ME3 (malic enzyme 3)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10873
Gene name Gene Name - the full gene name approved by the HGNC.
Malic enzyme 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ME3
Synonyms (NCBI Gene) Gene synonyms aliases
NADP-ME
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q14.2
Summary Summary of gene provided in NCBI Entrez Gene.
Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent is
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT028648 hsa-miR-30a-5p Proteomics 18668040
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(24)
GO ID Ontology Definition Evidence Reference
GO:0004470 Function Malic enzyme activity IDA 7818469
GO:0004470 Function Malic enzyme activity IEA
GO:0004473 Function Malate dehydrogenase (decarboxylating) (NADP+) activity IBA
GO:0004473 Function Malate dehydrogenase (decarboxylating) (NADP+) activity IDA 7818469
GO:0004473 Function Malate dehydrogenase (decarboxylating) (NADP+) activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
604626 6985 ENSG00000151376
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q16798
Protein name NADP-dependent malic enzyme, mitochondrial (NADP-ME) (EC 1.1.1.40) (Malic enzyme 3)
Protein function Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+) as a cofactor (PubMed:7818469). Can also reverse the decarboxylation reaction, but only with significantly lower efficiency (PubMed:7818469). {ECO:0000269|PubMed:781
PDB 8E76 , 8E78 , 8E8O , 8EYN , 8EYO
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00390 malic 114 → 295 Malic enzyme, N-terminal domain Domain
PF03949 Malic_M 305 → 557 Malic enzyme, NAD binding domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in organs with a low-division rate.
Sequence
Sequence length 604
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Pyruvate metabolism
Metabolic pathways
Carbon metabolism
PPAR signaling pathway 		  Citric acid cycle (TCA cycle)
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Glaucoma Glaucoma N/A N/A GWAS
Metabolic Syndrome Metabolic syndrome N/A N/A GWAS
Show/Hide Text Mining Associations (3)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 28467815, 38310106
Neoplasms Associate 28467815
Optic Atrophy Hereditary Leber Associate 36233195