Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Transcription factors Gene ontology Other IDs Protein
Entrez ID	10631
Gene name	Periostin
Gene symbol	POSTN
Synonyms (NCBI Gene)	OSF-2OSF2PDLPOSTNPN
Chromosome	13
Chromosome location	13q13.3
Summary	This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesio

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miRTarBase ID	miRNA	Experiments	Reference
MIRT735016	hsa-miR-181a-5p	qRT-PCR	33102604
MIRT756383	hsa-miR-219a-2-3p	Luciferase reporter assayWestern blottingqRT-PCRImmunoprecipitaion (IP)	35927233
MIRT2073911	hsa-miR-1200	CLIP-seq
MIRT2073912	hsa-miR-3140-5p	CLIP-seq
MIRT2073913	hsa-miR-4277	CLIP-seq
MIRT2597593	hsa-miR-1246	CLIP-seq
MIRT2597594	hsa-miR-1290	CLIP-seq
MIRT2597595	hsa-miR-140-3p	CLIP-seq
MIRT2597596	hsa-miR-18a	CLIP-seq
MIRT2597597	hsa-miR-18b	CLIP-seq
MIRT2597598	hsa-miR-19a	CLIP-seq
MIRT2597599	hsa-miR-19b	CLIP-seq
MIRT2597600	hsa-miR-3163	CLIP-seq
MIRT2597601	hsa-miR-33a	CLIP-seq
MIRT2597602	hsa-miR-33b	CLIP-seq
MIRT2597603	hsa-miR-3975	CLIP-seq
MIRT2597604	hsa-miR-4251	CLIP-seq
MIRT2597605	hsa-miR-4303	CLIP-seq
MIRT2597606	hsa-miR-4320	CLIP-seq
MIRT2597607	hsa-miR-4329	CLIP-seq
MIRT2597608	hsa-miR-4446-5p	CLIP-seq
MIRT2597609	hsa-miR-4459	CLIP-seq
MIRT2597610	hsa-miR-4659a-3p	CLIP-seq
MIRT2597611	hsa-miR-4659b-3p	CLIP-seq
MIRT2597612	hsa-miR-4662a-5p	CLIP-seq
MIRT2597613	hsa-miR-4676-5p	CLIP-seq
MIRT2597614	hsa-miR-4684-5p	CLIP-seq
MIRT2597615	hsa-miR-4693-3p	CLIP-seq
MIRT2597616	hsa-miR-4694-5p	CLIP-seq
MIRT2597617	hsa-miR-4695-5p	CLIP-seq
MIRT2597618	hsa-miR-4696	CLIP-seq
MIRT2597619	hsa-miR-4735-3p	CLIP-seq
MIRT2597620	hsa-miR-4755-5p	CLIP-seq
MIRT2597621	hsa-miR-4764-3p	CLIP-seq
MIRT2597622	hsa-miR-4768-5p	CLIP-seq
MIRT2597623	hsa-miR-4803	CLIP-seq
MIRT2597624	hsa-miR-518a-5p	CLIP-seq
MIRT2597625	hsa-miR-527	CLIP-seq
MIRT2597626	hsa-miR-543	CLIP-seq
MIRT2597627	hsa-miR-561	CLIP-seq
MIRT2597628	hsa-miR-575	CLIP-seq
MIRT2597629	hsa-miR-586	CLIP-seq
MIRT2597630	hsa-miR-642a	CLIP-seq
MIRT2597593	hsa-miR-1246	CLIP-seq
MIRT2597594	hsa-miR-1290	CLIP-seq
MIRT2597595	hsa-miR-140-3p	CLIP-seq
MIRT2597596	hsa-miR-18a	CLIP-seq
MIRT2597597	hsa-miR-18b	CLIP-seq
MIRT2597598	hsa-miR-19a	CLIP-seq
MIRT2597599	hsa-miR-19b	CLIP-seq
MIRT2597600	hsa-miR-3163	CLIP-seq
MIRT2597601	hsa-miR-33a	CLIP-seq
MIRT2597602	hsa-miR-33b	CLIP-seq
MIRT2597603	hsa-miR-3975	CLIP-seq
MIRT2597604	hsa-miR-4251	CLIP-seq
MIRT2597605	hsa-miR-4303	CLIP-seq
MIRT2597606	hsa-miR-4320	CLIP-seq
MIRT2597607	hsa-miR-4329	CLIP-seq
MIRT2597608	hsa-miR-4446-5p	CLIP-seq
MIRT2597609	hsa-miR-4459	CLIP-seq
MIRT2597610	hsa-miR-4659a-3p	CLIP-seq
MIRT2597611	hsa-miR-4659b-3p	CLIP-seq
MIRT2597612	hsa-miR-4662a-5p	CLIP-seq
MIRT2597613	hsa-miR-4676-5p	CLIP-seq
MIRT2597614	hsa-miR-4684-5p	CLIP-seq
MIRT2597615	hsa-miR-4693-3p	CLIP-seq
MIRT2597616	hsa-miR-4694-5p	CLIP-seq
MIRT2597617	hsa-miR-4695-5p	CLIP-seq
MIRT2597618	hsa-miR-4696	CLIP-seq
MIRT2597619	hsa-miR-4735-3p	CLIP-seq
MIRT2597620	hsa-miR-4755-5p	CLIP-seq
MIRT2597621	hsa-miR-4764-3p	CLIP-seq
MIRT2597622	hsa-miR-4768-5p	CLIP-seq
MIRT2597623	hsa-miR-4803	CLIP-seq
MIRT2597624	hsa-miR-518a-5p	CLIP-seq
MIRT2597625	hsa-miR-527	CLIP-seq
MIRT2597626	hsa-miR-543	CLIP-seq
MIRT2597627	hsa-miR-561	CLIP-seq
MIRT2597628	hsa-miR-575	CLIP-seq
MIRT2597629	hsa-miR-586	CLIP-seq
MIRT2597630	hsa-miR-642a	CLIP-seq

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Transcription factor	Regulation	Reference
CDX1	Unknown	22215184
TWIST2	Unknown	21801849
YY1	Repression	21839814

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001666	Process	Response to hypoxia	IEA
GO:0001953	Process	Negative regulation of cell-matrix adhesion	IEA
GO:0003073	Process	Regulation of systemic arterial blood pressure	IEA
GO:0005201	Function	Extracellular matrix structural constituent	RCA	20551380, 25037231, 27068509, 27559042, 28327460, 28675934
GO:0005515	Function	Protein binding	IPI	19478074
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005802	Component	Trans-Golgi network	IDA	19478074
GO:0005802	Component	Trans-Golgi network	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IDA	12235007
GO:0007155	Process	Cell adhesion	IEA
GO:0008201	Function	Heparin binding	IEA
GO:0008201	Function	Heparin binding	ISS
GO:0008593	Process	Regulation of Notch signaling pathway	IEA
GO:0009612	Process	Response to mechanical stimulus	IEA
GO:0009888	Process	Tissue development	IEA
GO:0014850	Process	Response to muscle activity	IEA
GO:0014911	Process	Positive regulation of smooth muscle cell migration	IEA
GO:0030198	Process	Extracellular matrix organization	IBA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0031012	Component	Extracellular matrix	HDA	20551380
GO:0031012	Component	Extracellular matrix	HDA	25037231, 27068509, 27559042, 28327460, 28675934
GO:0031012	Component	Extracellular matrix	IBA
GO:0031012	Component	Extracellular matrix	IDA	18450759
GO:0031012	Component	Extracellular matrix	IEA
GO:0031012	Component	Extracellular matrix	ISS
GO:0031594	Component	Neuromuscular junction	IEA
GO:0032355	Process	Response to estradiol	IEA
GO:0044344	Process	Cellular response to fibroblast growth factor stimulus	IEA
GO:0046872	Function	Metal ion binding	IDA	18450759
GO:0050839	Function	Cell adhesion molecule binding	IBA
GO:0071307	Process	Cellular response to vitamin K	IDA	18450759
GO:0071307	Process	Cellular response to vitamin K	IEA
GO:0071356	Process	Cellular response to tumor necrosis factor	IEA
GO:0071560	Process	Cellular response to transforming growth factor beta stimulus	IEA
GO:1900025	Process	Negative regulation of substrate adhesion-dependent cell spreading	IEA
GO:1990138	Process	Neuron projection extension	IEA
GO:1990523	Process	Bone regeneration	IEA
GO:2000343	Process	Positive regulation of chemokine (C-X-C motif) ligand 2 production	IEA

MIM	HGNC	e!Ensembl
608777	16953	ENSG00000133110

Q15063

Protein name

Periostin (PN) (Osteoblast-specific factor 2) (OSF-2)

Protein function

Induces cell attachment and spreading and plays a role in cell adhesion (PubMed:12235007). Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity)

PDB

5WT7 , 5YJG , 5YJH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02469	Fasciclin	109 → 232	Fasciclin domain	Domain
PF02469	Fasciclin	245 → 367	Fasciclin domain	Domain
PF02469	Fasciclin	379 → 494	Fasciclin domain	Domain
PF02469	Fasciclin	507 → 630	Fasciclin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Expressed in the kidney (PubMed:21763681). Expressed in the lung (PubMed:22079858). Up-regulated in epit

Sequence

MIPFLPMFSLLLLLIVNPINANNHYDKILAHSRIRGRDQGPNVCALQQILGTKKKYFSTC
KNWYKKSICGQKTTVLYECCPGYMRMEGMKGCPAVLPIDHVYGTLGIVGATTTQRYSDAS
KLREEIEGKGSFTYFAPSNEAWDNLDSDIRRGLESNVNVELLNALHSHMINKRMLTKDLK
NGMIIPSMYNNLGLFINHYPNGVVTVNCARIIHGNQIATNGVVHVIDRVLTQIGTSIQDF
IEAEDDLSSFRAAAITSDILEALGRDGHFTLFAPTNEAFEKLPRGVLERIMGDKVASEAL
MKYHILNTLQCSESIMGGAVFETLEGNTIEIGCDGDSITVNGIKMVNKKDIVTNNGVIHL
IDQVLIPDSAKQVIELAGKQQTTFTDLVAQLGLASALRPDGEYTLLAPVNNAFSDDTLSM
DQRLLKLILQNHILKVKVGLNELYNGQILETIGGKQLRVFVYRTAVCIENSCMEKGSKQG
RNGAIHIFREIIKPAEKSLHEKLKQDKRFSTFLSLLEAADLKELLTQPGDWTLFVPTNDA
FKGMTSEEKEILIRDKNALQNIILYHLTPGVFIGKGFEPGVTNILKTTQGSKIFLKEVND
TLLVNELKSKESDIMTTNGVIHVVDKLLYPADTPVGNDQLLEILNKLIKYIQIKFVRGST
FKEIPVTVYTTKIITKVVEPKIKVIEGSLQPIIKTEGPTLTKVKIEGEPEFRLIKEGETI
TEVIHGEPIIKKYTKIIDGVPVEITEKETREERIITGPEIKYTRISTGGGETEETLKKLL
QEEVTKVTKFIEGGDGHLFEDEEIKRLLQGDTPVRKLQANKKVQGSRRRLREGRSQ

Sequence length

836

Interactions

View interactions

POSTN (periostin)