Gene Gene information from NCBI Gene database.
Entrez ID 10714
Gene name DNA polymerase delta 3, accessory subunit
Gene symbol POLD3
Synonyms (NCBI Gene)
IMD122P66P68PPP1R128
Chromosome 11
Chromosome location 11q13.4
Summary This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3` to 5` exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the acti
miRNA miRNA information provided by mirtarbase database.
678
miRTarBase ID miRNA Experiments Reference
MIRT027117 hsa-miR-103a-3p Sequencing 20371350
MIRT049970 hsa-miR-29a-3p CLASH 23622248
MIRT045481 hsa-miR-149-5p CLASH 23622248
MIRT045077 hsa-miR-186-5p CLASH 23622248
MIRT038291 hsa-miR-130b-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
27
GO ID Ontology Definition Evidence Reference
GO:0000731 Process DNA synthesis involved in DNA repair NAS 7910606
GO:0003887 Function DNA-directed DNA polymerase activity IBA
GO:0005515 Function Protein binding IPI 15576034, 16000169, 16510448, 26496610, 28514442, 31449058, 33961781, 38554706
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611415 20932 ENSG00000077514
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15054
Protein name DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68)
Protein function Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Po
PDB 1U76 , 2N1G , 3E0J , 6S1M , 6S1N , 6S1O , 6TNY , 6TNZ , 9EKB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09507 CDC27 19 466 DNA polymerase subunit Cdc27 Family
Sequence
Sequence length 466
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  DNA replication
Base excision repair
Nucleotide excision repair
Mismatch repair
Homologous recombination
  Recognition of DNA damage by PCNA-containing replication complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
10
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia no classifications from unflagged records rs181857010 RCV005939513
Alkaline phosphatase, plasma level of, quantitative trait locus 2 Uncertain significance rs147850084 RCV005861317
Immunodeficiency 122 no classifications from unflagged records rs2547212557, rs181857010 RCV004584575
RCV004584576
Nonpapillary renal cell carcinoma no classifications from unflagged records rs181857010 RCV005939514
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 23815759
Alternating hemiplegia of childhood Associate 31633027
Atherosclerosis Associate 20842738
Breast Neoplasms Associate 19706770, 20818423
Cerebrovascular Disorders Associate 24349153
Colorectal Neoplasms Associate 24978480, 35786622
Colorectal Neoplasms Stimulate 26464652
Colorectal Neoplasms Hereditary Nonpolyposis Associate 31297992
Coronary Artery Disease Stimulate 20842738
Diabetes Mellitus Type 2 Associate 22740707