Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	10595
Gene name	Endoplasmic reticulum to nucleus signaling 2
Gene symbol	ERN2
Synonyms (NCBI Gene)	IRE1-BETAIRE1bIRE2phIRE2p
Chromosome	16
Chromosome location	16p12.2

155

Show/Hide all (155)

miRTarBase ID	miRNA	Experiments
MIRT969666	hsa-miR-1200	CLIP-seq
MIRT969667	hsa-miR-1207-3p	CLIP-seq
MIRT969668	hsa-miR-122	CLIP-seq
MIRT969669	hsa-miR-1224-3p	CLIP-seq
MIRT969670	hsa-miR-1245	CLIP-seq
MIRT969671	hsa-miR-1254	CLIP-seq
MIRT969672	hsa-miR-1260	CLIP-seq
MIRT969673	hsa-miR-1260b	CLIP-seq
MIRT969674	hsa-miR-1280	CLIP-seq
MIRT969675	hsa-miR-150	CLIP-seq
MIRT969676	hsa-miR-24	CLIP-seq
MIRT969677	hsa-miR-3116	CLIP-seq
MIRT969678	hsa-miR-3135b	CLIP-seq
MIRT969679	hsa-miR-3138	CLIP-seq
MIRT969680	hsa-miR-3155	CLIP-seq
MIRT969681	hsa-miR-3155b	CLIP-seq
MIRT969682	hsa-miR-3183	CLIP-seq
MIRT969683	hsa-miR-3194-5p	CLIP-seq
MIRT969684	hsa-miR-3199	CLIP-seq
MIRT969685	hsa-miR-3619-3p	CLIP-seq
MIRT969686	hsa-miR-3652	CLIP-seq
MIRT969687	hsa-miR-3663-5p	CLIP-seq
MIRT969688	hsa-miR-3670	CLIP-seq
MIRT969689	hsa-miR-4303	CLIP-seq
MIRT969690	hsa-miR-4324	CLIP-seq
MIRT969691	hsa-miR-4430	CLIP-seq
MIRT969692	hsa-miR-4435	CLIP-seq
MIRT969693	hsa-miR-4438	CLIP-seq
MIRT969694	hsa-miR-4649-3p	CLIP-seq
MIRT969695	hsa-miR-4691-3p	CLIP-seq
MIRT969696	hsa-miR-4713-5p	CLIP-seq
MIRT969697	hsa-miR-4723-3p	CLIP-seq
MIRT969698	hsa-miR-4755-3p	CLIP-seq
MIRT969699	hsa-miR-4776-5p	CLIP-seq
MIRT969700	hsa-miR-4794	CLIP-seq
MIRT969701	hsa-miR-4800-5p	CLIP-seq
MIRT969702	hsa-miR-484	CLIP-seq
MIRT969703	hsa-miR-5095	CLIP-seq
MIRT969704	hsa-miR-532-3p	CLIP-seq
MIRT969705	hsa-miR-544b	CLIP-seq
MIRT969706	hsa-miR-646	CLIP-seq
MIRT969707	hsa-miR-661	CLIP-seq
MIRT969667	hsa-miR-1207-3p	CLIP-seq
MIRT969684	hsa-miR-3199	CLIP-seq
MIRT969693	hsa-miR-4438	CLIP-seq
MIRT969703	hsa-miR-5095	CLIP-seq
MIRT969706	hsa-miR-646	CLIP-seq
MIRT1922025	hsa-miR-149	CLIP-seq
MIRT969676	hsa-miR-24	CLIP-seq
MIRT1922026	hsa-miR-3622b-5p	CLIP-seq
MIRT1922027	hsa-miR-4284	CLIP-seq
MIRT1987438	hsa-miR-1184	CLIP-seq
MIRT1922025	hsa-miR-149	CLIP-seq
MIRT969675	hsa-miR-150	CLIP-seq
MIRT969676	hsa-miR-24	CLIP-seq
MIRT1922027	hsa-miR-4284	CLIP-seq
MIRT1987439	hsa-miR-4418	CLIP-seq
MIRT1987440	hsa-miR-509-3-5p	CLIP-seq
MIRT1987441	hsa-miR-509-5p	CLIP-seq
MIRT1987438	hsa-miR-1184	CLIP-seq
MIRT969666	hsa-miR-1200	CLIP-seq
MIRT969667	hsa-miR-1207-3p	CLIP-seq
MIRT969669	hsa-miR-1224-3p	CLIP-seq
MIRT969670	hsa-miR-1245	CLIP-seq
MIRT969671	hsa-miR-1254	CLIP-seq
MIRT969672	hsa-miR-1260	CLIP-seq
MIRT969673	hsa-miR-1260b	CLIP-seq
MIRT969674	hsa-miR-1280	CLIP-seq
MIRT2221825	hsa-miR-1343	CLIP-seq
MIRT1922025	hsa-miR-149	CLIP-seq
MIRT969675	hsa-miR-150	CLIP-seq
MIRT969676	hsa-miR-24	CLIP-seq
MIRT969677	hsa-miR-3116	CLIP-seq
MIRT2221826	hsa-miR-3187-3p	CLIP-seq
MIRT969684	hsa-miR-3199	CLIP-seq
MIRT969687	hsa-miR-3663-5p	CLIP-seq
MIRT969688	hsa-miR-3670	CLIP-seq
MIRT2221827	hsa-miR-378g	CLIP-seq
MIRT2221828	hsa-miR-3934	CLIP-seq
MIRT2221829	hsa-miR-4252	CLIP-seq
MIRT1922027	hsa-miR-4284	CLIP-seq
MIRT969690	hsa-miR-4324	CLIP-seq
MIRT1987439	hsa-miR-4418	CLIP-seq
MIRT2221830	hsa-miR-4423-5p	CLIP-seq
MIRT969692	hsa-miR-4435	CLIP-seq
MIRT2221831	hsa-miR-4437	CLIP-seq
MIRT969693	hsa-miR-4438	CLIP-seq
MIRT2221832	hsa-miR-4659a-5p	CLIP-seq
MIRT2221833	hsa-miR-4659b-5p	CLIP-seq
MIRT2221834	hsa-miR-4674	CLIP-seq
MIRT2221835	hsa-miR-4698	CLIP-seq
MIRT2221836	hsa-miR-4701-5p	CLIP-seq
MIRT969696	hsa-miR-4713-5p	CLIP-seq
MIRT2221837	hsa-miR-4716-5p	CLIP-seq
MIRT2221838	hsa-miR-4731-5p	CLIP-seq
MIRT2221839	hsa-miR-4735-5p	CLIP-seq
MIRT969698	hsa-miR-4755-3p	CLIP-seq
MIRT2221840	hsa-miR-4775	CLIP-seq
MIRT2221841	hsa-miR-4776-3p	CLIP-seq
MIRT2221842	hsa-miR-4781-3p	CLIP-seq
MIRT969700	hsa-miR-4794	CLIP-seq
MIRT1987440	hsa-miR-509-3-5p	CLIP-seq
MIRT969703	hsa-miR-5095	CLIP-seq
MIRT1987441	hsa-miR-509-5p	CLIP-seq
MIRT2221843	hsa-miR-512-5p	CLIP-seq
MIRT969704	hsa-miR-532-3p	CLIP-seq
MIRT969705	hsa-miR-544b	CLIP-seq
MIRT2221844	hsa-miR-548s	CLIP-seq
MIRT2221845	hsa-miR-552	CLIP-seq
MIRT2221846	hsa-miR-588	CLIP-seq
MIRT2221847	hsa-miR-590-3p	CLIP-seq
MIRT969706	hsa-miR-646	CLIP-seq
MIRT969707	hsa-miR-661	CLIP-seq
MIRT1987438	hsa-miR-1184	CLIP-seq
MIRT969669	hsa-miR-1224-3p	CLIP-seq
MIRT969671	hsa-miR-1254	CLIP-seq
MIRT969672	hsa-miR-1260	CLIP-seq
MIRT969673	hsa-miR-1260b	CLIP-seq
MIRT969674	hsa-miR-1280	CLIP-seq
MIRT2221825	hsa-miR-1343	CLIP-seq
MIRT969675	hsa-miR-150	CLIP-seq
MIRT969676	hsa-miR-24	CLIP-seq
MIRT969677	hsa-miR-3116	CLIP-seq
MIRT2221827	hsa-miR-378g	CLIP-seq
MIRT1922027	hsa-miR-4284	CLIP-seq
MIRT1987439	hsa-miR-4418	CLIP-seq
MIRT2221831	hsa-miR-4437	CLIP-seq
MIRT2221834	hsa-miR-4674	CLIP-seq
MIRT969696	hsa-miR-4713-5p	CLIP-seq
MIRT2221839	hsa-miR-4735-5p	CLIP-seq
MIRT2221840	hsa-miR-4775	CLIP-seq
MIRT969700	hsa-miR-4794	CLIP-seq
MIRT1987440	hsa-miR-509-3-5p	CLIP-seq
MIRT1987441	hsa-miR-509-5p	CLIP-seq
MIRT969704	hsa-miR-532-3p	CLIP-seq
MIRT2221847	hsa-miR-590-3p	CLIP-seq
MIRT969707	hsa-miR-661	CLIP-seq
MIRT969668	hsa-miR-122	CLIP-seq
MIRT1922025	hsa-miR-149	CLIP-seq
MIRT969676	hsa-miR-24	CLIP-seq
MIRT969678	hsa-miR-3135b	CLIP-seq
MIRT969679	hsa-miR-3138	CLIP-seq
MIRT969685	hsa-miR-3619-3p	CLIP-seq
MIRT1922026	hsa-miR-3622b-5p	CLIP-seq
MIRT969686	hsa-miR-3652	CLIP-seq
MIRT1922027	hsa-miR-4284	CLIP-seq
MIRT969691	hsa-miR-4430	CLIP-seq
MIRT969699	hsa-miR-4776-5p	CLIP-seq
MIRT969701	hsa-miR-4800-5p	CLIP-seq
MIRT969671	hsa-miR-1254	CLIP-seq
MIRT969677	hsa-miR-3116	CLIP-seq
MIRT969684	hsa-miR-3199	CLIP-seq
MIRT969693	hsa-miR-4438	CLIP-seq
MIRT969703	hsa-miR-5095	CLIP-seq
MIRT969707	hsa-miR-661	CLIP-seq

Show/Hide all (46)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	11175748
GO:0000287	Function	Magnesium ion binding	IEA
GO:0003824	Function	Catalytic activity	IEA
GO:0004519	Function	Endonuclease activity	IDA	11175748
GO:0004519	Function	Endonuclease activity	IEA
GO:0004521	Function	RNA endonuclease activity	IBA
GO:0004521	Function	RNA endonuclease activity	IEA
GO:0004540	Function	RNA nuclease activity	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	11175748
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005524	Function	ATP binding	IDA	11175748
GO:0005524	Function	ATP binding	IEA
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006397	Process	MRNA processing	IEA
GO:0006401	Process	RNA catabolic process	IEA
GO:0006468	Process	Protein phosphorylation	IDA	11175748
GO:0006915	Process	Apoptotic process	IEA
GO:0016020	Component	Membrane	IEA
GO:0016075	Process	RRNA catabolic process	IDA	11175748
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0030263	Process	Apoptotic chromosome condensation	IMP	11175748
GO:0030968	Process	Endoplasmic reticulum unfolded protein response	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	IEA
GO:0034976	Process	Response to endoplasmic reticulum stress	TAS	22013210
GO:0036498	Process	IRE1-mediated unfolded protein response	IBA
GO:0044322	Component	Endoplasmic reticulum quality control compartment	IEA
GO:0045892	Process	Negative regulation of DNA-templated transcription	IMP	11175748
GO:0046330	Process	Positive regulation of JNK cascade	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051082	Function	Unfolded protein binding	IBA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IBA
GO:0070059	Process	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IEA
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1990604	Component	IRE1-TRAF2-ASK1 complex	IBA
GO:1990604	Component	IRE1-TRAF2-ASK1 complex	IEA
GO:1990604	Component	IRE1-TRAF2-ASK1 complex	ISS

MIM	HGNC	e!Ensembl
604034	16942	ENSG00000134398

Q76MJ5

Protein name

Serine/threonine-protein kinase/endoribonuclease IRE2 (Endoplasmic reticulum-to-nucleus signaling 2) (Inositol-requiring protein 2) (hIRE2p) (Ire1-beta) (IRE1b) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]

Protein function

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00069	Pkinase	520 → 781	Protein kinase domain	Domain
PF06479	Ribonuc_2-5A	787 → 910	Ribonuclease 2-5A	Family

Sequence

MASAVRGSRPWPRLGLQLQFAALLLGTLSPQVHTLRPENLLLVSTLDGSLHALSKQTGDL
KWTLRDDPVIEGPMYVTEMAFLSDPADGSLYILGTQKQQGLMKLPFTIPELVHASPCRSS
DGVFYTGRKQDAWFVVDPESGETQMTLTTEGPSTPRLYIGRTQYTVTMHDPRAPALRWNT
TYRRYSAPPMDGSPGKYMSHLASCGMGLLLTVDPGSGTVLWTQDLGVPVMGVYTWHQDGL
RQLPHLTLARDTLHFLALRWGHIRLPASGPRDTATLFSTLDTQLLMTLYVGKDETGFYVS
KALVHTGVALVPRGLTLAPADGPTTDEVTLQVSGEREGSPSTAVRYPSGSVALPSQWLLI
GHHELPPVLHTTMLRVHPTLGSGTAETRPPENTQAPAFFLELLSLSREKLWDSELHPEEK
TPDSYLGLGPQDLLAASLTAVLLGGWILFVMRQQQPQVVEKQQETPLAPADFAHISQDAQ
SLHSGASRRSQKRLQSPSKQAQPLDDPEAEQLTVVGKISFNPKDVLGRGAGGTFVFRGQF
EGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQE
YVENPDLDRGGLEPEVVLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSD
FGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGG
SHPFGDSLYRQANILTGAPCLAHLEEEVHDKVVARDLVGAMLSPLPQPRPSAPQVLAHPF
FWSRAKQLQFFQDVSDWLEKESEQEPLVRALEAGGCAVVRDNWHEHISMPLQTDLRKFRS
YKGTSVRDLLRAVRNKKHHYRELPVEVRQALGQVPDGFVQYFTNRFPRLLLHTHRAMRSC
ASESLFLPYYPPDSEARRPCPGATGR

Sequence length

926

Interactions

View interactions

ERN2 (endoplasmic reticulum to nucleus signaling 2)