Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	1072
Gene name	Cofilin 1
Gene symbol	CFL1
Synonyms (NCBI Gene)	CFLHEL-S-15cofilin
Chromosome	11
Chromosome location	11q13.1
Summary	The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distri

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miRTarBase ID	miRNA	Experiments	Reference
MIRT025334	hsa-miR-34a-5p	Proteomics	21566225
MIRT025334	hsa-miR-34a-5p	Proteomics	21566225
MIRT043254	hsa-miR-324-5p	CLASH	23622248
MIRT041842	hsa-miR-484	CLASH	23622248
MIRT041581	hsa-miR-193b-3p	CLASH	23622248
MIRT037082	hsa-miR-877-3p	CLASH	23622248
MIRT036064	hsa-miR-1301-3p	CLASH	23622248
MIRT887435	hsa-miR-103a	CLIP-seq
MIRT887436	hsa-miR-107	CLIP-seq
MIRT887437	hsa-miR-1252	CLIP-seq
MIRT887438	hsa-miR-1254	CLIP-seq
MIRT887439	hsa-miR-1271	CLIP-seq
MIRT887440	hsa-miR-182	CLIP-seq
MIRT887441	hsa-miR-2115	CLIP-seq
MIRT887442	hsa-miR-3116	CLIP-seq
MIRT887443	hsa-miR-3122	CLIP-seq
MIRT887444	hsa-miR-3151	CLIP-seq
MIRT887445	hsa-miR-3155	CLIP-seq
MIRT887446	hsa-miR-3155b	CLIP-seq
MIRT887447	hsa-miR-3157-3p	CLIP-seq
MIRT887448	hsa-miR-3157-5p	CLIP-seq
MIRT887449	hsa-miR-342-5p	CLIP-seq
MIRT887450	hsa-miR-361-3p	CLIP-seq
MIRT887451	hsa-miR-3665	CLIP-seq
MIRT887452	hsa-miR-370	CLIP-seq
MIRT887453	hsa-miR-3913-5p	CLIP-seq
MIRT887454	hsa-miR-3928	CLIP-seq
MIRT887455	hsa-miR-3934	CLIP-seq
MIRT887456	hsa-miR-3977	CLIP-seq
MIRT887457	hsa-miR-4283	CLIP-seq
MIRT887458	hsa-miR-4290	CLIP-seq
MIRT887459	hsa-miR-4419a	CLIP-seq
MIRT887460	hsa-miR-4434	CLIP-seq
MIRT887461	hsa-miR-4436b-3p	CLIP-seq
MIRT887462	hsa-miR-4438	CLIP-seq
MIRT887463	hsa-miR-4447	CLIP-seq
MIRT887464	hsa-miR-4471	CLIP-seq
MIRT887465	hsa-miR-4472	CLIP-seq
MIRT887466	hsa-miR-4489	CLIP-seq
MIRT887467	hsa-miR-4493	CLIP-seq
MIRT887468	hsa-miR-450b-3p	CLIP-seq
MIRT887469	hsa-miR-4510	CLIP-seq
MIRT887470	hsa-miR-4516	CLIP-seq
MIRT887471	hsa-miR-4527	CLIP-seq
MIRT887472	hsa-miR-4534	CLIP-seq
MIRT887473	hsa-miR-4651	CLIP-seq
MIRT887474	hsa-miR-4664-5p	CLIP-seq
MIRT887475	hsa-miR-4668-3p	CLIP-seq
MIRT887476	hsa-miR-4672	CLIP-seq
MIRT887477	hsa-miR-4685-5p	CLIP-seq
MIRT887478	hsa-miR-4690-3p	CLIP-seq
MIRT887479	hsa-miR-4713-3p	CLIP-seq
MIRT887480	hsa-miR-4715-5p	CLIP-seq
MIRT887481	hsa-miR-4716-3p	CLIP-seq
MIRT887482	hsa-miR-4723-5p	CLIP-seq
MIRT887483	hsa-miR-4729	CLIP-seq
MIRT887484	hsa-miR-4731-5p	CLIP-seq
MIRT887485	hsa-miR-4747-5p	CLIP-seq
MIRT887486	hsa-miR-4749-3p	CLIP-seq
MIRT887487	hsa-miR-4753-5p	CLIP-seq
MIRT887488	hsa-miR-4789-5p	CLIP-seq
MIRT887489	hsa-miR-4797-5p	CLIP-seq
MIRT887490	hsa-miR-4802-5p	CLIP-seq
MIRT887491	hsa-miR-493	CLIP-seq
MIRT887492	hsa-miR-5095	CLIP-seq
MIRT887493	hsa-miR-511	CLIP-seq
MIRT887494	hsa-miR-516a-3p	CLIP-seq
MIRT887495	hsa-miR-543	CLIP-seq
MIRT887496	hsa-miR-550a	CLIP-seq
MIRT887497	hsa-miR-608	CLIP-seq
MIRT887498	hsa-miR-625	CLIP-seq
MIRT887499	hsa-miR-637	CLIP-seq
MIRT887500	hsa-miR-638	CLIP-seq
MIRT887501	hsa-miR-661	CLIP-seq
MIRT887502	hsa-miR-769-3p	CLIP-seq
MIRT887503	hsa-miR-874	CLIP-seq
MIRT887504	hsa-miR-885-3p	CLIP-seq
MIRT887505	hsa-miR-96	CLIP-seq
MIRT887448	hsa-miR-3157-5p	CLIP-seq
MIRT887454	hsa-miR-3928	CLIP-seq
MIRT887456	hsa-miR-3977	CLIP-seq
MIRT887463	hsa-miR-4447	CLIP-seq
MIRT887465	hsa-miR-4472	CLIP-seq
MIRT887471	hsa-miR-4527	CLIP-seq
MIRT887478	hsa-miR-4690-3p	CLIP-seq
MIRT887491	hsa-miR-493	CLIP-seq
MIRT887493	hsa-miR-511	CLIP-seq
MIRT887437	hsa-miR-1252	CLIP-seq
MIRT887438	hsa-miR-1254	CLIP-seq
MIRT887442	hsa-miR-3116	CLIP-seq
MIRT887459	hsa-miR-4419a	CLIP-seq
MIRT887460	hsa-miR-4434	CLIP-seq
MIRT887464	hsa-miR-4471	CLIP-seq
MIRT887469	hsa-miR-4510	CLIP-seq
MIRT887470	hsa-miR-4516	CLIP-seq
MIRT887471	hsa-miR-4527	CLIP-seq
MIRT887485	hsa-miR-4747-5p	CLIP-seq
MIRT887496	hsa-miR-550a	CLIP-seq
MIRT887498	hsa-miR-625	CLIP-seq
MIRT887499	hsa-miR-637	CLIP-seq
MIRT887501	hsa-miR-661	CLIP-seq
MIRT887435	hsa-miR-103a	CLIP-seq
MIRT887436	hsa-miR-107	CLIP-seq
MIRT887437	hsa-miR-1252	CLIP-seq
MIRT887438	hsa-miR-1254	CLIP-seq
MIRT887439	hsa-miR-1271	CLIP-seq
MIRT887440	hsa-miR-182	CLIP-seq
MIRT1963217	hsa-miR-1909	CLIP-seq
MIRT887441	hsa-miR-2115	CLIP-seq
MIRT887442	hsa-miR-3116	CLIP-seq
MIRT887443	hsa-miR-3122	CLIP-seq
MIRT887444	hsa-miR-3151	CLIP-seq
MIRT1963218	hsa-miR-3154	CLIP-seq
MIRT887445	hsa-miR-3155	CLIP-seq
MIRT887446	hsa-miR-3155b	CLIP-seq
MIRT887447	hsa-miR-3157-3p	CLIP-seq
MIRT887448	hsa-miR-3157-5p	CLIP-seq
MIRT887449	hsa-miR-342-5p	CLIP-seq
MIRT887450	hsa-miR-361-3p	CLIP-seq
MIRT887451	hsa-miR-3665	CLIP-seq
MIRT887452	hsa-miR-370	CLIP-seq
MIRT887453	hsa-miR-3913-5p	CLIP-seq
MIRT887454	hsa-miR-3928	CLIP-seq
MIRT887455	hsa-miR-3934	CLIP-seq
MIRT887456	hsa-miR-3977	CLIP-seq
MIRT887457	hsa-miR-4283	CLIP-seq
MIRT887458	hsa-miR-4290	CLIP-seq
MIRT887459	hsa-miR-4419a	CLIP-seq
MIRT887460	hsa-miR-4434	CLIP-seq
MIRT887461	hsa-miR-4436b-3p	CLIP-seq
MIRT887462	hsa-miR-4438	CLIP-seq
MIRT887463	hsa-miR-4447	CLIP-seq
MIRT887464	hsa-miR-4471	CLIP-seq
MIRT887465	hsa-miR-4472	CLIP-seq
MIRT887466	hsa-miR-4489	CLIP-seq
MIRT887467	hsa-miR-4493	CLIP-seq
MIRT887468	hsa-miR-450b-3p	CLIP-seq
MIRT887469	hsa-miR-4510	CLIP-seq
MIRT1963219	hsa-miR-4514	CLIP-seq
MIRT887470	hsa-miR-4516	CLIP-seq
MIRT887471	hsa-miR-4527	CLIP-seq
MIRT887472	hsa-miR-4534	CLIP-seq
MIRT1963220	hsa-miR-4640-5p	CLIP-seq
MIRT1963221	hsa-miR-4645-5p	CLIP-seq
MIRT887473	hsa-miR-4651	CLIP-seq
MIRT887474	hsa-miR-4664-5p	CLIP-seq
MIRT887475	hsa-miR-4668-3p	CLIP-seq
MIRT887476	hsa-miR-4672	CLIP-seq
MIRT1963222	hsa-miR-4673	CLIP-seq
MIRT887477	hsa-miR-4685-5p	CLIP-seq
MIRT887478	hsa-miR-4690-3p	CLIP-seq
MIRT1963223	hsa-miR-4692	CLIP-seq
MIRT887479	hsa-miR-4713-3p	CLIP-seq
MIRT887480	hsa-miR-4715-5p	CLIP-seq
MIRT887481	hsa-miR-4716-3p	CLIP-seq
MIRT887482	hsa-miR-4723-5p	CLIP-seq
MIRT1963224	hsa-miR-4726-5p	CLIP-seq
MIRT887483	hsa-miR-4729	CLIP-seq
MIRT887484	hsa-miR-4731-5p	CLIP-seq
MIRT887485	hsa-miR-4747-5p	CLIP-seq
MIRT887486	hsa-miR-4749-3p	CLIP-seq
MIRT887487	hsa-miR-4753-5p	CLIP-seq
MIRT887488	hsa-miR-4789-5p	CLIP-seq
MIRT1963225	hsa-miR-4795-3p	CLIP-seq
MIRT887489	hsa-miR-4797-5p	CLIP-seq
MIRT887490	hsa-miR-4802-5p	CLIP-seq
MIRT887491	hsa-miR-493	CLIP-seq
MIRT887492	hsa-miR-5095	CLIP-seq
MIRT887493	hsa-miR-511	CLIP-seq
MIRT887494	hsa-miR-516a-3p	CLIP-seq
MIRT887495	hsa-miR-543	CLIP-seq
MIRT887496	hsa-miR-550a	CLIP-seq
MIRT887497	hsa-miR-608	CLIP-seq
MIRT887498	hsa-miR-625	CLIP-seq
MIRT887499	hsa-miR-637	CLIP-seq
MIRT887500	hsa-miR-638	CLIP-seq
MIRT887501	hsa-miR-661	CLIP-seq
MIRT887502	hsa-miR-769-3p	CLIP-seq
MIRT887503	hsa-miR-874	CLIP-seq
MIRT887504	hsa-miR-885-3p	CLIP-seq
MIRT1963226	hsa-miR-940	CLIP-seq
MIRT887505	hsa-miR-96	CLIP-seq
MIRT887435	hsa-miR-103a	CLIP-seq
MIRT887436	hsa-miR-107	CLIP-seq
MIRT887437	hsa-miR-1252	CLIP-seq
MIRT887438	hsa-miR-1254	CLIP-seq
MIRT887439	hsa-miR-1271	CLIP-seq
MIRT887440	hsa-miR-182	CLIP-seq
MIRT1963217	hsa-miR-1909	CLIP-seq
MIRT887441	hsa-miR-2115	CLIP-seq
MIRT887442	hsa-miR-3116	CLIP-seq
MIRT887443	hsa-miR-3122	CLIP-seq
MIRT887444	hsa-miR-3151	CLIP-seq
MIRT1963218	hsa-miR-3154	CLIP-seq
MIRT887445	hsa-miR-3155	CLIP-seq
MIRT887446	hsa-miR-3155b	CLIP-seq
MIRT887447	hsa-miR-3157-3p	CLIP-seq
MIRT887448	hsa-miR-3157-5p	CLIP-seq
MIRT887449	hsa-miR-342-5p	CLIP-seq
MIRT887450	hsa-miR-361-3p	CLIP-seq
MIRT887451	hsa-miR-3665	CLIP-seq
MIRT887452	hsa-miR-370	CLIP-seq
MIRT887453	hsa-miR-3913-5p	CLIP-seq
MIRT887454	hsa-miR-3928	CLIP-seq
MIRT887455	hsa-miR-3934	CLIP-seq
MIRT887456	hsa-miR-3977	CLIP-seq
MIRT887457	hsa-miR-4283	CLIP-seq
MIRT887458	hsa-miR-4290	CLIP-seq
MIRT887459	hsa-miR-4419a	CLIP-seq
MIRT887460	hsa-miR-4434	CLIP-seq
MIRT887461	hsa-miR-4436b-3p	CLIP-seq
MIRT887462	hsa-miR-4438	CLIP-seq
MIRT887463	hsa-miR-4447	CLIP-seq
MIRT887464	hsa-miR-4471	CLIP-seq
MIRT887465	hsa-miR-4472	CLIP-seq
MIRT887466	hsa-miR-4489	CLIP-seq
MIRT887467	hsa-miR-4493	CLIP-seq
MIRT887468	hsa-miR-450b-3p	CLIP-seq
MIRT887469	hsa-miR-4510	CLIP-seq
MIRT1963219	hsa-miR-4514	CLIP-seq
MIRT887470	hsa-miR-4516	CLIP-seq
MIRT887471	hsa-miR-4527	CLIP-seq
MIRT887472	hsa-miR-4534	CLIP-seq
MIRT1963220	hsa-miR-4640-5p	CLIP-seq
MIRT1963221	hsa-miR-4645-5p	CLIP-seq
MIRT887473	hsa-miR-4651	CLIP-seq
MIRT887474	hsa-miR-4664-5p	CLIP-seq
MIRT887475	hsa-miR-4668-3p	CLIP-seq
MIRT887476	hsa-miR-4672	CLIP-seq
MIRT1963222	hsa-miR-4673	CLIP-seq
MIRT887477	hsa-miR-4685-5p	CLIP-seq
MIRT887478	hsa-miR-4690-3p	CLIP-seq
MIRT1963223	hsa-miR-4692	CLIP-seq
MIRT887479	hsa-miR-4713-3p	CLIP-seq
MIRT887480	hsa-miR-4715-5p	CLIP-seq
MIRT887481	hsa-miR-4716-3p	CLIP-seq
MIRT887482	hsa-miR-4723-5p	CLIP-seq
MIRT1963224	hsa-miR-4726-5p	CLIP-seq
MIRT887483	hsa-miR-4729	CLIP-seq
MIRT887484	hsa-miR-4731-5p	CLIP-seq
MIRT887485	hsa-miR-4747-5p	CLIP-seq
MIRT887486	hsa-miR-4749-3p	CLIP-seq
MIRT887487	hsa-miR-4753-5p	CLIP-seq
MIRT887488	hsa-miR-4789-5p	CLIP-seq
MIRT887489	hsa-miR-4797-5p	CLIP-seq
MIRT887490	hsa-miR-4802-5p	CLIP-seq
MIRT887491	hsa-miR-493	CLIP-seq
MIRT887492	hsa-miR-5095	CLIP-seq
MIRT887494	hsa-miR-516a-3p	CLIP-seq
MIRT887495	hsa-miR-543	CLIP-seq
MIRT887496	hsa-miR-550a	CLIP-seq
MIRT887497	hsa-miR-608	CLIP-seq
MIRT887498	hsa-miR-625	CLIP-seq
MIRT887499	hsa-miR-637	CLIP-seq
MIRT887500	hsa-miR-638	CLIP-seq
MIRT887501	hsa-miR-661	CLIP-seq
MIRT887502	hsa-miR-769-3p	CLIP-seq
MIRT887503	hsa-miR-874	CLIP-seq
MIRT887504	hsa-miR-885-3p	CLIP-seq
MIRT1963226	hsa-miR-940	CLIP-seq
MIRT887505	hsa-miR-96	CLIP-seq
MIRT887435	hsa-miR-103a	CLIP-seq
MIRT887436	hsa-miR-107	CLIP-seq
MIRT887441	hsa-miR-2115	CLIP-seq
MIRT887443	hsa-miR-3122	CLIP-seq
MIRT887449	hsa-miR-342-5p	CLIP-seq
MIRT887450	hsa-miR-361-3p	CLIP-seq
MIRT887452	hsa-miR-370	CLIP-seq
MIRT887453	hsa-miR-3913-5p	CLIP-seq
MIRT887454	hsa-miR-3928	CLIP-seq
MIRT887459	hsa-miR-4419a	CLIP-seq
MIRT887460	hsa-miR-4434	CLIP-seq
MIRT887463	hsa-miR-4447	CLIP-seq
MIRT887465	hsa-miR-4472	CLIP-seq
MIRT887467	hsa-miR-4493	CLIP-seq
MIRT887469	hsa-miR-4510	CLIP-seq
MIRT887470	hsa-miR-4516	CLIP-seq
MIRT887472	hsa-miR-4534	CLIP-seq
MIRT887473	hsa-miR-4651	CLIP-seq
MIRT887474	hsa-miR-4664-5p	CLIP-seq
MIRT887475	hsa-miR-4668-3p	CLIP-seq
MIRT887476	hsa-miR-4672	CLIP-seq
MIRT887477	hsa-miR-4685-5p	CLIP-seq
MIRT887480	hsa-miR-4715-5p	CLIP-seq
MIRT887481	hsa-miR-4716-3p	CLIP-seq
MIRT887482	hsa-miR-4723-5p	CLIP-seq
MIRT887485	hsa-miR-4747-5p	CLIP-seq
MIRT887487	hsa-miR-4753-5p	CLIP-seq
MIRT887488	hsa-miR-4789-5p	CLIP-seq
MIRT887489	hsa-miR-4797-5p	CLIP-seq
MIRT887490	hsa-miR-4802-5p	CLIP-seq
MIRT887491	hsa-miR-493	CLIP-seq
MIRT887494	hsa-miR-516a-3p	CLIP-seq
MIRT887497	hsa-miR-608	CLIP-seq
MIRT887504	hsa-miR-885-3p	CLIP-seq
MIRT887435	hsa-miR-103a	CLIP-seq
MIRT887436	hsa-miR-107	CLIP-seq
MIRT887480	hsa-miR-4715-5p	CLIP-seq
MIRT887481	hsa-miR-4716-3p	CLIP-seq
MIRT887482	hsa-miR-4723-5p	CLIP-seq
MIRT887485	hsa-miR-4747-5p	CLIP-seq
MIRT887489	hsa-miR-4797-5p	CLIP-seq
MIRT887504	hsa-miR-885-3p	CLIP-seq
MIRT887452	hsa-miR-370	CLIP-seq
MIRT887439	hsa-miR-1271	CLIP-seq
MIRT887440	hsa-miR-182	CLIP-seq
MIRT887449	hsa-miR-342-5p	CLIP-seq
MIRT887473	hsa-miR-4651	CLIP-seq
MIRT887474	hsa-miR-4664-5p	CLIP-seq
MIRT887497	hsa-miR-608	CLIP-seq
MIRT887505	hsa-miR-96	CLIP-seq
MIRT887435	hsa-miR-103a	CLIP-seq
MIRT887436	hsa-miR-107	CLIP-seq
MIRT887438	hsa-miR-1254	CLIP-seq
MIRT887439	hsa-miR-1271	CLIP-seq
MIRT887440	hsa-miR-182	CLIP-seq
MIRT887442	hsa-miR-3116	CLIP-seq
MIRT887443	hsa-miR-3122	CLIP-seq
MIRT887445	hsa-miR-3155	CLIP-seq
MIRT887446	hsa-miR-3155b	CLIP-seq
MIRT887448	hsa-miR-3157-5p	CLIP-seq
MIRT887449	hsa-miR-342-5p	CLIP-seq
MIRT887450	hsa-miR-361-3p	CLIP-seq
MIRT887453	hsa-miR-3913-5p	CLIP-seq
MIRT887456	hsa-miR-3977	CLIP-seq
MIRT887462	hsa-miR-4438	CLIP-seq
MIRT887463	hsa-miR-4447	CLIP-seq
MIRT887464	hsa-miR-4471	CLIP-seq
MIRT887465	hsa-miR-4472	CLIP-seq
MIRT887471	hsa-miR-4527	CLIP-seq
MIRT887473	hsa-miR-4651	CLIP-seq
MIRT887474	hsa-miR-4664-5p	CLIP-seq
MIRT887475	hsa-miR-4668-3p	CLIP-seq
MIRT887477	hsa-miR-4685-5p	CLIP-seq
MIRT887478	hsa-miR-4690-3p	CLIP-seq
MIRT887480	hsa-miR-4715-5p	CLIP-seq
MIRT887481	hsa-miR-4716-3p	CLIP-seq
MIRT887482	hsa-miR-4723-5p	CLIP-seq
MIRT887485	hsa-miR-4747-5p	CLIP-seq
MIRT887489	hsa-miR-4797-5p	CLIP-seq
MIRT887492	hsa-miR-5095	CLIP-seq
MIRT887496	hsa-miR-550a	CLIP-seq
MIRT887497	hsa-miR-608	CLIP-seq
MIRT887498	hsa-miR-625	CLIP-seq
MIRT887499	hsa-miR-637	CLIP-seq
MIRT887501	hsa-miR-661	CLIP-seq
MIRT887504	hsa-miR-885-3p	CLIP-seq
MIRT887505	hsa-miR-96	CLIP-seq
MIRT887435	hsa-miR-103a	CLIP-seq
MIRT887436	hsa-miR-107	CLIP-seq
MIRT887438	hsa-miR-1254	CLIP-seq
MIRT887442	hsa-miR-3116	CLIP-seq
MIRT887445	hsa-miR-3155	CLIP-seq
MIRT887446	hsa-miR-3155b	CLIP-seq
MIRT887448	hsa-miR-3157-5p	CLIP-seq
MIRT887449	hsa-miR-342-5p	CLIP-seq
MIRT887450	hsa-miR-361-3p	CLIP-seq
MIRT887456	hsa-miR-3977	CLIP-seq
MIRT887462	hsa-miR-4438	CLIP-seq
MIRT887463	hsa-miR-4447	CLIP-seq
MIRT887464	hsa-miR-4471	CLIP-seq
MIRT887465	hsa-miR-4472	CLIP-seq
MIRT887471	hsa-miR-4527	CLIP-seq
MIRT887473	hsa-miR-4651	CLIP-seq
MIRT887474	hsa-miR-4664-5p	CLIP-seq
MIRT887475	hsa-miR-4668-3p	CLIP-seq
MIRT887477	hsa-miR-4685-5p	CLIP-seq
MIRT887478	hsa-miR-4690-3p	CLIP-seq
MIRT887480	hsa-miR-4715-5p	CLIP-seq
MIRT887481	hsa-miR-4716-3p	CLIP-seq
MIRT887482	hsa-miR-4723-5p	CLIP-seq
MIRT887485	hsa-miR-4747-5p	CLIP-seq
MIRT887489	hsa-miR-4797-5p	CLIP-seq
MIRT887492	hsa-miR-5095	CLIP-seq
MIRT887496	hsa-miR-550a	CLIP-seq
MIRT887497	hsa-miR-608	CLIP-seq
MIRT887498	hsa-miR-625	CLIP-seq
MIRT887499	hsa-miR-637	CLIP-seq
MIRT887501	hsa-miR-661	CLIP-seq
MIRT887504	hsa-miR-885-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000281	Process	Mitotic cytokinesis	IBA
GO:0000281	Process	Mitotic cytokinesis	IEA
GO:0001755	Process	Neural crest cell migration	IEA
GO:0001842	Process	Neural fold formation	IEA
GO:0003779	Function	Actin binding	IEA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	12361576, 15161933, 15846844, 16189514, 16713569, 17853892, 19424295, 20029029, 20133759, 21516116, 21525957, 24658140, 25416956, 25556234, 29892012, 30021884, 31515488, 31980649, 32296183, 32814053, 33961781, 35271311
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	8195165, 16130169
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	25556234
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005911	Component	Cell-cell junction	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IDA	29162887
GO:0006606	Process	Protein import into nucleus	IEA
GO:0007010	Process	Cytoskeleton organization	IMP	21834987
GO:0007015	Process	Actin filament organization	IEA
GO:0007162	Process	Negative regulation of cell adhesion	IEA
GO:0007266	Process	Rho protein signal transduction	TAS	10436159
GO:0008154	Process	Actin polymerization or depolymerization	IEA
GO:0009615	Process	Response to virus	IEP	16548883
GO:0010592	Process	Positive regulation of lamellipodium assembly	IEA
GO:0010593	Process	Negative regulation of lamellipodium assembly	IEA
GO:0014823	Process	Response to activity	IEA
GO:0015629	Component	Actin cytoskeleton	IBA
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016363	Component	Nuclear matrix	IEA
GO:0019903	Function	Protein phosphatase binding	IEA
GO:0021766	Process	Hippocampus development	IEA
GO:0022604	Process	Regulation of cell morphogenesis	IMP	21834987
GO:0030010	Process	Establishment of cell polarity	IEA
GO:0030027	Component	Lamellipodium	IBA
GO:0030027	Component	Lamellipodium	IEA
GO:0030027	Component	Lamellipodium	ISS
GO:0030030	Process	Cell projection organization	IEA
GO:0030036	Process	Actin cytoskeleton organization	TAS	10436159
GO:0030042	Process	Actin filament depolymerization	IDA	11812157
GO:0030042	Process	Actin filament depolymerization	IEA
GO:0030042	Process	Actin filament depolymerization	NAS	24052308
GO:0030043	Process	Actin filament fragmentation	IBA
GO:0030043	Process	Actin filament fragmentation	IEA
GO:0030175	Component	Filopodium	IEA
GO:0030307	Process	Positive regulation of cell growth	IEA
GO:0030424	Component	Axon	IEA
GO:0030426	Component	Growth cone	IEA
GO:0030835	Process	Negative regulation of actin filament depolymerization	IEA
GO:0030836	Process	Positive regulation of actin filament depolymerization	IEA
GO:0030864	Component	Cortical actin cytoskeleton	IEA
GO:0031252	Component	Cell leading edge	IEA
GO:0031258	Component	Lamellipodium membrane	IEA
GO:0031915	Process	Positive regulation of synaptic plasticity	IEA
GO:0031966	Component	Mitochondrial membrane	IEA
GO:0031982	Component	Vesicle	HDA	19190083
GO:0032232	Process	Negative regulation of actin filament bundle assembly	IEA
GO:0032587	Component	Ruffle membrane	IEA
GO:0040019	Process	Positive regulation of embryonic development	IEA
GO:0040019	Process	Positive regulation of embryonic development	ISS
GO:0042995	Component	Cell projection	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043066	Process	Negative regulation of apoptotic process	TAS	16130169
GO:0043197	Component	Dendritic spine	IEA
GO:0043200	Process	Response to amino acid	IEA
GO:0044794	Process	Host-mediated activation of viral process	IMP	25556234
GO:0045792	Process	Negative regulation of cell size	IEA
GO:0045862	Process	Positive regulation of proteolysis	IEA
GO:0048870	Process	Cell motility	IEA
GO:0050804	Process	Modulation of chemical synaptic transmission	IEA
GO:0051014	Process	Actin filament severing	IBA
GO:0051015	Function	Actin filament binding	IBA
GO:0051015	Function	Actin filament binding	IDA	11812157
GO:0051015	Function	Actin filament binding	IEA
GO:0051015	Function	Actin filament binding	ISS
GO:0051293	Process	Establishment of spindle localization	IEA
GO:0051293	Process	Establishment of spindle localization	ISS
GO:0051511	Process	Negative regulation of unidimensional cell growth	IEA
GO:0051894	Process	Positive regulation of focal adhesion assembly	IEA
GO:0060999	Process	Positive regulation of dendritic spine development	IEA
GO:0061001	Process	Regulation of dendritic spine morphogenesis	IMP	24464040
GO:0070062	Component	Extracellular exosome	HDA	19199708, 20458337, 23533145
GO:0070301	Process	Cellular response to hydrogen peroxide	IEA
GO:0071347	Process	Cellular response to interleukin-1	IEA
GO:0071354	Process	Cellular response to interleukin-6	IEA
GO:0071356	Process	Cellular response to tumor necrosis factor	IEA
GO:0071362	Process	Cellular response to ether	IEA
GO:0071364	Process	Cellular response to epidermal growth factor stimulus	IEA
GO:0090732	Component	Cofilin-actin rod	IEA
GO:0097060	Component	Synaptic membrane	IEA
GO:0098885	Process	Modification of postsynaptic actin cytoskeleton	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099092	Component	Postsynaptic density, intracellular component	IEA
GO:1902936	Function	Phosphatidylinositol bisphosphate binding	IEA
GO:1902951	Process	Negative regulation of dendritic spine maintenance	IEA
GO:1905873	Process	Positive regulation of protein localization to cell leading edge	IEA
GO:1905875	Process	Negative regulation of postsynaptic density organization	IEA
GO:1990314	Process	Cellular response to insulin-like growth factor stimulus	IEA
GO:2000146	Process	Negative regulation of cell motility	IEA
GO:2000147	Process	Positive regulation of cell motility	IEA
GO:2000784	Process	Positive regulation of establishment of cell polarity regulating cell shape	IEA
GO:2000814	Process	Positive regulation of barbed-end actin filament capping	IEA

MIM	HGNC	e!Ensembl
601442	1874	ENSG00000172757

P23528

Protein name

Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)

Protein function

Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:11812157). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions

PDB

1Q8G , 1Q8X , 3J0S , 4BEX , 5HVK , 5L6W , 6UBY , 6UC0 , 6UC4 , 6VAO

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00241	Cofilin_ADF	13 → 152	Cofilin/tropomyosin-type actin-binding protein	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely distributed in various tissues.

Sequence

MASGVAVSDGVIKVFNDMKVRKSSTPEEVKKRKKAVLFCLSEDKKNIILEEGKEILVGDV
GQTVDDPYATFVKMLPDKDCRYALYDATYETKESKKEDLVFIFWAPESAPLKSKMIYASS
KDAIKKKLTGIKHELQANCYEEVKDRCTLAEKLGGSAVISLEGKPL

Sequence length

166

Interactions

View interactions

	KEGG		Reactome
	Axon guidance Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton Pertussis Human immunodeficiency virus 1 infection		Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

CFL1 (cofilin 1)