Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10723
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 12 member 7
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC12A7
Synonyms (NCBI Gene) Gene synonyms aliases
KCC4
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5p15.33
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT016871 hsa-miR-335-5p Microarray 18185580
MIRT019302 hsa-miR-148b-3p Microarray 17612493
MIRT534287 hsa-miR-3133 PAR-CLIP 22012620
MIRT534286 hsa-miR-605-5p PAR-CLIP 22012620
MIRT534285 hsa-miR-4511 PAR-CLIP 22012620
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005886 Component Plasma membrane TAS
GO:0005887 Component Integral component of plasma membrane IEA
GO:0006811 Process Ion transport TAS
GO:0006884 Process Cell volume homeostasis IBA 21873635
GO:0007268 Process Chemical synaptic transmission IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604879 10915 ENSG00000113504
Protein
UniProt ID Q9Y666
Protein name Solute carrier family 12 member 7 (Electroneutral potassium-chloride cotransporter 4) (K-Cl cotransporter 4)
Protein function Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10913127). May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of
PDB 7D99
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00324 AA_permease 123 320 Amino acid permease Family
PF00324 AA_permease 411 696 Amino acid permease Family
PF03522 SLC12 708 834 Solute carrier family 12 Family
PF03522 SLC12 817 1083 Solute carrier family 12 Family
Tissue specificity TISSUE SPECIFICITY: Detected in muscle, brain, lung, heart and kidney. {ECO:0000269|PubMed:10347194}.
Sequence
MPTNFTVVPVEAHADGGGDETAERTEAPGTPEGPEPERPSPGDGNPRENSPFLNNVEVEQ
ESFFEGKNMALFEEEMDSNPMVSSLLNKLANYTNLSQGVVEHEEDEESRRREAKAPRMGT
FIGVYLPCLQNILGVILFLRLTWIVGVAGVLESFLIVAMCCTCTMLTAISMSAIATNGVV
PAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEIFLTYISPGAAIFQAEAA
GGEAAAMLHNMRVYGTCTLVLMALVVFVGVKYVNKLALVFLACVVLSILAIYAGVIKSAF
DPPDIPVCLLGNRTLSRRSF
DACVKAYGIHNNSATSALWGLFCNGSQPSAACDEYFIQNN
VTEIQGIPGAASGVFLENLWSTYAHAGAFVEKKGVPSVPVAEESRASALPYVLTDIAASF
TLLVGIYFPSVTGIMAGSNRSGDLKDAQKSIPTGTILAIVTTSFIYLSCIVLFGACIEGV
VLRDKFGEALQGNLVIGMLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAIARDGIVP
FLQVFGHGKANGEPTWALLLTVLICETGILIASLDSVAPILSMFFLMCYLFVNLACAVQT
LLRTPNWRPRFKFYHWTLSFLGMSLCLALMFICSWYYALSAMLIAGCIYKYIEYRGAEKE
WGDGIRGLSLNAARYALLRVEHGPPHTKNWRPQVLV
MLNLDAEQAVKHPRLLSFTSQLKA
GKGLTIVGSVLEGTYLDKHMEAQRAEENIRSLMSTEKTKGFCQLVVSSSLRDGMSHLIQS
AGLGGLKHNTVLMAWPASWKQEDNPFSWKNFVDTVR
DTTAAHQALLVAKNVDSFPQNQER
FGGGHIDVWWIVHDGGMLMLLPFLLRQHKVWRKCRMRIFTVAQVDDNSIQMKKDLQMFLY
HLRISAEVEVVEMVENDISAFTYERTLMMEQRSQMLKQMQLSKNEQEREAQLIHDRNTAS
HTAAAARTQAPPTPDKVQMTWTREKLIAEKYRSRDTSLSGFKDLFSMKPDQSNVRRMHTA
VKLNGVVLNKSQDAQLVLLNMPGPPKNRQGDENYMEFLEVLTEGLNRVLLVRGGGREVIT
IYS
Sequence length 1083
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Collecting duct acid secretion   Cation-coupled Chloride cotransporters
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Lung adenocarcinoma Lung adenocarcinoma Validation that loss of Tgfbr2 results in more aggressive and T cell-excluded KP lung tumors GWAS, CBGDA
Uterine Fibroids Uterine Fibroids GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adrenocortical Carcinoma Associate 26454676, 29884238
Aicardi Syndrome Associate 26454676
Neoplasm Metastasis Associate 36335317
Neoplasms Associate 19887603, 26454676, 29884238
Ovarian Neoplasms Associate 19887603
Prostatic Hyperplasia Associate 26158673
Squamous Cell Carcinoma of Head and Neck Associate 36335317