Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10714
Gene name Gene Name - the full gene name approved by the HGNC.
DNA polymerase delta 3, accessory subunit
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
POLD3
Synonyms (NCBI Gene) Gene synonyms aliases
IMD122, P66, P68, PPP1R128
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q13.4
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3` to 5` exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the acti
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027117 hsa-miR-103a-3p Sequencing 20371350
MIRT049970 hsa-miR-29a-3p CLASH 23622248
MIRT045481 hsa-miR-149-5p CLASH 23622248
MIRT045077 hsa-miR-186-5p CLASH 23622248
MIRT038291 hsa-miR-130b-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000731 Process DNA synthesis involved in DNA repair NAS 7910606
GO:0003887 Function DNA-directed DNA polymerase activity IBA
GO:0005515 Function Protein binding IPI 15576034, 16000169, 16510448, 26496610, 28514442, 31449058, 33961781, 38554706
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
611415 20932 ENSG00000077514
Protein
UniProt ID Q15054
Protein name DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68)
Protein function Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Po
PDB 1U76 , 2N1G , 3E0J , 6S1M , 6S1N , 6S1O , 6TNY , 6TNZ , 9EKB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09507 CDC27 19 466 DNA polymerase subunit Cdc27 Family
Sequence
Sequence length 466
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  DNA replication
Base excision repair
Nucleotide excision repair
Mismatch repair
Homologous recombination
  Recognition of DNA damage by PCNA-containing replication complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Colorectal Cancer Colorectal cancer, Early onset colorectal cancer N/A N/A GWAS
Hearing Loss hearing loss disorder N/A N/A GenCC
Pelvic Organ Prolapse Pelvic organ prolapse N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 23815759
Alternating hemiplegia of childhood Associate 31633027
Atherosclerosis Associate 20842738
Breast Neoplasms Associate 19706770, 20818423
Cerebrovascular Disorders Associate 24349153
Colorectal Neoplasms Associate 24978480, 35786622
Colorectal Neoplasms Stimulate 26464652
Colorectal Neoplasms Hereditary Nonpolyposis Associate 31297992
Coronary Artery Disease Stimulate 20842738
Diabetes Mellitus Type 2 Associate 22740707