Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10758
Gene name Gene Name - the full gene name approved by the HGNC.	TRAF3 interacting protein 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TRAF3IP2
Synonyms (NCBI Gene) Gene synonyms aliases	ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CANDF8, CIKS, PSORS13
Disease Acronyms (UniProt) Disease acronyms from UniProt database	CANDF8, PSORS13
Chromosome Chromosome number	6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	6q21
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gen

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miRTarBase ID	miRNA	Experiments	Reference
MIRT027633	hsa-miR-98-5p	Microarray	19088304
MIRT698080	hsa-miR-6872-3p	HITS-CLIP	23313552
MIRT698079	hsa-miR-8064	HITS-CLIP	23313552
MIRT686546	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT686545	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT686544	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT686543	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT686542	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT686541	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT686540	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT686539	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT686538	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT686537	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT686536	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT686535	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT686534	hsa-miR-302e	HITS-CLIP	23313552
MIRT686533	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT686532	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT686531	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT686530	hsa-miR-520b	HITS-CLIP	23313552
MIRT686529	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT686528	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT686527	hsa-miR-520e	HITS-CLIP	23313552
MIRT686526	hsa-miR-4438	HITS-CLIP	23313552
MIRT686525	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT686524	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT686523	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT686522	hsa-miR-520h	HITS-CLIP	23313552
MIRT686521	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT686520	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT686519	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT686518	hsa-miR-1253	HITS-CLIP	23313552
MIRT686517	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT686516	hsa-miR-3145-3p	HITS-CLIP	23313552
MIRT686515	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT686514	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT686513	hsa-miR-5095	HITS-CLIP	23313552
MIRT686512	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT686511	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT631573	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT631572	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT631571	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT631570	hsa-miR-4284	HITS-CLIP	23824327
MIRT631569	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT631568	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT631567	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT631566	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT631565	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT631564	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT631563	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT631562	hsa-miR-7977	HITS-CLIP	23824327
MIRT631561	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT631560	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT631559	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT631558	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT631557	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT631556	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT631555	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT631554	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT631553	hsa-miR-3689c	HITS-CLIP	23824327
MIRT631552	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT631551	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT631550	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT631549	hsa-miR-3122	HITS-CLIP	23824327
MIRT631548	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT631547	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT631546	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT631545	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT528704	hsa-miR-5586-3p	PAR-CLIP	20371350
MIRT528703	hsa-miR-6814-5p	PAR-CLIP	20371350
MIRT528702	hsa-miR-6812-3p	PAR-CLIP	20371350
MIRT528701	hsa-miR-150-5p	PAR-CLIP	20371350
MIRT528700	hsa-miR-532-3p	PAR-CLIP	20371350
MIRT569417	hsa-miR-2116-3p	PAR-CLIP	20371350
MIRT528699	hsa-miR-3120-5p	PAR-CLIP	20371350
MIRT528696	hsa-miR-4713-5p	PAR-CLIP	20371350
MIRT528695	hsa-miR-6888-3p	PAR-CLIP	20371350
MIRT516387	hsa-miR-6858-3p	PAR-CLIP	21572407
MIRT516386	hsa-miR-4676-5p	PAR-CLIP	21572407
MIRT516385	hsa-miR-575	PAR-CLIP	21572407
MIRT516383	hsa-miR-6514-5p	PAR-CLIP	21572407
MIRT516382	hsa-miR-1273f	PAR-CLIP	21572407
MIRT516381	hsa-miR-4534	PAR-CLIP	21572407
MIRT516380	hsa-miR-8082	PAR-CLIP	21572407
MIRT516379	hsa-miR-4653-3p	PAR-CLIP	21572407
MIRT516377	hsa-miR-3152-3p	PAR-CLIP	21572407
MIRT516376	hsa-miR-4662a-5p	PAR-CLIP	21572407
MIRT516374	hsa-miR-5096	PAR-CLIP	21572407
MIRT528704	hsa-miR-5586-3p	PAR-CLIP	22012620
MIRT528703	hsa-miR-6814-5p	PAR-CLIP	22012620
MIRT528702	hsa-miR-6812-3p	PAR-CLIP	22012620
MIRT528701	hsa-miR-150-5p	PAR-CLIP	22012620
MIRT528700	hsa-miR-532-3p	PAR-CLIP	22012620
MIRT528699	hsa-miR-3120-5p	PAR-CLIP	22012620
MIRT528698	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT528697	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT528696	hsa-miR-4713-5p	PAR-CLIP	22012620
MIRT528695	hsa-miR-6888-3p	PAR-CLIP	22012620
MIRT516387	hsa-miR-6858-3p	PAR-CLIP	23446348
MIRT516386	hsa-miR-4676-5p	PAR-CLIP	23446348
MIRT516385	hsa-miR-575	PAR-CLIP	23446348
MIRT516384	hsa-miR-2392	PAR-CLIP	23446348
MIRT516375	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516383	hsa-miR-6514-5p	PAR-CLIP	23446348
MIRT516382	hsa-miR-1273f	PAR-CLIP	23446348
MIRT516381	hsa-miR-4534	PAR-CLIP	23446348
MIRT516380	hsa-miR-8082	PAR-CLIP	23446348
MIRT516379	hsa-miR-4653-3p	PAR-CLIP	23446348
MIRT516378	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516377	hsa-miR-3152-3p	PAR-CLIP	23446348
MIRT516376	hsa-miR-4662a-5p	PAR-CLIP	23446348
MIRT516375	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516374	hsa-miR-5096	PAR-CLIP	23446348
MIRT698080	hsa-miR-6872-3p	HITS-CLIP	23313552
MIRT698079	hsa-miR-8064	HITS-CLIP	23313552
MIRT686546	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT686545	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT686544	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT686543	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT686542	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT686541	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT686540	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT686539	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT686538	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT686537	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT686536	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT686535	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT686534	hsa-miR-302e	HITS-CLIP	23313552
MIRT686533	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT686532	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT686531	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT686530	hsa-miR-520b	HITS-CLIP	23313552
MIRT686529	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT686528	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT686527	hsa-miR-520e	HITS-CLIP	23313552
MIRT686526	hsa-miR-4438	HITS-CLIP	23313552
MIRT686525	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT686524	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT686523	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT686522	hsa-miR-520h	HITS-CLIP	23313552
MIRT686521	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT686520	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT686519	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT686518	hsa-miR-1253	HITS-CLIP	23313552
MIRT686517	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT686516	hsa-miR-3145-3p	HITS-CLIP	23313552
MIRT686515	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT686514	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT686513	hsa-miR-5095	HITS-CLIP	23313552
MIRT686512	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT686511	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT631573	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT631572	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT631571	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT631570	hsa-miR-4284	HITS-CLIP	23824327
MIRT631569	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT631568	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT631567	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT631566	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT631565	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT631564	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT631563	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT631562	hsa-miR-7977	HITS-CLIP	23824327
MIRT631561	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT631560	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT631559	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT631558	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT631557	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT631556	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT631555	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT631554	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT631553	hsa-miR-3689c	HITS-CLIP	23824327
MIRT631552	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT631551	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT631550	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT631549	hsa-miR-3122	HITS-CLIP	23824327
MIRT631548	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT631547	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT631546	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT631545	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT528704	hsa-miR-5586-3p	PAR-CLIP	20371350
MIRT528703	hsa-miR-6814-5p	PAR-CLIP	20371350
MIRT528702	hsa-miR-6812-3p	PAR-CLIP	20371350
MIRT528701	hsa-miR-150-5p	PAR-CLIP	20371350
MIRT528700	hsa-miR-532-3p	PAR-CLIP	20371350
MIRT569417	hsa-miR-2116-3p	PAR-CLIP	20371350
MIRT528699	hsa-miR-3120-5p	PAR-CLIP	20371350
MIRT528696	hsa-miR-4713-5p	PAR-CLIP	20371350
MIRT528695	hsa-miR-6888-3p	PAR-CLIP	20371350
MIRT516387	hsa-miR-6858-3p	PAR-CLIP	21572407
MIRT516386	hsa-miR-4676-5p	PAR-CLIP	21572407
MIRT516385	hsa-miR-575	PAR-CLIP	21572407
MIRT516383	hsa-miR-6514-5p	PAR-CLIP	21572407
MIRT516382	hsa-miR-1273f	PAR-CLIP	21572407
MIRT516381	hsa-miR-4534	PAR-CLIP	21572407
MIRT516380	hsa-miR-8082	PAR-CLIP	21572407
MIRT516379	hsa-miR-4653-3p	PAR-CLIP	21572407
MIRT516377	hsa-miR-3152-3p	PAR-CLIP	21572407
MIRT516376	hsa-miR-4662a-5p	PAR-CLIP	21572407
MIRT516374	hsa-miR-5096	PAR-CLIP	21572407
MIRT528704	hsa-miR-5586-3p	PAR-CLIP	22012620
MIRT528703	hsa-miR-6814-5p	PAR-CLIP	22012620
MIRT528702	hsa-miR-6812-3p	PAR-CLIP	22012620
MIRT528701	hsa-miR-150-5p	PAR-CLIP	22012620
MIRT528700	hsa-miR-532-3p	PAR-CLIP	22012620
MIRT528699	hsa-miR-3120-5p	PAR-CLIP	22012620
MIRT528698	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT528697	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT528696	hsa-miR-4713-5p	PAR-CLIP	22012620
MIRT528695	hsa-miR-6888-3p	PAR-CLIP	22012620
MIRT516387	hsa-miR-6858-3p	PAR-CLIP	23446348
MIRT516386	hsa-miR-4676-5p	PAR-CLIP	23446348
MIRT516385	hsa-miR-575	PAR-CLIP	23446348
MIRT516384	hsa-miR-2392	PAR-CLIP	23446348
MIRT516375	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516383	hsa-miR-6514-5p	PAR-CLIP	23446348
MIRT516382	hsa-miR-1273f	PAR-CLIP	23446348
MIRT516381	hsa-miR-4534	PAR-CLIP	23446348
MIRT516380	hsa-miR-8082	PAR-CLIP	23446348
MIRT516379	hsa-miR-4653-3p	PAR-CLIP	23446348
MIRT516378	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516377	hsa-miR-3152-3p	PAR-CLIP	23446348
MIRT516376	hsa-miR-4662a-5p	PAR-CLIP	23446348
MIRT516375	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516374	hsa-miR-5096	PAR-CLIP	23446348
MIRT1450954	hsa-miR-1185	CLIP-seq
MIRT1450955	hsa-miR-133a	CLIP-seq
MIRT1450956	hsa-miR-133b	CLIP-seq
MIRT1450957	hsa-miR-3605-5p	CLIP-seq
MIRT1450958	hsa-miR-3679-5p	CLIP-seq
MIRT1450959	hsa-miR-4328	CLIP-seq
MIRT1450960	hsa-miR-4527	CLIP-seq
MIRT1450961	hsa-miR-4649-3p	CLIP-seq
MIRT1450962	hsa-miR-4731-3p	CLIP-seq
MIRT1450963	hsa-miR-4801	CLIP-seq
MIRT1450964	hsa-miR-1343	CLIP-seq
MIRT1450965	hsa-miR-3074-5p	CLIP-seq
MIRT1450966	hsa-miR-323-3p	CLIP-seq
MIRT1450967	hsa-miR-4488	CLIP-seq
MIRT1450968	hsa-miR-4639-5p	CLIP-seq
MIRT1450969	hsa-miR-4640-5p	CLIP-seq
MIRT1450970	hsa-miR-4697-5p	CLIP-seq
MIRT1450971	hsa-miR-4726-5p	CLIP-seq
MIRT1450972	hsa-miR-637	CLIP-seq
MIRT2134790	hsa-miR-188-5p	CLIP-seq
MIRT2134791	hsa-miR-3064-3p	CLIP-seq
MIRT1450966	hsa-miR-323-3p	CLIP-seq
MIRT1450968	hsa-miR-4639-5p	CLIP-seq
MIRT2134792	hsa-miR-548g	CLIP-seq
MIRT2134793	hsa-miR-642b	CLIP-seq
MIRT1450964	hsa-miR-1343	CLIP-seq
MIRT2649538	hsa-miR-147	CLIP-seq
MIRT2134790	hsa-miR-188-5p	CLIP-seq
MIRT2649539	hsa-miR-2278	CLIP-seq
MIRT2649540	hsa-miR-2467-3p	CLIP-seq
MIRT2134791	hsa-miR-3064-3p	CLIP-seq
MIRT1450965	hsa-miR-3074-5p	CLIP-seq
MIRT2649541	hsa-miR-3123	CLIP-seq
MIRT2649542	hsa-miR-3130-3p	CLIP-seq
MIRT2649543	hsa-miR-3194-3p	CLIP-seq
MIRT1450966	hsa-miR-323-3p	CLIP-seq
MIRT2649544	hsa-miR-330-3p	CLIP-seq
MIRT2649545	hsa-miR-3615	CLIP-seq
MIRT2649546	hsa-miR-3650	CLIP-seq
MIRT2649547	hsa-miR-3659	CLIP-seq
MIRT2649548	hsa-miR-3674	CLIP-seq
MIRT2649549	hsa-miR-3678-3p	CLIP-seq
MIRT2649550	hsa-miR-3689d	CLIP-seq
MIRT2649551	hsa-miR-3911	CLIP-seq
MIRT2649552	hsa-miR-3919	CLIP-seq
MIRT2649553	hsa-miR-3928	CLIP-seq
MIRT2649554	hsa-miR-4271	CLIP-seq
MIRT2649555	hsa-miR-4274	CLIP-seq
MIRT2649556	hsa-miR-4433	CLIP-seq
MIRT2649557	hsa-miR-4436b-5p	CLIP-seq
MIRT2649558	hsa-miR-4455	CLIP-seq
MIRT2649559	hsa-miR-4459	CLIP-seq
MIRT1450967	hsa-miR-4488	CLIP-seq
MIRT2649560	hsa-miR-4512	CLIP-seq
MIRT1450968	hsa-miR-4639-5p	CLIP-seq
MIRT1450969	hsa-miR-4640-5p	CLIP-seq
MIRT2649561	hsa-miR-4693-3p	CLIP-seq
MIRT1450970	hsa-miR-4697-5p	CLIP-seq
MIRT2649562	hsa-miR-4725-3p	CLIP-seq
MIRT1450971	hsa-miR-4726-5p	CLIP-seq
MIRT2649563	hsa-miR-4757-5p	CLIP-seq
MIRT2649564	hsa-miR-4768-3p	CLIP-seq
MIRT2649565	hsa-miR-4793-3p	CLIP-seq
MIRT2649566	hsa-miR-542-5p	CLIP-seq
MIRT2649567	hsa-miR-548aa	CLIP-seq
MIRT2649568	hsa-miR-548ac	CLIP-seq
MIRT2649569	hsa-miR-548d-3p	CLIP-seq
MIRT2134792	hsa-miR-548g	CLIP-seq
MIRT2649570	hsa-miR-548z	CLIP-seq
MIRT2649571	hsa-miR-587	CLIP-seq
MIRT1450972	hsa-miR-637	CLIP-seq
MIRT2134793	hsa-miR-642b	CLIP-seq
MIRT2649572	hsa-miR-644	CLIP-seq
MIRT2649573	hsa-miR-665	CLIP-seq
MIRT2649557	hsa-miR-4436b-5p	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001783	Process	B cell apoptotic process	IEA
GO:0002230	Process	Positive regulation of defense response to virus by host	IDA	23066157
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	12459498, 21516116, 24120361, 25416956
GO:0005575	Component	Cellular_component	ND
GO:0006954	Process	Inflammatory response	IEA
GO:0006959	Process	Humoral immune response	IBA	21873635
GO:0035556	Process	Intracellular signal transduction	NAS	10962033
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IBA	21873635
GO:0043123	Process	Positive regulation of I-kappaB kinase/NF-kappaB signaling	IEP	12761501
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	19825828
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	19825828
GO:0097400	Process	Interleukin-17-mediated signaling pathway	IMP	19825828, 24120361

MIM	HGNC	e!Ensembl
607043	1343	ENSG00000056972

Protein

UniProt ID

O43734

Protein name

E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)

Protein function

E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substra

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08357	SEFIR	410 → 552	SEFIR domain	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed.

Sequence

MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPT
MLHNSSGDFSQAHSTLKLANHQRPVSRQVTCLRTQVLEDSEDSFCRRHPGLGKAFPSGCS
AVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPL
RSREFPQFEPQRYPACAQMLPPNLSPHAPWNYHYHCPGSPDHQVPYGHDYPRAAYQQVIQ
PALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDT
AMEVVKFVNFLLVNGFQTAIDIFEDRIRGIDIIKWMERYLRDKTVMIIVAISPKYKQDVE
GAESQLDEDEHGLHTKYIHRMMQIEFIKQGSMNFRFIPVLFPNAKKEHVPTWLQNTHVYS
WPKNKKNILLRLLREEEYVAPPRGPLPTLQVVPL

Sequence length

574

Interactions

View interactions

	KEGG
	Cellular senescence IL-17 signaling pathway

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Inflammatory bowel disease	Inflammatory Bowel Diseases	rs137853579, rs137853580, rs121909601, rs149491038, rs368287711, rs387907326, rs587777338, rs758439420, rs1329427406, rs1264862631, rs1192830343, rs1373354533, rs1419560997, rs1591263883, rs1989014468	26192919
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	20953186, 20953188, 20953190, 23143594, 25903422

Show/Hide Unknown Diseases (8)

Disease term	Disease name	Source
Unknown
Schizophrenia	Schizophrenia	GWAS
Inflammatory Bowel Disease	Inflammatory Bowel Disease	GWAS
Metabolic Syndrome	Metabolic Syndrome	GWAS
Ulcerative colitis	Ulcerative colitis	GWAS
Psoriasis vulgaris	Psoriasis vulgaris	GWAS
Crohn Disease	Crohn Disease	GWAS
Coronary artery disease	Coronary artery disease	GWAS
Diabetes	Diabetes	GWAS

Show/Hide Text Mining Associations (41)

Disease Name	Relationship Type	References
Associations from Text Mining
Alopecia	Associate	29091937
Arthritis Psoriatic	Associate	20953186, 20953188, 22298274, 22513239, 25775161
Arthritis Rheumatoid	Associate	21749686, 23862741, 25014791, 28107378
Atherosclerosis	Associate	24561578
Autoimmune Diseases	Associate	24416204, 30528823
Behcet Syndrome	Associate	24416204
Breast Neoplasms	Associate	25881004
Candidiasis	Associate	33359359
Candidiasis Chronic Mucocutaneous	Associate	24120361, 33825088
Carcinoid Tumor	Associate	24892823
Carcinoma Hepatocellular	Associate	36344648
Carcinoma Renal Cell	Associate	33741027
Cocaine Related Disorders	Associate	26222413
Common Variable Immunodeficiency	Associate	20652909
Crohn Disease	Associate	26558270, 26937622
Cytokine Release Syndrome	Associate	39281206
Death	Associate	24561578
Dermatitis Atopic	Associate	33825088
Diabetes Mellitus Type 1	Associate	22344559
Heart Defects Congenital	Associate	39281206
Hyper IgM Immunodeficiency Syndrome	Associate	20652909
Hyperglycemia	Associate	31862399
Immunologic Deficiency Syndromes	Associate	20652909, 33359359, 33825088
Inflammation	Associate	37303492
Inflammatory Bowel Diseases	Associate	26937622
Interleukin 2 Receptor Alpha Deficiency of	Associate	24120361
Lupus Erythematosus Systemic	Associate	21886837, 38360126
Nasal Polyps	Associate	24892823
Neoplasm Metastasis	Associate	37303492
Osteoporotic Fractures	Stimulate	32602654
Parotitis Juvenile Recurrent	Associate	33825088
Paroxysmal ventricular fibrillation	Stimulate	32602654
Periodic fever familial autosomal dominant	Associate	30528823
Psoriasis	Associate	20953186, 20953188, 22298274, 22513239, 24120361, 25024377, 25775161, 30528823
Renal Artery Obstruction	Associate	23541442
Sjogren's Syndrome	Associate	30882006
Stevens Johnson Syndrome	Associate	25775161
Substance Related Disorders	Associate	26222413
Synovitis	Associate	31074012
Uveomeningoencephalitic Syndrome	Associate	24416204
Vascular Diseases	Associate	23541442, 24561578, 31074012

TRAF3IP2 (TRAF3 interacting protein 2)