Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10859
Gene name Gene Name - the full gene name approved by the HGNC.
Leukocyte immunoglobulin like receptor B1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LILRB1
Synonyms (NCBI Gene) Gene synonyms aliases
CD85J, ILT-2, ILT2, LIR-1, LIR1, MIR-7, MIR7, PIR-B, PIRB
Chromosome Chromosome number
19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
19q13.42
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT609970 hsa-miR-8485 HITS-CLIP 21572407
MIRT609969 hsa-miR-329-3p HITS-CLIP 21572407
MIRT609968 hsa-miR-362-3p HITS-CLIP 21572407
MIRT609967 hsa-miR-603 HITS-CLIP 21572407
MIRT625538 hsa-miR-4789-3p HITS-CLIP 21572407
Transcription factors
Transcription factor Regulation Reference
TRERF1 Repression 18652845
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001540 Function Amyloid-beta binding IDA 24052308
GO:0001915 Process Negative regulation of T cell mediated cytotoxicity IDA 21213105
GO:0002230 Process Positive regulation of defense response to virus by host IDA 18398485
GO:0002250 Process Adaptive immune response IEA
GO:0002309 Process T cell proliferation involved in immune response IDA 18094328
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604811 6605 ENSG00000104972
Protein
UniProt ID Q8NHL6
Protein name Leukocyte immunoglobulin-like receptor subfamily B member 1 (LIR-1) (Leukocyte immunoglobulin-like receptor 1) (CD85 antigen-like family member J) (Immunoglobulin-like transcript 2) (ILT-2) (Monocyte/macrophage immunoglobulin-like receptor 7) (MIR-7) (CD
Protein function Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles (PubMed:16455647, PubMed:28636952). Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inh
PDB 1G0X , 1P7Q , 1UFU , 1UGN , 1VDG , 3D2U , 4LL9 , 4NO0 , 5KNM , 6AEE , 6EWA , 6EWC , 6EWO , 6K60 , 6ZDX , 7KFK
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13895 Ig_2 28 118 Immunoglobulin domain Domain
PF00047 ig 329 410 Immunoglobulin domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in B cells, monocytes and various dendritic cell (DC) subsets including myeloid, plasmacytoid and tolerogenic DCs (at protein level) (PubMed:20448110, PubMed:24453251, PubMed:9285411, PubMed:9842885). Expressed in decidual ma
Sequence
MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVITQGSPVTLRCQGGQETQEYRL
YREKKTALWITRIPQELVKKGQFPIPSITWEHAGRYRCYYGSDTAGRSESSDPLELVV
TG
AYIKPTLSAQPSPVVNSGGNVILQCDSQVAFDGFSLCKEGEDEHPQCLNSQPHARGSSRA
IFSVGPVSPSRRWWYRCYAYDSNSPYEWSLPSDLLELLVLGVSKKPSLSVQPGPIVAPEE
TLTLQCGSDAGYNRFVLYKDGERDFLQLAGAQPQAGLSQANFTLGPVSRSYGGQYRCYGA
HNLSSEWSAPSDPLDILIAGQFYDRVSLSVQPGPTVASGENVTLLCQSQGWMQTFLLTKE
GAADDPWRLRSTYQSQKYQAEFPMGPVTSAHAGTYRCYGSQSSKPYLLTH
PSDPLELVVS
GPSGGPSSPTTGPTSTSGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVILLLLLLLLLF
LILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKHTQ
PEDGVEMDTRSPHDEDPQAVTYAEVKHSRPRREMASPPSPLSGEFLDTKDRQAEEDRQMD
TEAAASEAPQDVTYAQLHSLTLRREATEPPPSQEGPSPAVPSIYATLAIH
Sequence length 650
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Osteoclast differentiation
B cell receptor signaling pathway
  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
25656957
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Abortion Spontaneous Associate 26973020
Acidosis Associate 38069241
Adenocarcinoma of Lung Associate 28618418, 29806739, 35844799, 35984198
Adenoma Stimulate 25584614
Alzheimer Disease Associate 36010613
Anemia Sickle Cell Associate 37686397
Arthritis Juvenile Associate 25853899
Arthritis Rheumatoid Associate 26314621, 30711014, 32468016
Autism Spectrum Disorder Associate 36761165, 37545517
Autoimmune Diseases Associate 19912253, 24799764, 26314621, 36104364