CGA (glycoprotein hormones, alpha polypeptide)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1081
Gene name Gene Name - the full gene name approved by the HGNC.
Glycoprotein hormones, alpha polypeptide
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CGA
Synonyms (NCBI Gene) Gene synonyms aliases
CG-ALPHA, FSHA, GPA1, GPHA1, GPHa, HCG, LHA, TSHA
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q14.3
Summary Summary of gene provided in NCBI Entrez Gene.
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The a
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(9)
miRTarBase ID miRNA Experiments Reference
MIRT018742 hsa-miR-335-5p Microarray 18185580
MIRT888049 hsa-miR-2682 CLIP-seq
MIRT888050 hsa-miR-320a CLIP-seq
MIRT888051 hsa-miR-320b CLIP-seq
MIRT888052 hsa-miR-320c CLIP-seq
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
Transcription factor Regulation Reference
ATF1 Unknown 10341006
CREB1 Unknown 10341006
DLX3 Activation 22446105
ETS2 Activation 15637148
MSX1 Unknown 18379900
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(35)
GO ID Ontology Definition Evidence Reference
GO:0005179 Function Hormone activity IEA
GO:0005179 Function Hormone activity IMP 11207219
GO:0005515 Function Protein binding IPI 7922031, 11222739, 15662415, 22802634, 31467278
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
118850 1885 ENSG00000135346
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P01215
Protein name Glycoprotein hormones alpha chain (Anterior pituitary glycoprotein hormones common subunit alpha) (Choriogonadotropin alpha chain) (Chorionic gonadotrophin subunit alpha) (CG-alpha) (Follicle-stimulating hormone alpha chain) (FSH-alpha) (Follitropin alpha
Protein function Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH, follitropin/follicle stimulating hormone/FSH and choriogonadotropin/CG. These hormones bind specif
PDB 1DZ7 , 1E9J , 1FL7 , 1HCN , 1HD4 , 1HRP , 1QFW , 1XWD , 4AY9 , 4MQW , 7FIG , 7FIH , 7FII , 7T9I , 7UTZ , 7XW5 , 8I2G
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00236 Hormone_6 23 → 116 Glycoprotein hormone Domain
Sequence
Sequence length 116
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  cAMP signaling pathway
Neuroactive ligand-receptor interaction
Hormone signaling
GnRH signaling pathway
Ovarian steroidogenesis
Prolactin signaling pathway
Thyroid hormone synthesis
Regulation of lipolysis in adipocytes
GnRH secretion
Autoimmune thyroid disease 		  Androgen biosynthesis
Mineralocorticoid biosynthesis
Glycoprotein hormones
Thyroxine biosynthesis
Hormone ligand-binding receptors
G alpha (s) signalling events
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
ADORA2B mediated anti-inflammatory cytokines production
Reactions specific to the complex N-glycan synthesis pathway
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Atrial Fibrillation Atrial fibrillation N/A N/A GWAS
Show/Hide Text Mining Associations (16)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adrenal Gland Neoplasms Associate 10813107
Arrest of spermatogenesis Associate 21601192
Choriocarcinoma Associate 6210286, 9675133
Follicle stimulating hormone deficiency isolated Associate 32367462
Hypogonadism Associate 27656125
Hypothyroidism Stimulate 2461855
Infertility Male Associate 21601192
Neoplasms Associate 8200967
Ovarian Neoplasms Associate 15037419
Paroxysmal ventricular fibrillation Associate 27341989