Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10758
Gene name	TRAF3 interacting protein 2
Gene symbol	TRAF3IP2
Synonyms (NCBI Gene)	ACT1C6orf2C6orf4C6orf5C6orf6CANDF8CIKSPSORS13
Chromosome	6
Chromosome location	6q21
Summary	This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gen

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miRTarBase ID	miRNA	Experiments	Reference
MIRT027633	hsa-miR-98-5p	Microarray	19088304
MIRT698080	hsa-miR-6872-3p	HITS-CLIP	23313552
MIRT698079	hsa-miR-8064	HITS-CLIP	23313552
MIRT686546	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT686545	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT686544	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT686543	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT686542	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT686541	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT686540	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT686539	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT686538	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT686537	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT686536	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT686535	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT686534	hsa-miR-302e	HITS-CLIP	23313552
MIRT686533	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT686532	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT686531	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT686530	hsa-miR-520b	HITS-CLIP	23313552
MIRT686529	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT686528	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT686527	hsa-miR-520e	HITS-CLIP	23313552
MIRT686526	hsa-miR-4438	HITS-CLIP	23313552
MIRT686525	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT686524	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT686523	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT686522	hsa-miR-520h	HITS-CLIP	23313552
MIRT686521	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT686520	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT686519	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT686518	hsa-miR-1253	HITS-CLIP	23313552
MIRT686517	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT686516	hsa-miR-3145-3p	HITS-CLIP	23313552
MIRT686515	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT686514	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT686513	hsa-miR-5095	HITS-CLIP	23313552
MIRT686512	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT686511	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT631573	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT631572	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT631571	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT631570	hsa-miR-4284	HITS-CLIP	23824327
MIRT631569	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT631568	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT631567	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT631566	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT631565	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT631564	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT631563	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT631562	hsa-miR-7977	HITS-CLIP	23824327
MIRT631561	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT631560	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT631559	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT631558	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT631557	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT631556	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT631555	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT631554	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT631553	hsa-miR-3689c	HITS-CLIP	23824327
MIRT631552	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT631551	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT631550	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT631549	hsa-miR-3122	HITS-CLIP	23824327
MIRT631548	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT631547	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT631546	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT631545	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT528704	hsa-miR-5586-3p	PAR-CLIP	20371350
MIRT528703	hsa-miR-6814-5p	PAR-CLIP	20371350
MIRT528702	hsa-miR-6812-3p	PAR-CLIP	20371350
MIRT528701	hsa-miR-150-5p	PAR-CLIP	20371350
MIRT528700	hsa-miR-532-3p	PAR-CLIP	20371350
MIRT569417	hsa-miR-2116-3p	PAR-CLIP	20371350
MIRT528699	hsa-miR-3120-5p	PAR-CLIP	20371350
MIRT528696	hsa-miR-4713-5p	PAR-CLIP	20371350
MIRT528695	hsa-miR-6888-3p	PAR-CLIP	20371350
MIRT516387	hsa-miR-6858-3p	PAR-CLIP	21572407
MIRT516386	hsa-miR-4676-5p	PAR-CLIP	21572407
MIRT516385	hsa-miR-575	PAR-CLIP	21572407
MIRT516383	hsa-miR-6514-5p	PAR-CLIP	21572407
MIRT516382	hsa-miR-1273f	PAR-CLIP	21572407
MIRT516381	hsa-miR-4534	PAR-CLIP	21572407
MIRT516380	hsa-miR-8082	PAR-CLIP	21572407
MIRT516379	hsa-miR-4653-3p	PAR-CLIP	21572407
MIRT516377	hsa-miR-3152-3p	PAR-CLIP	21572407
MIRT516376	hsa-miR-4662a-5p	PAR-CLIP	21572407
MIRT516374	hsa-miR-5096	PAR-CLIP	21572407
MIRT528704	hsa-miR-5586-3p	PAR-CLIP	22012620
MIRT528703	hsa-miR-6814-5p	PAR-CLIP	22012620
MIRT528702	hsa-miR-6812-3p	PAR-CLIP	22012620
MIRT528701	hsa-miR-150-5p	PAR-CLIP	22012620
MIRT528700	hsa-miR-532-3p	PAR-CLIP	22012620
MIRT528699	hsa-miR-3120-5p	PAR-CLIP	22012620
MIRT528698	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT528697	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT528696	hsa-miR-4713-5p	PAR-CLIP	22012620
MIRT528695	hsa-miR-6888-3p	PAR-CLIP	22012620
MIRT516387	hsa-miR-6858-3p	PAR-CLIP	23446348
MIRT516386	hsa-miR-4676-5p	PAR-CLIP	23446348
MIRT516385	hsa-miR-575	PAR-CLIP	23446348
MIRT516384	hsa-miR-2392	PAR-CLIP	23446348
MIRT516375	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516383	hsa-miR-6514-5p	PAR-CLIP	23446348
MIRT516382	hsa-miR-1273f	PAR-CLIP	23446348
MIRT516381	hsa-miR-4534	PAR-CLIP	23446348
MIRT516380	hsa-miR-8082	PAR-CLIP	23446348
MIRT516379	hsa-miR-4653-3p	PAR-CLIP	23446348
MIRT516378	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516377	hsa-miR-3152-3p	PAR-CLIP	23446348
MIRT516376	hsa-miR-4662a-5p	PAR-CLIP	23446348
MIRT516375	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516374	hsa-miR-5096	PAR-CLIP	23446348
MIRT698080	hsa-miR-6872-3p	HITS-CLIP	23313552
MIRT698079	hsa-miR-8064	HITS-CLIP	23313552
MIRT686546	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT686545	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT686544	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT686543	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT686542	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT686541	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT686540	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT686539	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT686538	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT686537	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT686536	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT686535	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT686534	hsa-miR-302e	HITS-CLIP	23313552
MIRT686533	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT686532	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT686531	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT686530	hsa-miR-520b	HITS-CLIP	23313552
MIRT686529	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT686528	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT686527	hsa-miR-520e	HITS-CLIP	23313552
MIRT686526	hsa-miR-4438	HITS-CLIP	23313552
MIRT686525	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT686524	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT686523	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT686522	hsa-miR-520h	HITS-CLIP	23313552
MIRT686521	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT686520	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT686519	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT686518	hsa-miR-1253	HITS-CLIP	23313552
MIRT686517	hsa-miR-6770-5p	HITS-CLIP	23313552
MIRT686516	hsa-miR-3145-3p	HITS-CLIP	23313552
MIRT686515	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT686514	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT686513	hsa-miR-5095	HITS-CLIP	23313552
MIRT686512	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT686511	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT631573	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT631572	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT631571	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT631570	hsa-miR-4284	HITS-CLIP	23824327
MIRT631569	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT631568	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT631567	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT631566	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT631565	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT631564	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT631563	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT631562	hsa-miR-7977	HITS-CLIP	23824327
MIRT631561	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT631560	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT631559	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT631558	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT631557	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT631556	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT631555	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT631554	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT631553	hsa-miR-3689c	HITS-CLIP	23824327
MIRT631552	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT631551	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT631550	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT631549	hsa-miR-3122	HITS-CLIP	23824327
MIRT631548	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT631547	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT631546	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT631545	hsa-miR-6821-5p	HITS-CLIP	23824327
MIRT528704	hsa-miR-5586-3p	PAR-CLIP	20371350
MIRT528703	hsa-miR-6814-5p	PAR-CLIP	20371350
MIRT528702	hsa-miR-6812-3p	PAR-CLIP	20371350
MIRT528701	hsa-miR-150-5p	PAR-CLIP	20371350
MIRT528700	hsa-miR-532-3p	PAR-CLIP	20371350
MIRT569417	hsa-miR-2116-3p	PAR-CLIP	20371350
MIRT528699	hsa-miR-3120-5p	PAR-CLIP	20371350
MIRT528696	hsa-miR-4713-5p	PAR-CLIP	20371350
MIRT528695	hsa-miR-6888-3p	PAR-CLIP	20371350
MIRT516387	hsa-miR-6858-3p	PAR-CLIP	21572407
MIRT516386	hsa-miR-4676-5p	PAR-CLIP	21572407
MIRT516385	hsa-miR-575	PAR-CLIP	21572407
MIRT516383	hsa-miR-6514-5p	PAR-CLIP	21572407
MIRT516382	hsa-miR-1273f	PAR-CLIP	21572407
MIRT516381	hsa-miR-4534	PAR-CLIP	21572407
MIRT516380	hsa-miR-8082	PAR-CLIP	21572407
MIRT516379	hsa-miR-4653-3p	PAR-CLIP	21572407
MIRT516377	hsa-miR-3152-3p	PAR-CLIP	21572407
MIRT516376	hsa-miR-4662a-5p	PAR-CLIP	21572407
MIRT516374	hsa-miR-5096	PAR-CLIP	21572407
MIRT528704	hsa-miR-5586-3p	PAR-CLIP	22012620
MIRT528703	hsa-miR-6814-5p	PAR-CLIP	22012620
MIRT528702	hsa-miR-6812-3p	PAR-CLIP	22012620
MIRT528701	hsa-miR-150-5p	PAR-CLIP	22012620
MIRT528700	hsa-miR-532-3p	PAR-CLIP	22012620
MIRT528699	hsa-miR-3120-5p	PAR-CLIP	22012620
MIRT528698	hsa-miR-6499-3p	PAR-CLIP	22012620
MIRT528697	hsa-miR-143-5p	PAR-CLIP	22012620
MIRT528696	hsa-miR-4713-5p	PAR-CLIP	22012620
MIRT528695	hsa-miR-6888-3p	PAR-CLIP	22012620
MIRT516387	hsa-miR-6858-3p	PAR-CLIP	23446348
MIRT516386	hsa-miR-4676-5p	PAR-CLIP	23446348
MIRT516385	hsa-miR-575	PAR-CLIP	23446348
MIRT516384	hsa-miR-2392	PAR-CLIP	23446348
MIRT516375	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516383	hsa-miR-6514-5p	PAR-CLIP	23446348
MIRT516382	hsa-miR-1273f	PAR-CLIP	23446348
MIRT516381	hsa-miR-4534	PAR-CLIP	23446348
MIRT516380	hsa-miR-8082	PAR-CLIP	23446348
MIRT516379	hsa-miR-4653-3p	PAR-CLIP	23446348
MIRT516378	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT516377	hsa-miR-3152-3p	PAR-CLIP	23446348
MIRT516376	hsa-miR-4662a-5p	PAR-CLIP	23446348
MIRT516375	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT516374	hsa-miR-5096	PAR-CLIP	23446348
MIRT1450954	hsa-miR-1185	CLIP-seq
MIRT1450955	hsa-miR-133a	CLIP-seq
MIRT1450956	hsa-miR-133b	CLIP-seq
MIRT1450957	hsa-miR-3605-5p	CLIP-seq
MIRT1450958	hsa-miR-3679-5p	CLIP-seq
MIRT1450959	hsa-miR-4328	CLIP-seq
MIRT1450960	hsa-miR-4527	CLIP-seq
MIRT1450961	hsa-miR-4649-3p	CLIP-seq
MIRT1450962	hsa-miR-4731-3p	CLIP-seq
MIRT1450963	hsa-miR-4801	CLIP-seq
MIRT1450964	hsa-miR-1343	CLIP-seq
MIRT1450965	hsa-miR-3074-5p	CLIP-seq
MIRT1450966	hsa-miR-323-3p	CLIP-seq
MIRT1450967	hsa-miR-4488	CLIP-seq
MIRT1450968	hsa-miR-4639-5p	CLIP-seq
MIRT1450969	hsa-miR-4640-5p	CLIP-seq
MIRT1450970	hsa-miR-4697-5p	CLIP-seq
MIRT1450971	hsa-miR-4726-5p	CLIP-seq
MIRT1450972	hsa-miR-637	CLIP-seq
MIRT2134790	hsa-miR-188-5p	CLIP-seq
MIRT2134791	hsa-miR-3064-3p	CLIP-seq
MIRT1450966	hsa-miR-323-3p	CLIP-seq
MIRT1450968	hsa-miR-4639-5p	CLIP-seq
MIRT2134792	hsa-miR-548g	CLIP-seq
MIRT2134793	hsa-miR-642b	CLIP-seq
MIRT1450964	hsa-miR-1343	CLIP-seq
MIRT2649538	hsa-miR-147	CLIP-seq
MIRT2134790	hsa-miR-188-5p	CLIP-seq
MIRT2649539	hsa-miR-2278	CLIP-seq
MIRT2649540	hsa-miR-2467-3p	CLIP-seq
MIRT2134791	hsa-miR-3064-3p	CLIP-seq
MIRT1450965	hsa-miR-3074-5p	CLIP-seq
MIRT2649541	hsa-miR-3123	CLIP-seq
MIRT2649542	hsa-miR-3130-3p	CLIP-seq
MIRT2649543	hsa-miR-3194-3p	CLIP-seq
MIRT1450966	hsa-miR-323-3p	CLIP-seq
MIRT2649544	hsa-miR-330-3p	CLIP-seq
MIRT2649545	hsa-miR-3615	CLIP-seq
MIRT2649546	hsa-miR-3650	CLIP-seq
MIRT2649547	hsa-miR-3659	CLIP-seq
MIRT2649548	hsa-miR-3674	CLIP-seq
MIRT2649549	hsa-miR-3678-3p	CLIP-seq
MIRT2649550	hsa-miR-3689d	CLIP-seq
MIRT2649551	hsa-miR-3911	CLIP-seq
MIRT2649552	hsa-miR-3919	CLIP-seq
MIRT2649553	hsa-miR-3928	CLIP-seq
MIRT2649554	hsa-miR-4271	CLIP-seq
MIRT2649555	hsa-miR-4274	CLIP-seq
MIRT2649556	hsa-miR-4433	CLIP-seq
MIRT2649557	hsa-miR-4436b-5p	CLIP-seq
MIRT2649558	hsa-miR-4455	CLIP-seq
MIRT2649559	hsa-miR-4459	CLIP-seq
MIRT1450967	hsa-miR-4488	CLIP-seq
MIRT2649560	hsa-miR-4512	CLIP-seq
MIRT1450968	hsa-miR-4639-5p	CLIP-seq
MIRT1450969	hsa-miR-4640-5p	CLIP-seq
MIRT2649561	hsa-miR-4693-3p	CLIP-seq
MIRT1450970	hsa-miR-4697-5p	CLIP-seq
MIRT2649562	hsa-miR-4725-3p	CLIP-seq
MIRT1450971	hsa-miR-4726-5p	CLIP-seq
MIRT2649563	hsa-miR-4757-5p	CLIP-seq
MIRT2649564	hsa-miR-4768-3p	CLIP-seq
MIRT2649565	hsa-miR-4793-3p	CLIP-seq
MIRT2649566	hsa-miR-542-5p	CLIP-seq
MIRT2649567	hsa-miR-548aa	CLIP-seq
MIRT2649568	hsa-miR-548ac	CLIP-seq
MIRT2649569	hsa-miR-548d-3p	CLIP-seq
MIRT2134792	hsa-miR-548g	CLIP-seq
MIRT2649570	hsa-miR-548z	CLIP-seq
MIRT2649571	hsa-miR-587	CLIP-seq
MIRT1450972	hsa-miR-637	CLIP-seq
MIRT2134793	hsa-miR-642b	CLIP-seq
MIRT2649572	hsa-miR-644	CLIP-seq
MIRT2649573	hsa-miR-665	CLIP-seq
MIRT2649557	hsa-miR-4436b-5p	CLIP-seq

Show/Hide all (61)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IEA
GO:0001768	Process	Establishment of T cell polarity	IEA
GO:0001782	Process	B cell homeostasis	IEA
GO:0001783	Process	B cell apoptotic process	IEA
GO:0001822	Process	Kidney development	IEA
GO:0002230	Process	Positive regulation of defense response to virus by host	IDA	23066157
GO:0002269	Process	Leukocyte activation involved in inflammatory response	IEA
GO:0002334	Process	Transitional two stage B cell differentiation	IEA
GO:0002344	Process	B cell affinity maturation	IEA
GO:0002447	Process	Eosinophil mediated immunity	IEA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	12459498, 21516116, 24120361, 25416956
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IC	20554964
GO:0005737	Component	Cytoplasm	IEA
GO:0006606	Process	Protein import into nucleus	IEA
GO:0006954	Process	Inflammatory response	IDA	17277779
GO:0006954	Process	Inflammatory response	IEA
GO:0006955	Process	Immune response	IEA
GO:0006959	Process	Humoral immune response	IBA
GO:0006959	Process	Humoral immune response	IEA
GO:0007507	Process	Heart development	IEA
GO:0009410	Process	Response to xenobiotic stimulus	IEA
GO:0010467	Process	Gene expression	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0019724	Process	B cell mediated immunity	IEA
GO:0023019	Process	Signal transduction involved in regulation of gene expression	IEA
GO:0023035	Process	CD40 signaling pathway	IEA
GO:0030217	Process	T cell differentiation	IEA
GO:0031234	Component	Extrinsic component of cytoplasmic side of plasma membrane	IC	20554964
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0033209	Process	Tumor necrosis factor-mediated signaling pathway	IEA
GO:0034097	Process	Response to cytokine	IEA
GO:0034504	Process	Protein localization to nucleus	IEA
GO:0035556	Process	Intracellular signal transduction	NAS	10962033
GO:0038173	Process	Interleukin-17A-mediated signaling pathway	IDA	31376257, 35183823
GO:0038173	Process	Interleukin-17A-mediated signaling pathway	IDA	17277779, 19825828
GO:0038173	Process	Interleukin-17A-mediated signaling pathway	IEA
GO:0042092	Process	Type 2 immune response	IEA
GO:0042110	Process	T cell activation	IEA
GO:0042119	Process	Neutrophil activation	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEP	12761501
GO:0043588	Process	Skin development	IEA
GO:0048255	Process	MRNA stabilization	IEA
GO:0048535	Process	Lymph node development	IEA
GO:0048536	Process	Spleen development	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	19825828
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070254	Process	Mucus secretion	IEA
GO:0070534	Process	Protein K63-linked ubiquitination	IDA	19825828
GO:0071345	Process	Cellular response to cytokine stimulus	IEA
GO:0072538	Process	T-helper 17 type immune response	IEA
GO:0097398	Process	Cellular response to interleukin-17	IEA
GO:0097400	Process	Interleukin-17-mediated signaling pathway	IEA
GO:0097400	Process	Interleukin-17-mediated signaling pathway	IMP	19825828, 24120361
GO:0110012	Process	Protein localization to P-body	IEA
GO:1903882	Process	Negative regulation of interleukin-17-mediated signaling pathway	IDA	23042150
GO:1990959	Process	Eosinophil homeostasis	IEA

MIM	HGNC	e!Ensembl
607043	1343	ENSG00000056972

O43734

Protein name

E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)

Protein function

E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substra

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08357	SEFIR	410 → 552	SEFIR domain	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed.

Sequence

MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPT
MLHNSSGDFSQAHSTLKLANHQRPVSRQVTCLRTQVLEDSEDSFCRRHPGLGKAFPSGCS
AVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSL
GGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPL
RSREFPQFEPQRYPACAQMLPPNLSPHAPWNYHYHCPGSPDHQVPYGHDYPRAAYQQVIQ
PALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNR
AGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDT
AMEVVKFVNFLLVNGFQTAIDIFEDRIRGIDIIKWMERYLRDKTVMIIVAISPKYKQDVE
GAESQLDEDEHGLHTKYIHRMMQIEFIKQGSMNFRFIPVLFPNAKKEHVPTWLQNTHVYS
WPKNKKNILLRLLREEEYVAPPRGPLPTLQVVPL

Sequence length

574

Interactions

View interactions

	KEGG
	Cellular senescence IL-17 signaling pathway

253

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Candidiasis, familial, 8	Pathogenic; Likely pathogenic	rs1796107143, rs2128374357, rs1795637153, rs375800644, rs557983485, rs1304629512, rs1394840448, rs2536181585, rs1321899075, rs2536179287, rs1583225922, rs397518485	RCV001339332 RCV001362447 RCV003086545 RCV002610544 RCV003106690 RCV002889351 RCV002967903 RCV003002461 RCV003745755 RCV003745146 RCV000814831 RCV000074416
Discoid lupus erythematosus	Pathogenic	rs1583223171	RCV001002673
Melanoma	Likely pathogenic	rs375800644	RCV005930531

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Adrenocortical carcinoma, hereditary	Benign	rs33980500	RCV005888652
Cholangiocarcinoma	Benign	rs33980500	RCV005888656
Clear cell carcinoma of kidney	Benign	rs566584632	RCV005870967
Colorectal cancer	Benign	rs33980500	RCV005888654
Familial cancer of breast	Benign	rs566584632	RCV005870966
Psoriasis 13, susceptibility to	Uncertain significance; Benign; Likely benign; Conflicting classifications of pathogenicity	rs200074354, rs375324881, rs2536087765, rs33980500, rs61756667, rs144405088	RCV002210904 RCV005034359 RCV003988792 RCV000023605 RCV003224369 RCV002061038
Thymoma	Benign	rs566584632	RCV005870968
TRAF3IP2-related disorder	Likely benign; Benign; Conflicting classifications of pathogenicity	rs370730037, rs139767840, rs146226365, rs200703649, rs73764462, rs765112469	RCV003946129 RCV003937974 RCV003928119 RCV003903182 RCV003957997 RCV003895712
Uterine carcinosarcoma	Benign	rs33980500	RCV005888655
Uterine corpus endometrial carcinoma	Likely benign; Benign	rs755863841, rs566584632	RCV005936595 RCV005870969
Uveal melanoma	Benign	rs33980500	RCV005888653

Show/Hide Text Mining Associations (41)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Alopecia	Associate	29091937
Arthritis Psoriatic	Associate	20953186, 20953188, 22298274, 22513239, 25775161
Arthritis Rheumatoid	Associate	21749686, 23862741, 25014791, 28107378
Atherosclerosis	Associate	24561578
Autoimmune Diseases	Associate	24416204, 30528823
Behcet Syndrome	Associate	24416204
Breast Neoplasms	Associate	25881004
Candidiasis	Associate	33359359
Candidiasis Chronic Mucocutaneous	Associate	24120361, 33825088
Carcinoid Tumor	Associate	24892823
Carcinoma Hepatocellular	Associate	36344648
Carcinoma Renal Cell	Associate	33741027
Cocaine Related Disorders	Associate	26222413
Common Variable Immunodeficiency	Associate	20652909
Crohn Disease	Associate	26558270, 26937622
Cytokine Release Syndrome	Associate	39281206
Death	Associate	24561578
Dermatitis Atopic	Associate	33825088
Diabetes Mellitus Type 1	Associate	22344559
Heart Defects Congenital	Associate	39281206
Hyper IgM Immunodeficiency Syndrome	Associate	20652909
Hyperglycemia	Associate	31862399
Immunologic Deficiency Syndromes	Associate	20652909, 33359359, 33825088
Inflammation	Associate	37303492
Inflammatory Bowel Diseases	Associate	26937622
Interleukin 2 Receptor Alpha Deficiency of	Associate	24120361
Lupus Erythematosus Systemic	Associate	21886837, 38360126
Nasal Polyps	Associate	24892823
Neoplasm Metastasis	Associate	37303492
Osteoporotic Fractures	Stimulate	32602654
Parotitis Juvenile Recurrent	Associate	33825088
Paroxysmal ventricular fibrillation	Stimulate	32602654
Periodic fever familial autosomal dominant	Associate	30528823
Psoriasis	Associate	20953186, 20953188, 22298274, 22513239, 24120361, 25024377, 25775161, 30528823
Renal Artery Obstruction	Associate	23541442
Sjogren's Syndrome	Associate	30882006
Stevens Johnson Syndrome	Associate	25775161
Substance Related Disorders	Associate	26222413
Synovitis	Associate	31074012
Uveomeningoencephalitic Syndrome	Associate	24416204
Vascular Diseases	Associate	23541442, 24561578, 31074012

TRAF3IP2 (TRAF3 interacting protein 2)