CCT6B (chaperonin containing TCP1 subunit 6B)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10693
Gene name Gene Name - the full gene name approved by the HGNC.
Chaperonin containing TCP1 subunit 6B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CCT6B
Synonyms (NCBI Gene) Gene synonyms aliases
CCT-zeta-2, CCTZ-2, Cctz2, TCP-1-zeta-2, TSA303
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q12
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT031676 hsa-miR-16-5p Proteomics 18668040
MIRT051329 hsa-miR-15a-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(9)
GO ID Ontology Definition Evidence Reference
GO:0005524 Function ATP binding IEA
GO:0005829 Component Cytosol IDA
GO:0005832 Component Chaperonin-containing T-complex IBA 21873635
GO:0005832 Component Chaperonin-containing T-complex IDA 30955883
GO:0006457 Process Protein folding IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
610730 1621 ENSG00000132141
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q92526
Protein name T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (CCT-zeta-like) (Chaperonin containing T-complex polypeptide 1 subunit 6B) (TCP-1-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303)
Protein function Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00118 Cpn60_TCP1 30 → 526 TCP-1/cpn60 chaperonin family Family
Tissue specificity TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:8812458}.
Sequence
Sequence length 530
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Association of TriC/CCT with target proteins during biosynthesis
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (1)
Causal
Disease term Disease name dbSNP ID References
Burkitt`s lymphoma Burkitt Lymphoma, Burkitt Leukemia rs28933407, rs121918683, rs121918684 23143597
Show/Hide Unknown Diseases (2)
Unknown
Disease term Disease name Evidence References Source
Insomnia Insomnia GWAS
Breast cancer Breast cancer Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients GWAS, CBGDA
Show/Hide Text Mining Associations (4)
Associations from Text Mining
Disease Name Relationship Type References
Neoplasms Associate 36299463
Nonseminomatous germ cell tumor Associate 32650378
Testicular Germ Cell Tumor Associate 32650378
Varicocele Associate 26732106