Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10855
Gene name	Heparanase
Gene symbol	HPSE
Synonyms (NCBI Gene)	HPAHPA1HPR1HPSE1HSE1
Chromosome	4
Chromosome location	4q21.23
Summary	Heparan sulfate proteoglycans are major components of the basement membrane and extracellular matrix. The protein encoded by this gene is an enzyme that cleaves heparan sulfate proteoglycans to permit cell movement through remodeling of the extracellular

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miRTarBase ID	miRNA	Experiments	Reference
MIRT005537	hsa-miR-1258	ImmunohistochemistryIn situ hybridizationLuciferase reporter assayqRT-PCR	21266359
MIRT702813	hsa-miR-7153-3p	HITS-CLIP	23313552
MIRT702812	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT702806	hsa-miR-183-5p	HITS-CLIP	23313552
MIRT685087	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT673614	hsa-miR-6742-3p	HITS-CLIP	23313552
MIRT702811	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT702810	hsa-miR-6776-5p	HITS-CLIP	23313552
MIRT702809	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT702807	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT702808	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT702806	hsa-miR-183-5p	HITS-CLIP	23313552
MIRT702805	hsa-miR-1262	HITS-CLIP	23313552
MIRT702804	hsa-miR-4701-3p	HITS-CLIP	23313552
MIRT702803	hsa-miR-6736-5p	HITS-CLIP	23313552
MIRT680210	hsa-miR-5571-5p	HITS-CLIP	23313552
MIRT673619	hsa-miR-5697	HITS-CLIP	23313552
MIRT685087	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT685086	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT685085	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT685084	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT685083	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT685082	hsa-miR-1976	HITS-CLIP	23313552
MIRT685081	hsa-miR-1913	HITS-CLIP	23313552
MIRT685080	hsa-miR-324-3p	HITS-CLIP	23313552
MIRT685079	hsa-miR-5699-5p	HITS-CLIP	23313552
MIRT685078	hsa-miR-4758-3p	HITS-CLIP	23313552
MIRT685077	hsa-miR-3189-5p	HITS-CLIP	23313552
MIRT673601	hsa-miR-1297	HITS-CLIP	23313552
MIRT673600	hsa-miR-26a-5p	HITS-CLIP	23313552
MIRT673599	hsa-miR-26b-5p	HITS-CLIP	23313552
MIRT673598	hsa-miR-4465	HITS-CLIP	23313552
MIRT680209	hsa-miR-4279	HITS-CLIP	23313552
MIRT680210	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT673619	hsa-miR-5697	HITS-CLIP	23824327
MIRT673618	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT673617	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT673616	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT673615	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT673614	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT673613	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT673612	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT673611	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT673610	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT673609	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT673608	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT673607	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT673606	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT673604	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT673603	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT673601	hsa-miR-1297	HITS-CLIP	23824327
MIRT673600	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT673599	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT673598	hsa-miR-4465	HITS-CLIP	23824327
MIRT673597	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT673596	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT680209	hsa-miR-4279	HITS-CLIP	23824327
MIRT673595	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT673594	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT673619	hsa-miR-5697	HITS-CLIP	23824327
MIRT673618	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT673617	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT673616	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT673615	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT673614	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT673613	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT673612	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT673611	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT673610	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT673609	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT673608	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT673607	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT673606	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT673605	hsa-miR-4284	HITS-CLIP	23824327
MIRT673604	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT673603	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT673602	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT673601	hsa-miR-1297	HITS-CLIP	23824327
MIRT673600	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT673599	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT673598	hsa-miR-4465	HITS-CLIP	23824327
MIRT673597	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT673596	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT673595	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT673594	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT530358	hsa-miR-3133	PAR-CLIP	22012620
MIRT530357	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT530356	hsa-miR-3681-5p	PAR-CLIP	22012620
MIRT530355	hsa-miR-6849-5p	PAR-CLIP	22012620
MIRT530354	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT530353	hsa-miR-376b-5p	PAR-CLIP	22012620
MIRT530352	hsa-miR-376c-5p	PAR-CLIP	22012620
MIRT530351	hsa-miR-4536-5p	PAR-CLIP	22012620
MIRT530350	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT530349	hsa-miR-3161	PAR-CLIP	22012620
MIRT530348	hsa-miR-1261	PAR-CLIP	22012620
MIRT732777	hsa-miR-219a-2-3p	Luciferase reporter assayqRT-PCRWestern blotting	33968189
MIRT734843	hsa-miR-1252-5p	qRT-PCRFlow cytometry	33488100
MIRT702813	hsa-miR-7153-3p	HITS-CLIP	23313552
MIRT702812	hsa-miR-508-5p	HITS-CLIP	23313552
MIRT702806	hsa-miR-183-5p	HITS-CLIP	23313552
MIRT685087	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT673614	hsa-miR-6742-3p	HITS-CLIP	23313552
MIRT702811	hsa-miR-766-3p	HITS-CLIP	23313552
MIRT702810	hsa-miR-6776-5p	HITS-CLIP	23313552
MIRT702809	hsa-miR-542-3p	HITS-CLIP	23313552
MIRT702807	hsa-miR-6512-3p	HITS-CLIP	23313552
MIRT702808	hsa-miR-6720-5p	HITS-CLIP	23313552
MIRT702806	hsa-miR-183-5p	HITS-CLIP	23313552
MIRT702805	hsa-miR-1262	HITS-CLIP	23313552
MIRT702804	hsa-miR-4701-3p	HITS-CLIP	23313552
MIRT702803	hsa-miR-6736-5p	HITS-CLIP	23313552
MIRT680210	hsa-miR-5571-5p	HITS-CLIP	23313552
MIRT673619	hsa-miR-5697	HITS-CLIP	23313552
MIRT685087	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT685086	hsa-miR-4722-3p	HITS-CLIP	23313552
MIRT685085	hsa-miR-6727-3p	HITS-CLIP	23313552
MIRT685084	hsa-miR-6747-3p	HITS-CLIP	23313552
MIRT685083	hsa-miR-3653-5p	HITS-CLIP	23313552
MIRT685082	hsa-miR-1976	HITS-CLIP	23313552
MIRT685081	hsa-miR-1913	HITS-CLIP	23313552
MIRT685080	hsa-miR-324-3p	HITS-CLIP	23313552
MIRT685079	hsa-miR-5699-5p	HITS-CLIP	23313552
MIRT685078	hsa-miR-4758-3p	HITS-CLIP	23313552
MIRT685077	hsa-miR-3189-5p	HITS-CLIP	23313552
MIRT673601	hsa-miR-1297	HITS-CLIP	23313552
MIRT673600	hsa-miR-26a-5p	HITS-CLIP	23313552
MIRT673599	hsa-miR-26b-5p	HITS-CLIP	23313552
MIRT673598	hsa-miR-4465	HITS-CLIP	23313552
MIRT680209	hsa-miR-4279	HITS-CLIP	23313552
MIRT680210	hsa-miR-5571-5p	HITS-CLIP	23824327
MIRT673619	hsa-miR-5697	HITS-CLIP	23824327
MIRT673618	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT673617	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT673616	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT673615	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT673614	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT673613	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT673612	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT673611	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT673610	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT673609	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT673608	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT673607	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT673606	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT673604	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT673603	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT673601	hsa-miR-1297	HITS-CLIP	23824327
MIRT673600	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT673599	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT673598	hsa-miR-4465	HITS-CLIP	23824327
MIRT673597	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT673596	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT680209	hsa-miR-4279	HITS-CLIP	23824327
MIRT673595	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT673594	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT673619	hsa-miR-5697	HITS-CLIP	23824327
MIRT673618	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT673617	hsa-miR-660-3p	HITS-CLIP	23824327
MIRT673616	hsa-miR-939-3p	HITS-CLIP	23824327
MIRT673615	hsa-miR-6852-5p	HITS-CLIP	23824327
MIRT673614	hsa-miR-6742-3p	HITS-CLIP	23824327
MIRT673613	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT673612	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT673611	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT673610	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT673609	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT673608	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT673607	hsa-miR-6791-3p	HITS-CLIP	23824327
MIRT673606	hsa-miR-6829-3p	HITS-CLIP	23824327
MIRT673605	hsa-miR-4284	HITS-CLIP	23824327
MIRT673604	hsa-miR-23a-5p	HITS-CLIP	23824327
MIRT673603	hsa-miR-23b-5p	HITS-CLIP	23824327
MIRT673602	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT673601	hsa-miR-1297	HITS-CLIP	23824327
MIRT673600	hsa-miR-26a-5p	HITS-CLIP	23824327
MIRT673599	hsa-miR-26b-5p	HITS-CLIP	23824327
MIRT673598	hsa-miR-4465	HITS-CLIP	23824327
MIRT673597	hsa-miR-1343-3p	HITS-CLIP	23824327
MIRT673596	hsa-miR-6783-3p	HITS-CLIP	23824327
MIRT673595	hsa-miR-5001-3p	HITS-CLIP	23824327
MIRT673594	hsa-miR-6836-3p	HITS-CLIP	23824327
MIRT530358	hsa-miR-3133	PAR-CLIP	22012620
MIRT530357	hsa-miR-186-5p	PAR-CLIP	22012620
MIRT530356	hsa-miR-3681-5p	PAR-CLIP	22012620
MIRT530355	hsa-miR-6849-5p	PAR-CLIP	22012620
MIRT530354	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT530353	hsa-miR-376b-5p	PAR-CLIP	22012620
MIRT530352	hsa-miR-376c-5p	PAR-CLIP	22012620
MIRT530351	hsa-miR-4536-5p	PAR-CLIP	22012620
MIRT530350	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT530349	hsa-miR-3161	PAR-CLIP	22012620
MIRT530348	hsa-miR-1261	PAR-CLIP	22012620
MIRT1054424	hsa-miR-1224-5p	CLIP-seq
MIRT1054425	hsa-miR-1225-3p	CLIP-seq
MIRT1054426	hsa-miR-1228	CLIP-seq
MIRT1054427	hsa-miR-1233	CLIP-seq
MIRT1054428	hsa-miR-1283	CLIP-seq
MIRT1054429	hsa-miR-141	CLIP-seq
MIRT1054430	hsa-miR-183	CLIP-seq
MIRT1054431	hsa-miR-186	CLIP-seq
MIRT1054432	hsa-miR-200a	CLIP-seq
MIRT1054433	hsa-miR-200b	CLIP-seq
MIRT1054434	hsa-miR-200c	CLIP-seq
MIRT1054435	hsa-miR-24	CLIP-seq
MIRT1054436	hsa-miR-3120-5p	CLIP-seq
MIRT1054437	hsa-miR-3123	CLIP-seq
MIRT1054438	hsa-miR-3148	CLIP-seq
MIRT1054439	hsa-miR-3165	CLIP-seq
MIRT1054440	hsa-miR-3187-3p	CLIP-seq
MIRT1054441	hsa-miR-3197	CLIP-seq
MIRT1054442	hsa-miR-337-5p	CLIP-seq
MIRT1054443	hsa-miR-342-3p	CLIP-seq
MIRT1054444	hsa-miR-3605-5p	CLIP-seq
MIRT1054445	hsa-miR-3613-3p	CLIP-seq
MIRT1054446	hsa-miR-3614-5p	CLIP-seq
MIRT1054447	hsa-miR-3656	CLIP-seq
MIRT1054448	hsa-miR-3664-3p	CLIP-seq
MIRT1054449	hsa-miR-3675-3p	CLIP-seq
MIRT1054450	hsa-miR-3688-3p	CLIP-seq
MIRT1054451	hsa-miR-3915	CLIP-seq
MIRT1054452	hsa-miR-3925-5p	CLIP-seq
MIRT1054453	hsa-miR-3927	CLIP-seq
MIRT1054454	hsa-miR-4282	CLIP-seq
MIRT1054455	hsa-miR-429	CLIP-seq
MIRT1054456	hsa-miR-4435	CLIP-seq
MIRT1054457	hsa-miR-4451	CLIP-seq
MIRT1054458	hsa-miR-4455	CLIP-seq
MIRT1054459	hsa-miR-4459	CLIP-seq
MIRT1054460	hsa-miR-4485	CLIP-seq
MIRT1054461	hsa-miR-4536	CLIP-seq
MIRT1054462	hsa-miR-4641	CLIP-seq
MIRT1054463	hsa-miR-4684-5p	CLIP-seq
MIRT1054464	hsa-miR-4689	CLIP-seq
MIRT1054465	hsa-miR-4701-5p	CLIP-seq
MIRT1054466	hsa-miR-4716-5p	CLIP-seq
MIRT1054467	hsa-miR-4722-5p	CLIP-seq
MIRT1054468	hsa-miR-4731-5p	CLIP-seq
MIRT1054469	hsa-miR-4751	CLIP-seq
MIRT1054470	hsa-miR-4755-3p	CLIP-seq
MIRT1054471	hsa-miR-4774-5p	CLIP-seq
MIRT1054472	hsa-miR-4778-5p	CLIP-seq
MIRT1054473	hsa-miR-4781-3p	CLIP-seq
MIRT1054474	hsa-miR-494	CLIP-seq
MIRT1054475	hsa-miR-510	CLIP-seq
MIRT1054476	hsa-miR-548aa	CLIP-seq
MIRT1054477	hsa-miR-548m	CLIP-seq
MIRT1054478	hsa-miR-548s	CLIP-seq
MIRT1054479	hsa-miR-548v	CLIP-seq
MIRT1054480	hsa-miR-588	CLIP-seq
MIRT1054481	hsa-miR-595	CLIP-seq
MIRT1054482	hsa-miR-609	CLIP-seq
MIRT1054483	hsa-miR-661	CLIP-seq
MIRT1054484	hsa-miR-766	CLIP-seq
MIRT1054485	hsa-miR-873	CLIP-seq
MIRT1054424	hsa-miR-1224-5p	CLIP-seq
MIRT1054426	hsa-miR-1228	CLIP-seq
MIRT1054486	hsa-miR-1229	CLIP-seq
MIRT1054487	hsa-miR-1253	CLIP-seq
MIRT1054488	hsa-miR-1285	CLIP-seq
MIRT1054429	hsa-miR-141	CLIP-seq
MIRT1054430	hsa-miR-183	CLIP-seq
MIRT1054489	hsa-miR-197	CLIP-seq
MIRT1054432	hsa-miR-200a	CLIP-seq
MIRT1054433	hsa-miR-200b	CLIP-seq
MIRT1054434	hsa-miR-200c	CLIP-seq
MIRT1054490	hsa-miR-2117	CLIP-seq
MIRT1054491	hsa-miR-217	CLIP-seq
MIRT1054435	hsa-miR-24	CLIP-seq
MIRT1054492	hsa-miR-25	CLIP-seq
MIRT1054439	hsa-miR-3165	CLIP-seq
MIRT1054493	hsa-miR-3170	CLIP-seq
MIRT1054440	hsa-miR-3187-3p	CLIP-seq
MIRT1054494	hsa-miR-3187-5p	CLIP-seq
MIRT1054495	hsa-miR-32	CLIP-seq
MIRT1054442	hsa-miR-337-5p	CLIP-seq
MIRT1054443	hsa-miR-342-3p	CLIP-seq
MIRT1054446	hsa-miR-3614-5p	CLIP-seq
MIRT1054496	hsa-miR-363	CLIP-seq
MIRT1054497	hsa-miR-367	CLIP-seq
MIRT1054451	hsa-miR-3915	CLIP-seq
MIRT1054498	hsa-miR-4273	CLIP-seq
MIRT1054455	hsa-miR-429	CLIP-seq
MIRT1054499	hsa-miR-4418	CLIP-seq
MIRT1054500	hsa-miR-4433	CLIP-seq
MIRT1054456	hsa-miR-4435	CLIP-seq
MIRT1054458	hsa-miR-4455	CLIP-seq
MIRT1054460	hsa-miR-4485	CLIP-seq
MIRT1054501	hsa-miR-4677-3p	CLIP-seq
MIRT1054464	hsa-miR-4689	CLIP-seq
MIRT1054465	hsa-miR-4701-5p	CLIP-seq
MIRT1054466	hsa-miR-4716-5p	CLIP-seq
MIRT1054468	hsa-miR-4731-5p	CLIP-seq
MIRT1054469	hsa-miR-4751	CLIP-seq
MIRT1054470	hsa-miR-4755-3p	CLIP-seq
MIRT1054502	hsa-miR-4766-5p	CLIP-seq
MIRT1054471	hsa-miR-4774-5p	CLIP-seq
MIRT1054473	hsa-miR-4781-3p	CLIP-seq
MIRT1054503	hsa-miR-4793-3p	CLIP-seq
MIRT1054504	hsa-miR-509-3-5p	CLIP-seq
MIRT1054505	hsa-miR-509-5p	CLIP-seq
MIRT1054506	hsa-miR-5096	CLIP-seq
MIRT1054478	hsa-miR-548s	CLIP-seq
MIRT1054480	hsa-miR-588	CLIP-seq
MIRT1054481	hsa-miR-595	CLIP-seq
MIRT1054482	hsa-miR-609	CLIP-seq
MIRT1054507	hsa-miR-612	CLIP-seq
MIRT1054483	hsa-miR-661	CLIP-seq
MIRT1054484	hsa-miR-766	CLIP-seq
MIRT1054508	hsa-miR-767-5p	CLIP-seq
MIRT1054509	hsa-miR-92a	CLIP-seq
MIRT1054510	hsa-miR-92b	CLIP-seq
MIRT2012352	hsa-miR-103a	CLIP-seq
MIRT2012353	hsa-miR-107	CLIP-seq
MIRT2012354	hsa-miR-122	CLIP-seq
MIRT1054426	hsa-miR-1228	CLIP-seq
MIRT2012355	hsa-miR-1301	CLIP-seq
MIRT2012356	hsa-miR-1307	CLIP-seq
MIRT2012357	hsa-miR-1343	CLIP-seq
MIRT2012358	hsa-miR-150	CLIP-seq
MIRT2012359	hsa-miR-1827	CLIP-seq
MIRT2012360	hsa-miR-184	CLIP-seq
MIRT1054431	hsa-miR-186	CLIP-seq
MIRT1054433	hsa-miR-200b	CLIP-seq
MIRT1054434	hsa-miR-200c	CLIP-seq
MIRT2012361	hsa-miR-216b	CLIP-seq
MIRT1054491	hsa-miR-217	CLIP-seq
MIRT2012362	hsa-miR-26a	CLIP-seq
MIRT2012363	hsa-miR-26b	CLIP-seq
MIRT2012364	hsa-miR-2964a-3p	CLIP-seq
MIRT2012365	hsa-miR-302f	CLIP-seq
MIRT2012366	hsa-miR-3135b	CLIP-seq
MIRT2012367	hsa-miR-3157-5p	CLIP-seq
MIRT1054440	hsa-miR-3187-3p	CLIP-seq
MIRT1054442	hsa-miR-337-5p	CLIP-seq
MIRT2012368	hsa-miR-3652	CLIP-seq
MIRT1054448	hsa-miR-3664-3p	CLIP-seq
MIRT1054455	hsa-miR-429	CLIP-seq
MIRT1054499	hsa-miR-4418	CLIP-seq
MIRT2012369	hsa-miR-4430	CLIP-seq
MIRT1054456	hsa-miR-4435	CLIP-seq
MIRT1054460	hsa-miR-4485	CLIP-seq
MIRT2012370	hsa-miR-450b-5p	CLIP-seq
MIRT2012371	hsa-miR-4649-3p	CLIP-seq
MIRT2012372	hsa-miR-4691-3p	CLIP-seq
MIRT1054465	hsa-miR-4701-5p	CLIP-seq
MIRT2012373	hsa-miR-4718	CLIP-seq
MIRT1054467	hsa-miR-4722-5p	CLIP-seq
MIRT2012374	hsa-miR-4768-3p	CLIP-seq
MIRT1054473	hsa-miR-4781-3p	CLIP-seq
MIRT2012375	hsa-miR-4804-5p	CLIP-seq
MIRT2012376	hsa-miR-5047	CLIP-seq
MIRT2012377	hsa-miR-507	CLIP-seq
MIRT1054504	hsa-miR-509-3-5p	CLIP-seq
MIRT1054505	hsa-miR-509-5p	CLIP-seq
MIRT1054475	hsa-miR-510	CLIP-seq
MIRT2012378	hsa-miR-512-5p	CLIP-seq
MIRT1054478	hsa-miR-548s	CLIP-seq
MIRT2012379	hsa-miR-557	CLIP-seq
MIRT1054480	hsa-miR-588	CLIP-seq
MIRT2012380	hsa-miR-652	CLIP-seq
MIRT1054485	hsa-miR-873	CLIP-seq
MIRT2012381	hsa-miR-890	CLIP-seq
MIRT2012382	hsa-miR-891b	CLIP-seq
MIRT2012383	hsa-miR-940	CLIP-seq
MIRT2244680	hsa-miR-106a	CLIP-seq
MIRT2244681	hsa-miR-106b	CLIP-seq
MIRT2244682	hsa-miR-1234	CLIP-seq
MIRT2012357	hsa-miR-1343	CLIP-seq
MIRT2012358	hsa-miR-150	CLIP-seq
MIRT2244683	hsa-miR-17	CLIP-seq
MIRT1054430	hsa-miR-183	CLIP-seq
MIRT1054489	hsa-miR-197	CLIP-seq
MIRT2244684	hsa-miR-20a	CLIP-seq
MIRT2244685	hsa-miR-20b	CLIP-seq
MIRT2012362	hsa-miR-26a	CLIP-seq
MIRT2012363	hsa-miR-26b	CLIP-seq
MIRT2244686	hsa-miR-302a	CLIP-seq
MIRT2244687	hsa-miR-302b	CLIP-seq
MIRT2244688	hsa-miR-302c	CLIP-seq
MIRT2244689	hsa-miR-302d	CLIP-seq
MIRT2244690	hsa-miR-302e	CLIP-seq
MIRT2244691	hsa-miR-3159	CLIP-seq
MIRT2244692	hsa-miR-3622b-5p	CLIP-seq
MIRT2244693	hsa-miR-3689a-3p	CLIP-seq
MIRT2244694	hsa-miR-3689c	CLIP-seq
MIRT2244695	hsa-miR-372	CLIP-seq
MIRT2244696	hsa-miR-373	CLIP-seq
MIRT1054500	hsa-miR-4433	CLIP-seq
MIRT2244697	hsa-miR-4728-5p	CLIP-seq
MIRT2244698	hsa-miR-519d	CLIP-seq
MIRT2244699	hsa-miR-520a-3p	CLIP-seq
MIRT2244700	hsa-miR-520b	CLIP-seq
MIRT2244701	hsa-miR-520c-3p	CLIP-seq
MIRT2244702	hsa-miR-520d-3p	CLIP-seq
MIRT2244703	hsa-miR-520e	CLIP-seq
MIRT2244704	hsa-miR-520g	CLIP-seq
MIRT2244705	hsa-miR-520h	CLIP-seq
MIRT1054483	hsa-miR-661	CLIP-seq
MIRT1054484	hsa-miR-766	CLIP-seq
MIRT1054508	hsa-miR-767-5p	CLIP-seq
MIRT2012381	hsa-miR-890	CLIP-seq
MIRT2244706	hsa-miR-93	CLIP-seq
MIRT2547625	hsa-miR-10a	CLIP-seq
MIRT2547626	hsa-miR-10b	CLIP-seq
MIRT2012354	hsa-miR-122	CLIP-seq
MIRT1054426	hsa-miR-1228	CLIP-seq
MIRT1054428	hsa-miR-1283	CLIP-seq
MIRT2012356	hsa-miR-1307	CLIP-seq
MIRT2012357	hsa-miR-1343	CLIP-seq
MIRT2012362	hsa-miR-26a	CLIP-seq
MIRT2012363	hsa-miR-26b	CLIP-seq
MIRT1054436	hsa-miR-3120-5p	CLIP-seq
MIRT2012366	hsa-miR-3135b	CLIP-seq
MIRT1054439	hsa-miR-3165	CLIP-seq
MIRT1054441	hsa-miR-3197	CLIP-seq
MIRT2547627	hsa-miR-339-5p	CLIP-seq
MIRT1054445	hsa-miR-3613-3p	CLIP-seq
MIRT2012368	hsa-miR-3652	CLIP-seq
MIRT1054447	hsa-miR-3656	CLIP-seq
MIRT1054449	hsa-miR-3675-3p	CLIP-seq
MIRT2547628	hsa-miR-371-5p	CLIP-seq
MIRT2547629	hsa-miR-371b-5p	CLIP-seq
MIRT2547630	hsa-miR-3929	CLIP-seq
MIRT1054454	hsa-miR-4282	CLIP-seq
MIRT2547631	hsa-miR-4419b	CLIP-seq
MIRT2547632	hsa-miR-4421	CLIP-seq
MIRT2012369	hsa-miR-4430	CLIP-seq
MIRT2547633	hsa-miR-4478	CLIP-seq
MIRT2012371	hsa-miR-4649-3p	CLIP-seq
MIRT1054463	hsa-miR-4684-5p	CLIP-seq
MIRT2547634	hsa-miR-4698	CLIP-seq
MIRT1054472	hsa-miR-4778-5p	CLIP-seq
MIRT2547635	hsa-miR-485-5p	CLIP-seq
MIRT2547636	hsa-miR-548c-3p	CLIP-seq
MIRT2547625	hsa-miR-10a	CLIP-seq
MIRT2547626	hsa-miR-10b	CLIP-seq
MIRT2012354	hsa-miR-122	CLIP-seq
MIRT1054426	hsa-miR-1228	CLIP-seq
MIRT1054428	hsa-miR-1283	CLIP-seq
MIRT2012356	hsa-miR-1307	CLIP-seq
MIRT1054436	hsa-miR-3120-5p	CLIP-seq
MIRT2012366	hsa-miR-3135b	CLIP-seq
MIRT1054439	hsa-miR-3165	CLIP-seq
MIRT1054441	hsa-miR-3197	CLIP-seq
MIRT2547627	hsa-miR-339-5p	CLIP-seq
MIRT1054445	hsa-miR-3613-3p	CLIP-seq
MIRT2012368	hsa-miR-3652	CLIP-seq
MIRT1054447	hsa-miR-3656	CLIP-seq
MIRT1054449	hsa-miR-3675-3p	CLIP-seq
MIRT2547628	hsa-miR-371-5p	CLIP-seq
MIRT2547629	hsa-miR-371b-5p	CLIP-seq
MIRT2547630	hsa-miR-3929	CLIP-seq
MIRT1054454	hsa-miR-4282	CLIP-seq
MIRT2547631	hsa-miR-4419b	CLIP-seq
MIRT2547632	hsa-miR-4421	CLIP-seq
MIRT2012369	hsa-miR-4430	CLIP-seq
MIRT2547633	hsa-miR-4478	CLIP-seq
MIRT2012371	hsa-miR-4649-3p	CLIP-seq
MIRT1054463	hsa-miR-4684-5p	CLIP-seq
MIRT2547634	hsa-miR-4698	CLIP-seq
MIRT1054472	hsa-miR-4778-5p	CLIP-seq
MIRT2547635	hsa-miR-485-5p	CLIP-seq
MIRT2547636	hsa-miR-548c-3p	CLIP-seq

Show/Hide all (5)

Transcription factor	Regulation	Reference
EGR1	Activation	15709168;16007175
EGR1	Unknown	17656651;20403028
NFKB1	Activation	14558943;17715045
POU4F1	Unknown	16112651
RELA	Activation	14558943;17715045

Show/Hide all (46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004566	Function	Beta-glucuronidase activity	TAS	10395325
GO:0005515	Function	Protein binding	IPI	12927802, 15292202, 20561914, 20634491
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IDA	20309870
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005764	Component	Lysosome	IDA	15126626
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0006029	Process	Proteoglycan metabolic process	TAS	10446189
GO:0007155	Process	Cell adhesion	IEA
GO:0007160	Process	Cell-matrix adhesion	IBA
GO:0007160	Process	Cell-matrix adhesion	IDA	12773484
GO:0010575	Process	Positive regulation of vascular endothelial growth factor production	IDA	16452201
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0030194	Process	Positive regulation of blood coagulation	IDA	20634491
GO:0030200	Process	Heparan sulfate proteoglycan catabolic process	IDA	12213822
GO:0030200	Process	Heparan sulfate proteoglycan catabolic process	IEA
GO:0030202	Process	Heparin proteoglycan metabolic process	IEA
GO:0030305	Function	Heparanase activity	IDA	12927802
GO:0030305	Function	Heparanase activity	IDA	12213822
GO:0030305	Function	Heparanase activity	IEA
GO:0031012	Component	Extracellular matrix	IBA
GO:0033690	Process	Positive regulation of osteoblast proliferation	IDA	20309870
GO:0033690	Process	Positive regulation of osteoblast proliferation	IEA
GO:0035580	Component	Specific granule lumen	TAS
GO:0042060	Process	Wound healing	IEA
GO:0043202	Component	Lysosomal lumen	TAS
GO:0045121	Component	Membrane raft	IEA
GO:0045545	Function	Syndecan binding	IDA	15292202
GO:0046677	Process	Response to antibiotic	IEA
GO:0051797	Process	Regulation of hair follicle development	IDA	18557927
GO:0051798	Process	Positive regulation of hair follicle development	IEA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA	15044433
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0060055	Process	Angiogenesis involved in wound healing	IBA
GO:0060055	Process	Angiogenesis involved in wound healing	IEA
GO:0061028	Process	Establishment of endothelial barrier	IEA
GO:0061042	Process	Vascular wound healing	IEA
GO:0071806	Process	Protein transmembrane transport	IEA
GO:1904974	Component	Heparanase complex	IDA	12927802

MIM	HGNC	e!Ensembl
604724	5164	ENSG00000173083

Q9Y251

Protein name

Heparanase (EC 3.2.1.166) (Endo-glucoronidase) (Heparanase-1) (Hpa1) [Cleaved into: Heparanase 8 kDa subunit; Heparanase 50 kDa subunit]

Protein function

Endoglycosidase that cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains and core proteoglycans. Participates in extracellular matrix (ECM) degradation and remodeling. Selectively cleaves the linkage between a glucuron

PDB

5E8M , 5E97 , 5E98 , 5E9B , 5E9C , 5L9Y , 5L9Z , 5LA4 , 5LA7 , 6ZDM , 7PR7 , 7PR8 , 7PRT , 7RG8 , 7YI7 , 7YJC , 8B0B , 8B0C , 8BAC , 8CQI , 8E07 , 8E08 , 8JYG , 8OHQ , 8OHR

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03662	Glyco_hydro_79n	146 → 370	Glycosyl hydrolase family 79, N-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Highly expressed in placenta and spleen and weakly expressed in lymph node, thymus, peripheral blood leukocytes, bone marrow, endothelial cells, fetal liver and tumor tissues. Also expressed in hair follicles, specifically in both Henl

Sequence

MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI

Sequence length

543

Interactions

View interactions

	KEGG		Reactome
	Glycosaminoglycan degradation Metabolic pathways Proteoglycans in cancer		HS-GAG degradation Neutrophil degranulation

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
HPSE-related disorder	Benign; Likely benign	rs75865093, rs748371922, rs11031, rs61755719, rs145560091, rs139839221, rs11099592	RCV003929786 RCV003909787 RCV003917202 RCV003924498 RCV003934400 RCV003979029 RCV003982087

Show/Hide Text Mining Associations (141)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Abortion Habitual	Associate	12738509
Abortion Spontaneous	Inhibit	23907942
Acute Disease	Associate	20075159
Acute Kidney Injury	Stimulate	35336857
Adenocarcinoma	Stimulate	19749739
Adenocarcinoma Of Esophagus	Associate	19749739
Adenocarcinoma of Lung	Associate	23649655
Adenoma	Associate	26972718
Ameloblastoma	Associate	20339231
Antiphospholipid Syndrome	Associate	34107171
Arthritis Rheumatoid	Stimulate	18512775
Atherosclerosis	Associate	18032524
Autoimmune Diseases	Associate	17041566
Barrett Esophagus	Associate	19749739
Blood Coagulation Disorders	Associate	27322195
Bone Diseases	Associate	36980254
Brain Ischemia	Associate	32118374
Breast Neoplasms	Associate	17603633, 19108738, 19602586, 22513363, 23430739, 24083474, 24632672, 28038446, 30922347, 31566192, 33053017, 36139419, 39506780
Bronchiolitis Obliterans Syndrome	Associate	27758874
Calcinosis Cutis	Associate	25149140
Caliciviridae Infections	Inhibit	29753657
Carcinogenesis	Associate	19671168, 26488476, 26972718
Carcinoma Basal Cell	Stimulate	27828631
Carcinoma Hepatocellular	Associate	15334672, 15761980, 22952874, 23771368, 25149140, 25185798, 26839882
Carcinoma in Situ	Associate	19955948
Carcinoma Non Small Cell Lung	Associate	22488243, 36428962
Carcinoma Renal Cell	Associate	22133010, 23251556
Carcinoma Squamous Cell	Stimulate	27828631
Cardiovascular Diseases	Associate	18032524, 19368146
Cartilage Diseases	Associate	29803826, 37820587
Cerebral Infarction	Associate	18383324, 32118374
Chagas Cardiomyopathy	Associate	31538834
Cholangiocarcinoma	Associate	23704979
Colitis Ulcerative	Associate	17041566
Colonic Neoplasms	Associate	11021821, 12918105
Colorectal Neoplasms	Associate	11021821, 20193112
Congenital Hyperinsulinism	Associate	28038446
Corneal Injuries	Associate	29379222
Coronary Artery Disease	Associate	28086795
COVID 19	Stimulate	35319225
Crohn Disease	Associate	17041566
Cytomegalovirus Infections	Associate	34943994
Diabetes Complications	Associate	21364956
Diabetes Mellitus	Associate	28038446
Diabetes Mellitus Type 2	Stimulate	21364956
Diabetic Nephropathies	Associate	21600934, 23095131
Disease	Associate	36980254
Endometrial Neoplasms	Associate	16803537, 19003663, 32869952
Endometriosis	Associate	18674655
Esophageal Neoplasms	Associate	11676857, 15286661, 15810091, 16097072, 19749739
Esophageal Squamous Cell Carcinoma	Associate	11676857
Esophageal Squamous Cell Carcinoma	Inhibit	16097072, 35840985
Exostoses Multiple Hereditary	Associate	18452536
Fibrosis	Associate	31271612
Fractures Bone	Associate	20309870
Gastrointestinal Neoplasms	Associate	25351637
Glioblastoma	Associate	32075104, 37508554
Glioma	Associate	18647407, 29104277
Glucosephosphate Dehydrogenase Deficiency	Associate	32869952
Graft vs Host Disease	Associate	20075159, 34685503, 34848216, 34943994
Hantavirus Infections	Associate	35336857
Head and Neck Neoplasms	Associate	19074873, 24286246
Heat Stroke	Associate	37904703
Helicobacter Infections	Stimulate	30386106
Hematologic Neoplasms	Associate	19749739, 34943994
Hematologic Neoplasms	Stimulate	20576607
Hemorrhagic Fever with Renal Syndrome	Stimulate	35336857
Hepatic Veno Occlusive Disease	Associate	25335953, 34848216
Hypertension	Associate	19368146
Hypothyroidism Congenital Nongoitrous 2	Associate	17481627
Hypoxia	Associate	31327483
Infertility	Stimulate	23907942
Inflammation	Associate	15760902, 17041566, 17208203, 17217623, 19406828, 19955948, 20075159, 20576607, 21789398, 24565907, 29379222, 31044520, 34107171, 34685503, 34848216, 34943994, 35319225, 37904703 View all (3 more)
Inflammatory Bowel Diseases	Associate	17041566
Intervertebral Disc Degeneration	Associate	21789398
Intervertebral disc disease	Associate	21789398
Intracranial Thrombosis	Associate	32118374
Keratoconus	Stimulate	29379222
Kidney Failure Chronic	Associate	19368146
Leukemia	Associate	11823035
Leukemia Myeloid Acute	Associate	11823035
Liver Neoplasms	Associate	15334672
Lung Injury	Associate	30205969
Lung Neoplasms	Associate	11759110, 18618498, 22471483, 23649655
Lymphatic Metastasis	Associate	15040016, 15286661, 15475937, 20193112, 20339231, 24766948, 25343173, 30386106
Lymphatic Metastasis	Stimulate	15810091, 16803537, 22133010, 26569485
Malignant mesenchymal tumor	Associate	19802384
Melanoma	Associate	16867222, 18288398, 20803552, 25343173, 27732945, 31044520
Metabolic Diseases	Associate	28038446
Mouth Neoplasms	Associate	20859999, 24766948, 25295847
Mucopolysaccharidosis III	Associate	22276173
Multiple Myeloma	Associate	15471949, 17339423, 18812315, 20097882, 23048032, 23430739, 26762172, 27016342, 32899927, 36980254
Myocardial Infarction	Associate	15227729
Neoplasm Metastasis	Associate	11759110, 11779847, 12918105, 15286661, 15471949, 15475937, 15761980, 15810091, 16867222, 16970801, 17603633, 18283334, 18609704, 18812315, 19074873 View all (29 more)
Neoplasm Metastasis	Stimulate	15471949, 19749739, 19916174
Neoplasms	Associate	11021821, 11710943, 11759110, 11779847, 11823035, 11953884, 15286661, 15334672, 15471949, 15475937, 15760902, 15761980, 15810091, 16097072, 16388520 View all (69 more)
Neoplasms	Stimulate	14504050, 16803537, 17217623, 17603633, 18283334, 27732945
Neoplasms	Inhibit	22952874, 32075104
Neoplasms Cystic Mucinous and Serous	Associate	20339231
Nephrotic Syndrome	Associate	15610235
No Reflow Phenomenon	Stimulate	35228564
Obesity	Associate	36139419
Osteolysis	Associate	32899927
Osteoporosis	Associate	20309870
Ovarian Neoplasms	Associate	17419711, 17437011, 35299895
Pancreatic Neoplasms	Associate	11953884
Pancreatic Neoplasms	Stimulate	16388520
Parkinson Disease	Stimulate	24189015
Phenylketonurias	Associate	15334672
Pre Eclampsia	Associate	26388242
Prostatic Neoplasms	Associate	22363633
Proteinuria	Associate	15610235, 35336857
Purpura Thrombocytopenic Idiopathic	Associate	28823219
Renal Insufficiency Chronic	Associate	24189015, 24256696
Rhabdomyosarcoma	Associate	19715595
Rhabdomyosarcoma Embryonal	Associate	19715595
Salivary Gland Neoplasms	Associate	17032504
Salivary Gland Neoplasms	Stimulate	26569485
Sarcoma	Associate	24887057, 31566192
Squamous Cell Carcinoma of Head and Neck	Associate	17217623, 24286246, 24766948, 37481997
Squamous Intraepithelial Lesions	Associate	19955948
ST Elevation Myocardial Infarction	Associate	35228564
Stomach Neoplasms	Associate	15040016, 15475937, 15682491, 18609704, 19469644, 19916174, 20137078, 22276173, 22363633, 25337202, 27685626, 30386106, 31257534
Stomach Neoplasms	Stimulate	17717429
Stroke	Associate	32118374
Subarachnoid Hemorrhage	Associate	16178861
Thrombocytopenia Neonatal Alloimmune	Associate	11370330, 16178861, 23155369, 23865077
Thrombosis	Associate	23155369
Thyroid Neoplasms	Associate	11779847, 26488476
Tongue Neoplasms	Associate	17955520
Transfusion Reaction	Associate	23865077
Triple Negative Breast Neoplasms	Associate	39506780
Urinary Bladder Neoplasms	Stimulate	18283334
Urinary Bladder Neoplasms	Associate	22363633, 23065570, 28794202
Urologic Diseases	Associate	18283334
Uterine Cervical Neoplasms	Associate	14504050, 19955948, 24286246, 27166252
Uterine Cervicitis	Associate	32869952
Uterine Diseases	Associate	17481627
Vasculopathy Retinal With Cerebral Leukodystrophy	Associate	34848216
Ventricular Dysfunction Left	Associate	31538834
Virus Diseases	Associate	34943994

HPSE (heparanase)