Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10788
Gene name Gene Name - the full gene name approved by the HGNC.	IQ motif containing GTPase activating protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IQGAP2
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	5q13.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, an

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miRTarBase ID	miRNA	Experiments	Reference
MIRT442395	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442394	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT442393	hsa-miR-641	PAR-CLIP	22100165
MIRT442392	hsa-miR-549a	PAR-CLIP	22100165
MIRT442391	hsa-miR-208a-3p	PAR-CLIP	22100165
MIRT442390	hsa-miR-208b-3p	PAR-CLIP	22100165
MIRT442389	hsa-miR-499a-5p	PAR-CLIP	22100165
MIRT442395	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442394	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT442393	hsa-miR-641	PAR-CLIP	22100165
MIRT442392	hsa-miR-549a	PAR-CLIP	22100165
MIRT442391	hsa-miR-208a-3p	PAR-CLIP	22100165
MIRT442390	hsa-miR-208b-3p	PAR-CLIP	22100165
MIRT442389	hsa-miR-499a-5p	PAR-CLIP	22100165
MIRT442395	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442394	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT442393	hsa-miR-641	PAR-CLIP	22100165
MIRT442392	hsa-miR-549a	PAR-CLIP	22100165
MIRT442391	hsa-miR-208a-3p	PAR-CLIP	22100165
MIRT442390	hsa-miR-208b-3p	PAR-CLIP	22100165
MIRT442389	hsa-miR-499a-5p	PAR-CLIP	22100165
MIRT442395	hsa-miR-548e-5p	PAR-CLIP	22100165
MIRT442394	hsa-miR-3617-5p	PAR-CLIP	22100165
MIRT442393	hsa-miR-641	PAR-CLIP	22100165
MIRT442392	hsa-miR-549a	PAR-CLIP	22100165
MIRT442391	hsa-miR-208a-3p	PAR-CLIP	22100165
MIRT442390	hsa-miR-208b-3p	PAR-CLIP	22100165
MIRT442389	hsa-miR-499a-5p	PAR-CLIP	22100165
MIRT1070047	hsa-miR-101	CLIP-seq
MIRT1070048	hsa-miR-128	CLIP-seq
MIRT1070049	hsa-miR-133a	CLIP-seq
MIRT1070050	hsa-miR-133b	CLIP-seq
MIRT1070051	hsa-miR-27a	CLIP-seq
MIRT1070052	hsa-miR-27b	CLIP-seq
MIRT1070053	hsa-miR-3074-3p	CLIP-seq
MIRT1070054	hsa-miR-3616-5p	CLIP-seq
MIRT1070055	hsa-miR-3647-5p	CLIP-seq
MIRT1070056	hsa-miR-3671	CLIP-seq
MIRT1070057	hsa-miR-3691-5p	CLIP-seq
MIRT1070058	hsa-miR-3911	CLIP-seq
MIRT1070059	hsa-miR-4272	CLIP-seq
MIRT1070060	hsa-miR-4302	CLIP-seq
MIRT1070061	hsa-miR-4326	CLIP-seq
MIRT1070062	hsa-miR-4328	CLIP-seq
MIRT1070063	hsa-miR-4752	CLIP-seq
MIRT1070064	hsa-miR-4773	CLIP-seq
MIRT1070065	hsa-miR-4781-3p	CLIP-seq
MIRT1070066	hsa-miR-573	CLIP-seq
MIRT1070067	hsa-miR-607	CLIP-seq
MIRT2017192	hsa-miR-1225-5p	CLIP-seq
MIRT2017193	hsa-miR-181a	CLIP-seq
MIRT2017194	hsa-miR-181b	CLIP-seq
MIRT2017195	hsa-miR-181c	CLIP-seq
MIRT2017196	hsa-miR-181d	CLIP-seq
MIRT2017197	hsa-miR-4262	CLIP-seq
MIRT1070047	hsa-miR-101	CLIP-seq
MIRT1070048	hsa-miR-128	CLIP-seq
MIRT2249128	hsa-miR-190	CLIP-seq
MIRT2249129	hsa-miR-190b	CLIP-seq
MIRT2249130	hsa-miR-1911	CLIP-seq
MIRT1070051	hsa-miR-27a	CLIP-seq
MIRT1070052	hsa-miR-27b	CLIP-seq
MIRT1070053	hsa-miR-3074-3p	CLIP-seq
MIRT2249131	hsa-miR-3201	CLIP-seq
MIRT1070057	hsa-miR-3691-5p	CLIP-seq
MIRT1070058	hsa-miR-3911	CLIP-seq
MIRT1070060	hsa-miR-4302	CLIP-seq
MIRT2249132	hsa-miR-4307	CLIP-seq
MIRT1070063	hsa-miR-4752	CLIP-seq
MIRT2249133	hsa-miR-4760-3p	CLIP-seq
MIRT2249134	hsa-miR-4791	CLIP-seq
MIRT2249135	hsa-miR-513a-5p	CLIP-seq
MIRT2249136	hsa-miR-587	CLIP-seq
MIRT2249137	hsa-miR-664	CLIP-seq
MIRT2249138	hsa-miR-759	CLIP-seq
MIRT2249139	hsa-miR-885-5p	CLIP-seq
MIRT2389459	hsa-miR-579	CLIP-seq

Show/Hide all(29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	TAS	8756646
GO:0005095	Function	GTPase inhibitor activity	TAS	8756646
GO:0005096	Function	GTPase activator activity	IBA	21873635
GO:0005516	Function	Calmodulin binding	IBA	21873635
GO:0005516	Function	Calmodulin binding	IPI	21299499
GO:0005547	Function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	22493426
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005737	Component	Cytoplasm	IDA	12515716
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	TAS
GO:0005902	Component	Microvillus	IEA
GO:0007165	Process	Signal transduction	TAS	8756646
GO:0009986	Component	Cell surface	IDA	12515716
GO:0015629	Component	Actin cytoskeleton	TAS	8756646
GO:0030027	Component	Lamellipodium	IDA	12515716
GO:0030175	Component	Filopodium	IDA	12515716
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031267	Function	Small GTPase binding	IDA	12515716
GO:0032956	Process	Regulation of actin cytoskeleton organization	IBA	21873635
GO:0034260	Process	Negative regulation of GTPase activity	IEA
GO:0034314	Process	Arp2/3 complex-mediated actin nucleation	IDA	12515716
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0043547	Process	Positive regulation of GTPase activity	IEA
GO:0051015	Function	Actin filament binding	IBA	21873635
GO:0051015	Function	Actin filament binding	IDA	12515716
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070493	Process	Thrombin-activated receptor signaling pathway	IDA	12515716
GO:0071933	Function	Arp2/3 complex binding	IDA	12515716
GO:2000249	Process	Regulation of actin cytoskeleton reorganization	IDA	12515716

MIM	HGNC	e!Ensembl
605401	6111	ENSG00000145703

Protein

UniProt ID

Q13576

Protein name

Ras GTPase-activating-like protein IQGAP2

Protein function

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

PDB

3IEZ , 4EZA , 5CJP

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00307	CH	41 → 158	Calponin homology (CH) domain	Domain
PF00612	IQ	691 → 711	IQ calmodulin-binding motif	Motif
PF00612	IQ	721 → 741	IQ calmodulin-binding motif	Motif
PF00616	RasGAP	938 → 1150	GTPase-activator protein for Ras-like GTPase	Family
PF03836	RasGAP_C	1367 → 1498	RasGAP C-terminus	Family

Tissue specificity

TISSUE SPECIFICITY: Isoform 2 expression is enhanced in testis.

Sequence

MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELP
PTTELEEGLRNGVYLAKLAKFFAPKMVSEKKIYDVEQTRYKKSGLHFRHTDNTVQWLRAM
ESIGLPKIFYPETTDVYDRKNIPRMIYCIHALSLYLFKLGIAPQIQDLLGKVDFTEEEIS
NMRKELEKYGIQMPSFSKIGGILANELSVDEAALHAAVIAINEAVEKGIAEQTVVTLRNP
NAVLTLVDDNLAPEYQKELWDAKKKKEENARLKNSCISEEERDAYEELLTQAEIQGNINK
VNRQAAVDHINAVIPEGDPENTLLALKKPEAQLPAVYPFAAAMYQNELFNLQKQNTMNYL
AHEELLIAVEMLSAVALLNQALESNDLVSVQNQLRSPAIGLNNLDKAYVERYANTLLSVK
LEVLSQGQDNLSWNEIQNCIDMVNAQIQEENDRVVAVGYINEAIDEGNPLRTLETLLLPT
ANISDVDPAHAQHYQDVLYHAKSQKLGDSESVSKVLWLDEIQQAVDDANVDKDRAKQWVT
LVVDVNQCLEGKKSSDILSVLKSSTSNANDIIPECADKYYDALVKAKELKSERVSSDGSW
LKLNLHKKYDYYYNTDSKESSWVTPESCLYKESWLTGKEIEDIIEEVTVGYIRENIWSAS
EELLLRFQATSSGPILREEFEARKSFLHEQEENVVKIQAFWKGYKQRKEYMHRRQTFIDN
TDSIVKIQSWFRMATARKSYLSRLQYFRDHNNEIVKIQSLLRANKARDDYKTLVGSENPP
LTVIRKFVYLLDQSDLDFQEELEVARLREEVVTKIRANQQLEKDLNLMDIKIGLLVKNRI
TLEDVISHSKKLNKKKGGEMEILNNTDNQGIKSLSKERRKTLETYQQLFYLLQTNPLYLA
KLIFQMPQNKSTKFMDTVIFTLYNYASNQREEYLLLKLFKTALEEEIKSKVDQVQDIVTG
NPTVIKMVVSFNRGARGQNTLRQLLAPVVKEIIDDKSLIINTNPVEVYKAWVNQLETQTG
EASKLPYDVTTEQALTYPEVKNKLEASIENLRRVTDKVLNSIISSLDLLPYGLRYIAKVL
KNSIHEKFPDATEDELLKIVGNLLYYRYMNPAIVAPDGFDIIDMTAGGQINSDQRRNLGS
VAKVLQHAASNKLFEGENEHLSSMNNYLSETYQEFRKYFKEACNVPEPEEKFNMDKYTDL
VTVSKPVIYISIEEIISTHSLLLEHQDAIAPEKNDLLSELLGSLGEVPTVESFLGEGAVD
PNDPNKANTLSQLSKTEISLVLTSKYDIEDGEAIDSRSLMIKTKKLIIDVIRNQPGNTLT
EILETPATAQQEVDHATDMVSRAMIDSRTPEEMKHSQSMIEDAQLPLEQKKRKIQRNLRT
LEQTGHVSSENKYQDILNEIAKDIRNQRIYRKLRKAELAKLQQTLNALNKKAAFYEEQIN
YYDTYIKTCLDNLKRKNTRRSIKLDGKGEPKGAKRAKPVKYTAAKLHEKGVLLDIDDLQT
NQFKNVTFDIIATEDVGIFDVRSKFLGVEMEKVQLNIQDLLQMQYEGVAVMKMFDKVKVN
VNLLIYLLNKKFYGK

Sequence length

1575

Interactions

View interactions

	KEGG		Reactome
	Regulation of actin cytoskeleton		RHO GTPases activate IQGAPs Neutrophil degranulation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	27846195

Show/Hide Unknown Diseases (1)

Disease term	Disease name	Evidence	References	Source
Unknown
Brain neoplasms	Brain Neoplasms, Malignant neoplasm of brain, Benign neoplasm of brain, unspecified, Brain Tumor, Primary, Recurrent Brain Neoplasm, Primary malignant neoplasm of brain		27935819	ClinVar

Show/Hide Text Mining Associations (24)

Disease Name	Relationship Type	References
Associations from Text Mining
Age Related Hearing Impairment 1	Associate	20068591
Carcinoma Hepatocellular	Associate	20977743, 24998570, 36320006
Diabetic Retinopathy	Associate	34935307
Disease	Associate	34034707
Epstein Barr Virus Infections	Stimulate	37504571
Fibrosis	Associate	20977743
Hepatic Adenomas Familial	Associate	20977743
Hepatitis C	Associate	27401546
Hirschsprung Disease	Associate	23270508
Influenza Human	Associate	34276655
Lymphatic Metastasis	Associate	40171809
Lymphoma Large B Cell Diffuse	Associate	34034707
Lymphoma Non Hodgkin	Associate	37543576
Nasopharyngeal Carcinoma	Associate	37504571
Neoplasm Metastasis	Associate	36362301
Neoplasms	Associate	19898621
Neoplasms	Inhibit	24849319, 24998570, 29073199, 34034707, 36320006, 36362301
Pancreatic Neoplasms	Associate	21487324
Rectal Neoplasms	Associate	26865277
Stomach Neoplasms	Inhibit	29073199, 34034707
Stomach Neoplasms	Associate	32183047
Thyroid Cancer Papillary	Associate	40171809
Urinary Bladder Neoplasms	Inhibit	36362301
Vascular Diseases	Associate	34935307

IQGAP2 (IQ motif containing GTPase activating protein 2)