NCKAP1 (NCK associated protein 1)
Gene | |
Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10787 |
Gene name
Gene Name - the full gene name approved by the HGNC.
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NCK associated protein 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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NCKAP1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
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HEM2, NAP1, NAP125, p125Nap1 |
Chromosome
Chromosome number
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2 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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2q32.1 |
miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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Protein | |||||||||||
UniProt ID | Q9Y2A7 | ||||||||||
Protein name | Nck-associated protein 1 (NAP 1) (Membrane-associated protein HEM-2) (p125Nap1) | ||||||||||
Protein function | Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. As component of the WAVE1 compl | ||||||||||
PDB | 3P8C , 4N78 , 7USC , 7USD , 7USE | ||||||||||
Family and domains |
Pfam
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Tissue specificity | TISSUE SPECIFICITY: Expressed in all tissues examined except peripheral blood leukocytes, with highest expression in brain, heart, and skeletal muscle. Expressed in cells of various brain regions including Purkinje cells and dentate nucleus of the cerebel | ||||||||||
Sequence |
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Sequence length | 1128 | ||||||||||
Interactions | View interactions |
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease information provided by ClinVar, GenCC, and GWAS databases.
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