CETN1 (centrin 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1068
Gene name Gene Name - the full gene name approved by the HGNC.
Centrin 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CETN1
Synonyms (NCBI Gene) Gene synonyms aliases
CEN1, CETN
Chromosome Chromosome number
18
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
18p11.32
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the regio
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
miRTarBase ID miRNA Experiments Reference
MIRT022033 hsa-miR-128-3p Microarray 17612493
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(28)
GO ID Ontology Definition Evidence Reference
GO:0000226 Process Microtubule cytoskeleton organization IBA
GO:0000922 Component Spindle pole IDA 8175926
GO:0005509 Function Calcium ion binding IBA
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 20643351, 25416956, 28514442, 29892012, 31515488, 32296183, 33961781
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
603187 1866 ENSG00000177143
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q12798
Protein name Centrin-1 (Caltractin isoform 2)
Protein function Plays a fundamental role in microtubule-organizing center structure and function (PubMed:8175926). Plays a role in sperm cilia formation (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13499 EF-hand_7 30 → 94 EF-hand domain pair Domain
PF13499 EF-hand_7 103 → 167 EF-hand domain pair Domain
Sequence
Sequence length 172
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Aggrephagy
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Anxiety Disorder Anxiety N/A N/A GWAS
Show/Hide Text Mining Associations (22)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 18804527, 19844956, 28275088
Calculi Associate 34160472
Carcinoma Endometrioid Associate 27348205
Carcinoma Renal Cell Associate 17483815
Cholangiocarcinoma Associate 21029254
Colorectal Neoplasms Associate 21127395, 25585623, 35597866
Congenital Abnormalities Associate 33619679
Familial Multiple Coagulation Factor Deficiency I Associate 20142513
Graves Disease Associate 10052680
Immunologic Deficiency Syndromes Associate 36742411