Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10734
Gene name Gene Name - the full gene name approved by the HGNC.	STAG3 cohesin complex component
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	STAG3
Synonyms (NCBI Gene) Gene synonyms aliases	SA3, SPGF61
Disease Acronyms (UniProt) Disease acronyms from UniProt database	SPGF61
Chromosome Chromosome number	7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	7q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate sp

Show/Hide all(1)

SNP ID	Visualize variation	Clinical significance	Consequence
rs1296715259	A>C,G,T	Likely-pathogenic	Splice acceptor variant, intron variant

Show/Hide all(58)

miRTarBase ID	miRNA	Experiments
MIRT1394520	hsa-let-7a	CLIP-seq
MIRT1394521	hsa-let-7b	CLIP-seq
MIRT1394522	hsa-let-7c	CLIP-seq
MIRT1394523	hsa-let-7d	CLIP-seq
MIRT1394524	hsa-let-7e	CLIP-seq
MIRT1394525	hsa-let-7f	CLIP-seq
MIRT1394526	hsa-let-7g	CLIP-seq
MIRT1394527	hsa-let-7i	CLIP-seq
MIRT1394528	hsa-miR-128	CLIP-seq
MIRT1394529	hsa-miR-1321	CLIP-seq
MIRT1394530	hsa-miR-148a	CLIP-seq
MIRT1394531	hsa-miR-148b	CLIP-seq
MIRT1394532	hsa-miR-152	CLIP-seq
MIRT1394533	hsa-miR-1915	CLIP-seq
MIRT1394534	hsa-miR-202	CLIP-seq
MIRT1394535	hsa-miR-23a	CLIP-seq
MIRT1394536	hsa-miR-23b	CLIP-seq
MIRT1394537	hsa-miR-23c	CLIP-seq
MIRT1394538	hsa-miR-3150a-3p	CLIP-seq
MIRT1394539	hsa-miR-3152-5p	CLIP-seq
MIRT1394540	hsa-miR-3162-5p	CLIP-seq
MIRT1394541	hsa-miR-3175	CLIP-seq
MIRT1394542	hsa-miR-3199	CLIP-seq
MIRT1394543	hsa-miR-4446-3p	CLIP-seq
MIRT1394544	hsa-miR-4458	CLIP-seq
MIRT1394545	hsa-miR-4487	CLIP-seq
MIRT1394546	hsa-miR-4500	CLIP-seq
MIRT1394547	hsa-miR-4515	CLIP-seq
MIRT1394548	hsa-miR-4633-3p	CLIP-seq
MIRT1394549	hsa-miR-4640-5p	CLIP-seq
MIRT1394550	hsa-miR-4652-5p	CLIP-seq
MIRT1394551	hsa-miR-4656	CLIP-seq
MIRT1394552	hsa-miR-4667-5p	CLIP-seq
MIRT1394553	hsa-miR-4685-5p	CLIP-seq
MIRT1394554	hsa-miR-4700-5p	CLIP-seq
MIRT1394555	hsa-miR-4726-5p	CLIP-seq
MIRT1394556	hsa-miR-4731-5p	CLIP-seq
MIRT1394557	hsa-miR-4739	CLIP-seq
MIRT1394558	hsa-miR-4753-3p	CLIP-seq
MIRT1394559	hsa-miR-4756-5p	CLIP-seq
MIRT1394560	hsa-miR-4774-3p	CLIP-seq
MIRT1394561	hsa-miR-4786-3p	CLIP-seq
MIRT1394562	hsa-miR-522	CLIP-seq
MIRT1394563	hsa-miR-526b	CLIP-seq
MIRT1394564	hsa-miR-661	CLIP-seq
MIRT1394565	hsa-miR-939	CLIP-seq
MIRT1394566	hsa-miR-98	CLIP-seq
MIRT1394535	hsa-miR-23a	CLIP-seq
MIRT1394536	hsa-miR-23b	CLIP-seq
MIRT1394537	hsa-miR-23c	CLIP-seq
MIRT1394539	hsa-miR-3152-5p	CLIP-seq
MIRT2118390	hsa-miR-4268	CLIP-seq
MIRT2118391	hsa-miR-4448	CLIP-seq
MIRT1394558	hsa-miR-4753-3p	CLIP-seq
MIRT2118392	hsa-miR-4768-5p	CLIP-seq
MIRT1394560	hsa-miR-4774-3p	CLIP-seq
MIRT1394562	hsa-miR-522	CLIP-seq
MIRT2118393	hsa-miR-579	CLIP-seq

Show/Hide all(12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000785	Component	Chromatin	IBA	21873635
GO:0000795	Component	Synaptonemal complex	TAS	10698974
GO:0003682	Function	Chromatin binding	IBA	21873635
GO:0005615	Component	Extracellular space	HDA	22664934
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0007062	Process	Sister chromatid cohesion	IBA	21873635
GO:0007130	Process	Synaptonemal complex assembly	TAS	10698974
GO:0008278	Component	Cohesin complex	IBA	21873635
GO:0030893	Component	Meiotic cohesin complex	IDA	21242291

MIM	HGNC	e!Ensembl
608489	11356	ENSG00000066923

Protein

UniProt ID

Q9UJ98

Protein name

Cohesin subunit SA-3 (SCC3 homolog 3) (Stromal antigen 3) (Stromalin-3)

Protein function

Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be tra

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08514	STAG	173 → 286	STAG domain	Family

Tissue specificity

TISSUE SPECIFICITY: Testis specific.

Sequence

MSSPLQRAVGDTKRALSASSSSSASLPFDDRDSNHTSEGNGDSLLADEDTDFEDSLNRNV
KKRAAKRPPKTTPVAKHPKKGSRVVHRHSRKQSEPPANDLFNAVKAAKSDMQSLVDEWLD
SYKQDQDAGFLELVNFFIQSCGCKGIVTPEMFKKMSNSEIIQHLTEQFNEDSGDYPLIAP
GPSWKKFQGSFCEFVRTLVCQCQYSLLYDGFPMDDLISLLTGLSDSQVRAFRHTSTLAAM
KLMTSLVKVALQLSVHQDNNQRQYEAERNKGPGQRAPERLESLLEKRKELQEHQEEIEGM
MNALFRGVFVHRYRDVLPEIRAICIEEIGCWMQSYSTSFLTDSYLKYIGWTLHDKHREVR
LKCVKALKGLYGNRDLTTRLELFTSRFKDRMVSMVMDREYDVAVEAVRLLILILKNMEGV
LTDADCESVYPVVYASHRGLASAAGEFLYWKLFYPECEIRMMGGREQRQSPGAQRTFFQL
LLSFFVESELHDHAAYLVDSLWDCAGARLKDWEGLTSLLLEKDQNLGDVQESTLIEILVS
SARQASEGHPPVGRVTGRKGLTSKERKTQADDRVKLTEHLIPLLPQLLAKFSADAEKVTP
LLQLLSCFDLHIYCTGRLEKHLELFLQQLQEVVVKHAEPAVLEAGAHALYLLCNPEFTFF
SRADFARSQLVDLLTDRFQQELEELLQSSFLDEDEVYNLAATLKRLSAFYNTHDLTRWEL
YEPCCQLLQKAVDTGEVPHQVILPALTLVYFSILWTLTHISKSDASQKQLSSLRDRMVAF
CELCQSCLSDVDTEIQEQAFVLLSDLLLIFSPQMIVGGRDFLRPLVFFPEATLQSELASF
LMDHVFIQPGDLGSGDSQEDHLQIERLHQRRRLLAGFCKLLLYGVLEMDAASDVFKHYNK
FYNDYGDIIKETLTRARQIDRSHCSRILLLSLKQLYTELLQEHGPQGLNELPAFIEMRDL
ARRFALSFGPQQLQNRDLVVMLHKEGIQFSLSELPPAGSSNQPPNLAFLELLSEFSPRLF
HQDKQLLLSYLEKCLQHVSQAPGHPWGPVTTYCHSLSPVENTAETSPQVLPSSKRRRVEG
PAKPNREDVSSSQEESLQLNSIPPTPTLTSTAVKSRQPLWGLKEMEEEDGSELDFAQGQP
VAGTERSRFLGPQYFQTPHNPSGPGLGNQLMRLSLMEEDEEEELEIQDESNEERQDTDMQ
ASSYSSTSERGLDLLDSTELDIEDF

Sequence length

1225

Interactions

View interactions

	KEGG
	Oocyte meiosis

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Alzheimer disease	Alzheimer`s Disease	rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039 View all (65 more)	30617256
Premature ovarian failure	PREMATURE OVARIAN FAILURE 8	rs587776535, rs71647804, rs137853320, rs606231206, rs121918655, rs121918656, rs606231207, rs606231208, rs80359775, rs397507719, rs200503569, rs587777267, rs730880018, rs587777268, rs587777269 View all (40 more)

Show/Hide Unknown Diseases (3)

Disease term	Disease name	References	Source
Unknown
Mental depression	Major Depressive Disorder	29071344	ClinVar
Spermatogenic Failure	spermatogenic failure 61		GenCC
Premature Ovarian Failure	premature ovarian failure 8		GenCC

Show/Hide Text Mining Associations (20)

Disease Name	Relationship Type	References
Associations from Text Mining
Arrest of spermatogenesis	Associate	37867192
Azoospermia	Associate	32634216, 33980954
Azoospermia Nonobstructive	Associate	31115363
Carcinoma Hepatocellular	Associate	34888264
Carcinoma Hepatocellular	Inhibit	35941537
Carcinoma Ovarian Epithelial	Associate	20635389
Chromosome Aberrations	Associate	35503298
Infertility	Associate	18706547, 32634216
Infertility Male	Associate	18706547, 31115363, 32634216, 34954426
Lung Diseases	Associate	26425700
Melanoma	Associate	27500726
Neoplasms	Associate	20635389, 27462861, 36179046
Neoplasms	Inhibit	27500726, 35941537
Ovarian Dysgenesis 2	Associate	35503298
Ovarian Neoplasms	Associate	20635389, 33036707
Primary Ovarian Insufficiency	Associate	26059840, 32634216, 33036707, 35503298
Sertoli Cell Only Syndrome	Associate	18706547
Spermatogenic Failure Nonobstructive Y Linked	Associate	31115363
Squamous Cell Carcinoma of Head and Neck	Associate	39323031
Trisomy 13 Syndrome	Associate	31464342

STAG3 (STAG3 cohesin complex component)