Gene Gene information from NCBI Gene database.
Entrez ID 10890
Gene name RAB10, member RAS oncogene family
Gene symbol RAB10
Synonyms (NCBI Gene)
-
Chromosome 2
Chromosome location 2p23.3
Summary RAB10 belongs to the RAS (see HRAS; MIM 190020) superfamily of small GTPases. RAB proteins localize to exocytic and endocytic compartments and regulate intracellular vesicle trafficking (Bao et al., 1998 [PubMed 9918381]).[supplied by OMIM, Mar 2009]
miRNA miRNA information provided by mirtarbase database.
1225
miRTarBase ID miRNA Experiments Reference
MIRT019696 hsa-miR-375 qRT-PCR;Microarray 20584986
MIRT025986 hsa-miR-148a-3p Sequencing 20371350
MIRT052065 hsa-let-7b-5p CLASH 23622248
MIRT051750 hsa-let-7c-5p CLASH 23622248
MIRT037193 hsa-miR-877-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
75
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000145 Component Exocyst ISS
GO:0000166 Function Nucleotide binding IEA
GO:0003924 Function GTPase activity IEA
GO:0003925 Function G protein activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
612672 9759 ENSG00000084733
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61026
Protein name Ras-related protein Rab-10 (EC 3.6.5.2)
Protein function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:21248164). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form
PDB 5LPN , 5SZJ
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00071 Ras 11 172 Ras family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in the hippocampus (PubMed:29562525). Expressed in neutrophils (at protein level) (PubMed:29127255). Expressed in the testis (at protein level) (PubMed:28067790). {ECO:0000269|PubMed:28067790, ECO:0000269|PubMed:29127255, ECO
Sequence
Sequence length 200
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocytosis
AMPK signaling pathway
  Neutrophil degranulation
RAB geranylgeranylation
RAB GEFs exchange GTP for GDP on RABs
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
2
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
CIC-rearranged sarcoma not provided rs1574556310 RCV000993815
Papillary renal cell carcinoma type 1 not provided rs1574556310 RCV005912200
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acute Kidney Injury Associate 35482482
Alzheimer Disease Associate 26082458, 33794991
Breast Neoplasms Associate 37709911, 39375417
Carcinoma Hepatocellular Stimulate 12450215
Colorectal Neoplasms Associate 37377893
Colorectal Neoplasms Stimulate 38430146
Diabetes Complications Associate 35806251
Esophageal Squamous Cell Carcinoma Associate 29693138, 36636641
Glioma Associate 31812014
Insulin Resistance Associate 35806251