YME1L1 (YME1 like 1 ATPase)
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10730 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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YME1 like 1 ATPase |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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YME1L1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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FTSH, MEG4, OPA11, PAMP, YME1L |
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Chromosome
Chromosome number
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10 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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10p12.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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The protein encoded by this gene is the human ortholog of yeast mitochondrial AAA metalloprotease, Yme1p. It is localized in the mitochondria and can functionally complement a yme1 disruptant yeast strain. It is proposed that this gene plays a role in mit |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | Q96TA2 | ||||||||||||||||||||
| Protein name | ATP-dependent zinc metalloprotease YME1L1 (EC 3.4.24.-) (EC 3.6.-.-) (ATP-dependent metalloprotease FtsH1) (Meg-4) (Presenilin-associated metalloprotease) (PAMP) (YME1-like protein 1) | ||||||||||||||||||||
| Protein function | ATP-dependent metalloprotease that catalyzes the degradation of folded and unfolded proteins with a suitable degron sequence in the mitochondrial intermembrane region (PubMed:24315374, PubMed:26923599, PubMed:27786171, PubMed:31695197, PubMed:33 | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: High expression in cardiac and skeletal muscle mitochondria. {ECO:0000269|PubMed:22262461}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 773 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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