Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10855
Gene name Gene Name - the full gene name approved by the HGNC.	Heparanase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	HPSE
Synonyms (NCBI Gene) Gene synonyms aliases	HPA, HPA1, HPR1, HPSE1, HSE1
Chromosome Chromosome number	4
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	4q21.23
Summary Summary of gene provided in NCBI Entrez Gene.	Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005537	hsa-miR-1258	Immunohistochemistry, In situ hybridization, Luciferase reporter assay, qRT-PCR	21266359
MIRT702813	hsa-miR-7153-3p	HITS-CLIP	23313552
MIRT702812	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT702806	hsa-miR-183-5p	HITS-CLIP	23313552
MIRT685087	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT673614	hsa-miR-6742-3p	HITS-CLIP	23313552
MIRT702811	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT702810	hsa-miR-6776-5p	HITS-CLIP	23313552
MIRT702809	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT702807	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT702808	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT702806	hsa-miR-183-5p	HITS-CLIP	23313552
MIRT702805	hsa-miR-1262	HITS-CLIP	23313552
MIRT702804	hsa-miR-4701-3p	HITS-CLIP	23313552
MIRT702803	hsa-miR-6736-5p	HITS-CLIP	23313552
MIRT680210	hsa-miR-5571-5p	HITS-CLIP	23313552
MIRT673619	hsa-miR-5697	HITS-CLIP	23313552
MIRT685087	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT685086	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT685085	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT685084	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT685083	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT685082	hsa-miR-1976	HITS-CLIP	23313552
MIRT685081	hsa-miR-1913	HITS-CLIP	23313552
MIRT685080	hsa-miR-324-3p	HITS-CLIP	23313552
MIRT685079	hsa-miR-5699-5p	HITS-CLIP	23313552
MIRT685078	hsa-miR-4758-3p	HITS-CLIP	23313552
MIRT685077	hsa-miR-3189-5p	HITS-CLIP	23313552
MIRT673601	hsa-miR-1297	HITS-CLIP	23313552
MIRT673600	hsa-miR-26a-5p	HITS-CLIP	23313552
MIRT673599	hsa-miR-26b-5p	HITS-CLIP	23313552
MIRT673598	hsa-miR-4465	HITS-CLIP	23313552
MIRT680209	hsa-miR-4279	HITS-CLIP	23313552
MIRT680210	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT673619	hsa-miR-5697	HITS-CLIP	23824327
MIRT673618	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT673617	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT673616	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT673615	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT673614	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT673613	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT673612	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT673611	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT673610	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT673609	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT673608	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT673607	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT673606	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT673604	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT673603	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT673601	hsa-miR-1297	HITS-CLIP	23824327
MIRT673600	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT673599	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT673598	hsa-miR-4465	HITS-CLIP	23824327
MIRT673597	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT673596	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT680209	hsa-miR-4279	HITS-CLIP	23824327
MIRT673595	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT673594	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT673619	hsa-miR-5697	HITS-CLIP	23824327
MIRT673618	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT673617	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT673616	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT673615	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT673614	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT673613	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT673612	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT673611	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT673610	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT673609	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT673608	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT673607	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT673606	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT673605	hsa-miR-4284	HITS-CLIP	23824327
MIRT673604	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT673603	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT673602	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT673601	hsa-miR-1297	HITS-CLIP	23824327
MIRT673600	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT673599	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT673598	hsa-miR-4465	HITS-CLIP	23824327
MIRT673597	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT673596	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT673595	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT673594	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT530358	hsa-miR-3133	PAR-CLIP	22012620
MIRT530357	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT530356	hsa-miR-3681-5p	PAR-CLIP	22012620
MIRT530355	hsa-miR-6849-5p	PAR-CLIP	22012620
MIRT530354	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT530353	hsa-miR-376b-5p	PAR-CLIP	22012620
MIRT530352	hsa-miR-376c-5p	PAR-CLIP	22012620
MIRT530351	hsa-miR-4536-5p	PAR-CLIP	22012620
MIRT530350	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT530349	hsa-miR-3161	PAR-CLIP	22012620
MIRT530348	hsa-miR-1261	PAR-CLIP	22012620
MIRT732777	hsa-miR-219a-2-3p	Luciferase reporter assay, qRT-PCR, Western blotting	33968189
MIRT734843	hsa-miR-1252-5p	qRT-PCR, Flow cytometry	33488100
MIRT702813	hsa-miR-7153-3p	HITS-CLIP	23313552
MIRT702812	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT702806	hsa-miR-183-5p	HITS-CLIP	23313552
MIRT685087	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT673614	hsa-miR-6742-3p	HITS-CLIP	23313552
MIRT702811	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT702810	hsa-miR-6776-5p	HITS-CLIP	23313552
MIRT702809	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT702807	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT702808	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT702806	hsa-miR-183-5p	HITS-CLIP	23313552
MIRT702805	hsa-miR-1262	HITS-CLIP	23313552
MIRT702804	hsa-miR-4701-3p	HITS-CLIP	23313552
MIRT702803	hsa-miR-6736-5p	HITS-CLIP	23313552
MIRT680210	hsa-miR-5571-5p	HITS-CLIP	23313552
MIRT673619	hsa-miR-5697	HITS-CLIP	23313552
MIRT685087	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT685086	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT685085	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT685084	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT685083	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT685082	hsa-miR-1976	HITS-CLIP	23313552
MIRT685081	hsa-miR-1913	HITS-CLIP	23313552
MIRT685080	hsa-miR-324-3p	HITS-CLIP	23313552
MIRT685079	hsa-miR-5699-5p	HITS-CLIP	23313552
MIRT685078	hsa-miR-4758-3p	HITS-CLIP	23313552
MIRT685077	hsa-miR-3189-5p	HITS-CLIP	23313552
MIRT673601	hsa-miR-1297	HITS-CLIP	23313552
MIRT673600	hsa-miR-26a-5p	HITS-CLIP	23313552
MIRT673599	hsa-miR-26b-5p	HITS-CLIP	23313552
MIRT673598	hsa-miR-4465	HITS-CLIP	23313552
MIRT680209	hsa-miR-4279	HITS-CLIP	23313552
MIRT680210	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT673619	hsa-miR-5697	HITS-CLIP	23824327
MIRT673618	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT673617	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT673616	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT673615	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT673614	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT673613	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT673612	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT673611	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT673610	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT673609	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT673608	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT673607	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT673606	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT673604	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT673603	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT673601	hsa-miR-1297	HITS-CLIP	23824327
MIRT673600	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT673599	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT673598	hsa-miR-4465	HITS-CLIP	23824327
MIRT673597	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT673596	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT680209	hsa-miR-4279	HITS-CLIP	23824327
MIRT673595	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT673594	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT673619	hsa-miR-5697	HITS-CLIP	23824327
MIRT673618	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT673617	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT673616	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT673615	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT673614	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT673613	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT673612	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT673611	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT673610	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT673609	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT673608	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT673607	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT673606	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT673605	hsa-miR-4284	HITS-CLIP	23824327
MIRT673604	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT673603	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT673602	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT673601	hsa-miR-1297	HITS-CLIP	23824327
MIRT673600	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT673599	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT673598	hsa-miR-4465	HITS-CLIP	23824327
MIRT673597	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT673596	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT673595	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT673594	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT530358	hsa-miR-3133	PAR-CLIP	22012620
MIRT530357	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT530356	hsa-miR-3681-5p	PAR-CLIP	22012620
MIRT530355	hsa-miR-6849-5p	PAR-CLIP	22012620
MIRT530354	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT530353	hsa-miR-376b-5p	PAR-CLIP	22012620
MIRT530352	hsa-miR-376c-5p	PAR-CLIP	22012620
MIRT530351	hsa-miR-4536-5p	PAR-CLIP	22012620
MIRT530350	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT530349	hsa-miR-3161	PAR-CLIP	22012620
MIRT530348	hsa-miR-1261	PAR-CLIP	22012620
MIRT1054424	hsa-miR-1224-5p	CLIP-seq
MIRT1054425	hsa-miR-1225-3p	CLIP-seq
MIRT1054426	hsa-miR-1228	CLIP-seq
MIRT1054427	hsa-miR-1233	CLIP-seq
MIRT1054428	hsa-miR-1283	CLIP-seq
MIRT1054429	hsa-miR-141	CLIP-seq
MIRT1054430	hsa-miR-183	CLIP-seq
MIRT1054431	hsa-miR-186	CLIP-seq
MIRT1054432	hsa-miR-200a	CLIP-seq
MIRT1054433	hsa-miR-200b	CLIP-seq
MIRT1054434	hsa-miR-200c	CLIP-seq
MIRT1054435	hsa-miR-24	CLIP-seq
MIRT1054436	hsa-miR-3120-5p	CLIP-seq
MIRT1054437	hsa-miR-3123	CLIP-seq
MIRT1054438	hsa-miR-3148	CLIP-seq
MIRT1054439	hsa-miR-3165	CLIP-seq
MIRT1054440	hsa-miR-3187-3p	CLIP-seq
MIRT1054441	hsa-miR-3197	CLIP-seq
MIRT1054442	hsa-miR-337-5p	CLIP-seq
MIRT1054443	hsa-miR-342-3p	CLIP-seq
MIRT1054444	hsa-miR-3605-5p	CLIP-seq
MIRT1054445	hsa-miR-3613-3p	CLIP-seq
MIRT1054446	hsa-miR-3614-5p	CLIP-seq
MIRT1054447	hsa-miR-3656	CLIP-seq
MIRT1054448	hsa-miR-3664-3p	CLIP-seq
MIRT1054449	hsa-miR-3675-3p	CLIP-seq
MIRT1054450	hsa-miR-3688-3p	CLIP-seq
MIRT1054451	hsa-miR-3915	CLIP-seq
MIRT1054452	hsa-miR-3925-5p	CLIP-seq
MIRT1054453	hsa-miR-3927	CLIP-seq
MIRT1054454	hsa-miR-4282	CLIP-seq
MIRT1054455	hsa-miR-429	CLIP-seq
MIRT1054456	hsa-miR-4435	CLIP-seq
MIRT1054457	hsa-miR-4451	CLIP-seq
MIRT1054458	hsa-miR-4455	CLIP-seq
MIRT1054459	hsa-miR-4459	CLIP-seq
MIRT1054460	hsa-miR-4485	CLIP-seq
MIRT1054461	hsa-miR-4536	CLIP-seq
MIRT1054462	hsa-miR-4641	CLIP-seq
MIRT1054463	hsa-miR-4684-5p	CLIP-seq
MIRT1054464	hsa-miR-4689	CLIP-seq
MIRT1054465	hsa-miR-4701-5p	CLIP-seq
MIRT1054466	hsa-miR-4716-5p	CLIP-seq
MIRT1054467	hsa-miR-4722-5p	CLIP-seq
MIRT1054468	hsa-miR-4731-5p	CLIP-seq
MIRT1054469	hsa-miR-4751	CLIP-seq
MIRT1054470	hsa-miR-4755-3p	CLIP-seq
MIRT1054471	hsa-miR-4774-5p	CLIP-seq
MIRT1054472	hsa-miR-4778-5p	CLIP-seq
MIRT1054473	hsa-miR-4781-3p	CLIP-seq
MIRT1054474	hsa-miR-494	CLIP-seq
MIRT1054475	hsa-miR-510	CLIP-seq
MIRT1054476	hsa-miR-548aa	CLIP-seq
MIRT1054477	hsa-miR-548m	CLIP-seq
MIRT1054478	hsa-miR-548s	CLIP-seq
MIRT1054479	hsa-miR-548v	CLIP-seq
MIRT1054480	hsa-miR-588	CLIP-seq
MIRT1054481	hsa-miR-595	CLIP-seq
MIRT1054482	hsa-miR-609	CLIP-seq
MIRT1054483	hsa-miR-661	CLIP-seq
MIRT1054484	hsa-miR-766	CLIP-seq
MIRT1054485	hsa-miR-873	CLIP-seq
MIRT1054424	hsa-miR-1224-5p	CLIP-seq
MIRT1054426	hsa-miR-1228	CLIP-seq
MIRT1054486	hsa-miR-1229	CLIP-seq
MIRT1054487	hsa-miR-1253	CLIP-seq
MIRT1054488	hsa-miR-1285	CLIP-seq
MIRT1054429	hsa-miR-141	CLIP-seq
MIRT1054430	hsa-miR-183	CLIP-seq
MIRT1054489	hsa-miR-197	CLIP-seq
MIRT1054432	hsa-miR-200a	CLIP-seq
MIRT1054433	hsa-miR-200b	CLIP-seq
MIRT1054434	hsa-miR-200c	CLIP-seq
MIRT1054490	hsa-miR-2117	CLIP-seq
MIRT1054491	hsa-miR-217	CLIP-seq
MIRT1054435	hsa-miR-24	CLIP-seq
MIRT1054492	hsa-miR-25	CLIP-seq
MIRT1054439	hsa-miR-3165	CLIP-seq
MIRT1054493	hsa-miR-3170	CLIP-seq
MIRT1054440	hsa-miR-3187-3p	CLIP-seq
MIRT1054494	hsa-miR-3187-5p	CLIP-seq
MIRT1054495	hsa-miR-32	CLIP-seq
MIRT1054442	hsa-miR-337-5p	CLIP-seq
MIRT1054443	hsa-miR-342-3p	CLIP-seq
MIRT1054446	hsa-miR-3614-5p	CLIP-seq
MIRT1054496	hsa-miR-363	CLIP-seq
MIRT1054497	hsa-miR-367	CLIP-seq
MIRT1054451	hsa-miR-3915	CLIP-seq
MIRT1054498	hsa-miR-4273	CLIP-seq
MIRT1054455	hsa-miR-429	CLIP-seq
MIRT1054499	hsa-miR-4418	CLIP-seq
MIRT1054500	hsa-miR-4433	CLIP-seq
MIRT1054456	hsa-miR-4435	CLIP-seq
MIRT1054458	hsa-miR-4455	CLIP-seq
MIRT1054460	hsa-miR-4485	CLIP-seq
MIRT1054501	hsa-miR-4677-3p	CLIP-seq
MIRT1054464	hsa-miR-4689	CLIP-seq
MIRT1054465	hsa-miR-4701-5p	CLIP-seq
MIRT1054466	hsa-miR-4716-5p	CLIP-seq
MIRT1054468	hsa-miR-4731-5p	CLIP-seq
MIRT1054469	hsa-miR-4751	CLIP-seq
MIRT1054470	hsa-miR-4755-3p	CLIP-seq
MIRT1054502	hsa-miR-4766-5p	CLIP-seq
MIRT1054471	hsa-miR-4774-5p	CLIP-seq
MIRT1054473	hsa-miR-4781-3p	CLIP-seq
MIRT1054503	hsa-miR-4793-3p	CLIP-seq
MIRT1054504	hsa-miR-509-3-5p	CLIP-seq
MIRT1054505	hsa-miR-509-5p	CLIP-seq
MIRT1054506	hsa-miR-5096	CLIP-seq
MIRT1054478	hsa-miR-548s	CLIP-seq
MIRT1054480	hsa-miR-588	CLIP-seq
MIRT1054481	hsa-miR-595	CLIP-seq
MIRT1054482	hsa-miR-609	CLIP-seq
MIRT1054507	hsa-miR-612	CLIP-seq
MIRT1054483	hsa-miR-661	CLIP-seq
MIRT1054484	hsa-miR-766	CLIP-seq
MIRT1054508	hsa-miR-767-5p	CLIP-seq
MIRT1054509	hsa-miR-92a	CLIP-seq
MIRT1054510	hsa-miR-92b	CLIP-seq
MIRT2012352	hsa-miR-103a	CLIP-seq
MIRT2012353	hsa-miR-107	CLIP-seq
MIRT2012354	hsa-miR-122	CLIP-seq
MIRT1054426	hsa-miR-1228	CLIP-seq
MIRT2012355	hsa-miR-1301	CLIP-seq
MIRT2012356	hsa-miR-1307	CLIP-seq
MIRT2012357	hsa-miR-1343	CLIP-seq
MIRT2012358	hsa-miR-150	CLIP-seq
MIRT2012359	hsa-miR-1827	CLIP-seq
MIRT2012360	hsa-miR-184	CLIP-seq
MIRT1054431	hsa-miR-186	CLIP-seq
MIRT1054433	hsa-miR-200b	CLIP-seq
MIRT1054434	hsa-miR-200c	CLIP-seq
MIRT2012361	hsa-miR-216b	CLIP-seq
MIRT1054491	hsa-miR-217	CLIP-seq
MIRT2012362	hsa-miR-26a	CLIP-seq
MIRT2012363	hsa-miR-26b	CLIP-seq
MIRT2012364	hsa-miR-2964a-3p	CLIP-seq
MIRT2012365	hsa-miR-302f	CLIP-seq
MIRT2012366	hsa-miR-3135b	CLIP-seq
MIRT2012367	hsa-miR-3157-5p	CLIP-seq
MIRT1054440	hsa-miR-3187-3p	CLIP-seq
MIRT1054442	hsa-miR-337-5p	CLIP-seq
MIRT2012368	hsa-miR-3652	CLIP-seq
MIRT1054448	hsa-miR-3664-3p	CLIP-seq
MIRT1054455	hsa-miR-429	CLIP-seq
MIRT1054499	hsa-miR-4418	CLIP-seq
MIRT2012369	hsa-miR-4430	CLIP-seq
MIRT1054456	hsa-miR-4435	CLIP-seq
MIRT1054460	hsa-miR-4485	CLIP-seq
MIRT2012370	hsa-miR-450b-5p	CLIP-seq
MIRT2012371	hsa-miR-4649-3p	CLIP-seq
MIRT2012372	hsa-miR-4691-3p	CLIP-seq
MIRT1054465	hsa-miR-4701-5p	CLIP-seq
MIRT2012373	hsa-miR-4718	CLIP-seq
MIRT1054467	hsa-miR-4722-5p	CLIP-seq
MIRT2012374	hsa-miR-4768-3p	CLIP-seq
MIRT1054473	hsa-miR-4781-3p	CLIP-seq
MIRT2012375	hsa-miR-4804-5p	CLIP-seq
MIRT2012376	hsa-miR-5047	CLIP-seq
MIRT2012377	hsa-miR-507	CLIP-seq
MIRT1054504	hsa-miR-509-3-5p	CLIP-seq
MIRT1054505	hsa-miR-509-5p	CLIP-seq
MIRT1054475	hsa-miR-510	CLIP-seq
MIRT2012378	hsa-miR-512-5p	CLIP-seq
MIRT1054478	hsa-miR-548s	CLIP-seq
MIRT2012379	hsa-miR-557	CLIP-seq
MIRT1054480	hsa-miR-588	CLIP-seq
MIRT2012380	hsa-miR-652	CLIP-seq
MIRT1054485	hsa-miR-873	CLIP-seq
MIRT2012381	hsa-miR-890	CLIP-seq
MIRT2012382	hsa-miR-891b	CLIP-seq
MIRT2012383	hsa-miR-940	CLIP-seq
MIRT2244680	hsa-miR-106a	CLIP-seq
MIRT2244681	hsa-miR-106b	CLIP-seq
MIRT2244682	hsa-miR-1234	CLIP-seq
MIRT2012357	hsa-miR-1343	CLIP-seq
MIRT2012358	hsa-miR-150	CLIP-seq
MIRT2244683	hsa-miR-17	CLIP-seq
MIRT1054430	hsa-miR-183	CLIP-seq
MIRT1054489	hsa-miR-197	CLIP-seq
MIRT2244684	hsa-miR-20a	CLIP-seq
MIRT2244685	hsa-miR-20b	CLIP-seq
MIRT2012362	hsa-miR-26a	CLIP-seq
MIRT2012363	hsa-miR-26b	CLIP-seq
MIRT2244686	hsa-miR-302a	CLIP-seq
MIRT2244687	hsa-miR-302b	CLIP-seq
MIRT2244688	hsa-miR-302c	CLIP-seq
MIRT2244689	hsa-miR-302d	CLIP-seq
MIRT2244690	hsa-miR-302e	CLIP-seq
MIRT2244691	hsa-miR-3159	CLIP-seq
MIRT2244692	hsa-miR-3622b-5p	CLIP-seq
MIRT2244693	hsa-miR-3689a-3p	CLIP-seq
MIRT2244694	hsa-miR-3689c	CLIP-seq
MIRT2244695	hsa-miR-372	CLIP-seq
MIRT2244696	hsa-miR-373	CLIP-seq
MIRT1054500	hsa-miR-4433	CLIP-seq
MIRT2244697	hsa-miR-4728-5p	CLIP-seq
MIRT2244698	hsa-miR-519d	CLIP-seq
MIRT2244699	hsa-miR-520a-3p	CLIP-seq
MIRT2244700	hsa-miR-520b	CLIP-seq
MIRT2244701	hsa-miR-520c-3p	CLIP-seq
MIRT2244702	hsa-miR-520d-3p	CLIP-seq
MIRT2244703	hsa-miR-520e	CLIP-seq
MIRT2244704	hsa-miR-520g	CLIP-seq
MIRT2244705	hsa-miR-520h	CLIP-seq
MIRT1054483	hsa-miR-661	CLIP-seq
MIRT1054484	hsa-miR-766	CLIP-seq
MIRT1054508	hsa-miR-767-5p	CLIP-seq
MIRT2012381	hsa-miR-890	CLIP-seq
MIRT2244706	hsa-miR-93	CLIP-seq
MIRT2547625	hsa-miR-10a	CLIP-seq
MIRT2547626	hsa-miR-10b	CLIP-seq
MIRT2012354	hsa-miR-122	CLIP-seq
MIRT1054426	hsa-miR-1228	CLIP-seq
MIRT1054428	hsa-miR-1283	CLIP-seq
MIRT2012356	hsa-miR-1307	CLIP-seq
MIRT2012357	hsa-miR-1343	CLIP-seq
MIRT2012362	hsa-miR-26a	CLIP-seq
MIRT2012363	hsa-miR-26b	CLIP-seq
MIRT1054436	hsa-miR-3120-5p	CLIP-seq
MIRT2012366	hsa-miR-3135b	CLIP-seq
MIRT1054439	hsa-miR-3165	CLIP-seq
MIRT1054441	hsa-miR-3197	CLIP-seq
MIRT2547627	hsa-miR-339-5p	CLIP-seq
MIRT1054445	hsa-miR-3613-3p	CLIP-seq
MIRT2012368	hsa-miR-3652	CLIP-seq
MIRT1054447	hsa-miR-3656	CLIP-seq
MIRT1054449	hsa-miR-3675-3p	CLIP-seq
MIRT2547628	hsa-miR-371-5p	CLIP-seq
MIRT2547629	hsa-miR-371b-5p	CLIP-seq
MIRT2547630	hsa-miR-3929	CLIP-seq
MIRT1054454	hsa-miR-4282	CLIP-seq
MIRT2547631	hsa-miR-4419b	CLIP-seq
MIRT2547632	hsa-miR-4421	CLIP-seq
MIRT2012369	hsa-miR-4430	CLIP-seq
MIRT2547633	hsa-miR-4478	CLIP-seq
MIRT2012371	hsa-miR-4649-3p	CLIP-seq
MIRT1054463	hsa-miR-4684-5p	CLIP-seq
MIRT2547634	hsa-miR-4698	CLIP-seq
MIRT1054472	hsa-miR-4778-5p	CLIP-seq
MIRT2547635	hsa-miR-485-5p	CLIP-seq
MIRT2547636	hsa-miR-548c-3p	CLIP-seq
MIRT2547625	hsa-miR-10a	CLIP-seq
MIRT2547626	hsa-miR-10b	CLIP-seq
MIRT2012354	hsa-miR-122	CLIP-seq
MIRT1054426	hsa-miR-1228	CLIP-seq
MIRT1054428	hsa-miR-1283	CLIP-seq
MIRT2012356	hsa-miR-1307	CLIP-seq
MIRT1054436	hsa-miR-3120-5p	CLIP-seq
MIRT2012366	hsa-miR-3135b	CLIP-seq
MIRT1054439	hsa-miR-3165	CLIP-seq
MIRT1054441	hsa-miR-3197	CLIP-seq
MIRT2547627	hsa-miR-339-5p	CLIP-seq
MIRT1054445	hsa-miR-3613-3p	CLIP-seq
MIRT2012368	hsa-miR-3652	CLIP-seq
MIRT1054447	hsa-miR-3656	CLIP-seq
MIRT1054449	hsa-miR-3675-3p	CLIP-seq
MIRT2547628	hsa-miR-371-5p	CLIP-seq
MIRT2547629	hsa-miR-371b-5p	CLIP-seq
MIRT2547630	hsa-miR-3929	CLIP-seq
MIRT1054454	hsa-miR-4282	CLIP-seq
MIRT2547631	hsa-miR-4419b	CLIP-seq
MIRT2547632	hsa-miR-4421	CLIP-seq
MIRT2012369	hsa-miR-4430	CLIP-seq
MIRT2547633	hsa-miR-4478	CLIP-seq
MIRT2012371	hsa-miR-4649-3p	CLIP-seq
MIRT1054463	hsa-miR-4684-5p	CLIP-seq
MIRT2547634	hsa-miR-4698	CLIP-seq
MIRT1054472	hsa-miR-4778-5p	CLIP-seq
MIRT2547635	hsa-miR-485-5p	CLIP-seq
MIRT2547636	hsa-miR-548c-3p	CLIP-seq

Transcription factors

Show/Hide all(5)

Transcription factor	Regulation	Reference
EGR1	Activation	15709168;16007175
EGR1	Unknown	17656651;20403028
NFKB1	Activation	14558943;17715045
POU4F1	Unknown	16112651
RELA	Activation	14558943;17715045

Show/Hide all(46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004566	Function	Beta-glucuronidase activity	TAS	10395325
GO:0005515	Function	Protein binding	IPI	12927802, 15292202, 20561914, 20634491
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IDA	20309870
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005764	Component	Lysosome	IDA	15126626
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0006029	Process	Proteoglycan metabolic process	TAS	10446189
GO:0007155	Process	Cell adhesion	IEA
GO:0007160	Process	Cell-matrix adhesion	IBA
GO:0007160	Process	Cell-matrix adhesion	IDA	12773484
GO:0010575	Process	Positive regulation of vascular endothelial growth factor production	IDA	16452201
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0030194	Process	Positive regulation of blood coagulation	IDA	20634491
GO:0030200	Process	Heparan sulfate proteoglycan catabolic process	IDA	12213822
GO:0030200	Process	Heparan sulfate proteoglycan catabolic process	IEA
GO:0030202	Process	Heparin proteoglycan metabolic process	IEA
GO:0030305	Function	Heparanase activity	IDA	12927802
GO:0030305	Function	Heparanase activity	IDA	12213822
GO:0030305	Function	Heparanase activity	IEA
GO:0031012	Component	Extracellular matrix	IBA
GO:0033690	Process	Positive regulation of osteoblast proliferation	IDA	20309870
GO:0033690	Process	Positive regulation of osteoblast proliferation	IEA
GO:0035580	Component	Specific granule lumen	TAS
GO:0042060	Process	Wound healing	IEA
GO:0043202	Component	Lysosomal lumen	TAS
GO:0045121	Component	Membrane raft	IEA
GO:0045545	Function	Syndecan binding	IDA	15292202
GO:0046677	Process	Response to antibiotic	IEA
GO:0051797	Process	Regulation of hair follicle development	IDA	18557927
GO:0051798	Process	Positive regulation of hair follicle development	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	15044433
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0060055	Process	Angiogenesis involved in wound healing	IBA
GO:0060055	Process	Angiogenesis involved in wound healing	IEA
GO:0061028	Process	Establishment of endothelial barrier	IEA
GO:0061042	Process	Vascular wound healing	IEA
GO:0071806	Process	Protein transmembrane transport	IEA
GO:1904974	Component	Heparanase complex	IDA	12927802

MIM	HGNC	e!Ensembl
604724	5164	ENSG00000173083

Protein

UniProt ID

Q9Y251

Protein name

Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]

Protein function

Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuron

PDB

5E8M , 5E97 , 5E98 , 5E9B , 5E9C , 5L9Y , 5L9Z , 5LA4 , 5LA7 , 6ZDM , 7PR7 , 7PR8 , 7PRT , 7RG8 , 7YI7 , 7YJC , 8B0B , 8B0C , 8BAC , 8CQI , 8E07 , 8E08 , 8JYG , 8OHQ , 8OHR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03662	Glyco_hydro_79n	146 → 370	Glycosyl hydrolase family 79, N-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair follicles, specifically in both Henl

Sequence

MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI

Sequence length

543

Interactions

View interactions

	KEGG		Reactome
	Glycosaminoglycan degradation Metabolic pathways Proteoglycans in cancer		HS-GAG degradation Neutrophil degranulation

HPSE (heparanase)