Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10777
Gene name Gene Name - the full gene name approved by the HGNC.	CAMP regulated phosphoprotein 21
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ARPP21
Synonyms (NCBI Gene) Gene synonyms aliases	ARPP-21, R3HDM3, RCS, TARPP
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p22.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing resu

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022981	hsa-miR-124-3p	Microarray	18668037
MIRT800480	hsa-miR-1183	CLIP-seq
MIRT800481	hsa-miR-1185	CLIP-seq
MIRT800482	hsa-miR-1260	CLIP-seq
MIRT800483	hsa-miR-1260b	CLIP-seq
MIRT800484	hsa-miR-185	CLIP-seq
MIRT800485	hsa-miR-188-3p	CLIP-seq
MIRT800486	hsa-miR-3148	CLIP-seq
MIRT800487	hsa-miR-3155	CLIP-seq
MIRT800488	hsa-miR-3155b	CLIP-seq
MIRT800489	hsa-miR-3156-3p	CLIP-seq
MIRT800490	hsa-miR-3188	CLIP-seq
MIRT800491	hsa-miR-3646	CLIP-seq
MIRT800492	hsa-miR-3662	CLIP-seq
MIRT800493	hsa-miR-3679-5p	CLIP-seq
MIRT800494	hsa-miR-4306	CLIP-seq
MIRT800495	hsa-miR-4311	CLIP-seq
MIRT800496	hsa-miR-4327	CLIP-seq
MIRT800497	hsa-miR-4428	CLIP-seq
MIRT800498	hsa-miR-4446-5p	CLIP-seq
MIRT800499	hsa-miR-4493	CLIP-seq
MIRT800500	hsa-miR-450b-3p	CLIP-seq
MIRT800501	hsa-miR-4644	CLIP-seq
MIRT800502	hsa-miR-4727-5p	CLIP-seq
MIRT800503	hsa-miR-4769-3p	CLIP-seq
MIRT800504	hsa-miR-4775	CLIP-seq
MIRT800505	hsa-miR-484	CLIP-seq
MIRT800506	hsa-miR-513a-3p	CLIP-seq
MIRT800507	hsa-miR-548p	CLIP-seq
MIRT800508	hsa-miR-590-3p	CLIP-seq
MIRT800509	hsa-miR-769-3p	CLIP-seq
MIRT800510	hsa-miR-875-3p	CLIP-seq
MIRT800511	hsa-miR-890	CLIP-seq
MIRT1936375	hsa-miR-2110	CLIP-seq
MIRT1936376	hsa-miR-3150a-3p	CLIP-seq
MIRT1936377	hsa-miR-3160-3p	CLIP-seq
MIRT1936378	hsa-miR-3175	CLIP-seq
MIRT1936379	hsa-miR-4260	CLIP-seq
MIRT1936380	hsa-miR-4300	CLIP-seq
MIRT1936381	hsa-miR-920	CLIP-seq
MIRT1936382	hsa-miR-939	CLIP-seq
MIRT2479529	hsa-miR-4276	CLIP-seq
MIRT2479530	hsa-miR-4536	CLIP-seq

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GO ID	Ontology	Definition	Evidence
GO:0003674	Function	Molecular_function	ND
GO:0003676	Function	Nucleic acid binding	IEA
GO:0005516	Function	Calmodulin binding	IEA
GO:0005575	Component	Cellular_component	ND
GO:0005737	Component	Cytoplasm	IEA
GO:0008150	Process	Biological_process	ND
GO:0034605	Process	Cellular response to heat	IEA

MIM	HGNC	e!Ensembl
605488	16968	ENSG00000172995

Protein

UniProt ID

Q9UBL0

Protein name

cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein)

Protein function

Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01424	R3H	165 → 223	R3H domain	Domain
PF12752	SUZ	245 → 300	SUZ domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level). {ECO:0000269|PubMed:15096520, ECO:0000269|PubMed:8120638}.

Sequence

MSEQGDLNQAIAEEGGTEQETATPENGIVKSESLDEEEKLELQRRLEAQNQERRKSKSGA
GKGKLTRSLAVCEESSARPGGESLQDQESIHLQLSSFSSLQEEDKSRKDDSEREKEKDKN
KDKTSEKPKIRMLSKDCSQEYTDSTGIDLHEFLINTLKNNSRDRMILLKMEQEIIDFIAD
NNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTGKSVIINKTSSTRIPEQRFCEHLKD
EKGEESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDS
VCSQESLFVENSRLLEDSNICNETYKKRQLFRGNRDGSGRTSGSRQSSSENELKWSDHQR
AWSSTDSDSSNRNLKPAMTKTASFGGITVLTRGDSTSSTRSTGKLSKAGSESSSSAGSSG
SLSRTHPPLQSTPLVSGVAAGSPGCVPYPENGIGGQVAPSSTSYILLPLEAATGIPPGSI
LLNPHTGQPFVNPDGTPAIYNPPTSQQPLRSAMVGQSQQQPPQQQPSPQPQQQVQPPQPQ
MAGPLVTQRDDVATQFGQMTLSRQSSGETPEPPSGPVYPSSLMPQPAQQPSYVIASTGQQ
LPTGGFSGSGPPISQQVLQPPPSPQGFVQQPPPAQMPVYYYPSGQYPTSTTQQYRPMAPV
QYNAQRSQQMPQAAQQAGYQPVLSGQQGFQGLIGVQQPPQSQNVINNQQGTPVQSVMVSY
PTMSSYQVPMTQGSQGLPQQSYQQPIMLPNQAGQGSLPATGMPVYCNVTPPTPQNNLRLI
GPHCPSSTVPVMSASCRTNCASMSNAGWQVKF

Sequence length

812

Interactions

View interactions

Show/Hide Unknown Diseases (8)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Major Depressive Disorder		29942085	ClinVar
Amyotrophic Lateral Sclerosis	amyotrophic lateral sclerosis			GenCC
Neuroticism	Neuroticism			GWAS
Asthma	Asthma			GWAS
Diabetes	Diabetes			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Heart Failure	Heart Failure			GWAS

Show/Hide Text Mining Associations (4)

Disease Name	Relationship Type	References
Associations from Text Mining
Alzheimer Disease	Associate	21116278
Glioblastoma	Associate	25351872
Obesity	Associate	36297114
Wilms Tumor	Associate	34334530

ARPP21 (cAMP regulated phosphoprotein 21)