Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10890
Gene name Gene Name - the full gene name approved by the HGNC.
RAB10, member RAS oncogene family
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
RAB10
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p23.3
Summary Summary of gene provided in NCBI Entrez Gene.
RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019696 hsa-miR-375 qRT-PCR;Microarray 20584986
MIRT025986 hsa-miR-148a-3p Sequencing 20371350
MIRT052065 hsa-let-7b-5p CLASH 23622248
MIRT051750 hsa-let-7c-5p CLASH 23622248
MIRT037193 hsa-miR-877-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000145 Component Exocyst ISS
GO:0003924 Function GTPase activity IEA
GO:0005515 Function Protein binding IPI 25416956, 26824392, 29125462, 30021884, 30614533, 31046837, 31663853, 32017888
GO:0005525 Function GTP binding IDA 20937701
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612672 9759 ENSG00000084733
Protein
UniProt ID P61026
Protein name Ras-related protein Rab-10 (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form
PDB 5LPN , 5SZJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 11 172 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the hippocampus (PubMed:29562525). Expressed in neutrophils (at protein level) (PubMed:29127255). Expressed in the testis (at protein level) (PubMed:28067790). {ECO:0000269|PubMed:28067790, ECO:0000269|PubMed:29127255, ECO
Sequence
Sequence length 200
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocytosis
AMPK signaling pathway
  Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Leukemia Leukemia, Myelocytic, Acute rs121909646, rs121913488, rs587776834, rs752746786, rs869312821, rs767454740, rs1554564297 27903959
Associations from Text Mining
Disease Name Relationship Type References
Acute Kidney Injury Associate 35482482
Alzheimer Disease Associate 26082458, 33794991
Breast Neoplasms Associate 37709911, 39375417
Carcinoma Hepatocellular Stimulate 12450215
Colorectal Neoplasms Associate 37377893
Colorectal Neoplasms Stimulate 38430146
Diabetes Complications Associate 35806251
Esophageal Squamous Cell Carcinoma Associate 29693138, 36636641
Glioma Associate 31812014
Insulin Resistance Associate 35806251