POLD3 (DNA polymerase delta 3, accessory subunit)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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10714 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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DNA polymerase delta 3, accessory subunit |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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POLD3 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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IMD122, P66, P68, PPP1R128 |
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Chromosome
Chromosome number
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11 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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11q13.4 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes the 66-kDa subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3` to 5` exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein plays a role in regulating the acti |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | Q15054 | ||||||||||
| Protein name | DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) | ||||||||||
| Protein function | Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Po | ||||||||||
| PDB | 1U76 , 2N1G , 3E0J , 6S1M , 6S1N , 6S1O , 6TNY , 6TNZ , 9EKB | ||||||||||
| Family and domains |
Pfam
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| Sequence |
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| Sequence length | 466 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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