Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	10610
Gene name	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
Gene symbol	ST6GALNAC2
Synonyms (NCBI Gene)	SAITL1SIAT7SIAT7BSIATL1ST6GalNAIISTHM
Chromosome	17
Chromosome location	17q25.1
Summary	ST6GALNAC2 belongs to a family of sialyltransferases that add sialic acids to the nonreducing ends of glycoconjugates. At the cell surface, these modifications have roles in cell-cell and cell-substrate interactions, bacterial adhesion, and protein target

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miRTarBase ID	miRNA	Experiments
MIRT2118139	hsa-miR-1255a	CLIP-seq
MIRT2118140	hsa-miR-1255b	CLIP-seq
MIRT2118141	hsa-miR-1289	CLIP-seq
MIRT2118142	hsa-miR-136	CLIP-seq
MIRT2118143	hsa-miR-1587	CLIP-seq
MIRT2118144	hsa-miR-3127-5p	CLIP-seq
MIRT2118145	hsa-miR-3135b	CLIP-seq
MIRT2118146	hsa-miR-3140-3p	CLIP-seq
MIRT2118147	hsa-miR-3187-3p	CLIP-seq
MIRT2118148	hsa-miR-3193	CLIP-seq
MIRT2118149	hsa-miR-3198	CLIP-seq
MIRT2118150	hsa-miR-320e	CLIP-seq
MIRT2118151	hsa-miR-337-3p	CLIP-seq
MIRT2118152	hsa-miR-342-5p	CLIP-seq
MIRT2118153	hsa-miR-34b	CLIP-seq
MIRT2118154	hsa-miR-3652	CLIP-seq
MIRT2118155	hsa-miR-3685	CLIP-seq
MIRT2118156	hsa-miR-384	CLIP-seq
MIRT2118157	hsa-miR-3918	CLIP-seq
MIRT2118158	hsa-miR-4254	CLIP-seq
MIRT2118159	hsa-miR-4294	CLIP-seq
MIRT2118160	hsa-miR-4309	CLIP-seq
MIRT2118161	hsa-miR-432	CLIP-seq
MIRT2118162	hsa-miR-4430	CLIP-seq
MIRT2118163	hsa-miR-4435	CLIP-seq
MIRT2118164	hsa-miR-4492	CLIP-seq
MIRT2118165	hsa-miR-4498	CLIP-seq
MIRT2118166	hsa-miR-4651	CLIP-seq
MIRT2118167	hsa-miR-4656	CLIP-seq
MIRT2118168	hsa-miR-4664-5p	CLIP-seq
MIRT2118169	hsa-miR-4674	CLIP-seq
MIRT2118170	hsa-miR-4675	CLIP-seq
MIRT2118171	hsa-miR-4701-5p	CLIP-seq
MIRT2118172	hsa-miR-4731-5p	CLIP-seq
MIRT2118173	hsa-miR-4741	CLIP-seq
MIRT2118174	hsa-miR-4760-5p	CLIP-seq
MIRT2118175	hsa-miR-4772-5p	CLIP-seq
MIRT2118176	hsa-miR-548s	CLIP-seq
MIRT2118177	hsa-miR-561	CLIP-seq
MIRT2118178	hsa-miR-588	CLIP-seq
MIRT2118179	hsa-miR-596	CLIP-seq
MIRT2118180	hsa-miR-608	CLIP-seq
MIRT2118181	hsa-miR-676	CLIP-seq
MIRT2118182	hsa-miR-762	CLIP-seq
MIRT2340185	hsa-miR-1178	CLIP-seq
MIRT2340186	hsa-miR-148a	CLIP-seq
MIRT2340187	hsa-miR-148b	CLIP-seq
MIRT2340188	hsa-miR-152	CLIP-seq
MIRT2340189	hsa-miR-3199	CLIP-seq
MIRT2340190	hsa-miR-338-3p	CLIP-seq
MIRT2340191	hsa-miR-3675-3p	CLIP-seq
MIRT2118155	hsa-miR-3685	CLIP-seq
MIRT2118156	hsa-miR-384	CLIP-seq
MIRT2340192	hsa-miR-4506	CLIP-seq
MIRT2340193	hsa-miR-4530	CLIP-seq
MIRT2118177	hsa-miR-561	CLIP-seq
MIRT2340194	hsa-miR-617	CLIP-seq
MIRT2340195	hsa-miR-628-5p	CLIP-seq
MIRT2340196	hsa-miR-642a	CLIP-seq
MIRT2433612	hsa-miR-149	CLIP-seq
MIRT2433613	hsa-miR-150	CLIP-seq
MIRT2433614	hsa-miR-3064-5p	CLIP-seq
MIRT2433615	hsa-miR-3119	CLIP-seq
MIRT2433616	hsa-miR-3156-3p	CLIP-seq
MIRT2433617	hsa-miR-4301	CLIP-seq
MIRT2433618	hsa-miR-4713-5p	CLIP-seq
MIRT2433619	hsa-miR-4794	CLIP-seq
MIRT2433620	hsa-miR-4795-3p	CLIP-seq
MIRT2433621	hsa-miR-532-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000139	Component	Golgi membrane	IEA
GO:0000139	Component	Golgi membrane	TAS
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IBA
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IDA	10742600, 29251719
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	IEA
GO:0001665	Function	Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity	TAS
GO:0005794	Component	Golgi apparatus	IEA
GO:0006486	Process	Protein glycosylation	IDA	29251719
GO:0006486	Process	Protein glycosylation	IEA
GO:0006493	Process	Protein O-linked glycosylation	IBA
GO:0006493	Process	Protein O-linked glycosylation	IDA	10742600
GO:0008373	Function	Sialyltransferase activity	IEA
GO:0008373	Function	Sialyltransferase activity	TAS
GO:0016020	Component	Membrane	IEA
GO:0016266	Process	Protein O-linked glycosylation via N-acetyl-galactosamine	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA
GO:0019082	Process	Viral protein processing	TAS
GO:1990743	Process	Protein sialylation	IDA	10742600

MIM	HGNC	e!Ensembl
610137	10867	ENSG00000070731

Q9UJ37

Protein name

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (EC 2.4.3.3) (GalNAc alpha-2,6-sialyltransferase II) (ST6GalNAc II) (ST6GalNAcII) (SThM) (Sialyltransferase 7B) (SIAT7-B)

Protein function

Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed:10742600, PubMed:29251719). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or thre

PDB

6APJ , 6APL

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00777	Glyco_transf_29	90 → 373	Glycosyltransferase family 29 (sialyltransferase)	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in skeletal muscle, heart, kidney, placenta, lung and leukocytes. {ECO:0000269|PubMed:10742600}.

Sequence

MGLPRGSFFWLLLLLTAACSGLLFALYFSAVQRYPGPAAGARDTTSFEAFFQSKASNSWT
GKGQACRHLLHLAIQRHPHFRGLFNLSIPVLLWGDLFTPALWDRLSQHKAPYGWRGLSHQ
VIASTLSLLNGSESAKLFAPPRDTPPKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNG
AVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDLQYIFIPSDIRDYVML
RSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDL
YMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYFERKMKPLIFYANHDLSLEAALW
RDLHKAGILQLYQR

Sequence length

374

Interactions

View interactions

	KEGG		Reactome
	Mucin type O-glycan biosynthesis Metabolic pathways		Sialic acid metabolism Termination of O-glycan biosynthesis

ST6GALNAC2 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2)