Gene Gene information from NCBI Gene database.
Entrez ID 10793
Gene name Zinc finger protein 273
Gene symbol ZNF273
Synonyms (NCBI Gene)
HZF9
Chromosome 7
Chromosome location 7q11.21
Summary This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicing results in multiple tra
miRNA miRNA information provided by mirtarbase database.
656
miRTarBase ID miRNA Experiments Reference
MIRT021054 hsa-miR-155-5p Proteomics;Other 20584899
MIRT024753 hsa-miR-215-5p Microarray 19074876
MIRT026919 hsa-miR-192-5p Microarray 19074876
MIRT642718 hsa-miR-4639-3p HITS-CLIP 23824327
MIRT642717 hsa-miR-6849-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000981 Function DNA-binding transcription factor activity, RNA polymerase II-specific IBA
GO:0003677 Function DNA binding IEA
GO:0005515 Function Protein binding IPI 25416956
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604756 13067 ENSG00000198039
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14593
Protein name Zinc finger protein 273 (Zinc finger protein HZF9)
Protein function May be involved in transcriptional regulation.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01352 KRAB 36 77 KRAB box Family
PF00096 zf-C2H2 234 256 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 262 284 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 290 312 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 318 340 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 346 368 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 374 396 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 402 423 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 430 452 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 458 480 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 486 508 Zinc finger, C2H2 type Domain
PF00096 zf-C2H2 514 536 Zinc finger, C2H2 type Domain
Sequence
MSSAPRGPPSVAPLPAGIGRSTAKTPGLPGSLEMGPLTFRDVAIEFSLEEWQCLDTSQQN
LYRNVMLDNYRNLVFLG
IAVSKPDLITCLEQGKEPCNMKRHAMVAKPPVVCSHFAQDLWP
KQGLKDSFQKVILRRYGKYGHENLQLRKGCKSADEHKVHKRGYNGLNQCLTTTQSKIFQC
DKYVKVLHKFSNSNIHKKRQTGKKPFKCKECGKSCCILSQLTQHKKTATRVNFYKCKTCG
KAFNQFSNLTKHKIIH
PEVNPYKCEECGKAFNQSLTLTKHKKIHTEEKPYKCEDCGKVFS
VFSVLTKHKIIH
TGTKPYNCEECGKGFSIFSTLTKHKIIHTGEKPYKCNECGKAFNWSST
LTKHKRIH
TGEKPYKCEECGKAFNQSSTLTRHKIVHTGEKPYKCEECGKAFKRSTTLTKH
KRI
YTKEKPYKCEECGKAFSVFSTLTKHKIIHTGAKPYKCEECGSAFRAFSTLTEHKRVH
TGEKPYKCNECGKAFNWSSTLTKHKRIHTGEKPYKCEECGKAFNRSSNLTRHKKIHTGEK
PYKPKRCDSAFDNTPNFSRHKRNHMGEKS
Sequence length 569
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Generic Transcription Pathway
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
COLOR VISION DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Leukemia Myeloid Acute Associate 29688850
★☆☆☆☆
Found in Text Mining only
Leukemia Myelomonocytic Acute Associate 29688850
★☆☆☆☆
Found in Text Mining only
Myotonic Dystrophy Associate 18804219, 19864209, 20971734, 21224892, 21232131, 21660927, 22073373
★☆☆☆☆
Found in Text Mining only
Neuromuscular Diseases Associate 21232131
★☆☆☆☆
Found in Text Mining only