Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10763
Gene name Gene Name - the full gene name approved by the HGNC.	Nestin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	NES
Synonyms (NCBI Gene) Gene synonyms aliases	Nbla00170
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q23.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the intermediate filament protein family and is expressed primarily in nerve cells. [provided by RefSeq, Sep 2011]

Show/Hide all(20)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020595	hsa-miR-155-5p	Proteomics	18668040
MIRT035540	hsa-miR-125b-5p	Luciferase reporter assay	23016664
MIRT035540	hsa-miR-125b-5p	Luciferase reporter assay	23016664
MIRT035540	hsa-miR-125b-5p	Luciferase reporter assay	23016664
MIRT438696	hsa-miR-432-5p	Flow, Immunocytochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24657437
MIRT438696	hsa-miR-432-5p	Flow, Immunocytochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24657437
MIRT438696	hsa-miR-432-5p	Flow, Immunocytochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24657437
MIRT438696	hsa-miR-432-5p	Flow, Immunocytochemistry, Luciferase reporter assay, qRT-PCR, Western blot	24657437
MIRT756178	hsa-miR-4488	Luciferase reporter assay, Western blotting, qRT-PCR, Immunohistochemistry (IHC)	38008717
MIRT756179	hsa-miR-4443	Luciferase reporter assay, Western blotting, qRT-PCR, Immunohistochemistry (IHC)	38008717
MIRT1180674	hsa-miR-1909	CLIP-seq
MIRT1180675	hsa-miR-204	CLIP-seq
MIRT1180676	hsa-miR-211	CLIP-seq
MIRT1180677	hsa-miR-3121-5p	CLIP-seq
MIRT1180678	hsa-miR-3689a-3p	CLIP-seq
MIRT1180679	hsa-miR-3689c	CLIP-seq
MIRT1180680	hsa-miR-3938	CLIP-seq
MIRT1180681	hsa-miR-4728-5p	CLIP-seq
MIRT1180682	hsa-miR-4755-5p	CLIP-seq
MIRT1180683	hsa-miR-623	CLIP-seq

Transcription factors

Show/Hide all(3)

Transcription factor	Regulation	Reference
MYCN	Activation	15117961
SOX10	Unknown	19845757
SOX9	Unknown	19845757

Show/Hide all(20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000086	Process	G2/M transition of mitotic cell cycle	IDA	19384922
GO:0003674	Function	Molecular_function	ND
GO:0005515	Function	Protein binding	IPI	26496610, 28514442, 30021884
GO:0005737	Component	Cytoplasm	IDA	19384922
GO:0005882	Component	Intermediate filament	IBA	21873635
GO:0005882	Component	Intermediate filament	NAS	9917366
GO:0007417	Process	Central nervous system development	NAS	9917366
GO:0007420	Process	Brain development	ISS
GO:0019215	Function	Intermediate filament binding	ISS
GO:0030844	Process	Positive regulation of intermediate filament depolymerization	IBA	21873635
GO:0030844	Process	Positive regulation of intermediate filament depolymerization	ISS
GO:0031076	Process	Embryonic camera-type eye development	ISS
GO:0031730	Function	CCR5 chemokine receptor binding	IBA	21873635
GO:0032091	Process	Negative regulation of protein binding	IDA	21185309
GO:0043086	Process	Negative regulation of catalytic activity	IDA	21185309
GO:0043524	Process	Negative regulation of neuron apoptotic process	IEA
GO:0045111	Component	Intermediate filament cytoskeleton	IDA
GO:0048858	Process	Cell projection morphogenesis	IEA
GO:0072089	Process	Stem cell proliferation	IMP	19384922
GO:2000179	Process	Positive regulation of neural precursor cell proliferation	ISS

MIM	HGNC	e!Ensembl
600915	7756	ENSG00000132688

Protein

UniProt ID

P48681

Protein name

Nestin

Protein function

Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00038	Filament	7 → 160	Intermediate filament protein	Coiled-coil
PF00038	Filament	178 → 312	Intermediate filament protein	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: CNS stem cells.

Sequence

MEGCMGEESFQMWELNRRLEAYLARVKALEEQNELLSAELGGLRAQSADTSWRAHADDEL
AALRALVDQRWREKHAAEVARDNLAEELEGVAGRCQQLRLARERTTEEVARNRRAVEAEK
CARAWLSSQVAELERELEALRVAHEEERVGLNAQAACAPRCPAPPRGPPAPAPEVEELAR
RLGEAWRGAVRGYQERVAHMETSLGQARERLGRAVQGAREGRLELQQLQAERGGLLERRA
ALEQRLEGRWQERLRATEKFQLAVEALEQEKQGLQSQIAQVLEGRQQLAHLKMSLSLEVA
TYRTLLEAENSRLQTPGGGSKTSLSFQDPKLELQFPRTPEGRRLGSLLPVLSPTSLPSPL
PATLETPVPAFLKNQEFLQARTPTLASTPIPPTPQAPSPAVDAEIRAQDAPLSLLQTQGG
RKQAPEPLRAEARVAIPASVLPGPEEPGGQRQEASTGQSPEDHASLAPPLSPDHSSLEAK
DGESGGSRVFSICRGEGEGQIWGLVEKETAIEGKVVSSLQQEIWEEEDLNRKEIQDSQVP
LEKETLKSLGEEIQESLKTLENQSHETLERENQECPRSLEEDLETLKSLEKENKELLKDV
EVVRPLEKEAVGQLKPTGKEDTQTLQSLQKENQELMKSLEGNLETFLFPGTENQELVSSL
QENLESLTALEKENQEPLRSPEVGDEEALRPLTKENQEPLRSLEDENKEAFRSLEKENQE
PLKTLEEEDQSIVRPLETENHKSLRSLEEQDQETLRTLEKETQQRRRSLGEQDQMTLRPP
EKVDLEPLKSLDQEIARPLENENQEFLKSLKEESVEAVKSLETEILESLKSAGQENLETL
KSPETQAPLWTPEEINQGAMNPLEKEIQEPLESVEVNQETFRLLEEENQESLRSLGAWNL
ENLRSPEEVDKESQRNLEEEENLGKGEYQESLRSLEEEGQELPQSADVQRWEDTVEKDQE
LAQESPPGMAGVENEDEAELNLREQDGFTGKEEVVEQGELNATEEVWIPGEGHPESPEPK
EQRGLVEGASVKGGAEGLQDPEGQSQQVGAPGLQAPQGLPEAIEPLVEDDVAPGGDQASP
EVMLGSEPAMGESAAGAEPGPGQGVGGLGDPGHLTREEVMEPPLEEESLEAKRVQGLEGP
RKDLEEAGGLGTEFSELPGKSRDPWEPPREGREESEAEAPRGAEEAFPAETLGHTGSDAP
SPWPLGSEEAEEDVPPVLVSPSPTYTPILEDAPGPQPQAEGSQEASWGVQGRAEALGKVE
SEQEELGSGEIPEGPQEEGEESREESEEDELGETLPDSTPLGFYLRSPTSPRWDPTGEQR
PPPQGETGKEGWDPAVLASEGLEAPPSEKEEGEEGEEECGRDSDLSEEFEDLGTEAPFLP
GVPGEVAEPLGQVPQLLLDPAAWDRDGESDGFADEEESGEEGEEDQEEGREPGAGRWGPG
SSVGSLQALSSSQRGEFLESDSVSVSVPWDDSLRGAVAGAPKTALETESQDSAEPSGSEE
ESDPVSLEREDKVPGPLEIPSGMEDAGPGADIIGVNGQGPNLEGKSQHVNGGVMNGLEQS
EEVGQGMPLVSEGDRGSPFQEEEGSALKTSWAGAPVHLGQGQFLKFTQREGDRESWSSGE
D

Sequence length

1621

Interactions

View interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Epilepsy	Epilepsy, Tonic-Clonic, Familial, Epilepsy, Tonic-Clonic, Symptomatic	rs113994140, rs28937874, rs1589762127, rs104894166, rs28939075, rs2134001459, rs104894167, rs119488099, rs119488100, rs387906420, rs121917752, rs121918622, rs281865564, rs387907313, rs397514670 View all (165 more)	16137769

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining
Ameloblastoma	Associate	33395399
Coronary Disease	Associate	18724036
Glioblastoma	Associate	34948016, 36333778
Lung Neoplasms	Associate	37784249
Lymphoma Extranodal NK T Cell	Associate	34872521
Melanoma	Associate	20882037, 39273022
Multiple Myeloma	Associate	24329895
Neoplasm Metastasis	Associate	37379245, 39273022
Neoplasms	Associate	27312238, 33251771, 39273022
Oncogene Addiction	Associate	17167184
Osteosarcoma	Associate	18925963
Ovarian Neoplasms	Associate	37628927
Testicular Germ Cell Tumor	Associate	17167184

NES (nestin)