Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10628
Gene name Gene Name - the full gene name approved by the HGNC.
Thioredoxin interacting protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TXNIP
Synonyms (NCBI Gene) Gene synonyms aliases
ARRDC6, EST01027, HHCPA78, THIF, VDUP1
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inh
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT005561 hsa-miR-373-3p Luciferase reporter assay, qRT-PCR, Western blot 21271679
MIRT019486 hsa-miR-148b-3p Microarray 17612493
MIRT022063 hsa-miR-128-3p Microarray 17612493
MIRT025014 hsa-miR-183-5p Sequencing 20371350
MIRT025554 hsa-miR-34a-5p Sequencing 20371350
Transcription factors
Transcription factor Regulation Reference
FOXO1 Repression 23803610
FOXO3 Activation 20656682
HDAC1 Repression 19351825
HDAC10 Repression 20680488
KLF6 Unknown 19808645
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000122 Process Negative regulation of transcription by RNA polymerase II IEA
GO:0004857 Function Enzyme inhibitor activity IEA
GO:0005515 Function Protein binding IPI 10814541, 14632196, 17260951, 23880345, 26919541, 28514442, 32296183
GO:0005634 Component Nucleus IEA
GO:0005737 Component Cytoplasm IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606599 16952 ENSG00000265972
Protein
UniProt ID Q9H3M7
Protein name Thioredoxin-interacting protein (Thioredoxin-binding protein 2) (Vitamin D3 up-regulated protein 1)
Protein function May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translo
PDB 4GEI , 4GEJ , 4GFX , 4LL1 , 4LL4 , 4ROF , 4ROJ , 5CQ2 , 5DF6 , 5DWS , 5DZD
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00339 Arrestin_N 10 152 Arrestin (or S-antigen), N-terminal domain Domain
PF02752 Arrestin_C 174 300 Arrestin (or S-antigen), C-terminal domain Domain
Sequence
Sequence length 391
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  NOD-like receptor signaling pathway   The NLRP3 inflammasome
Purinergic signaling in leishmaniasis infection
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Diffuse lymphoma Diffuse Large B-Cell Lymphoma rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291 16081686
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 19192274
Unknown
Disease term Disease name Evidence References Source
Endometriosis Endometriosis 21063030 ClinVar
Associations from Text Mining
Disease Name Relationship Type References
Acidosis Associate 30717828, 38069241
Acidosis Lactic Associate 30755400
Acidosis Lactic Stimulate 38195466
Acute Coronary Syndrome Associate 36830671
Airway Remodeling Associate 25041788
Alzheimer Disease Stimulate 30741672
Alzheimer Disease Associate 34153352, 36422510
Anemia Aplastic Associate 39596362
Angina Stable Associate 36830671
Angina Unstable Stimulate 29245343, 30034557