ADCY2 (adenylate cyclase 2)

Gene

• Entrez ID: 108
• Gene name: Adenylate cyclase 2
• Gene symbol: ADCY2
• Synonyms (NCBI Gene): AC2, HBAC2
• Chromosome: 5
• Chromosome location: 5p15.31
• Summary: This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is sti

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT673408	hsa-miR-3922-5p	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT572894	hsa-miR-4643	PAR-CLIP	20371350
MIRT572892	hsa-miR-4714-5p	PAR-CLIP	20371350
MIRT572893	hsa-miR-4318	PAR-CLIP	20371350
MIRT572891	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT572890	hsa-miR-4539	PAR-CLIP	20371350
MIRT572889	hsa-miR-7114-5p	PAR-CLIP	20371350
MIRT572888	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT572887	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT572886	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT647015	hsa-miR-3135b	qRT-PCR	31824817
MIRT647015	hsa-miR-3135b	qRT-PCR	31824817
MIRT736147	hsa-miR-345-3p	qRT-PCR	31824817
MIRT736147	hsa-miR-345-3p	qRT-PCR	31824817
MIRT673408	hsa-miR-3922-5p	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT572894	hsa-miR-4643	PAR-CLIP	20371350
MIRT572892	hsa-miR-4714-5p	PAR-CLIP	20371350
MIRT572893	hsa-miR-4318	PAR-CLIP	20371350
MIRT572891	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT572890	hsa-miR-4539	PAR-CLIP	20371350
MIRT572889	hsa-miR-7114-5p	PAR-CLIP	20371350
MIRT572888	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT572887	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT572886	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT756043	hsa-miR-1224-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35831436
MIRT767957	hsa-miR-1260	CLIP-seq
MIRT767958	hsa-miR-1260b	CLIP-seq
MIRT767959	hsa-miR-1270	CLIP-seq
MIRT767960	hsa-miR-1273f	CLIP-seq
MIRT767961	hsa-miR-129-5p	CLIP-seq
MIRT767962	hsa-miR-1297	CLIP-seq
MIRT767963	hsa-miR-1321	CLIP-seq
MIRT767964	hsa-miR-141	CLIP-seq
MIRT767965	hsa-miR-188-3p	CLIP-seq
MIRT767966	hsa-miR-193a-5p	CLIP-seq
MIRT767967	hsa-miR-200a	CLIP-seq
MIRT767968	hsa-miR-218	CLIP-seq
MIRT767969	hsa-miR-2467-3p	CLIP-seq
MIRT767970	hsa-miR-26a	CLIP-seq
MIRT767971	hsa-miR-26b	CLIP-seq
MIRT767972	hsa-miR-3150a-3p	CLIP-seq
MIRT767973	hsa-miR-3156-3p	CLIP-seq
MIRT767974	hsa-miR-3175	CLIP-seq
MIRT767975	hsa-miR-3678-3p	CLIP-seq
MIRT767976	hsa-miR-3977	CLIP-seq
MIRT767977	hsa-miR-4252	CLIP-seq
MIRT767978	hsa-miR-432	CLIP-seq
MIRT767979	hsa-miR-4419a	CLIP-seq
MIRT767980	hsa-miR-4444	CLIP-seq
MIRT767981	hsa-miR-4465	CLIP-seq
MIRT767982	hsa-miR-450b-5p	CLIP-seq
MIRT767983	hsa-miR-4510	CLIP-seq
MIRT767984	hsa-miR-4531	CLIP-seq
MIRT767985	hsa-miR-4667-5p	CLIP-seq
MIRT767986	hsa-miR-4700-5p	CLIP-seq
MIRT767987	hsa-miR-4728-5p	CLIP-seq
MIRT767988	hsa-miR-4739	CLIP-seq
MIRT767989	hsa-miR-4756-3p	CLIP-seq
MIRT767990	hsa-miR-4756-5p	CLIP-seq
MIRT767991	hsa-miR-507	CLIP-seq
MIRT767992	hsa-miR-520d-5p	CLIP-seq
MIRT767993	hsa-miR-524-5p	CLIP-seq
MIRT767994	hsa-miR-543	CLIP-seq
MIRT767995	hsa-miR-548p	CLIP-seq
MIRT767996	hsa-miR-553	CLIP-seq
MIRT767997	hsa-miR-557	CLIP-seq
MIRT767998	hsa-miR-620	CLIP-seq
MIRT767999	hsa-miR-636	CLIP-seq
MIRT768000	hsa-miR-939	CLIP-seq
MIRT1926470	hsa-miR-122	CLIP-seq
MIRT1926471	hsa-miR-1227	CLIP-seq
MIRT1926472	hsa-miR-1271	CLIP-seq
MIRT1926473	hsa-miR-1299	CLIP-seq
MIRT1926474	hsa-miR-1324	CLIP-seq
MIRT1926475	hsa-miR-1343	CLIP-seq
MIRT1926476	hsa-miR-182	CLIP-seq
MIRT1926477	hsa-miR-28-5p	CLIP-seq
MIRT1926478	hsa-miR-3139	CLIP-seq
MIRT1926479	hsa-miR-3140-3p	CLIP-seq
MIRT1926480	hsa-miR-3199	CLIP-seq
MIRT1926481	hsa-miR-3614-3p	CLIP-seq
MIRT1926482	hsa-miR-3622a-5p	CLIP-seq
MIRT1926483	hsa-miR-378	CLIP-seq
MIRT1926484	hsa-miR-378b	CLIP-seq
MIRT1926485	hsa-miR-378c	CLIP-seq
MIRT1926486	hsa-miR-378d	CLIP-seq
MIRT1926487	hsa-miR-378e	CLIP-seq
MIRT1926488	hsa-miR-378f	CLIP-seq
MIRT1926489	hsa-miR-378g	CLIP-seq
MIRT1926490	hsa-miR-378h	CLIP-seq
MIRT1926491	hsa-miR-378i	CLIP-seq
MIRT1926492	hsa-miR-3973	CLIP-seq
MIRT1926493	hsa-miR-422a	CLIP-seq
MIRT1926494	hsa-miR-4269	CLIP-seq
MIRT1926495	hsa-miR-4330	CLIP-seq
MIRT1926496	hsa-miR-4437	CLIP-seq
MIRT1926497	hsa-miR-4438	CLIP-seq
MIRT1926498	hsa-miR-4470	CLIP-seq
MIRT1926499	hsa-miR-4638-3p	CLIP-seq
MIRT1926500	hsa-miR-4674	CLIP-seq
MIRT1926501	hsa-miR-4715-3p	CLIP-seq
MIRT1926502	hsa-miR-4782-5p	CLIP-seq
MIRT1926503	hsa-miR-5095	CLIP-seq
MIRT1926504	hsa-miR-5096	CLIP-seq
MIRT1926505	hsa-miR-516b	CLIP-seq
MIRT1926506	hsa-miR-532-3p	CLIP-seq
MIRT1926507	hsa-miR-548l	CLIP-seq
MIRT1926508	hsa-miR-617	CLIP-seq
MIRT1926509	hsa-miR-708	CLIP-seq
MIRT1926510	hsa-miR-96	CLIP-seq
MIRT1926470	hsa-miR-122	CLIP-seq
MIRT2167501	hsa-miR-1224-3p	CLIP-seq
MIRT1926471	hsa-miR-1227	CLIP-seq
MIRT2167502	hsa-miR-1245	CLIP-seq
MIRT767957	hsa-miR-1260	CLIP-seq
MIRT767958	hsa-miR-1260b	CLIP-seq
MIRT2167503	hsa-miR-128	CLIP-seq
MIRT2167504	hsa-miR-1280	CLIP-seq
MIRT2167505	hsa-miR-1323	CLIP-seq
MIRT1926475	hsa-miR-1343	CLIP-seq
MIRT767964	hsa-miR-141	CLIP-seq
MIRT2167506	hsa-miR-1910	CLIP-seq
MIRT767967	hsa-miR-200a	CLIP-seq
MIRT2167507	hsa-miR-224	CLIP-seq
MIRT2167508	hsa-miR-27a	CLIP-seq
MIRT2167509	hsa-miR-27b	CLIP-seq
MIRT2167510	hsa-miR-3122	CLIP-seq
MIRT2167511	hsa-miR-3168	CLIP-seq
MIRT2167512	hsa-miR-3170	CLIP-seq
MIRT1926480	hsa-miR-3199	CLIP-seq
MIRT1926482	hsa-miR-3622a-5p	CLIP-seq
MIRT1926483	hsa-miR-378	CLIP-seq
MIRT1926484	hsa-miR-378b	CLIP-seq
MIRT1926485	hsa-miR-378c	CLIP-seq
MIRT1926486	hsa-miR-378d	CLIP-seq
MIRT1926487	hsa-miR-378e	CLIP-seq
MIRT1926488	hsa-miR-378f	CLIP-seq
MIRT1926489	hsa-miR-378g	CLIP-seq
MIRT1926490	hsa-miR-378h	CLIP-seq
MIRT1926491	hsa-miR-378i	CLIP-seq
MIRT2167513	hsa-miR-3913-5p	CLIP-seq
MIRT1926492	hsa-miR-3973	CLIP-seq
MIRT1926493	hsa-miR-422a	CLIP-seq
MIRT1926494	hsa-miR-4269	CLIP-seq
MIRT2167514	hsa-miR-4279	CLIP-seq
MIRT1926496	hsa-miR-4437	CLIP-seq
MIRT1926497	hsa-miR-4438	CLIP-seq
MIRT1926499	hsa-miR-4638-3p	CLIP-seq
MIRT1926500	hsa-miR-4674	CLIP-seq
MIRT1926501	hsa-miR-4715-3p	CLIP-seq
MIRT1926503	hsa-miR-5095	CLIP-seq
MIRT1926504	hsa-miR-5096	CLIP-seq
MIRT1926506	hsa-miR-532-3p	CLIP-seq
MIRT2167515	hsa-miR-548o	CLIP-seq
MIRT1926508	hsa-miR-617	CLIP-seq
MIRT767966	hsa-miR-193a-5p	CLIP-seq
MIRT767972	hsa-miR-3150a-3p	CLIP-seq
MIRT767974	hsa-miR-3175	CLIP-seq
MIRT2383926	hsa-miR-4299	CLIP-seq
MIRT768000	hsa-miR-939	CLIP-seq
MIRT2426020	hsa-miR-3190	CLIP-seq
MIRT1926470	hsa-miR-122	CLIP-seq
MIRT1926470	hsa-miR-122	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	ISS
GO:0004016	Function	Adenylate cyclase activity	IBA
GO:0004016	Function	Adenylate cyclase activity	IEA
GO:0004016	Function	Adenylate cyclase activity	ISS
GO:0004016	Function	Adenylate cyclase activity	NAS	1427768
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	11549699
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	11549699
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006171	Process	CAMP biosynthetic process	IBA
GO:0006171	Process	CAMP biosynthetic process	IEA
GO:0006171	Process	CAMP biosynthetic process	ISS
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISS
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0008179	Function	Adenylate cyclase binding	ISS
GO:0009190	Process	Cyclic nucleotide biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016829	Function	Lyase activity	IEA
GO:0016849	Function	Phosphorus-oxygen lyase activity	IEA
GO:0030145	Function	Manganese ion binding	ISS
GO:0030425	Component	Dendrite	ISS
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0045121	Component	Membrane raft	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:1904322	Process	Cellular response to forskolin	ISS

Other IDs

• MIM: 103071
• HGNC: 233
• e!Ensembl: ENSG00000078295

Protein

• UniProt ID: Q08462
• Protein name: Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2)
• Protein function: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16214	AC_N	28 → 266	Adenylyl cyclase N-terminal extracellular and transmembrane region	Family
  PF00211	Guanylate_cyc	281 → 465	Adenylate and Guanylate cyclase catalytic domain	Domain
  PF06327	DUF1053	495 → 600	Domain of Unknown Function (DUF1053)	Family
  PF00211	Guanylate_cyc	878 → 1078	Adenylate and Guanylate cyclase catalytic domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus. {ECO:0000269|PubMed:11549699, ECO:0000269|PubMe
• Sequence:

  MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLA
  LLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAM
  GYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT
  PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQ
  ERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFT
  RLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK
  MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG
  VPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPR
  HTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL
  RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAF
  KYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASP
  LLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS
  ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHT
  HAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKK
  EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY
  TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS
  QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI
  WGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEM
  SRSLSQSNVAS

• Sequence length: 1091

Pathways

KEGG:

Purine metabolism
Metabolic pathways
Endocrine resistance
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Phospholipase D signaling pathway
Hormone signaling
Oocyte meiosis
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Apelin signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Thermogenesis
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
GABAergic synapse
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Ovarian steroidogenesis
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Oxytocin signaling pathway
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Aldosterone synthesis and secretion
Relaxin signaling pathway
Cortisol synthesis and secretion
Parathyroid hormone synthesis, secretion and action
Cushing syndrome
Growth hormone synthesis, secretion and action
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Bile secretion
Morphine addiction
Human cytomegalovirus infection
Human T-cell leukemia virus 1 infection
Pathways in cancer
Chemical carcinogenesis - receptor activation
Dilated cardiomyopathy

Reactome:

Glucagon signaling in metabolic regulation
PKA activation
PKA activation in glucagon signalling
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
G alpha (s) signalling events
G alpha (z) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog 'off' state
ADORA2B mediated anti-inflammatory cytokines production
FCGR3A-mediated IL10 synthesis

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
ADCY2-related disorder	Uncertain significance	rs1300093452	RCV003992099

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	22982105, 38039290
Arrhythmogenic Right Ventricular Dysplasia	Associate	30664203
Asthma	Associate	21912604, 27901618, 34727921
Atresia of small intestine	Associate	21853033
Bipolar Disorder	Associate	24618891, 27063557
Carcinoma Renal Cell	Associate	32788609, 32789468
Cardiomyopathy Dilated	Associate	27427220
Colorectal Neoplasms	Associate	21528083, 35545337
COVID 19	Associate	35844595
Melanoma	Associate	35871080
Mouth Neoplasms	Associate	32887903
Polycystic Ovary Syndrome	Associate	31278444
Pulmonary Disease Chronic Obstructive	Associate	22461431