Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10630
Gene name Gene Name - the full gene name approved by the HGNC.
Podoplanin
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PDPN
Synonyms (NCBI Gene) Gene synonyms aliases
AGGRUS, D2-40, GP36, GP40, Gp38, HT1A-1, OTS8, PA2.26, T1A, T1A-2, T1A2, TI1A
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.21
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a di
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT007320 hsa-miR-363-3p Luciferase reporter assay 23246488
MIRT007320 hsa-miR-363-3p Luciferase reporter assay 23246488
MIRT007320 hsa-miR-363-3p Luciferase reporter assay 23246488
MIRT667012 hsa-miR-302f HITS-CLIP 23706177
MIRT667009 hsa-miR-4695-5p HITS-CLIP 23706177
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001726 Component Ruffle ISS
GO:0001946 Process Lymphangiogenesis ISS
GO:0005102 Function Signaling receptor binding IDA 18215137
GO:0005372 Function Water transmembrane transporter activity ISS
GO:0005515 Function Protein binding IPI 17046996, 17616532, 18215137, 18541721, 19268462, 20962267, 25458834, 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608863 29602 ENSG00000162493
Protein
UniProt ID Q86YL7
Protein name Podoplanin (Aggrus) (Glycoprotein 36) (Gp36) (PA2.26 antigen) (T1-alpha) (T1A) [Cleaved into: 29kDa cytosolic podoplanin intracellular domain (PICD)]
Protein function Mediates effects on cell migration and adhesion through its different partners. During development plays a role in blood and lymphatic vessels separation by binding CLEC1B, triggering CLEC1B activation in platelets and leading to platelet activa
PDB 3WSR , 4YO0 , 5XCV , 7C94 , 7CQC , 7CQD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05808 Podoplanin 28 161 Family
Tissue specificity TISSUE SPECIFICITY: Highly expressed in placenta, lung, skeletal muscle and brain. Weakly expressed in brain, kidney and liver. In placenta, expressed on the apical plasma membrane of endothelium. In lung, expressed in alveolar epithelium. Up-regulated in
Sequence
Sequence length 162
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    GPVI-mediated activation cascade
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Prostate cancer Prostate cancer (late onset) N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Abnormalities Drug Induced Associate 21059220
Adenocarcinoma Associate 20923309, 30257286
Adenocarcinoma of Lung Associate 36376711
Aicardi Syndrome Stimulate 31452946
Ameloblastoma Associate 25820557
Arthritis Stimulate 28793332
Arthritis Rheumatoid Associate 21385358, 24932813, 32668112, 36208493
Arthritis Rheumatoid Stimulate 29476097, 34855235
Astrocytoma Associate 20665731
Atypical Squamous Cells of the Cervix Associate 21340215