PHTF1 (putative homeodomain transcription factor 1)

Gene

• Entrez ID: 10745
• Gene name: Putative homeodomain transcription factor 1
• Gene symbol: PHTF1
• Synonyms (NCBI Gene): PHTF
• Chromosome: 1
• Chromosome location: 1p13.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024866	hsa-miR-215-5p	Microarray	19074876
MIRT026618	hsa-miR-192-5p	Microarray	19074876
MIRT030876	hsa-miR-21-5p	Microarray	18591254
MIRT050325	hsa-miR-25-3p	CLASH	23622248
MIRT042377	hsa-miR-484	CLASH	23622248
MIRT040056	hsa-miR-615-3p	CLASH	23622248
MIRT1232449	hsa-miR-101	CLIP-seq
MIRT1232450	hsa-miR-1278	CLIP-seq
MIRT1232451	hsa-miR-128	CLIP-seq
MIRT1232452	hsa-miR-27a	CLIP-seq
MIRT1232453	hsa-miR-27b	CLIP-seq
MIRT1232454	hsa-miR-3123	CLIP-seq
MIRT1232455	hsa-miR-3646	CLIP-seq
MIRT1232456	hsa-miR-3925-5p	CLIP-seq
MIRT1232457	hsa-miR-3976	CLIP-seq
MIRT1232458	hsa-miR-4724-5p	CLIP-seq
MIRT1232459	hsa-miR-4753-3p	CLIP-seq
MIRT1232460	hsa-miR-539	CLIP-seq
MIRT1232449	hsa-miR-101	CLIP-seq
MIRT2593168	hsa-miR-1207-3p	CLIP-seq
MIRT1232450	hsa-miR-1278	CLIP-seq
MIRT1232451	hsa-miR-128	CLIP-seq
MIRT2593169	hsa-miR-140-3p	CLIP-seq
MIRT1232452	hsa-miR-27a	CLIP-seq
MIRT1232453	hsa-miR-27b	CLIP-seq
MIRT2593170	hsa-miR-3152-3p	CLIP-seq
MIRT2593171	hsa-miR-3647-3p	CLIP-seq
MIRT2593172	hsa-miR-4422	CLIP-seq
MIRT1232458	hsa-miR-4724-5p	CLIP-seq
MIRT2593173	hsa-miR-511	CLIP-seq
MIRT2593174	hsa-miR-520d-5p	CLIP-seq
MIRT2593175	hsa-miR-524-5p	CLIP-seq
MIRT2593176	hsa-miR-552	CLIP-seq
MIRT2593177	hsa-miR-599	CLIP-seq
MIRT2593178	hsa-miR-664	CLIP-seq
MIRT1232449	hsa-miR-101	CLIP-seq
MIRT2593168	hsa-miR-1207-3p	CLIP-seq
MIRT1232450	hsa-miR-1278	CLIP-seq
MIRT1232451	hsa-miR-128	CLIP-seq
MIRT2593169	hsa-miR-140-3p	CLIP-seq
MIRT1232452	hsa-miR-27a	CLIP-seq
MIRT1232453	hsa-miR-27b	CLIP-seq
MIRT2593170	hsa-miR-3152-3p	CLIP-seq
MIRT2593171	hsa-miR-3647-3p	CLIP-seq
MIRT2593172	hsa-miR-4422	CLIP-seq
MIRT1232458	hsa-miR-4724-5p	CLIP-seq
MIRT2593173	hsa-miR-511	CLIP-seq
MIRT2593174	hsa-miR-520d-5p	CLIP-seq
MIRT2593175	hsa-miR-524-5p	CLIP-seq
MIRT2593176	hsa-miR-552	CLIP-seq
MIRT2593177	hsa-miR-599	CLIP-seq
MIRT2593178	hsa-miR-664	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005801	Component	Cis-Golgi network	IEA
GO:0016021	Component	Integral component of membrane	IEA

Other IDs

• MIM: 604950
• HGNC: 8939
• e!Ensembl: ENSG00000116793

Protein

• UniProt ID: Q9UMS5
• Protein name: Protein PHTF1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12129	Phtf-FEM1B_bdg	5 → 151	Male germ-cell putative homeodomain transcription factor	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed with highest levels in testis. {ECO:0000269|PubMed:10729229}.
• Sequence:

  MASNERDAISWYQKKIGAYDQQIWEKSIEQTQIKGLKNKPKKMGHIKPDLIDVDLIRGST
  FAKAKPEIPWTSLTRKGLVRVVFFPLFSNWWIQVTSLRIFVWLLLLYFMQVIAIVLYLMM
  PIVNISEVLGPLCLMLLMGTVHCQIVSTQITRPSGNNGNRRRRKLRKTVNGDGSRENGNN
  SSDKVRGIETLESVPIIGGFWETIFGNRIKRVKLISNKGTETDNDPSCVHPIIKRRQCRP
  EIRMWQTREKAKFSDGEKCRREAFRRLGNGVSDDLSSEEDGEARTQMILLRRSVEGASSD
  NGCEVKNRKSILSRHLNSQVKKTTTRWCHIVRDSDSLAESEFESAAFSQGSRSGVSGGSR
  SLNMSRRDSESTRHDSETEDMLWDDLLHGPECRSSVTSDSEGAHVNTLHSGTKRDPKEDV
  FQQNHLFWLQNSSPSSDRVSAIIWEGNECKKMDMSVLEISGIIMSRVNAYQQGVGYQMLG
  NVVTIGLAFFPFLHRLFREKSLDQLKSISAEEILTLFCGAPPVTPIIVLSIINFFERLCL
  TWMFFFMMCVAERTYKQRFLFAKLFSHITSARKARKYEIPHFRLKKVENIKIWLSLRSYL
  KRRGPQRSVDVVVSSVFLLTLSIAFICCAQVLQGHKTFLNDAYNWEFLIWETALLLFLLR
  LASLGSETNKKYSNVSILLTEQINLYLKMEKKPNKKEQLTLVNNVLKLSTKLLKELDTPF
  RLYGLTMNPLIYNITRVVILSAVSGVISDLLGFNIRLWKIKS

• Sequence length: 762

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	19503088

Unknown
Disease term	Disease name	Evidence	References	Source
Hypothyroidism	Hypothyroidism			GWAS
Crohn Disease	Crohn Disease			GWAS
Giant Cell Arteritis	Giant Cell Arteritis			GWAS
Systemic lupus erythematosus	Systemic lupus erythematosus			GWAS
Hyperthyroidism	Hyperthyroidism			GWAS
Carcinoma	Carcinoma			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Anemia Pernicious	Associate	34145262
Arthritis Juvenile	Associate	20722033
Arthritis Rheumatoid	Associate	27898717, 33740106
Autoimmune Diseases	Associate	22493691
Breast Neoplasms	Associate	26472073
Cardiomyopathies	Associate	33288658
Crohn Disease	Associate	20722033
Diabetes Mellitus Type 1	Associate	20089178, 34521982
Hypothyroidism	Associate	22493691
Multiple Sclerosis	Associate	20722033
Muscular Dystrophy Duchenne	Associate	33740106
Tuberculosis Meningeal	Associate	33740106