Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10765
Gene name	Lysine demethylase 5B
Gene symbol	KDM5B
Synonyms (NCBI Gene)	CT31JARID1BMRT65PLU-1PLU1PPP1R98PUT1RBBP2H1ARBP2-H1
Chromosome	1
Chromosome location	1q32.1
Summary	This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein pl

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SNP ID	Visualize variation	Clinical significance	Consequence
rs375695605	G>A,C	Pathogenic	Coding sequence variant, missense variant
rs755833290	AA>-,AAA	Likely-pathogenic	Frameshift variant, coding sequence variant
rs1558478047	A>C	Likely-pathogenic	Stop gained, coding sequence variant
rs1558479778	G>-	Pathogenic	Frameshift variant, coding sequence variant
rs1558498928	G>A	Likely-pathogenic	Stop gained, coding sequence variant
rs1558501648	->A	Pathogenic	Intron variant, frameshift variant, coding sequence variant
rs1572705473	->A	Likely-pathogenic	Coding sequence variant, frameshift variant

627

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016728	hsa-miR-335-5p	Microarray	18185580
MIRT020412	hsa-miR-29c-3p	Sequencing	20371350
MIRT046553	hsa-let-7i-5p	CLASH	23622248
MIRT038506	hsa-miR-296-3p	CLASH	23622248
MIRT656976	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT656975	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT656974	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT656973	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT656972	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT183432	hsa-miR-5688	PAR-CLIP	23592263
MIRT183431	hsa-miR-495-3p	PAR-CLIP	23592263
MIRT474870	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT474869	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT474868	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT474867	hsa-miR-651-3p	PAR-CLIP	23592263
MIRT474866	hsa-miR-1911-3p	PAR-CLIP	23592263
MIRT474865	hsa-miR-6753-5p	PAR-CLIP	23592263
MIRT474864	hsa-miR-3681-5p	PAR-CLIP	23592263
MIRT474863	hsa-miR-6849-5p	PAR-CLIP	23592263
MIRT474862	hsa-miR-3185	PAR-CLIP	23592263
MIRT474861	hsa-miR-6124	PAR-CLIP	23592263
MIRT474860	hsa-miR-376b-5p	PAR-CLIP	23592263
MIRT474859	hsa-miR-376c-5p	PAR-CLIP	23592263
MIRT474858	hsa-miR-1261	PAR-CLIP	23592263
MIRT731954	hsa-miR-424-5p	Luciferase reporter assay	28082020
MIRT731954	hsa-miR-424-5p	Luciferase reporter assay	28082020
MIRT731954	hsa-miR-424-5p	Luciferase reporter assay	28082020
MIRT731954	hsa-miR-424-5p	Luciferase reporter assay	28082020
MIRT731954	hsa-miR-424-5p	Luciferase reporter assay	28082020
MIRT731954	hsa-miR-424-5p	Luciferase reporter assay	28082020
MIRT656976	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT656975	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT656974	hsa-miR-515-5p	HITS-CLIP	23824327
MIRT656973	hsa-miR-519e-5p	HITS-CLIP	23824327
MIRT656972	hsa-miR-629-3p	HITS-CLIP	23824327
MIRT183432	hsa-miR-5688	PAR-CLIP	23592263
MIRT183431	hsa-miR-495-3p	PAR-CLIP	23592263
MIRT474870	hsa-miR-548az-5p	PAR-CLIP	23592263
MIRT474869	hsa-miR-548t-5p	PAR-CLIP	23592263
MIRT474868	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT474867	hsa-miR-651-3p	PAR-CLIP	23592263
MIRT474866	hsa-miR-1911-3p	PAR-CLIP	23592263
MIRT474865	hsa-miR-6753-5p	PAR-CLIP	23592263
MIRT474864	hsa-miR-3681-5p	PAR-CLIP	23592263
MIRT474863	hsa-miR-6849-5p	PAR-CLIP	23592263
MIRT474862	hsa-miR-3185	PAR-CLIP	23592263
MIRT474861	hsa-miR-6124	PAR-CLIP	23592263
MIRT474860	hsa-miR-376b-5p	PAR-CLIP	23592263
MIRT474859	hsa-miR-376c-5p	PAR-CLIP	23592263
MIRT474858	hsa-miR-1261	PAR-CLIP	23592263
MIRT1084738	hsa-miR-1185	CLIP-seq
MIRT1084739	hsa-miR-1208	CLIP-seq
MIRT1084740	hsa-miR-1224-5p	CLIP-seq
MIRT1084741	hsa-miR-1237	CLIP-seq
MIRT1084742	hsa-miR-1258	CLIP-seq
MIRT1084743	hsa-miR-1269	CLIP-seq
MIRT1084744	hsa-miR-1269b	CLIP-seq
MIRT1084745	hsa-miR-1289	CLIP-seq
MIRT1084746	hsa-miR-1304	CLIP-seq
MIRT1084747	hsa-miR-1305	CLIP-seq
MIRT1084748	hsa-miR-132	CLIP-seq
MIRT1084749	hsa-miR-149	CLIP-seq
MIRT1084750	hsa-miR-155	CLIP-seq
MIRT1084751	hsa-miR-194	CLIP-seq
MIRT1084752	hsa-miR-19a	CLIP-seq
MIRT1084753	hsa-miR-19b	CLIP-seq
MIRT1084754	hsa-miR-21	CLIP-seq
MIRT1084755	hsa-miR-212	CLIP-seq
MIRT1084756	hsa-miR-219-1-3p	CLIP-seq
MIRT1084757	hsa-miR-2467-3p	CLIP-seq
MIRT1084758	hsa-miR-29a	CLIP-seq
MIRT1084759	hsa-miR-29b	CLIP-seq
MIRT1084760	hsa-miR-29c	CLIP-seq
MIRT1084761	hsa-miR-3064-5p	CLIP-seq
MIRT1084762	hsa-miR-3065-5p	CLIP-seq
MIRT1084763	hsa-miR-3117-3p	CLIP-seq
MIRT1084764	hsa-miR-3117-5p	CLIP-seq
MIRT1084765	hsa-miR-3127-3p	CLIP-seq
MIRT1084766	hsa-miR-3140-5p	CLIP-seq
MIRT1084767	hsa-miR-3147	CLIP-seq
MIRT1084768	hsa-miR-3148	CLIP-seq
MIRT1084769	hsa-miR-3174	CLIP-seq
MIRT1084770	hsa-miR-3198	CLIP-seq
MIRT1084771	hsa-miR-3202	CLIP-seq
MIRT1084772	hsa-miR-320e	CLIP-seq
MIRT1084773	hsa-miR-323-3p	CLIP-seq
MIRT1084774	hsa-miR-331-3p	CLIP-seq
MIRT1084775	hsa-miR-338-5p	CLIP-seq
MIRT1084776	hsa-miR-339-5p	CLIP-seq
MIRT1084777	hsa-miR-3591-5p	CLIP-seq
MIRT1084778	hsa-miR-3605-5p	CLIP-seq
MIRT1084779	hsa-miR-3613-3p	CLIP-seq
MIRT1084780	hsa-miR-3616-5p	CLIP-seq
MIRT1084781	hsa-miR-3647-5p	CLIP-seq
MIRT1084782	hsa-miR-3662	CLIP-seq
MIRT1084783	hsa-miR-3671	CLIP-seq
MIRT1084784	hsa-miR-3679-5p	CLIP-seq
MIRT1084785	hsa-miR-3686	CLIP-seq
MIRT1084786	hsa-miR-3690	CLIP-seq
MIRT1084787	hsa-miR-3692	CLIP-seq
MIRT1084788	hsa-miR-3915	CLIP-seq
MIRT1084789	hsa-miR-4251	CLIP-seq
MIRT1084790	hsa-miR-4254	CLIP-seq
MIRT1084791	hsa-miR-4255	CLIP-seq
MIRT1084792	hsa-miR-4270	CLIP-seq
MIRT1084793	hsa-miR-4282	CLIP-seq
MIRT1084794	hsa-miR-4294	CLIP-seq
MIRT1084795	hsa-miR-4297	CLIP-seq
MIRT1084796	hsa-miR-4303	CLIP-seq
MIRT1084797	hsa-miR-4305	CLIP-seq
MIRT1084798	hsa-miR-4309	CLIP-seq
MIRT1084799	hsa-miR-4310	CLIP-seq
MIRT1084800	hsa-miR-4329	CLIP-seq
MIRT1084801	hsa-miR-4422	CLIP-seq
MIRT1084802	hsa-miR-4441	CLIP-seq
MIRT1084803	hsa-miR-4475	CLIP-seq
MIRT1084804	hsa-miR-4476	CLIP-seq
MIRT1084805	hsa-miR-4477b	CLIP-seq
MIRT1084806	hsa-miR-4490	CLIP-seq
MIRT1084807	hsa-miR-452	CLIP-seq
MIRT1084808	hsa-miR-4529-3p	CLIP-seq
MIRT1084809	hsa-miR-4659a-3p	CLIP-seq
MIRT1084810	hsa-miR-4659b-3p	CLIP-seq
MIRT1084811	hsa-miR-4663	CLIP-seq
MIRT1084812	hsa-miR-4676-3p	CLIP-seq
MIRT1084813	hsa-miR-4680-3p	CLIP-seq
MIRT1084814	hsa-miR-4687-3p	CLIP-seq
MIRT1084815	hsa-miR-4689	CLIP-seq
MIRT1084816	hsa-miR-4704-5p	CLIP-seq
MIRT1084817	hsa-miR-4705	CLIP-seq
MIRT1084818	hsa-miR-4709-3p	CLIP-seq
MIRT1084819	hsa-miR-4709-5p	CLIP-seq
MIRT1084820	hsa-miR-4719	CLIP-seq
MIRT1084821	hsa-miR-4776-3p	CLIP-seq
MIRT1084822	hsa-miR-4794	CLIP-seq
MIRT1084823	hsa-miR-4795-5p	CLIP-seq
MIRT1084824	hsa-miR-499-3p	CLIP-seq
MIRT1084825	hsa-miR-499a-3p	CLIP-seq
MIRT1084826	hsa-miR-532-5p	CLIP-seq
MIRT1084827	hsa-miR-539	CLIP-seq
MIRT1084828	hsa-miR-541	CLIP-seq
MIRT1084829	hsa-miR-543	CLIP-seq
MIRT1084830	hsa-miR-548g	CLIP-seq
MIRT1084831	hsa-miR-548t	CLIP-seq
MIRT1084832	hsa-miR-562	CLIP-seq
MIRT1084833	hsa-miR-571	CLIP-seq
MIRT1084834	hsa-miR-573	CLIP-seq
MIRT1084835	hsa-miR-590-3p	CLIP-seq
MIRT1084836	hsa-miR-590-5p	CLIP-seq
MIRT1084837	hsa-miR-599	CLIP-seq
MIRT1084838	hsa-miR-603	CLIP-seq
MIRT1084839	hsa-miR-605	CLIP-seq
MIRT1084840	hsa-miR-607	CLIP-seq
MIRT1084841	hsa-miR-628-5p	CLIP-seq
MIRT1084842	hsa-miR-654-5p	CLIP-seq
MIRT1084843	hsa-miR-875-3p	CLIP-seq
MIRT1084844	hsa-miR-936	CLIP-seq
MIRT2021539	hsa-miR-103a	CLIP-seq
MIRT2021540	hsa-miR-107	CLIP-seq
MIRT2021541	hsa-miR-1178	CLIP-seq
MIRT2021542	hsa-miR-1179	CLIP-seq
MIRT1084738	hsa-miR-1185	CLIP-seq
MIRT1084739	hsa-miR-1208	CLIP-seq
MIRT1084740	hsa-miR-1224-5p	CLIP-seq
MIRT2021543	hsa-miR-1226	CLIP-seq
MIRT2021544	hsa-miR-1292	CLIP-seq
MIRT1084746	hsa-miR-1304	CLIP-seq
MIRT1084747	hsa-miR-1305	CLIP-seq
MIRT1084750	hsa-miR-155	CLIP-seq
MIRT2021545	hsa-miR-1911	CLIP-seq
MIRT1084751	hsa-miR-194	CLIP-seq
MIRT2021546	hsa-miR-2052	CLIP-seq
MIRT2021547	hsa-miR-298	CLIP-seq
MIRT1084758	hsa-miR-29a	CLIP-seq
MIRT1084759	hsa-miR-29b	CLIP-seq
MIRT1084760	hsa-miR-29c	CLIP-seq
MIRT2021548	hsa-miR-300	CLIP-seq
MIRT2021549	hsa-miR-3074-3p	CLIP-seq
MIRT2021550	hsa-miR-3158-5p	CLIP-seq
MIRT2021551	hsa-miR-3175	CLIP-seq
MIRT1084771	hsa-miR-3202	CLIP-seq
MIRT1084772	hsa-miR-320e	CLIP-seq
MIRT1084775	hsa-miR-338-5p	CLIP-seq
MIRT1084778	hsa-miR-3605-5p	CLIP-seq
MIRT1084779	hsa-miR-3613-3p	CLIP-seq
MIRT1084780	hsa-miR-3616-5p	CLIP-seq
MIRT1084781	hsa-miR-3647-5p	CLIP-seq
MIRT2021552	hsa-miR-3663-5p	CLIP-seq
MIRT1084783	hsa-miR-3671	CLIP-seq
MIRT1084784	hsa-miR-3679-5p	CLIP-seq
MIRT2021553	hsa-miR-3681	CLIP-seq
MIRT1084785	hsa-miR-3686	CLIP-seq
MIRT2021554	hsa-miR-3688-5p	CLIP-seq
MIRT1084787	hsa-miR-3692	CLIP-seq
MIRT2021555	hsa-miR-369-3p	CLIP-seq
MIRT2021556	hsa-miR-3714	CLIP-seq
MIRT2021557	hsa-miR-374a	CLIP-seq
MIRT2021558	hsa-miR-374b	CLIP-seq
MIRT2021559	hsa-miR-376c	CLIP-seq
MIRT2021560	hsa-miR-381	CLIP-seq
MIRT1084788	hsa-miR-3915	CLIP-seq
MIRT2021561	hsa-miR-3919	CLIP-seq
MIRT2021562	hsa-miR-409-3p	CLIP-seq
MIRT2021563	hsa-miR-4275	CLIP-seq
MIRT1084793	hsa-miR-4282	CLIP-seq
MIRT1084795	hsa-miR-4297	CLIP-seq
MIRT1084799	hsa-miR-4310	CLIP-seq
MIRT2021564	hsa-miR-4330	CLIP-seq
MIRT2021565	hsa-miR-4418	CLIP-seq
MIRT1084801	hsa-miR-4422	CLIP-seq
MIRT2021566	hsa-miR-4438	CLIP-seq
MIRT2021567	hsa-miR-4457	CLIP-seq
MIRT2021568	hsa-miR-4471	CLIP-seq
MIRT1084803	hsa-miR-4475	CLIP-seq
MIRT1084804	hsa-miR-4476	CLIP-seq
MIRT2021569	hsa-miR-4484	CLIP-seq
MIRT1084806	hsa-miR-4490	CLIP-seq
MIRT2021570	hsa-miR-4499	CLIP-seq
MIRT1084807	hsa-miR-452	CLIP-seq
MIRT2021571	hsa-miR-4670-3p	CLIP-seq
MIRT1084812	hsa-miR-4676-3p	CLIP-seq
MIRT1084815	hsa-miR-4689	CLIP-seq
MIRT1084817	hsa-miR-4705	CLIP-seq
MIRT2021572	hsa-miR-4718	CLIP-seq
MIRT1084820	hsa-miR-4719	CLIP-seq
MIRT2021573	hsa-miR-4733-3p	CLIP-seq
MIRT2021574	hsa-miR-4753-3p	CLIP-seq
MIRT2021575	hsa-miR-4773	CLIP-seq
MIRT1084823	hsa-miR-4795-5p	CLIP-seq
MIRT2021576	hsa-miR-4797-5p	CLIP-seq
MIRT1084824	hsa-miR-499-3p	CLIP-seq
MIRT1084825	hsa-miR-499a-3p	CLIP-seq
MIRT2021577	hsa-miR-509-3-5p	CLIP-seq
MIRT2021578	hsa-miR-5095	CLIP-seq
MIRT2021579	hsa-miR-509-5p	CLIP-seq
MIRT2021580	hsa-miR-513b	CLIP-seq
MIRT1084826	hsa-miR-532-5p	CLIP-seq
MIRT1084828	hsa-miR-541	CLIP-seq
MIRT2021581	hsa-miR-548an	CLIP-seq
MIRT1084830	hsa-miR-548g	CLIP-seq
MIRT1084831	hsa-miR-548t	CLIP-seq
MIRT1084834	hsa-miR-573	CLIP-seq
MIRT2021582	hsa-miR-577	CLIP-seq
MIRT1084835	hsa-miR-590-3p	CLIP-seq
MIRT1084837	hsa-miR-599	CLIP-seq
MIRT2021583	hsa-miR-600	CLIP-seq
MIRT1084838	hsa-miR-603	CLIP-seq
MIRT1084839	hsa-miR-605	CLIP-seq
MIRT1084840	hsa-miR-607	CLIP-seq
MIRT1084842	hsa-miR-654-5p	CLIP-seq
MIRT2021584	hsa-miR-7	CLIP-seq
MIRT2021585	hsa-miR-942	CLIP-seq
MIRT2021539	hsa-miR-103a	CLIP-seq
MIRT2253059	hsa-miR-105	CLIP-seq
MIRT2021540	hsa-miR-107	CLIP-seq
MIRT2021542	hsa-miR-1179	CLIP-seq
MIRT1084738	hsa-miR-1185	CLIP-seq
MIRT1084739	hsa-miR-1208	CLIP-seq
MIRT1084740	hsa-miR-1224-5p	CLIP-seq
MIRT2021543	hsa-miR-1226	CLIP-seq
MIRT2253060	hsa-miR-1243	CLIP-seq
MIRT1084743	hsa-miR-1269	CLIP-seq
MIRT1084744	hsa-miR-1269b	CLIP-seq
MIRT1084745	hsa-miR-1289	CLIP-seq
MIRT2253061	hsa-miR-1294	CLIP-seq
MIRT1084746	hsa-miR-1304	CLIP-seq
MIRT2253062	hsa-miR-150	CLIP-seq
MIRT1084750	hsa-miR-155	CLIP-seq
MIRT2253063	hsa-miR-18a	CLIP-seq
MIRT2253064	hsa-miR-18b	CLIP-seq
MIRT2021545	hsa-miR-1911	CLIP-seq
MIRT1084751	hsa-miR-194	CLIP-seq
MIRT2021546	hsa-miR-2052	CLIP-seq
MIRT2021547	hsa-miR-298	CLIP-seq
MIRT1084758	hsa-miR-29a	CLIP-seq
MIRT1084759	hsa-miR-29b	CLIP-seq
MIRT1084760	hsa-miR-29c	CLIP-seq
MIRT2253065	hsa-miR-30a	CLIP-seq
MIRT2253066	hsa-miR-30b	CLIP-seq
MIRT2253067	hsa-miR-30c	CLIP-seq
MIRT2253068	hsa-miR-30d	CLIP-seq
MIRT2253069	hsa-miR-30e	CLIP-seq
MIRT1084764	hsa-miR-3117-5p	CLIP-seq
MIRT1084766	hsa-miR-3140-5p	CLIP-seq
MIRT2253070	hsa-miR-3159	CLIP-seq
MIRT1084769	hsa-miR-3174	CLIP-seq
MIRT2253071	hsa-miR-3183	CLIP-seq
MIRT1084770	hsa-miR-3198	CLIP-seq
MIRT1084772	hsa-miR-320e	CLIP-seq
MIRT1084773	hsa-miR-323-3p	CLIP-seq
MIRT2253072	hsa-miR-34c-3p	CLIP-seq
MIRT1084778	hsa-miR-3605-5p	CLIP-seq
MIRT2253073	hsa-miR-3606	CLIP-seq
MIRT2253074	hsa-miR-3609	CLIP-seq
MIRT2253075	hsa-miR-3616-3p	CLIP-seq
MIRT1084780	hsa-miR-3616-5p	CLIP-seq
MIRT2253076	hsa-miR-3617	CLIP-seq
MIRT1084781	hsa-miR-3647-5p	CLIP-seq
MIRT2253077	hsa-miR-3654	CLIP-seq
MIRT1084783	hsa-miR-3671	CLIP-seq
MIRT1084784	hsa-miR-3679-5p	CLIP-seq
MIRT1084785	hsa-miR-3686	CLIP-seq
MIRT2021554	hsa-miR-3688-5p	CLIP-seq
MIRT1084787	hsa-miR-3692	CLIP-seq
MIRT2021555	hsa-miR-369-3p	CLIP-seq
MIRT2021556	hsa-miR-3714	CLIP-seq
MIRT2021557	hsa-miR-374a	CLIP-seq
MIRT2021558	hsa-miR-374b	CLIP-seq
MIRT2021559	hsa-miR-376c	CLIP-seq
MIRT1084788	hsa-miR-3915	CLIP-seq
MIRT2021561	hsa-miR-3919	CLIP-seq
MIRT2253078	hsa-miR-4252	CLIP-seq
MIRT1084792	hsa-miR-4270	CLIP-seq
MIRT2021563	hsa-miR-4275	CLIP-seq
MIRT2253079	hsa-miR-4278	CLIP-seq
MIRT2253080	hsa-miR-4279	CLIP-seq
MIRT1084793	hsa-miR-4282	CLIP-seq
MIRT1084794	hsa-miR-4294	CLIP-seq
MIRT1084795	hsa-miR-4297	CLIP-seq
MIRT1084797	hsa-miR-4305	CLIP-seq
MIRT1084798	hsa-miR-4309	CLIP-seq
MIRT1084799	hsa-miR-4310	CLIP-seq
MIRT2253081	hsa-miR-4316	CLIP-seq
MIRT1084801	hsa-miR-4422	CLIP-seq
MIRT2021566	hsa-miR-4438	CLIP-seq
MIRT1084802	hsa-miR-4441	CLIP-seq
MIRT2253082	hsa-miR-4446-3p	CLIP-seq
MIRT2021567	hsa-miR-4457	CLIP-seq
MIRT1084803	hsa-miR-4475	CLIP-seq
MIRT2021569	hsa-miR-4484	CLIP-seq
MIRT1084806	hsa-miR-4490	CLIP-seq
MIRT2021570	hsa-miR-4499	CLIP-seq
MIRT1084807	hsa-miR-452	CLIP-seq
MIRT1084808	hsa-miR-4529-3p	CLIP-seq
MIRT2253083	hsa-miR-4635	CLIP-seq
MIRT2021571	hsa-miR-4670-3p	CLIP-seq
MIRT2253084	hsa-miR-4675	CLIP-seq
MIRT1084812	hsa-miR-4676-3p	CLIP-seq
MIRT2253085	hsa-miR-4677-3p	CLIP-seq
MIRT2253086	hsa-miR-4679	CLIP-seq
MIRT1084813	hsa-miR-4680-3p	CLIP-seq
MIRT1084815	hsa-miR-4689	CLIP-seq
MIRT2253087	hsa-miR-4691-3p	CLIP-seq
MIRT2253088	hsa-miR-4699-3p	CLIP-seq
MIRT1084816	hsa-miR-4704-5p	CLIP-seq
MIRT1084817	hsa-miR-4705	CLIP-seq
MIRT1084818	hsa-miR-4709-3p	CLIP-seq
MIRT2253089	hsa-miR-4716-3p	CLIP-seq
MIRT2021572	hsa-miR-4718	CLIP-seq
MIRT1084820	hsa-miR-4719	CLIP-seq
MIRT2253090	hsa-miR-4721	CLIP-seq
MIRT2253091	hsa-miR-4723-3p	CLIP-seq
MIRT2021573	hsa-miR-4733-3p	CLIP-seq
MIRT2253092	hsa-miR-4735-3p	CLIP-seq
MIRT2253093	hsa-miR-4741	CLIP-seq
MIRT2021574	hsa-miR-4753-3p	CLIP-seq
MIRT2253094	hsa-miR-4775	CLIP-seq
MIRT1084821	hsa-miR-4776-3p	CLIP-seq
MIRT1084823	hsa-miR-4795-5p	CLIP-seq
MIRT2021576	hsa-miR-4797-5p	CLIP-seq
MIRT2253095	hsa-miR-495	CLIP-seq
MIRT1084824	hsa-miR-499-3p	CLIP-seq
MIRT1084825	hsa-miR-499a-3p	CLIP-seq
MIRT2021578	hsa-miR-5095	CLIP-seq
MIRT2253096	hsa-miR-513c	CLIP-seq
MIRT2253097	hsa-miR-514b-5p	CLIP-seq
MIRT2253098	hsa-miR-516a-3p	CLIP-seq
MIRT2253099	hsa-miR-520g	CLIP-seq
MIRT2253100	hsa-miR-520h	CLIP-seq
MIRT1084826	hsa-miR-532-5p	CLIP-seq
MIRT1084829	hsa-miR-543	CLIP-seq
MIRT2253101	hsa-miR-548ae	CLIP-seq
MIRT2253102	hsa-miR-548ah	CLIP-seq
MIRT2253103	hsa-miR-548aj	CLIP-seq
MIRT2253104	hsa-miR-548am	CLIP-seq
MIRT2021581	hsa-miR-548an	CLIP-seq
MIRT2253105	hsa-miR-548x	CLIP-seq
MIRT1084832	hsa-miR-562	CLIP-seq
MIRT1084834	hsa-miR-573	CLIP-seq
MIRT1084835	hsa-miR-590-3p	CLIP-seq
MIRT1084837	hsa-miR-599	CLIP-seq
MIRT2021583	hsa-miR-600	CLIP-seq
MIRT1084838	hsa-miR-603	CLIP-seq
MIRT1084839	hsa-miR-605	CLIP-seq
MIRT1084840	hsa-miR-607	CLIP-seq
MIRT2253106	hsa-miR-641	CLIP-seq
MIRT2021584	hsa-miR-7	CLIP-seq
MIRT2253107	hsa-miR-921	CLIP-seq
MIRT2021585	hsa-miR-942	CLIP-seq
MIRT1084739	hsa-miR-1208	CLIP-seq
MIRT2021546	hsa-miR-2052	CLIP-seq
MIRT1084758	hsa-miR-29a	CLIP-seq
MIRT1084759	hsa-miR-29b	CLIP-seq
MIRT1084760	hsa-miR-29c	CLIP-seq
MIRT2253072	hsa-miR-34c-3p	CLIP-seq
MIRT1084787	hsa-miR-3692	CLIP-seq
MIRT2021559	hsa-miR-376c	CLIP-seq
MIRT2021561	hsa-miR-3919	CLIP-seq
MIRT1084793	hsa-miR-4282	CLIP-seq
MIRT1084799	hsa-miR-4310	CLIP-seq
MIRT1084807	hsa-miR-452	CLIP-seq
MIRT2253083	hsa-miR-4635	CLIP-seq
MIRT1084812	hsa-miR-4676-3p	CLIP-seq
MIRT1084818	hsa-miR-4709-3p	CLIP-seq
MIRT2021574	hsa-miR-4753-3p	CLIP-seq
MIRT2021576	hsa-miR-4797-5p	CLIP-seq
MIRT1084824	hsa-miR-499-3p	CLIP-seq
MIRT1084825	hsa-miR-499a-3p	CLIP-seq
MIRT1084838	hsa-miR-603	CLIP-seq
MIRT2021541	hsa-miR-1178	CLIP-seq
MIRT1084739	hsa-miR-1208	CLIP-seq
MIRT2021546	hsa-miR-2052	CLIP-seq
MIRT1084758	hsa-miR-29a	CLIP-seq
MIRT1084759	hsa-miR-29b	CLIP-seq
MIRT1084760	hsa-miR-29c	CLIP-seq
MIRT1084785	hsa-miR-3686	CLIP-seq
MIRT2021559	hsa-miR-376c	CLIP-seq
MIRT2021564	hsa-miR-4330	CLIP-seq
MIRT1084801	hsa-miR-4422	CLIP-seq
MIRT1084807	hsa-miR-452	CLIP-seq
MIRT2021571	hsa-miR-4670-3p	CLIP-seq
MIRT1084812	hsa-miR-4676-3p	CLIP-seq
MIRT1084817	hsa-miR-4705	CLIP-seq
MIRT1084824	hsa-miR-499-3p	CLIP-seq
MIRT1084825	hsa-miR-499a-3p	CLIP-seq
MIRT2021582	hsa-miR-577	CLIP-seq
MIRT1084837	hsa-miR-599	CLIP-seq
MIRT1084838	hsa-miR-603	CLIP-seq
MIRT2021541	hsa-miR-1178	CLIP-seq
MIRT1084764	hsa-miR-3117-5p	CLIP-seq
MIRT2021559	hsa-miR-376c	CLIP-seq
MIRT1084797	hsa-miR-4305	CLIP-seq
MIRT2021571	hsa-miR-4670-3p	CLIP-seq
MIRT1084816	hsa-miR-4704-5p	CLIP-seq
MIRT1084837	hsa-miR-599	CLIP-seq
MIRT2021541	hsa-miR-1178	CLIP-seq
MIRT1084739	hsa-miR-1208	CLIP-seq
MIRT1084741	hsa-miR-1237	CLIP-seq
MIRT1084742	hsa-miR-1258	CLIP-seq
MIRT1084743	hsa-miR-1269	CLIP-seq
MIRT1084744	hsa-miR-1269b	CLIP-seq
MIRT2021544	hsa-miR-1292	CLIP-seq
MIRT2555958	hsa-miR-139-5p	CLIP-seq
MIRT1084749	hsa-miR-149	CLIP-seq
MIRT2253062	hsa-miR-150	CLIP-seq
MIRT1084750	hsa-miR-155	CLIP-seq
MIRT2555959	hsa-miR-1827	CLIP-seq
MIRT2253063	hsa-miR-18a	CLIP-seq
MIRT2253064	hsa-miR-18b	CLIP-seq
MIRT1084752	hsa-miR-19a	CLIP-seq
MIRT1084753	hsa-miR-19b	CLIP-seq
MIRT2021546	hsa-miR-2052	CLIP-seq
MIRT1084757	hsa-miR-2467-3p	CLIP-seq
MIRT2021547	hsa-miR-298	CLIP-seq
MIRT1084758	hsa-miR-29a	CLIP-seq
MIRT1084759	hsa-miR-29b	CLIP-seq
MIRT1084760	hsa-miR-29c	CLIP-seq
MIRT2021548	hsa-miR-300	CLIP-seq
MIRT1084761	hsa-miR-3064-5p	CLIP-seq
MIRT1084763	hsa-miR-3117-3p	CLIP-seq
MIRT1084764	hsa-miR-3117-5p	CLIP-seq
MIRT1084765	hsa-miR-3127-3p	CLIP-seq
MIRT1084767	hsa-miR-3147	CLIP-seq
MIRT2021551	hsa-miR-3175	CLIP-seq
MIRT2555960	hsa-miR-3184	CLIP-seq
MIRT2555961	hsa-miR-3192	CLIP-seq
MIRT1084771	hsa-miR-3202	CLIP-seq
MIRT1084772	hsa-miR-320e	CLIP-seq
MIRT1084777	hsa-miR-3591-5p	CLIP-seq
MIRT2253074	hsa-miR-3609	CLIP-seq
MIRT2555962	hsa-miR-3612	CLIP-seq
MIRT1084779	hsa-miR-3613-3p	CLIP-seq
MIRT2021553	hsa-miR-3681	CLIP-seq
MIRT1084785	hsa-miR-3686	CLIP-seq
MIRT2021559	hsa-miR-376c	CLIP-seq
MIRT2021560	hsa-miR-381	CLIP-seq
MIRT2555963	hsa-miR-423-5p	CLIP-seq
MIRT1084791	hsa-miR-4255	CLIP-seq
MIRT1084793	hsa-miR-4282	CLIP-seq
MIRT1084795	hsa-miR-4297	CLIP-seq
MIRT1084797	hsa-miR-4305	CLIP-seq
MIRT1084799	hsa-miR-4310	CLIP-seq
MIRT2555964	hsa-miR-4314	CLIP-seq
MIRT2021564	hsa-miR-4330	CLIP-seq
MIRT1084801	hsa-miR-4422	CLIP-seq
MIRT2555965	hsa-miR-4459	CLIP-seq
MIRT2021568	hsa-miR-4471	CLIP-seq
MIRT1084804	hsa-miR-4476	CLIP-seq
MIRT1084806	hsa-miR-4490	CLIP-seq
MIRT2555966	hsa-miR-4496	CLIP-seq
MIRT1084807	hsa-miR-452	CLIP-seq
MIRT1084808	hsa-miR-4529-3p	CLIP-seq
MIRT2555967	hsa-miR-4646-5p	CLIP-seq
MIRT2021571	hsa-miR-4670-3p	CLIP-seq
MIRT1084812	hsa-miR-4676-3p	CLIP-seq
MIRT2555968	hsa-miR-4676-5p	CLIP-seq
MIRT1084814	hsa-miR-4687-3p	CLIP-seq
MIRT2555969	hsa-miR-4688	CLIP-seq
MIRT2555970	hsa-miR-4695-5p	CLIP-seq
MIRT1084816	hsa-miR-4704-5p	CLIP-seq
MIRT1084817	hsa-miR-4705	CLIP-seq
MIRT1084819	hsa-miR-4709-5p	CLIP-seq
MIRT2021572	hsa-miR-4718	CLIP-seq
MIRT2253092	hsa-miR-4735-3p	CLIP-seq
MIRT1084822	hsa-miR-4794	CLIP-seq
MIRT2555971	hsa-miR-4799-5p	CLIP-seq
MIRT2555972	hsa-miR-486-3p	CLIP-seq
MIRT2555973	hsa-miR-490-3p	CLIP-seq
MIRT2253095	hsa-miR-495	CLIP-seq
MIRT1084824	hsa-miR-499-3p	CLIP-seq
MIRT1084825	hsa-miR-499a-3p	CLIP-seq
MIRT2253099	hsa-miR-520g	CLIP-seq
MIRT2253100	hsa-miR-520h	CLIP-seq
MIRT1084826	hsa-miR-532-5p	CLIP-seq
MIRT1084827	hsa-miR-539	CLIP-seq
MIRT1084828	hsa-miR-541	CLIP-seq
MIRT2253101	hsa-miR-548ae	CLIP-seq
MIRT2253102	hsa-miR-548ah	CLIP-seq
MIRT2253103	hsa-miR-548aj	CLIP-seq
MIRT2253104	hsa-miR-548am	CLIP-seq
MIRT1084831	hsa-miR-548t	CLIP-seq
MIRT2555974	hsa-miR-548v	CLIP-seq
MIRT2253105	hsa-miR-548x	CLIP-seq
MIRT2555975	hsa-miR-575	CLIP-seq
MIRT2021582	hsa-miR-577	CLIP-seq
MIRT2555976	hsa-miR-582-5p	CLIP-seq
MIRT1084835	hsa-miR-590-3p	CLIP-seq
MIRT1084837	hsa-miR-599	CLIP-seq
MIRT1084838	hsa-miR-603	CLIP-seq
MIRT1084839	hsa-miR-605	CLIP-seq
MIRT2555977	hsa-miR-650	CLIP-seq
MIRT1084842	hsa-miR-654-5p	CLIP-seq
MIRT2555978	hsa-miR-665	CLIP-seq
MIRT2555979	hsa-miR-760	CLIP-seq
MIRT1084844	hsa-miR-936	CLIP-seq
MIRT2021541	hsa-miR-1178	CLIP-seq
MIRT1084739	hsa-miR-1208	CLIP-seq
MIRT1084741	hsa-miR-1237	CLIP-seq
MIRT1084743	hsa-miR-1269	CLIP-seq
MIRT1084744	hsa-miR-1269b	CLIP-seq
MIRT2021544	hsa-miR-1292	CLIP-seq
MIRT1084748	hsa-miR-132	CLIP-seq
MIRT2555958	hsa-miR-139-5p	CLIP-seq
MIRT1084749	hsa-miR-149	CLIP-seq
MIRT2253062	hsa-miR-150	CLIP-seq
MIRT1084750	hsa-miR-155	CLIP-seq
MIRT2253063	hsa-miR-18a	CLIP-seq
MIRT2253064	hsa-miR-18b	CLIP-seq
MIRT1084752	hsa-miR-19a	CLIP-seq
MIRT1084753	hsa-miR-19b	CLIP-seq
MIRT1084755	hsa-miR-212	CLIP-seq
MIRT2683275	hsa-miR-2355-5p	CLIP-seq
MIRT1084757	hsa-miR-2467-3p	CLIP-seq
MIRT2021547	hsa-miR-298	CLIP-seq
MIRT1084758	hsa-miR-29a	CLIP-seq
MIRT1084759	hsa-miR-29b	CLIP-seq
MIRT1084760	hsa-miR-29c	CLIP-seq
MIRT2021548	hsa-miR-300	CLIP-seq
MIRT1084761	hsa-miR-3064-5p	CLIP-seq
MIRT1084764	hsa-miR-3117-5p	CLIP-seq
MIRT1084765	hsa-miR-3127-3p	CLIP-seq
MIRT1084767	hsa-miR-3147	CLIP-seq
MIRT2021551	hsa-miR-3175	CLIP-seq
MIRT2555960	hsa-miR-3184	CLIP-seq
MIRT1084772	hsa-miR-320e	CLIP-seq
MIRT1084777	hsa-miR-3591-5p	CLIP-seq
MIRT2253074	hsa-miR-3609	CLIP-seq
MIRT1084779	hsa-miR-3613-3p	CLIP-seq
MIRT2683276	hsa-miR-3679-3p	CLIP-seq
MIRT2021553	hsa-miR-3681	CLIP-seq
MIRT1084785	hsa-miR-3686	CLIP-seq
MIRT2021559	hsa-miR-376c	CLIP-seq
MIRT2021560	hsa-miR-381	CLIP-seq
MIRT2555963	hsa-miR-423-5p	CLIP-seq
MIRT1084791	hsa-miR-4255	CLIP-seq
MIRT1084793	hsa-miR-4282	CLIP-seq
MIRT1084795	hsa-miR-4297	CLIP-seq
MIRT1084797	hsa-miR-4305	CLIP-seq
MIRT1084799	hsa-miR-4310	CLIP-seq
MIRT2021564	hsa-miR-4330	CLIP-seq
MIRT1084801	hsa-miR-4422	CLIP-seq
MIRT2021568	hsa-miR-4471	CLIP-seq
MIRT1084806	hsa-miR-4490	CLIP-seq
MIRT2555966	hsa-miR-4496	CLIP-seq
MIRT1084807	hsa-miR-452	CLIP-seq
MIRT1084808	hsa-miR-4529-3p	CLIP-seq
MIRT2021571	hsa-miR-4670-3p	CLIP-seq
MIRT1084812	hsa-miR-4676-3p	CLIP-seq
MIRT2555968	hsa-miR-4676-5p	CLIP-seq
MIRT1084814	hsa-miR-4687-3p	CLIP-seq
MIRT2555969	hsa-miR-4688	CLIP-seq
MIRT1084816	hsa-miR-4704-5p	CLIP-seq
MIRT1084817	hsa-miR-4705	CLIP-seq
MIRT1084819	hsa-miR-4709-5p	CLIP-seq
MIRT2021572	hsa-miR-4718	CLIP-seq
MIRT2253092	hsa-miR-4735-3p	CLIP-seq
MIRT1084822	hsa-miR-4794	CLIP-seq
MIRT2555971	hsa-miR-4799-5p	CLIP-seq
MIRT2555972	hsa-miR-486-3p	CLIP-seq
MIRT2555973	hsa-miR-490-3p	CLIP-seq
MIRT2253095	hsa-miR-495	CLIP-seq
MIRT1084824	hsa-miR-499-3p	CLIP-seq
MIRT1084825	hsa-miR-499a-3p	CLIP-seq
MIRT2683277	hsa-miR-513a-3p	CLIP-seq
MIRT2253099	hsa-miR-520g	CLIP-seq
MIRT2253100	hsa-miR-520h	CLIP-seq
MIRT1084826	hsa-miR-532-5p	CLIP-seq
MIRT1084827	hsa-miR-539	CLIP-seq
MIRT1084828	hsa-miR-541	CLIP-seq
MIRT2253101	hsa-miR-548ae	CLIP-seq
MIRT2253102	hsa-miR-548ah	CLIP-seq
MIRT2253103	hsa-miR-548aj	CLIP-seq
MIRT2253104	hsa-miR-548am	CLIP-seq
MIRT2683278	hsa-miR-548c-3p	CLIP-seq
MIRT1084831	hsa-miR-548t	CLIP-seq
MIRT2555974	hsa-miR-548v	CLIP-seq
MIRT2253105	hsa-miR-548x	CLIP-seq
MIRT2555975	hsa-miR-575	CLIP-seq
MIRT2021582	hsa-miR-577	CLIP-seq
MIRT2555976	hsa-miR-582-5p	CLIP-seq
MIRT1084835	hsa-miR-590-3p	CLIP-seq
MIRT1084837	hsa-miR-599	CLIP-seq
MIRT1084838	hsa-miR-603	CLIP-seq
MIRT1084839	hsa-miR-605	CLIP-seq
MIRT1084842	hsa-miR-654-5p	CLIP-seq
MIRT2555979	hsa-miR-760	CLIP-seq
MIRT1084844	hsa-miR-936	CLIP-seq

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IBA
GO:0003676	Function	Nucleic acid binding	EXP	20403335
GO:0003676	Function	Nucleic acid binding	IMP	20403335
GO:0003677	Function	DNA binding	IDA	15640446
GO:0003677	Function	DNA binding	IEA
GO:0003714	Function	Transcription corepressor activity	IDA	12657635
GO:0005515	Function	Protein binding	IPI	12657635, 24937458
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	20403335
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	12657635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005829	Component	Cytosol	IDA
GO:0006325	Process	Chromatin organization	IEA
GO:0006338	Process	Chromatin remodeling	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IBA
GO:0007338	Process	Single fertilization	IEA
GO:0008270	Function	Zinc ion binding	IDA	24952722, 27214403
GO:0008270	Function	Zinc ion binding	IEA
GO:0008270	Function	Zinc ion binding	IMP	28262558
GO:0009791	Process	Post-embryonic development	IEA
GO:0010628	Process	Positive regulation of gene expression	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0032452	Function	Histone demethylase activity	TAS
GO:0032453	Function	Histone H3K4 demethylase activity	IDA	18048344
GO:0032453	Function	Histone H3K4 demethylase activity	IEA
GO:0032453	Function	Histone H3K4 demethylase activity	IMP	24952722, 27214403, 28262558
GO:0033601	Process	Positive regulation of mammary gland epithelial cell proliferation	IEA
GO:0034647	Function	Histone H3K4me/H3K4me2/H3K4me3 demethylase activity	IBA
GO:0034647	Function	Histone H3K4me/H3K4me2/H3K4me3 demethylase activity	IDA	20228790
GO:0034647	Function	Histone H3K4me/H3K4me2/H3K4me3 demethylase activity	IEA
GO:0034647	Function	Histone H3K4me/H3K4me2/H3K4me3 demethylase activity	IMP	20403335
GO:0042393	Function	Histone binding	IDA	24952722
GO:0044344	Process	Cellular response to fibroblast growth factor stimulus	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IDA	12657635
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0048511	Process	Rhythmic process	IEA
GO:0051213	Function	Dioxygenase activity	IEA
GO:0060444	Process	Branching involved in mammary gland duct morphogenesis	IEA
GO:0060763	Process	Mammary duct terminal end bud growth	IEA
GO:0060992	Process	Response to fungicide	IEA
GO:0061038	Process	Uterus morphogenesis	IEA
GO:0070306	Process	Lens fiber cell differentiation	IEA
GO:1990830	Process	Cellular response to leukemia inhibitory factor	IEA
GO:1990837	Function	Sequence-specific double-stranded DNA binding	IMP	20403335
GO:2000864	Process	Regulation of estradiol secretion	IEA

MIM	HGNC	e!Ensembl
605393	18039	ENSG00000117139

Q9UGL1

Protein name

Lysine-specific demethylase 5B (EC 1.14.11.67) (Cancer/testis antigen 31) (CT31) (Histone demethylase JARID1B) (Jumonji/ARID domain-containing protein 1B) (PLU-1) (Retinoblastoma-binding protein 2 homolog 1) (RBP2-H1) ([histone H3]-trimethyl-L-lysine(4) d

Protein function

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated,

PDB

2MA5 , 2MNY , 2MNZ , 5A1F , 5A3N , 5A3P , 5A3T , 5A3W , 5FPL , 5FPU , 5FUN , 5FUP , 5FV3 , 5FY4 , 5FY5 , 5FY9 , 5FYB , 5FYS , 5FYT , 5FYU , 5FYV , 5FYY , 5FYZ , 5FZ0 , 5FZ1 , 5FZ3 , 5FZ4 , 5FZ6 , 5FZ7 , 5FZ8 , 5FZ9 , 5FZA , 5FZB , 5FZC , 5FZD , 5FZE , 5FZF , 5FZG , 5FZH , 5FZI , 5FZK , 5FZL , 5FZM , 5LW9 , 5LWB , 6EIN , 6EIU , 6EIY , 6EJ0 , 6EJ1 , 6EK6

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02375	JmjN	33 → 66	jmjN domain	Family
PF01388	ARID	99 → 183	ARID/BRIGHT DNA binding domain	Domain
PF00628	PHD	311 → 359	PHD-finger	Domain
PF02373	JmjC	486 → 602	JmjC domain, hydroxylase	Domain
PF02928	zf-C5HC2	692 → 744	C5HC2 zinc finger	Domain
PF08429	PLU-1	757 → 1088	PLU-1-like protein	Family
PF00628	PHD	1178 → 1224	PHD-finger	Domain
PF00628	PHD	1486 → 1538	PHD-finger	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer (at protein level). {ECO:0000269|PubMed:10336460, ECO:0000269|PubMed:10616211, ECO:0000269|PubMed:1087866

Sequence

MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTG
ICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKI
PHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILN
PYNLFLSGDSLRCLQKPNLTTDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMN
IKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRS
KKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQE
CSKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEED
VTVEYGADIASKEFGSGFPVRDGKIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADIC
GMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPE
LFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAV
NFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIE
DEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVK
ELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAESYNEWALNVNEALEAKINKKKSLVSFK
ALIEESEMKKFPDNDLLRHLRLVTQDAEKCASVAQQLLNGKRQTRYRSGGGKSQNQLTVN
ELRQFVTQLYALPCVLSQTPLLKDLLNRVEDFQQHSQKLLSEETPSAAELQDLLDVSFEF
DVELPQLAEMRIRLEQARWLEEVQQACLDPSSLTLDDMRRLIDLGVGLAPYSAVEKAMAR
LQELLTVSEHWDDKAKSLLKARPRHSLNSLATAVKEIEEIPAYLPNGAALKDSVQRARDW
LQDVEGLQAGGRVPVLDTLIELVTRGRSIPVHLNSLPRLETLVAEVQAWKECAVNTFLTE
NSPYSLLEVLCPRCDIGLLGLKRKQRKLKEPLPNGKKKSTKLESLSDLERALTESKETAS
AMATLGEARLREMEALQSLRLANEGKLLSPLQDVDIKICLCQKAPAAPMIQCELCRDAFH
TSCVAVPSISQGLRIWLCPHCRRSEKPPLEKILPLLASLQRIRVRLPEGDALRYMIERTV
NWQHRAQQLLSSGNLKFVQDRVGSGLLYSRWQASAGQVSDTNKVSQPPGTTSFSLPDDWD
NRTSYLHSPFSTGRSCIPLHGVSPEVNELLMEAQLLQVSLPEIQELYQTLLAKPSPAQQT
DRSSPVRPSSEKNDCCRGKRDGINSLERKLKRRLEREGLSSERWERVKKMRTPKKKKIKL
SHPKDMNNFKLERERSYELVRSAETHSLPSDTSYSEQEDSEDEDAICPAVSCLQPEGDEV
DWVQCDGSCNQWFHQVCVGVSPEMAEKEDYICVRCTVKDAPSRK

Sequence length

1544

Interactions

View interactions

	Reactome
			HDMs demethylate histones TFAP2 (AP-2) family regulates transcription of cell cycle factors

154

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Intellectual disability, autosomal recessive 65	Likely pathogenic; Pathogenic	rs1287727763, rs2102232815, rs527951173, rs367833330, rs750775126, rs2527627635, rs2527627970, rs2527426205, rs2527411037, rs2527486492, rs2527565001, rs746837045, rs2527456144, rs1388990301, rs2527421668 View all (9 more)	RCV001542642 RCV001553744 RCV004698867 RCV005931967 RCV004067578 RCV002814365 RCV003146795 RCV003146799 RCV003153175 RCV003225619 RCV003225716 RCV003759817 RCV003335839 RCV004784148 RCV003492902 RCV003989382 RCV004555978 RCV004566512 RCV000678687 RCV000678689 RCV000678690 RCV000678691 RCV000768394 RCV001007614
KDM5B-related disorder	Likely pathogenic	rs1287727763, rs1388990301, rs2527565074, rs2527411857, rs148131534	RCV004728767 RCV004550641 RCV004550605 RCV004552445 RCV004554159
Neurodevelopmental disorder	Likely pathogenic; Pathogenic	rs866525850	RCV006249811
See cases	Likely pathogenic; Pathogenic	rs776299767	RCV002252976

Show/Hide Unknown Diseases (26)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign; Likely benign	rs61751237	RCV005904528
Adrenocortical carcinoma, hereditary	Conflicting classifications of pathogenicity; Benign; Likely benign	rs558975598, rs61751237	RCV005867151 RCV005904530
Autism spectrum disorder	Likely benign; Conflicting classifications of pathogenicity	rs1656790377, rs760186894	RCV003127259 RCV003127343
Bladder exstrophy-epispadias-cloacal extrophy complex	Uncertain significance	rs145517771	RCV003389436
Cervical cancer	Benign; Likely benign	rs61751237	RCV005904531
Cholangiocarcinoma	Benign; Likely benign	rs61751237	RCV005904539
Chronic lymphocytic leukemia/small lymphocytic lymphoma	Benign; Likely benign	rs61751237	RCV005904541
Clear cell carcinoma of kidney	Benign; Likely benign	rs61751237	RCV005904533
Colon adenocarcinoma	Conflicting classifications of pathogenicity; Benign	rs558975598, rs144390145	RCV005867150 RCV005908669
Colorectal cancer	Benign; Likely benign	rs61751237	RCV005904535
Developmental disorder	Uncertain significance	rs2102304180	RCV003127258
Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype	Uncertain significance	rs2527535592	RCV003315275
Familial cancer of breast	Benign; Conflicting classifications of pathogenicity; Likely benign	rs1892164, rs542983923, rs144390145, rs61751237	RCV005920622 RCV005922465 RCV005908668 RCV005904527
Familial pancreatic carcinoma	Benign; Likely benign	rs144390145, rs61751237	RCV005908673 RCV005904534
Gastric cancer	Benign; Likely benign	rs61751237	RCV005904537
Hepatocellular carcinoma	Conflicting classifications of pathogenicity	rs542983923	RCV005922466
Intellectual disability	Conflicting classifications of pathogenicity	rs758824583, rs200973415	RCV005626454 RCV005626756
Lung cancer	Benign; Likely benign	rs61751237	RCV005904540
Malignant tumor of esophagus	Benign; Likely benign	rs144390145, rs61751237	RCV005908671 RCV005904529
Malignant tumor of urinary bladder	Benign	rs144390145	RCV005908670
Melanoma	Benign; Likely benign	rs61751237	RCV005904538
Ovarian cancer	Benign; Likely benign	rs144390145, rs61751237	RCV005908672 RCV005904532
Ovarian serous cystadenocarcinoma	Benign	rs144390145	RCV005908674
Sarcoma	Benign; Likely benign	rs61751237	RCV005904536
Thyroid cancer, nonmedullary, 1	Benign	rs144390145	RCV005908675
Uterine corpus endometrial carcinoma	Conflicting classifications of pathogenicity	rs558975598	RCV005867152

Show/Hide Text Mining Associations (70)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Agenesis of Corpus Callosum	Associate	34573379
Autism Spectrum Disorder	Associate	28344757, 28720891, 34573379
Autistic Disorder	Associate	39202393
Body Dysmorphic Disorders	Associate	34573379, 35278764
Bovine Respiratory Disease Complex	Associate	37788244
Breast Neoplasms	Associate	10336460, 17363312, 21821892, 21969366, 22371483, 22420752, 24937458, 26125737, 26207617, 26917489, 28138513, 29282222, 30472020, 31060229, 31776402, 31805991, 33592583, 36697763 View all (3 more)
Breast Neoplasms	Inhibit	24412361
Breast Neoplasms	Stimulate	30588710, 37254514
Camptodactyly 1	Associate	29276005
Carcinogenesis	Associate	20226085, 22371483, 24412361, 30092824, 36697763
Carcinoma Ductal Breast	Associate	26125737
Carcinoma Hepatocellular	Associate	28566884, 30353907, 31737652, 33355042, 37137887
Carcinoma Non Small Cell Lung	Associate	30092824
Carcinoma Ovarian Epithelial	Stimulate	25663457
Carcinoma Renal Cell	Associate	27279483
Clear cell metastatic renal cell carcinoma	Associate	27279483
Colorectal Neoplasms	Associate	27635108
Developmental Disabilities	Associate	29276005, 34573379, 35278764, 39202393
Diastrophic dysplasia	Associate	34573379, 39202393
Dislocation of Hip Congenital with Hyperextensibility of Fingers and Facial Dysmorphism	Associate	35278764
Ectodermal Dysplasia	Associate	34573379
Ectodermal Dysplasia	Stimulate	37887281
Epilepsies Myoclonic	Associate	35278764
Epileptic Syndromes	Associate	35278764
Esophageal Squamous Cell Carcinoma	Associate	35333349
Facial Dysmorphism with Multiple Malformations	Associate	29276005, 34573379
Glioma	Associate	37254514
Head and Neck Neoplasms	Associate	30080846
Heart Defects Congenital	Associate	32341405, 34324492
Inflammation	Associate	24412361
Intellectual Disability	Associate	34573379, 35278764, 39202393
Learning Disabilities	Associate	32341405
Leukemia	Associate	26655717, 32007477
Leukemia Biphenotypic Acute	Associate	26655717
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	32007477
Lung Neoplasms	Associate	20226085, 21546573
Lymphatic Metastasis	Associate	26125737
Lymphatic Metastasis	Stimulate	30092824
Lymphoma Mantle Cell	Associate	25755704
Melanoma	Inhibit	15803180
Melanoma	Associate	16645588, 23764003, 26967479, 28143781, 29246117, 31229500, 35650266, 37308689
Mental Disorders	Associate	39202393
Mental Retardation Autosomal Recessive 4	Associate	39202393
Multiple Myeloma	Stimulate	28262558
Multiple Myeloma	Associate	31548641
Neoplasm Metastasis	Inhibit	15803180
Neoplasms	Inhibit	16645588, 17363312, 24412361, 24952722, 26461474
Neoplasms	Associate	20226085, 20973793, 21969366, 22615382, 23764003, 24952722, 25663457, 25951238, 26125737, 27584795, 27635108, 29282222, 30080846, 30092824, 30588710 View all (6 more)
Neoplasms	Stimulate	30353907
Neoplasms Squamous Cell	Inhibit	27584795
Neuroblastoma	Associate	25951238
Nevus Pigmented	Inhibit	15803180
Pancreatic Neoplasms	Associate	39239542
Peripheral Nervous System Diseases	Associate	31548641
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	29565495
Prostatic Neoplasms	Stimulate	18048344
Prostatic Neoplasms	Associate	36404720
Retinoblastoma	Associate	22615382
Seizures	Associate	35278764
Simpson Golabi Behmel syndrome	Associate	39202393
Skin Abnormalities	Associate	39202393
Sleep Wake Disorders	Associate	39202393
Squamous Cell Carcinoma of Head and Neck	Associate	27584795
Stomach Neoplasms	Associate	27874950, 30412518
Testicular Neoplasms	Stimulate	21546573
Triple Negative Breast Neoplasms	Inhibit	24412361
Triple Negative Breast Neoplasms	Associate	26917489, 31776402
Urinary Bladder Neoplasms	Stimulate	20226085
Urinary Bladder Neoplasms	Associate	23579952, 37105962
Uveal melanoma	Associate	36212716

KDM5B (lysine demethylase 5B)