HEXIM1 (HEXIM P-TEFb complex subunit 1)

Gene

• Entrez ID: 10614
• Gene name: HEXIM P-TEFb complex subunit 1
• Gene symbol: HEXIM1
• Synonyms (NCBI Gene): CLP1, EDG1, HIS1, MAQ1
• Chromosome: 17
• Chromosome location: 17q21.31
• Summary: Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT051053	hsa-miR-17-5p	CLASH	23622248
MIRT050765	hsa-miR-17-3p	CLASH	23622248
MIRT050623	hsa-miR-20a-5p	CLASH	23622248
MIRT046764	hsa-miR-222-3p	CLASH	23622248
MIRT042951	hsa-miR-324-3p	CLASH	23622248
MIRT041122	hsa-miR-503-5p	CLASH	23622248
MIRT702980	hsa-miR-548av-3p	HITS-CLIP	23313552
MIRT702979	hsa-miR-1252-3p	HITS-CLIP	23313552
MIRT702978	hsa-miR-495-3p	HITS-CLIP	23313552
MIRT702977	hsa-miR-5688	HITS-CLIP	23313552
MIRT702976	hsa-miR-7-1-3p	HITS-CLIP	23313552
MIRT702975	hsa-miR-7-2-3p	HITS-CLIP	23313552
MIRT702974	hsa-miR-203a-3p	HITS-CLIP	23313552
MIRT702973	hsa-miR-3975	HITS-CLIP	23313552
MIRT702972	hsa-miR-2467-5p	HITS-CLIP	23313552
MIRT702971	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT702970	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT702969	hsa-miR-3188	HITS-CLIP	23313552
MIRT702968	hsa-miR-8065	HITS-CLIP	23313552
MIRT702967	hsa-miR-4697-3p	HITS-CLIP	23313552
MIRT702966	hsa-miR-223-3p	HITS-CLIP	23313552
MIRT702965	hsa-miR-5093	HITS-CLIP	23313552
MIRT702980	hsa-miR-548av-3p	HITS-CLIP	23313552
MIRT702979	hsa-miR-1252-3p	HITS-CLIP	23313552
MIRT702978	hsa-miR-495-3p	HITS-CLIP	23313552
MIRT702977	hsa-miR-5688	HITS-CLIP	23313552
MIRT702976	hsa-miR-7-1-3p	HITS-CLIP	23313552
MIRT702975	hsa-miR-7-2-3p	HITS-CLIP	23313552
MIRT702974	hsa-miR-203a-3p	HITS-CLIP	23313552
MIRT702973	hsa-miR-3975	HITS-CLIP	23313552
MIRT702972	hsa-miR-2467-5p	HITS-CLIP	23313552
MIRT702971	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT702970	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT702969	hsa-miR-3188	HITS-CLIP	23313552
MIRT702968	hsa-miR-8065	HITS-CLIP	23313552
MIRT702967	hsa-miR-4697-3p	HITS-CLIP	23313552
MIRT702966	hsa-miR-223-3p	HITS-CLIP	23313552
MIRT702965	hsa-miR-5093	HITS-CLIP	23313552
MIRT1044711	hsa-miR-1208	CLIP-seq
MIRT1044712	hsa-miR-1245	CLIP-seq
MIRT1044713	hsa-miR-1266	CLIP-seq
MIRT1044714	hsa-miR-1468	CLIP-seq
MIRT1044715	hsa-miR-181a	CLIP-seq
MIRT1044716	hsa-miR-181b	CLIP-seq
MIRT1044717	hsa-miR-181c	CLIP-seq
MIRT1044718	hsa-miR-181d	CLIP-seq
MIRT1044719	hsa-miR-18a	CLIP-seq
MIRT1044720	hsa-miR-18b	CLIP-seq
MIRT1044721	hsa-miR-2053	CLIP-seq
MIRT1044722	hsa-miR-2114	CLIP-seq
MIRT1044723	hsa-miR-2117	CLIP-seq
MIRT1044724	hsa-miR-23a	CLIP-seq
MIRT1044725	hsa-miR-23b	CLIP-seq
MIRT1044726	hsa-miR-23c	CLIP-seq
MIRT1044727	hsa-miR-300	CLIP-seq
MIRT1044728	hsa-miR-3074-3p	CLIP-seq
MIRT1044729	hsa-miR-3121-5p	CLIP-seq
MIRT1044730	hsa-miR-3127-3p	CLIP-seq
MIRT1044731	hsa-miR-3127-5p	CLIP-seq
MIRT1044732	hsa-miR-3133	CLIP-seq
MIRT1044733	hsa-miR-3152-5p	CLIP-seq
MIRT1044734	hsa-miR-3162-3p	CLIP-seq
MIRT1044735	hsa-miR-3168	CLIP-seq
MIRT1044736	hsa-miR-3173-3p	CLIP-seq
MIRT1044737	hsa-miR-3187-3p	CLIP-seq
MIRT1044738	hsa-miR-3545-3p	CLIP-seq
MIRT1044739	hsa-miR-3607-3p	CLIP-seq
MIRT1044740	hsa-miR-3613-3p	CLIP-seq
MIRT1044741	hsa-miR-361-3p	CLIP-seq
MIRT1044742	hsa-miR-3616-5p	CLIP-seq
MIRT1044743	hsa-miR-3647-5p	CLIP-seq
MIRT1044744	hsa-miR-3664-3p	CLIP-seq
MIRT1044745	hsa-miR-381	CLIP-seq
MIRT1044746	hsa-miR-3918	CLIP-seq
MIRT1044747	hsa-miR-409-3p	CLIP-seq
MIRT1044748	hsa-miR-410	CLIP-seq
MIRT1044749	hsa-miR-4262	CLIP-seq
MIRT1044750	hsa-miR-4273	CLIP-seq
MIRT1044751	hsa-miR-4313	CLIP-seq
MIRT1044752	hsa-miR-4330	CLIP-seq
MIRT1044753	hsa-miR-4428	CLIP-seq
MIRT1044754	hsa-miR-4435	CLIP-seq
MIRT1044755	hsa-miR-4450	CLIP-seq
MIRT1044756	hsa-miR-4452	CLIP-seq
MIRT1044757	hsa-miR-4477b	CLIP-seq
MIRT1044758	hsa-miR-4512	CLIP-seq
MIRT1044759	hsa-miR-4518	CLIP-seq
MIRT1044760	hsa-miR-4539	CLIP-seq
MIRT1044761	hsa-miR-4635	CLIP-seq
MIRT1044762	hsa-miR-4643	CLIP-seq
MIRT1044763	hsa-miR-466	CLIP-seq
MIRT1044764	hsa-miR-4677-5p	CLIP-seq
MIRT1044765	hsa-miR-4701-5p	CLIP-seq
MIRT1044766	hsa-miR-4735-3p	CLIP-seq
MIRT1044767	hsa-miR-4761-5p	CLIP-seq
MIRT1044768	hsa-miR-4768-3p	CLIP-seq
MIRT1044769	hsa-miR-4773	CLIP-seq
MIRT1044770	hsa-miR-4774-3p	CLIP-seq
MIRT1044771	hsa-miR-4779	CLIP-seq
MIRT1044772	hsa-miR-4789-3p	CLIP-seq
MIRT1044773	hsa-miR-4789-5p	CLIP-seq
MIRT1044774	hsa-miR-491-3p	CLIP-seq
MIRT1044775	hsa-miR-495	CLIP-seq
MIRT1044776	hsa-miR-513a-3p	CLIP-seq
MIRT1044777	hsa-miR-548ac	CLIP-seq
MIRT1044778	hsa-miR-548ae	CLIP-seq
MIRT1044779	hsa-miR-548aj	CLIP-seq
MIRT1044780	hsa-miR-548am	CLIP-seq
MIRT1044781	hsa-miR-548d-3p	CLIP-seq
MIRT1044782	hsa-miR-548s	CLIP-seq
MIRT1044783	hsa-miR-548x	CLIP-seq
MIRT1044784	hsa-miR-548z	CLIP-seq
MIRT1044785	hsa-miR-561	CLIP-seq
MIRT1044786	hsa-miR-573	CLIP-seq
MIRT1044787	hsa-miR-588	CLIP-seq
MIRT1044788	hsa-miR-599	CLIP-seq
MIRT1044789	hsa-miR-624	CLIP-seq
MIRT2009741	hsa-miR-1207-3p	CLIP-seq
MIRT1044711	hsa-miR-1208	CLIP-seq
MIRT2009742	hsa-miR-1224-5p	CLIP-seq
MIRT2009743	hsa-miR-1236	CLIP-seq
MIRT2009744	hsa-miR-1252	CLIP-seq
MIRT2009745	hsa-miR-125a-3p	CLIP-seq
MIRT1044715	hsa-miR-181a	CLIP-seq
MIRT1044716	hsa-miR-181b	CLIP-seq
MIRT1044717	hsa-miR-181c	CLIP-seq
MIRT1044718	hsa-miR-181d	CLIP-seq
MIRT2009746	hsa-miR-216a	CLIP-seq
MIRT1044724	hsa-miR-23a	CLIP-seq
MIRT1044725	hsa-miR-23b	CLIP-seq
MIRT1044726	hsa-miR-23c	CLIP-seq
MIRT1044729	hsa-miR-3121-5p	CLIP-seq
MIRT1044730	hsa-miR-3127-3p	CLIP-seq
MIRT1044732	hsa-miR-3133	CLIP-seq
MIRT2009747	hsa-miR-3169	CLIP-seq
MIRT2009748	hsa-miR-340	CLIP-seq
MIRT1044739	hsa-miR-3607-3p	CLIP-seq
MIRT2009749	hsa-miR-3612	CLIP-seq
MIRT1044740	hsa-miR-3613-3p	CLIP-seq
MIRT1044741	hsa-miR-361-3p	CLIP-seq
MIRT2009750	hsa-miR-3662	CLIP-seq
MIRT2009751	hsa-miR-3665	CLIP-seq
MIRT1044747	hsa-miR-409-3p	CLIP-seq
MIRT1044748	hsa-miR-410	CLIP-seq
MIRT1044749	hsa-miR-4262	CLIP-seq
MIRT1044751	hsa-miR-4313	CLIP-seq
MIRT2009752	hsa-miR-4436b-3p	CLIP-seq
MIRT1044755	hsa-miR-4450	CLIP-seq
MIRT1044756	hsa-miR-4452	CLIP-seq
MIRT2009753	hsa-miR-4459	CLIP-seq
MIRT2009754	hsa-miR-4515	CLIP-seq
MIRT1044762	hsa-miR-4643	CLIP-seq
MIRT1044763	hsa-miR-466	CLIP-seq
MIRT2009755	hsa-miR-4695-5p	CLIP-seq
MIRT2009756	hsa-miR-4698	CLIP-seq
MIRT2009757	hsa-miR-4712-5p	CLIP-seq
MIRT2009758	hsa-miR-4729	CLIP-seq
MIRT2009759	hsa-miR-4736	CLIP-seq
MIRT2009760	hsa-miR-4751	CLIP-seq
MIRT2009761	hsa-miR-4777-3p	CLIP-seq
MIRT1044772	hsa-miR-4789-3p	CLIP-seq
MIRT1044773	hsa-miR-4789-5p	CLIP-seq
MIRT1044788	hsa-miR-599	CLIP-seq
MIRT2009762	hsa-miR-605	CLIP-seq
MIRT2009763	hsa-miR-642b	CLIP-seq
MIRT2009764	hsa-miR-650	CLIP-seq
MIRT2009765	hsa-miR-770-5p	CLIP-seq
MIRT1044711	hsa-miR-1208	CLIP-seq
MIRT2009743	hsa-miR-1236	CLIP-seq
MIRT2009744	hsa-miR-1252	CLIP-seq
MIRT2009745	hsa-miR-125a-3p	CLIP-seq
MIRT1044715	hsa-miR-181a	CLIP-seq
MIRT1044716	hsa-miR-181b	CLIP-seq
MIRT1044717	hsa-miR-181c	CLIP-seq
MIRT1044718	hsa-miR-181d	CLIP-seq
MIRT2242095	hsa-miR-1910	CLIP-seq
MIRT1044723	hsa-miR-2117	CLIP-seq
MIRT1044724	hsa-miR-23a	CLIP-seq
MIRT1044725	hsa-miR-23b	CLIP-seq
MIRT1044726	hsa-miR-23c	CLIP-seq
MIRT1044729	hsa-miR-3121-5p	CLIP-seq
MIRT1044730	hsa-miR-3127-3p	CLIP-seq
MIRT2242096	hsa-miR-3167	CLIP-seq
MIRT2009747	hsa-miR-3169	CLIP-seq
MIRT2242097	hsa-miR-3182	CLIP-seq
MIRT1044737	hsa-miR-3187-3p	CLIP-seq
MIRT2009748	hsa-miR-340	CLIP-seq
MIRT1044739	hsa-miR-3607-3p	CLIP-seq
MIRT1044740	hsa-miR-3613-3p	CLIP-seq
MIRT1044741	hsa-miR-361-3p	CLIP-seq
MIRT2009751	hsa-miR-3665	CLIP-seq
MIRT2242098	hsa-miR-3920	CLIP-seq
MIRT1044747	hsa-miR-409-3p	CLIP-seq
MIRT1044748	hsa-miR-410	CLIP-seq
MIRT1044749	hsa-miR-4262	CLIP-seq
MIRT2242099	hsa-miR-4264	CLIP-seq
MIRT2242100	hsa-miR-4267	CLIP-seq
MIRT1044750	hsa-miR-4273	CLIP-seq
MIRT1044751	hsa-miR-4313	CLIP-seq
MIRT2242101	hsa-miR-4328	CLIP-seq
MIRT1044752	hsa-miR-4330	CLIP-seq
MIRT1044754	hsa-miR-4435	CLIP-seq
MIRT2009752	hsa-miR-4436b-3p	CLIP-seq
MIRT1044755	hsa-miR-4450	CLIP-seq
MIRT1044756	hsa-miR-4452	CLIP-seq
MIRT1044757	hsa-miR-4477b	CLIP-seq
MIRT2242102	hsa-miR-4493	CLIP-seq
MIRT2009754	hsa-miR-4515	CLIP-seq
MIRT2242103	hsa-miR-455-3p	CLIP-seq
MIRT1044764	hsa-miR-4677-5p	CLIP-seq
MIRT1044765	hsa-miR-4701-5p	CLIP-seq
MIRT2009759	hsa-miR-4736	CLIP-seq
MIRT2242104	hsa-miR-4753-3p	CLIP-seq
MIRT2242105	hsa-miR-4762-3p	CLIP-seq
MIRT2242106	hsa-miR-4768-5p	CLIP-seq
MIRT1044782	hsa-miR-548s	CLIP-seq
MIRT1044787	hsa-miR-588	CLIP-seq
MIRT2242107	hsa-miR-592	CLIP-seq
MIRT2242108	hsa-miR-597	CLIP-seq
MIRT2009762	hsa-miR-605	CLIP-seq
MIRT2009763	hsa-miR-642b	CLIP-seq
MIRT2242109	hsa-miR-876-5p	CLIP-seq
MIRT2009744	hsa-miR-1252	CLIP-seq
MIRT2009745	hsa-miR-125a-3p	CLIP-seq
MIRT1044715	hsa-miR-181a	CLIP-seq
MIRT1044716	hsa-miR-181b	CLIP-seq
MIRT1044717	hsa-miR-181c	CLIP-seq
MIRT1044718	hsa-miR-181d	CLIP-seq
MIRT2009746	hsa-miR-216a	CLIP-seq
MIRT2009747	hsa-miR-3169	CLIP-seq
MIRT2009750	hsa-miR-3662	CLIP-seq
MIRT2009751	hsa-miR-3665	CLIP-seq
MIRT1044747	hsa-miR-409-3p	CLIP-seq
MIRT1044748	hsa-miR-410	CLIP-seq
MIRT1044749	hsa-miR-4262	CLIP-seq
MIRT2009752	hsa-miR-4436b-3p	CLIP-seq
MIRT2009754	hsa-miR-4515	CLIP-seq
MIRT1044762	hsa-miR-4643	CLIP-seq
MIRT1044763	hsa-miR-466	CLIP-seq
MIRT2009756	hsa-miR-4698	CLIP-seq
MIRT2009759	hsa-miR-4736	CLIP-seq
MIRT1044772	hsa-miR-4789-3p	CLIP-seq
MIRT1044773	hsa-miR-4789-5p	CLIP-seq
MIRT2009763	hsa-miR-642b	CLIP-seq
MIRT2451133	hsa-miR-4798-5p	CLIP-seq
MIRT2009744	hsa-miR-1252	CLIP-seq
MIRT2009745	hsa-miR-125a-3p	CLIP-seq
MIRT2545748	hsa-miR-129-5p	CLIP-seq
MIRT2545749	hsa-miR-2052	CLIP-seq
MIRT2009746	hsa-miR-216a	CLIP-seq
MIRT2009747	hsa-miR-3169	CLIP-seq
MIRT2009749	hsa-miR-3612	CLIP-seq
MIRT2009750	hsa-miR-3662	CLIP-seq
MIRT2009751	hsa-miR-3665	CLIP-seq
MIRT2545750	hsa-miR-4260	CLIP-seq
MIRT2009752	hsa-miR-4436b-3p	CLIP-seq
MIRT2009753	hsa-miR-4459	CLIP-seq
MIRT2009754	hsa-miR-4515	CLIP-seq
MIRT1044760	hsa-miR-4539	CLIP-seq
MIRT2545751	hsa-miR-4652-3p	CLIP-seq
MIRT2009755	hsa-miR-4695-5p	CLIP-seq
MIRT2009756	hsa-miR-4698	CLIP-seq
MIRT2009757	hsa-miR-4712-5p	CLIP-seq
MIRT2009759	hsa-miR-4736	CLIP-seq
MIRT2009761	hsa-miR-4777-3p	CLIP-seq
MIRT2545752	hsa-miR-486-3p	CLIP-seq
MIRT2009762	hsa-miR-605	CLIP-seq
MIRT2009763	hsa-miR-642b	CLIP-seq
MIRT2009764	hsa-miR-650	CLIP-seq
MIRT2009765	hsa-miR-770-5p	CLIP-seq
MIRT2009744	hsa-miR-1252	CLIP-seq
MIRT2009745	hsa-miR-125a-3p	CLIP-seq
MIRT2009747	hsa-miR-3169	CLIP-seq
MIRT2009749	hsa-miR-3612	CLIP-seq
MIRT2009750	hsa-miR-3662	CLIP-seq
MIRT2009751	hsa-miR-3665	CLIP-seq
MIRT2009752	hsa-miR-4436b-3p	CLIP-seq
MIRT2009753	hsa-miR-4459	CLIP-seq
MIRT2009754	hsa-miR-4515	CLIP-seq
MIRT2009755	hsa-miR-4695-5p	CLIP-seq
MIRT2009756	hsa-miR-4698	CLIP-seq
MIRT2682275	hsa-miR-4713-5p	CLIP-seq
MIRT2009759	hsa-miR-4736	CLIP-seq
MIRT2009763	hsa-miR-642b	CLIP-seq
MIRT2009764	hsa-miR-650	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	18483487
GO:0002218	Process	Activation of innate immune response	IDA	28712728
GO:0002376	Process	Immune system process	IEA
GO:0004860	Function	Protein kinase inhibitor activity	IDA	28431135
GO:0004861	Function	Cyclin-dependent protein serine/threonine kinase inhibitor activity	IBA
GO:0004861	Function	Cyclin-dependent protein serine/threonine kinase inhibitor activity	IDA	14580347
GO:0004861	Function	Cyclin-dependent protein serine/threonine kinase inhibitor activity	IEA
GO:0005515	Function	Protein binding	IPI	12832472, 14580347, 15713661, 15941832, 17724342, 18281698, 18483487, 19387490, 19883659, 20562857, 21044950, 21533037, 23455922, 24360279, 24981860, 25470060, 28514442, 30824372, 32296183, 32707033, 33961781, 35271311, 39251607
GO:0005634	Component	Nucleus	IDA	12581153, 28712728
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	12581153
GO:0005737	Component	Cytoplasm	IEA
GO:0007507	Process	Heart development	IEA
GO:0017069	Function	SnRNA binding	IDA	14580347
GO:0017069	Function	SnRNA binding	IEA
GO:0032897	Process	Negative regulation of viral transcription	IMP	18249148
GO:0034244	Process	Negative regulation of transcription elongation by RNA polymerase II	IC	18483487
GO:0034244	Process	Negative regulation of transcription elongation by RNA polymerase II	IDA	14580347
GO:0042802	Function	Identical protein binding	IPI	17724342, 31515488
GO:0045087	Process	Innate immune response	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IEA
GO:0097322	Function	7SK snRNA binding	IBA
GO:0097322	Function	7SK snRNA binding	IDA	12832472, 18249148, 18483487, 19883659, 28431135
GO:0106140	Function	P-TEFb complex binding	IDA	18249148, 18483487, 28431135
GO:0120259	Component	7SK snRNP	IDA	18249148, 18483487, 28431135
GO:0140416	Function	Transcription regulator inhibitor activity	IDA	14580347
GO:1901798	Process	Positive regulation of signal transduction by p53 class mediator	IMP	22948151

Other IDs

• MIM: 607328
• HGNC: 24953
• e!Ensembl: ENSG00000186834

Protein

• UniProt ID: O94992
• Protein name: Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1)
• Protein function: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15201869, PubMed:15713661). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a lar
• PDB: 2GD7, 3S9G
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15313	HEXIM	164 → 301	Hexamethylene bis-acetamide-inducible protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. {ECO:0000269|PubMed:12941847, ECO:0000269|PubMed:15713661}.
• Sequence:

  MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQLGGRPG
  PEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDSSAGGDFPPPAEVEPTPEAELLAQ
  PCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDE
  KQSLRASRIRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYSKRAAAKSDDTSDDD
  FMEEGGEEDGGSDGMGGDGSEFLQRDFSETYERYHTESLQNMSKQELIKEYLELEKCLSR
  MEDENNRLRLESKRLGGDDARVRELELELDRLRAENLQLLTENELHRQQERAPLSKFGD

• Sequence length: 359