ARPP21 (cAMP regulated phosphoprotein 21)

Gene

• Entrez ID: 10777
• Gene name: CAMP regulated phosphoprotein 21
• Gene symbol: ARPP21
• Synonyms (NCBI Gene): ARPP-21, R3HDM3, RCS, TARPP
• Chromosome: 3
• Chromosome location: 3p22.3
• Summary: This gene encodes a cAMP-regulated phosphoprotein. The encoded protein is enriched in the caudate nucleus and cerebellar cortex. A similar protein in mouse may be involved in regulating the effects of dopamine in the basal ganglia. Alternate splicing resu

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022981	hsa-miR-124-3p	Microarray	18668037
MIRT800480	hsa-miR-1183	CLIP-seq
MIRT800481	hsa-miR-1185	CLIP-seq
MIRT800482	hsa-miR-1260	CLIP-seq
MIRT800483	hsa-miR-1260b	CLIP-seq
MIRT800484	hsa-miR-185	CLIP-seq
MIRT800485	hsa-miR-188-3p	CLIP-seq
MIRT800486	hsa-miR-3148	CLIP-seq
MIRT800487	hsa-miR-3155	CLIP-seq
MIRT800488	hsa-miR-3155b	CLIP-seq
MIRT800489	hsa-miR-3156-3p	CLIP-seq
MIRT800490	hsa-miR-3188	CLIP-seq
MIRT800491	hsa-miR-3646	CLIP-seq
MIRT800492	hsa-miR-3662	CLIP-seq
MIRT800493	hsa-miR-3679-5p	CLIP-seq
MIRT800494	hsa-miR-4306	CLIP-seq
MIRT800495	hsa-miR-4311	CLIP-seq
MIRT800496	hsa-miR-4327	CLIP-seq
MIRT800497	hsa-miR-4428	CLIP-seq
MIRT800498	hsa-miR-4446-5p	CLIP-seq
MIRT800499	hsa-miR-4493	CLIP-seq
MIRT800500	hsa-miR-450b-3p	CLIP-seq
MIRT800501	hsa-miR-4644	CLIP-seq
MIRT800502	hsa-miR-4727-5p	CLIP-seq
MIRT800503	hsa-miR-4769-3p	CLIP-seq
MIRT800504	hsa-miR-4775	CLIP-seq
MIRT800505	hsa-miR-484	CLIP-seq
MIRT800506	hsa-miR-513a-3p	CLIP-seq
MIRT800507	hsa-miR-548p	CLIP-seq
MIRT800508	hsa-miR-590-3p	CLIP-seq
MIRT800509	hsa-miR-769-3p	CLIP-seq
MIRT800510	hsa-miR-875-3p	CLIP-seq
MIRT800511	hsa-miR-890	CLIP-seq
MIRT1936375	hsa-miR-2110	CLIP-seq
MIRT1936376	hsa-miR-3150a-3p	CLIP-seq
MIRT1936377	hsa-miR-3160-3p	CLIP-seq
MIRT1936378	hsa-miR-3175	CLIP-seq
MIRT1936379	hsa-miR-4260	CLIP-seq
MIRT1936380	hsa-miR-4300	CLIP-seq
MIRT1936381	hsa-miR-920	CLIP-seq
MIRT1936382	hsa-miR-939	CLIP-seq
MIRT2479529	hsa-miR-4276	CLIP-seq
MIRT2479530	hsa-miR-4536	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003676	Function	Nucleic acid binding	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005516	Function	Calmodulin binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA

Other IDs

• MIM: 605488
• HGNC: 16968
• e!Ensembl: ENSG00000172995

Protein

• UniProt ID: Q9UBL0
• Protein name: cAMP-regulated phosphoprotein 21 (ARPP-21) (Thymocyte cAMP-regulated phosphoprotein)
• Protein function: Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01424	R3H	165 → 223	R3H domain	Domain
  PF12752	SUZ	245 → 300	SUZ domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level). {ECO:0000269|PubMed:15096520, ECO:0000269|PubMed:8120638}.
• Sequence:

  MSEQGDLNQAIAEEGGTEQETATPENGIVKSESLDEEEKLELQRRLEAQNQERRKSKSGA
  GKGKLTRSLAVCEESSARPGGESLQDQESIHLQLSSFSSLQEEDKSRKDDSEREKEKDKN
  KDKTSEKPKIRMLSKDCSQEYTDSTGIDLHEFLINTLKNNSRDRMILLKMEQEIIDFIAD
  NNNHYKKFPQMSSYQRMLVHRVAAYFGLDHNVDQTGKSVIINKTSSTRIPEQRFCEHLKD
  EKGEESQKRFILKRDNSSIDKEDNQQNRMHPFRDDRRSKSIEEREEEYQRVRERIFAHDS
  VCSQESLFVENSRLLEDSNICNETYKKRQLFRGNRDGSGRTSGSRQSSSENELKWSDHQR
  AWSSTDSDSSNRNLKPAMTKTASFGGITVLTRGDSTSSTRSTGKLSKAGSESSSSAGSSG
  SLSRTHPPLQSTPLVSGVAAGSPGCVPYPENGIGGQVAPSSTSYILLPLEAATGIPPGSI
  LLNPHTGQPFVNPDGTPAIYNPPTSQQPLRSAMVGQSQQQPPQQQPSPQPQQQVQPPQPQ
  MAGPLVTQRDDVATQFGQMTLSRQSSGETPEPPSGPVYPSSLMPQPAQQPSYVIASTGQQ
  LPTGGFSGSGPPISQQVLQPPPSPQGFVQQPPPAQMPVYYYPSGQYPTSTTQQYRPMAPV
  QYNAQRSQQMPQAAQQAGYQPVLSGQQGFQGLIGVQQPPQSQNVINNQQGTPVQSVMVSY
  PTMSSYQVPMTQGSQGLPQQSYQQPIMLPNQAGQGSLPATGMPVYCNVTPPTPQNNLRLI
  GPHCPSSTVPVMSASCRTNCASMSNAGWQVKF

• Sequence length: 812

Associated diseases

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Monomelic amyotrophy	Uncertain significance	rs2470990060	RCV003234973
Prostate cancer	Uncertain significance	rs193920911	RCV000149237

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	21116278
Glioblastoma	Associate	25351872
Obesity	Associate	36297114
Wilms Tumor	Associate	34334530