Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	108
Gene name Gene Name - the full gene name approved by the HGNC.	Adenylate cyclase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ADCY2
Synonyms (NCBI Gene) Gene synonyms aliases	AC2, HBAC2
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5p15.31
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is sti

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miRTarBase ID	miRNA	Experiments	Reference
MIRT673408	hsa-miR-3922-5p	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT572894	hsa-miR-4643	PAR-CLIP	20371350
MIRT572892	hsa-miR-4714-5p	PAR-CLIP	20371350
MIRT572893	hsa-miR-4318	PAR-CLIP	20371350
MIRT572891	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT572890	hsa-miR-4539	PAR-CLIP	20371350
MIRT572889	hsa-miR-7114-5p	PAR-CLIP	20371350
MIRT572888	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT572887	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT572886	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT647015	hsa-miR-3135b	qRT-PCR	31824817
MIRT647015	hsa-miR-3135b	qRT-PCR	31824817
MIRT736147	hsa-miR-345-3p	qRT-PCR	31824817
MIRT736147	hsa-miR-345-3p	qRT-PCR	31824817
MIRT673408	hsa-miR-3922-5p	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT647019	hsa-miR-500b-3p	HITS-CLIP	23824327
MIRT647018	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT647017	hsa-miR-215-3p	HITS-CLIP	23824327
MIRT647016	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT647015	hsa-miR-3135b	HITS-CLIP	23824327
MIRT647014	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT647013	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT647012	hsa-miR-3652	HITS-CLIP	23824327
MIRT647011	hsa-miR-4430	HITS-CLIP	23824327
MIRT647010	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT647009	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT647008	hsa-miR-5698	HITS-CLIP	23824327
MIRT572894	hsa-miR-4643	PAR-CLIP	20371350
MIRT572892	hsa-miR-4714-5p	PAR-CLIP	20371350
MIRT572893	hsa-miR-4318	PAR-CLIP	20371350
MIRT572891	hsa-miR-146a-3p	PAR-CLIP	20371350
MIRT572890	hsa-miR-4539	PAR-CLIP	20371350
MIRT572889	hsa-miR-7114-5p	PAR-CLIP	20371350
MIRT572888	hsa-miR-4680-5p	PAR-CLIP	20371350
MIRT572887	hsa-miR-3190-3p	PAR-CLIP	20371350
MIRT572886	hsa-miR-6833-5p	PAR-CLIP	20371350
MIRT756043	hsa-miR-1224-5p	Luciferase reporter assay, Western blotting, qRT-PCR	35831436
MIRT767957	hsa-miR-1260	CLIP-seq
MIRT767958	hsa-miR-1260b	CLIP-seq
MIRT767959	hsa-miR-1270	CLIP-seq
MIRT767960	hsa-miR-1273f	CLIP-seq
MIRT767961	hsa-miR-129-5p	CLIP-seq
MIRT767962	hsa-miR-1297	CLIP-seq
MIRT767963	hsa-miR-1321	CLIP-seq
MIRT767964	hsa-miR-141	CLIP-seq
MIRT767965	hsa-miR-188-3p	CLIP-seq
MIRT767966	hsa-miR-193a-5p	CLIP-seq
MIRT767967	hsa-miR-200a	CLIP-seq
MIRT767968	hsa-miR-218	CLIP-seq
MIRT767969	hsa-miR-2467-3p	CLIP-seq
MIRT767970	hsa-miR-26a	CLIP-seq
MIRT767971	hsa-miR-26b	CLIP-seq
MIRT767972	hsa-miR-3150a-3p	CLIP-seq
MIRT767973	hsa-miR-3156-3p	CLIP-seq
MIRT767974	hsa-miR-3175	CLIP-seq
MIRT767975	hsa-miR-3678-3p	CLIP-seq
MIRT767976	hsa-miR-3977	CLIP-seq
MIRT767977	hsa-miR-4252	CLIP-seq
MIRT767978	hsa-miR-432	CLIP-seq
MIRT767979	hsa-miR-4419a	CLIP-seq
MIRT767980	hsa-miR-4444	CLIP-seq
MIRT767981	hsa-miR-4465	CLIP-seq
MIRT767982	hsa-miR-450b-5p	CLIP-seq
MIRT767983	hsa-miR-4510	CLIP-seq
MIRT767984	hsa-miR-4531	CLIP-seq
MIRT767985	hsa-miR-4667-5p	CLIP-seq
MIRT767986	hsa-miR-4700-5p	CLIP-seq
MIRT767987	hsa-miR-4728-5p	CLIP-seq
MIRT767988	hsa-miR-4739	CLIP-seq
MIRT767989	hsa-miR-4756-3p	CLIP-seq
MIRT767990	hsa-miR-4756-5p	CLIP-seq
MIRT767991	hsa-miR-507	CLIP-seq
MIRT767992	hsa-miR-520d-5p	CLIP-seq
MIRT767993	hsa-miR-524-5p	CLIP-seq
MIRT767994	hsa-miR-543	CLIP-seq
MIRT767995	hsa-miR-548p	CLIP-seq
MIRT767996	hsa-miR-553	CLIP-seq
MIRT767997	hsa-miR-557	CLIP-seq
MIRT767998	hsa-miR-620	CLIP-seq
MIRT767999	hsa-miR-636	CLIP-seq
MIRT768000	hsa-miR-939	CLIP-seq
MIRT1926470	hsa-miR-122	CLIP-seq
MIRT1926471	hsa-miR-1227	CLIP-seq
MIRT1926472	hsa-miR-1271	CLIP-seq
MIRT1926473	hsa-miR-1299	CLIP-seq
MIRT1926474	hsa-miR-1324	CLIP-seq
MIRT1926475	hsa-miR-1343	CLIP-seq
MIRT1926476	hsa-miR-182	CLIP-seq
MIRT1926477	hsa-miR-28-5p	CLIP-seq
MIRT1926478	hsa-miR-3139	CLIP-seq
MIRT1926479	hsa-miR-3140-3p	CLIP-seq
MIRT1926480	hsa-miR-3199	CLIP-seq
MIRT1926481	hsa-miR-3614-3p	CLIP-seq
MIRT1926482	hsa-miR-3622a-5p	CLIP-seq
MIRT1926483	hsa-miR-378	CLIP-seq
MIRT1926484	hsa-miR-378b	CLIP-seq
MIRT1926485	hsa-miR-378c	CLIP-seq
MIRT1926486	hsa-miR-378d	CLIP-seq
MIRT1926487	hsa-miR-378e	CLIP-seq
MIRT1926488	hsa-miR-378f	CLIP-seq
MIRT1926489	hsa-miR-378g	CLIP-seq
MIRT1926490	hsa-miR-378h	CLIP-seq
MIRT1926491	hsa-miR-378i	CLIP-seq
MIRT1926492	hsa-miR-3973	CLIP-seq
MIRT1926493	hsa-miR-422a	CLIP-seq
MIRT1926494	hsa-miR-4269	CLIP-seq
MIRT1926495	hsa-miR-4330	CLIP-seq
MIRT1926496	hsa-miR-4437	CLIP-seq
MIRT1926497	hsa-miR-4438	CLIP-seq
MIRT1926498	hsa-miR-4470	CLIP-seq
MIRT1926499	hsa-miR-4638-3p	CLIP-seq
MIRT1926500	hsa-miR-4674	CLIP-seq
MIRT1926501	hsa-miR-4715-3p	CLIP-seq
MIRT1926502	hsa-miR-4782-5p	CLIP-seq
MIRT1926503	hsa-miR-5095	CLIP-seq
MIRT1926504	hsa-miR-5096	CLIP-seq
MIRT1926505	hsa-miR-516b	CLIP-seq
MIRT1926506	hsa-miR-532-3p	CLIP-seq
MIRT1926507	hsa-miR-548l	CLIP-seq
MIRT1926508	hsa-miR-617	CLIP-seq
MIRT1926509	hsa-miR-708	CLIP-seq
MIRT1926510	hsa-miR-96	CLIP-seq
MIRT1926470	hsa-miR-122	CLIP-seq
MIRT2167501	hsa-miR-1224-3p	CLIP-seq
MIRT1926471	hsa-miR-1227	CLIP-seq
MIRT2167502	hsa-miR-1245	CLIP-seq
MIRT767957	hsa-miR-1260	CLIP-seq
MIRT767958	hsa-miR-1260b	CLIP-seq
MIRT2167503	hsa-miR-128	CLIP-seq
MIRT2167504	hsa-miR-1280	CLIP-seq
MIRT2167505	hsa-miR-1323	CLIP-seq
MIRT1926475	hsa-miR-1343	CLIP-seq
MIRT767964	hsa-miR-141	CLIP-seq
MIRT2167506	hsa-miR-1910	CLIP-seq
MIRT767967	hsa-miR-200a	CLIP-seq
MIRT2167507	hsa-miR-224	CLIP-seq
MIRT2167508	hsa-miR-27a	CLIP-seq
MIRT2167509	hsa-miR-27b	CLIP-seq
MIRT2167510	hsa-miR-3122	CLIP-seq
MIRT2167511	hsa-miR-3168	CLIP-seq
MIRT2167512	hsa-miR-3170	CLIP-seq
MIRT1926480	hsa-miR-3199	CLIP-seq
MIRT1926482	hsa-miR-3622a-5p	CLIP-seq
MIRT1926483	hsa-miR-378	CLIP-seq
MIRT1926484	hsa-miR-378b	CLIP-seq
MIRT1926485	hsa-miR-378c	CLIP-seq
MIRT1926486	hsa-miR-378d	CLIP-seq
MIRT1926487	hsa-miR-378e	CLIP-seq
MIRT1926488	hsa-miR-378f	CLIP-seq
MIRT1926489	hsa-miR-378g	CLIP-seq
MIRT1926490	hsa-miR-378h	CLIP-seq
MIRT1926491	hsa-miR-378i	CLIP-seq
MIRT2167513	hsa-miR-3913-5p	CLIP-seq
MIRT1926492	hsa-miR-3973	CLIP-seq
MIRT1926493	hsa-miR-422a	CLIP-seq
MIRT1926494	hsa-miR-4269	CLIP-seq
MIRT2167514	hsa-miR-4279	CLIP-seq
MIRT1926496	hsa-miR-4437	CLIP-seq
MIRT1926497	hsa-miR-4438	CLIP-seq
MIRT1926499	hsa-miR-4638-3p	CLIP-seq
MIRT1926500	hsa-miR-4674	CLIP-seq
MIRT1926501	hsa-miR-4715-3p	CLIP-seq
MIRT1926503	hsa-miR-5095	CLIP-seq
MIRT1926504	hsa-miR-5096	CLIP-seq
MIRT1926506	hsa-miR-532-3p	CLIP-seq
MIRT2167515	hsa-miR-548o	CLIP-seq
MIRT1926508	hsa-miR-617	CLIP-seq
MIRT767966	hsa-miR-193a-5p	CLIP-seq
MIRT767972	hsa-miR-3150a-3p	CLIP-seq
MIRT767974	hsa-miR-3175	CLIP-seq
MIRT2383926	hsa-miR-4299	CLIP-seq
MIRT768000	hsa-miR-939	CLIP-seq
MIRT2426020	hsa-miR-3190	CLIP-seq
MIRT1926470	hsa-miR-122	CLIP-seq
MIRT1926470	hsa-miR-122	CLIP-seq

Show/Hide all(32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	ISS
GO:0004016	Function	Adenylate cyclase activity	IBA
GO:0004016	Function	Adenylate cyclase activity	IEA
GO:0004016	Function	Adenylate cyclase activity	ISS
GO:0004016	Function	Adenylate cyclase activity	NAS	1427768
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IDA	11549699
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	11549699
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006171	Process	CAMP biosynthetic process	IBA
GO:0006171	Process	CAMP biosynthetic process	IEA
GO:0006171	Process	CAMP biosynthetic process	ISS
GO:0007188	Process	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISS
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0008179	Function	Adenylate cyclase binding	ISS
GO:0009190	Process	Cyclic nucleotide biosynthetic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	ISS
GO:0016829	Function	Lyase activity	IEA
GO:0016849	Function	Phosphorus-oxygen lyase activity	IEA
GO:0030145	Function	Manganese ion binding	ISS
GO:0030425	Component	Dendrite	ISS
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0045121	Component	Membrane raft	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:1904322	Process	Cellular response to forskolin	ISS

MIM	HGNC	e!Ensembl
103071	233	ENSG00000078295

Protein

UniProt ID

Q08462

Protein name

Adenylate cyclase type 2 (EC 4.6.1.1) (ATP pyrophosphate-lyase 2) (Adenylate cyclase type II) (Adenylyl cyclase 2)

Protein function

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16214	AC_N	28 → 266	Adenylyl cyclase N-terminal extracellular and transmembrane region	Family
PF00211	Guanylate_cyc	281 → 465	Adenylate and Guanylate cyclase catalytic domain	Domain
PF06327	DUF1053	495 → 600	Domain of Unknown Function (DUF1053)	Family
PF00211	Guanylate_cyc	878 → 1078	Adenylate and Guanylate cyclase catalytic domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus. {ECO:0000269|PubMed:11549699, ECO:0000269|PubMe

Sequence

MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLA
LLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAM
GYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT
PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQ
ERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFT
RLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK
MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG
VPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPR
HTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL
RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAF
KYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASP
LLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS
ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHT
HAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKK
EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY
TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHS
QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI
WGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEM
SRSLSQSNVAS

Sequence length

1091

Interactions

View interactions

	KEGG		Reactome
	Purine metabolism Metabolic pathways Endocrine resistance Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway Hormone signaling Oocyte meiosis Longevity regulating pathway Longevity regulating pathway - multiple species Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway Gap junction Platelet activation Circadian entrainment Thermogenesis Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse GABAergic synapse Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Ovarian steroidogenesis Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Oxytocin signaling pathway Glucagon signaling pathway Regulation of lipolysis in adipocytes Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Cushing syndrome Growth hormone synthesis, secretion and action Salivary secretion Gastric acid secretion Pancreatic secretion Bile secretion Morphine addiction Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation Dilated cardiomyopathy		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Bipolar Disorder	Bipolar disorder, Bipolar I disorder	N/A	N/A	GWAS
Insomnia	Insomnia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Alzheimer Disease	Associate	22982105, 38039290
Arrhythmogenic Right Ventricular Dysplasia	Associate	30664203
Asthma	Associate	21912604, 27901618, 34727921
Atresia of small intestine	Associate	21853033
Bipolar Disorder	Associate	24618891, 27063557
Carcinoma Renal Cell	Associate	32788609, 32789468
Cardiomyopathy Dilated	Associate	27427220
Colorectal Neoplasms	Associate	21528083, 35545337
COVID 19	Associate	35844595
Melanoma	Associate	35871080
Mouth Neoplasms	Associate	32887903
Polycystic Ovary Syndrome	Associate	31278444
Pulmonary Disease Chronic Obstructive	Associate	22461431

ADCY2 (adenylate cyclase 2)