hsa-miR-4804-3p	CLIP-seq
MIRT904252	hsa-miR-484	CLIP-seq
MIRT904253	hsa-miR-494	CLIP-seq
MIRT2507227	hsa-miR-495	CLIP-seq
MIRT904254	hsa-miR-515-5p	CLIP-seq
MIRT1968134	hsa-miR-520d-5p	CLIP-seq
MIRT1968135	hsa-miR-520g	CLIP-seq
MIRT1968136	hsa-miR-520h	CLIP-seq
MIRT2507228	hsa-miR-522	CLIP-seq
MIRT1968137	hsa-miR-524-5p	CLIP-seq
MIRT2678467	hsa-miR-548al	CLIP-seq
MIRT2507229	hsa-miR-548c-3p	CLIP-seq
MIRT1968138	hsa-miR-548u	CLIP-seq
MIRT2507230	hsa-miR-561	CLIP-seq
MIRT2507231	hsa-miR-582-3p	CLIP-seq
MIRT904255	hsa-miR-583	CLIP-seq
MIRT904256	hsa-miR-589	CLIP-seq
MIRT1968139	hsa-miR-600	CLIP-seq
MIRT2507232	hsa-miR-601	CLIP-seq
MIRT1968140	hsa-miR-760	CLIP-seq
MIRT2507233	hsa-miR-762	CLIP-seq

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000338	Process	Protein deneddylation	IDA	19141280
GO:0000338	Process	Protein deneddylation	IEA
GO:0005515	Function	Protein binding	IPI	20399188, 25043011, 25416956, 27173435, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	24421388
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005634	Component	Nucleus	TAS	8689678
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	24421388
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006468	Process	Protein phosphorylation	IDA	9535219
GO:0007250	Process	Activation of NF-kappaB-inducing kinase activity	IMP	22992343
GO:0008180	Component	COP9 signalosome	IBA
GO:0008180	Component	COP9 signalosome	IDA	9535219, 18850735
GO:0008180	Component	COP9 signalosome	IEA
GO:0008180	Component	COP9 signalosome	IPI	25043011
GO:0008180	Component	COP9 signalosome	ISS
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	23689509
GO:0010387	Process	COP9 signalosome assembly	IEA
GO:0045116	Process	Protein neddylation	NAS	24421388
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	9535219
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:2000434	Process	Regulation of protein neddylation	NAS	24421388

MIM	HGNC	e!Ensembl
616011	24335	ENSG00000198612

Q99627

Protein name

COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)

Protein function

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the culli

PDB

4D10 , 4D18 , 4WSN , 6R6H , 6R7F , 6R7H , 6R7I , 6R7N , 8H38 , 8H3A , 8H3F

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10075	CSN8_PSD8_EIF3K	31 → 171	CSN8/PSMD8/EIF3K family	Family

Sequence

MPVAVMAESAFSFKKLLDQCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRI
PPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFAL
VSQAYTSIIADDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFI
PLSEPAPVPPIPNEQQLARLTDYVAFLEN

Sequence length

209

Interactions

View interactions

	Reactome
			DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (8)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Carcinoma Hepatocellular	Associate	21499307	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Associate	35854198	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	33261601	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia	Associate	33261601	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Stimulate	33261601	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	33261601	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	21499307	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	27903243, 31223289, 31311398, 33261601, 39272999	★★★★★ ★☆☆☆☆ Found in Text Mining only

COPS8 (COP9 signalosome subunit 8)