Gene Gene information from NCBI Gene database.
Entrez ID 10766
Gene name Transducer of ERBB2, 2
Gene symbol TOB2
Synonyms (NCBI Gene)
APRO5TOB4TOBLTROB2
Chromosome 22
Chromosome location 22q13.2
Summary TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]
miRNA miRNA information provided by mirtarbase database.
1484
miRTarBase ID miRNA Experiments Reference
MIRT005483 hsa-miR-378a-3p ImmunoblotLuciferase reporter assayqRT-PCR 21242960
MIRT006203 hsa-miR-302a-3p Luciferase reporter assay 22012620
MIRT006203 hsa-miR-302a-3p Luciferase reporter assay 22012620
MIRT006203 hsa-miR-302a-3p Luciferase reporter assay 22012620
MIRT006203 hsa-miR-302a-3p Luciferase reporter assay 22012620
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0003714 Function Transcription corepressor activity IBA
GO:0005515 Function Protein binding IPI 19838187, 23340509, 25416956, 28514442, 32296183, 33961781, 35044719
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus TAS 10602502
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
607396 11980 ENSG00000183864
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14106
Protein name Protein Tob2 (Protein Tob4) (Transducer of erbB-2 2)
Protein function Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07742 BTG 1 112 BTG family Family
PF07145 PAM2 128 145 Ataxin-2 C-terminal region Motif
PF07145 PAM2 248 265 Ataxin-2 C-terminal region Motif
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLKKKYEGHWYPEKPLKGSGFRCVHI
GEMVDPVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQIGEKGAVKVL
YLDDSEGC
GAPELDKEIKSSFNPDAQVFVPIGSQDSSLSNSPSPSFGQSPSPTFIPRSAQPITFTTAS
FAATKFGSTKMKKGGGAASGGGVASSGAGGQQPPQQPRMARSPTNSLLKHKSLSLSMHSL
NFITANPAPQSQLSPNAKEFVYNGGGSPSLFFDAADGQGSGTPGPFGGSGAGTCNSSSFD
MAQVFGGGANSLFLEKTPFVEGLSYNLNTMQYPSQQFQPVVLAN
Sequence length 344
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  RNA degradation