Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10766
Gene name Gene Name - the full gene name approved by the HGNC.
Transducer of ERBB2, 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TOB2
Synonyms (NCBI Gene) Gene synonyms aliases
APRO5, TOB4, TOBL, TROB2
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
TOB2 belongs to the TOB (see TOB1; MIM 605523)/BTG1 (MIM 109580) family of antiproliferative proteins, which are involved in the regulation of cell cycle progression.[supplied by OMIM, Apr 2004]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005483 hsa-miR-378a-3p Immunoblot, Luciferase reporter assay, qRT-PCR 21242960
MIRT006203 hsa-miR-302a-3p Luciferase reporter assay 22012620
MIRT006203 hsa-miR-302a-3p Luciferase reporter assay 22012620
MIRT006203 hsa-miR-302a-3p Luciferase reporter assay 22012620
MIRT006203 hsa-miR-302a-3p Luciferase reporter assay 22012620
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003714 Function Transcription corepressor activity IBA
GO:0005515 Function Protein binding IPI 19838187, 23340509, 25416956, 28514442, 32296183, 33961781, 35044719
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus TAS 10602502
GO:0005737 Component Cytoplasm IBA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607396 11980 ENSG00000183864
Protein
UniProt ID Q14106
Protein name Protein Tob2 (Protein Tob4) (Transducer of erbB-2 2)
Protein function Anti-proliferative protein inhibits cell cycle progression from the G0/G1 to S phases.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07742 BTG 1 112 BTG family Family
PF07145 PAM2 128 145 Ataxin-2 C-terminal region Motif
PF07145 PAM2 248 265 Ataxin-2 C-terminal region Motif
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
MQLEIKVALNFIISYLYNKLPRRRADLFGEELERLLKKKYEGHWYPEKPLKGSGFRCVHI
GEMVDPVVELAAKRSGLAVEDVRANVPEELSVWIDPFEVSYQIGEKGAVKVL
YLDDSEGC
GAPELDKEIKSSFNPDAQVFVPIGSQDSSLSNSPSPSFGQSPSPTFIPRSAQPITFTTAS
FAATKFGSTKMKKGGGAASGGGVASSGAGGQQPPQQPRMARSPTNSLLKHKSLSLSMHSL
NFITANPAPQSQLSPNAKEFVYNGGGSPSLFFDAADGQGSGTPGPFGGSGAGTCNSSSFD
MAQVFGGGANSLFLEKTPFVEGLSYNLNTMQYPSQQFQPVVLAN
Sequence length 344
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  RNA degradation  
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Asthma Atopic asthma, Asthma, Pediatric asthma N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Androgen Insensitivity Syndrome Associate 23259508
Inflammation Associate 33247598
Neoplasms Inhibit 28922388