Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10884
Gene name	Mitochondrial ribosomal protein S30
Gene symbol	MRPS30
Synonyms (NCBI Gene)	MRP-S30PAPPDCD9S30mtmL65
Chromosome	5
Chromosome location	5p12
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% prot

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miRTarBase ID	miRNA	Experiments	Reference
MIRT002009	mmu-miR-30e-3p	Luciferase reporter assay	17726050
MIRT707126	hsa-miR-548n	HITS-CLIP	21572407
MIRT549920	hsa-miR-548av-5p	HITS-CLIP	21572407
MIRT549919	hsa-miR-548k	HITS-CLIP	21572407
MIRT549918	hsa-miR-8054	HITS-CLIP	21572407
MIRT549917	hsa-miR-16-2-3p	HITS-CLIP	21572407
MIRT549916	hsa-miR-195-3p	HITS-CLIP	21572407
MIRT549915	hsa-miR-6508-5p	HITS-CLIP	21572407
MIRT549914	hsa-miR-8067	HITS-CLIP	21572407
MIRT690335	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT690334	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT690333	hsa-miR-940	HITS-CLIP	23313552
MIRT690332	hsa-miR-3929	HITS-CLIP	23313552
MIRT690331	hsa-miR-4419b	HITS-CLIP	23313552
MIRT690330	hsa-miR-4478	HITS-CLIP	23313552
MIRT690329	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT690328	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT690327	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT690326	hsa-miR-146a-5p	HITS-CLIP	23313552
MIRT690325	hsa-miR-146b-5p	HITS-CLIP	23313552
MIRT690323	hsa-miR-7153-5p	HITS-CLIP	23313552
MIRT690324	hsa-miR-1827	HITS-CLIP	23313552
MIRT690322	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT690321	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT690319	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT690320	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT690318	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT690317	hsa-miR-1273e	HITS-CLIP	23313552
MIRT690316	hsa-miR-665	HITS-CLIP	23313552
MIRT690315	hsa-miR-4729	HITS-CLIP	23313552
MIRT690314	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT690313	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT690312	hsa-miR-570-3p	HITS-CLIP	23313552
MIRT690311	hsa-miR-3926	HITS-CLIP	23313552
MIRT690310	hsa-miR-5696	HITS-CLIP	23313552
MIRT690309	hsa-miR-548s	HITS-CLIP	23313552
MIRT549920	hsa-miR-548av-5p	PAR-CLIP	21572407
MIRT549919	hsa-miR-548k	PAR-CLIP	21572407
MIRT549918	hsa-miR-8054	PAR-CLIP	21572407
MIRT549917	hsa-miR-16-2-3p	PAR-CLIP	21572407
MIRT549916	hsa-miR-195-3p	PAR-CLIP	21572407
MIRT549915	hsa-miR-6508-5p	PAR-CLIP	21572407
MIRT549914	hsa-miR-8067	PAR-CLIP	21572407
MIRT707126	hsa-miR-548n	HITS-CLIP	21572407
MIRT549920	hsa-miR-548av-5p	HITS-CLIP	21572407
MIRT549919	hsa-miR-548k	HITS-CLIP	21572407
MIRT549918	hsa-miR-8054	HITS-CLIP	21572407
MIRT549917	hsa-miR-16-2-3p	HITS-CLIP	21572407
MIRT549916	hsa-miR-195-3p	HITS-CLIP	21572407
MIRT549915	hsa-miR-6508-5p	HITS-CLIP	21572407
MIRT549914	hsa-miR-8067	HITS-CLIP	21572407
MIRT690335	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT690334	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT690333	hsa-miR-940	HITS-CLIP	23313552
MIRT690332	hsa-miR-3929	HITS-CLIP	23313552
MIRT690331	hsa-miR-4419b	HITS-CLIP	23313552
MIRT690330	hsa-miR-4478	HITS-CLIP	23313552
MIRT690329	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT690328	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT690327	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT690326	hsa-miR-146a-5p	HITS-CLIP	23313552
MIRT690325	hsa-miR-146b-5p	HITS-CLIP	23313552
MIRT690323	hsa-miR-7153-5p	HITS-CLIP	23313552
MIRT690324	hsa-miR-1827	HITS-CLIP	23313552
MIRT690322	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT690321	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT690319	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT690320	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT690318	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT690317	hsa-miR-1273e	HITS-CLIP	23313552
MIRT690316	hsa-miR-665	HITS-CLIP	23313552
MIRT690315	hsa-miR-4729	HITS-CLIP	23313552
MIRT690314	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT690313	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT690312	hsa-miR-570-3p	HITS-CLIP	23313552
MIRT690311	hsa-miR-3926	HITS-CLIP	23313552
MIRT690310	hsa-miR-5696	HITS-CLIP	23313552
MIRT690309	hsa-miR-548s	HITS-CLIP	23313552
MIRT549920	hsa-miR-548av-5p	PAR-CLIP	21572407
MIRT549919	hsa-miR-548k	PAR-CLIP	21572407
MIRT549918	hsa-miR-8054	PAR-CLIP	21572407
MIRT549917	hsa-miR-16-2-3p	PAR-CLIP	21572407
MIRT549916	hsa-miR-195-3p	PAR-CLIP	21572407
MIRT549915	hsa-miR-6508-5p	PAR-CLIP	21572407
MIRT549914	hsa-miR-8067	PAR-CLIP	21572407
MIRT1160365	hsa-miR-105	CLIP-seq
MIRT1160366	hsa-miR-216a	CLIP-seq
MIRT1160367	hsa-miR-300	CLIP-seq
MIRT1160368	hsa-miR-361-5p	CLIP-seq
MIRT1160369	hsa-miR-3662	CLIP-seq
MIRT1160370	hsa-miR-381	CLIP-seq
MIRT1160371	hsa-miR-3908	CLIP-seq
MIRT1160372	hsa-miR-3942-5p	CLIP-seq
MIRT1160373	hsa-miR-4528	CLIP-seq
MIRT1160374	hsa-miR-4645-3p	CLIP-seq
MIRT1160375	hsa-miR-4666-3p	CLIP-seq
MIRT1160376	hsa-miR-4703-5p	CLIP-seq
MIRT1160377	hsa-miR-4762-5p	CLIP-seq
MIRT1160378	hsa-miR-4766-3p	CLIP-seq
MIRT1160379	hsa-miR-511	CLIP-seq
MIRT1160380	hsa-miR-520d-5p	CLIP-seq
MIRT1160381	hsa-miR-524-5p	CLIP-seq
MIRT1160382	hsa-miR-544	CLIP-seq
MIRT1160383	hsa-miR-633	CLIP-seq
MIRT1160384	hsa-miR-656	CLIP-seq
MIRT1160385	hsa-miR-935	CLIP-seq
MIRT2046068	hsa-miR-1179	CLIP-seq
MIRT2046069	hsa-miR-205	CLIP-seq
MIRT1160366	hsa-miR-216a	CLIP-seq
MIRT2046070	hsa-miR-3122	CLIP-seq
MIRT2046071	hsa-miR-3167	CLIP-seq
MIRT1160369	hsa-miR-3662	CLIP-seq
MIRT2046072	hsa-miR-3913-5p	CLIP-seq
MIRT2046073	hsa-miR-4326	CLIP-seq
MIRT2046074	hsa-miR-450b-3p	CLIP-seq
MIRT1160373	hsa-miR-4528	CLIP-seq
MIRT1160374	hsa-miR-4645-3p	CLIP-seq
MIRT1160377	hsa-miR-4762-5p	CLIP-seq
MIRT1160380	hsa-miR-520d-5p	CLIP-seq
MIRT1160381	hsa-miR-524-5p	CLIP-seq
MIRT1160382	hsa-miR-544	CLIP-seq
MIRT2046075	hsa-miR-567	CLIP-seq
MIRT1160383	hsa-miR-633	CLIP-seq
MIRT1160384	hsa-miR-656	CLIP-seq
MIRT2046076	hsa-miR-769-3p	CLIP-seq
MIRT2046077	hsa-miR-876-5p	CLIP-seq
MIRT1160385	hsa-miR-935	CLIP-seq
MIRT1160365	hsa-miR-105	CLIP-seq
MIRT2046068	hsa-miR-1179	CLIP-seq
MIRT2275146	hsa-miR-1260	CLIP-seq
MIRT2275147	hsa-miR-1260b	CLIP-seq
MIRT2275148	hsa-miR-188-3p	CLIP-seq
MIRT1160366	hsa-miR-216a	CLIP-seq
MIRT1160367	hsa-miR-300	CLIP-seq
MIRT2046070	hsa-miR-3122	CLIP-seq
MIRT2275149	hsa-miR-3156-3p	CLIP-seq
MIRT2046071	hsa-miR-3167	CLIP-seq
MIRT1160368	hsa-miR-361-5p	CLIP-seq
MIRT1160370	hsa-miR-381	CLIP-seq
MIRT1160371	hsa-miR-3908	CLIP-seq
MIRT2046072	hsa-miR-3913-5p	CLIP-seq
MIRT1160372	hsa-miR-3942-5p	CLIP-seq
MIRT2275150	hsa-miR-4277	CLIP-seq
MIRT2046073	hsa-miR-4326	CLIP-seq
MIRT2046074	hsa-miR-450b-3p	CLIP-seq
MIRT1160373	hsa-miR-4528	CLIP-seq
MIRT1160374	hsa-miR-4645-3p	CLIP-seq
MIRT1160375	hsa-miR-4666-3p	CLIP-seq
MIRT1160376	hsa-miR-4703-5p	CLIP-seq
MIRT2275151	hsa-miR-4705	CLIP-seq
MIRT1160377	hsa-miR-4762-5p	CLIP-seq
MIRT1160378	hsa-miR-4766-3p	CLIP-seq
MIRT2275152	hsa-miR-513c	CLIP-seq
MIRT2275153	hsa-miR-514b-5p	CLIP-seq
MIRT1160380	hsa-miR-520d-5p	CLIP-seq
MIRT1160381	hsa-miR-524-5p	CLIP-seq
MIRT2046075	hsa-miR-567	CLIP-seq
MIRT1160383	hsa-miR-633	CLIP-seq
MIRT2046076	hsa-miR-769-3p	CLIP-seq
MIRT2046077	hsa-miR-876-5p	CLIP-seq
MIRT1160385	hsa-miR-935	CLIP-seq
MIRT2275154	hsa-miR-944	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	28892042
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	27023846
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005762	Component	Mitochondrial large ribosomal subunit	IBA
GO:0005762	Component	Mitochondrial large ribosomal subunit	IDA	28892042
GO:0005762	Component	Mitochondrial large ribosomal subunit	NAS	25278503
GO:0005840	Component	Ribosome	IEA
GO:0006412	Process	Translation	IEA
GO:0006915	Process	Apoptotic process	TAS	10640817
GO:0032543	Process	Mitochondrial translation	NAS	27023846
GO:1990904	Component	Ribonucleoprotein complex	IEA

MIM	HGNC	e!Ensembl
611991	8769	ENSG00000112996

Q9NP92

Protein name

Large ribosomal subunit protein mL65 (39S ribosomal protein S30, mitochondrial) (MRP-S30) (S30mt) (Large ribosomal subunit protein mS30) (Programmed cell death protein 9)

PDB

3J7Y , 3J9M , 5OOL , 5OOM , 6I9R , 6NU2 , 6NU3 , 6VLZ , 6VMI , 6ZM5 , 6ZM6 , 6ZS9 , 6ZSA , 6ZSB , 6ZSC , 6ZSD , 6ZSE , 6ZSG , 7A5F , 7A5G , 7A5H , 7A5I , 7A5J , 7A5K , 7L08 , 7L20 , 7O9K , 7O9M , 7ODR , 7ODS , 7ODT , 7OF0 , 7OF2 , 7OF3 , 7OF4 , 7OF5 , 7OF6 , 7OF7 , 7OG4 , 7OI6 , 7OI7 , 7OI8 , 7OI9 , 7OIA , 7OIB , 7OIC , 7OID , 7OIE , 7PD3 , 7PO4 , 7QH6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07147	PDCD9	1 → 429	Mitochondrial 28S ribosomal protein S30 (PDCD9)	Family

Tissue specificity

TISSUE SPECIFICITY: Heart, skeletal muscle, kidney and liver. Lower expression in placenta and peripheral blood leukocytes. {ECO:0000269|PubMed:10640817, ECO:0000269|PubMed:11279123}.

Sequence

MAAARCWRPLLRGPRLSLHTAANAAATATETTCQDVAATPVARYPPIVASMTADSKAARL
RRIERWQATVHAAESVDEKLRILTKMQFMKYMVYPQTFALNADRWYQYFTKTVFLSGLPP
PPAEPEPEPEPEPEPALDLAALRAVACDCLLQEHFYLRRRRRVHRYEESEVISLPFLDQL
VSTLVGLLSPHNPALAAAALDYRCPVHFYWVRGEEIIPRGHRRGRIDDLRYQIDDKPNNQ
IRISKQLAEFVPLDYSVPIEIPTIKCKPDKLPLFKRQYENHIFVGSKTADPCCYGHTQFH
LLPDKLRRERLLRQNCADQIEVVFRANAIASLFAWTGAQAMYQGFWSEADVTRPFVSQAV
ITDGKYFSFFCYQLNTLALTTQADQNNPRKNICWGTQSKPLYETIEDNDVKGFNDDVLLQ
IVHFLLNRPKEEKSQLLEN

Sequence length

439

Interactions

View interactions

	Reactome
			Mitochondrial translation elongation Mitochondrial translation termination

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (15)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANOREXIA NERVOSA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CHRONIC KIDNEY DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR POSITIVE BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SECONDARY MALIGNANT NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SUBSTANCE ABUSE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	19232126, 20095854, 20699374, 22452962, 24218030, 24388359, 24528085, 27640304, 29351903, 29727689, 33735170	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hereditary Breast and Ovarian Cancer Syndrome	Associate	29727689	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	35137654, 35191803	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	24388359	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pyelonephritis	Associate	37581436	★★★★★ ★☆☆☆☆ Found in Text Mining only
Triple Negative Breast Neoplasms	Associate	35191803	★★★★★ ★☆☆☆☆ Found in Text Mining only

MRPS30 (mitochondrial ribosomal protein S30)