Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	1058
Gene name	Centromere protein A
Gene symbol	CENPA
Synonyms (NCBI Gene)	CENP-ACenH3
Chromosome	2
Chromosome location	2p23.3
Summary	Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024281	hsa-miR-215-5p	Microarray	19074876
MIRT026545	hsa-miR-192-5p	Microarray	19074876
MIRT509494	hsa-miR-411-5p	PAR-CLIP	21572407
MIRT509493	hsa-miR-187-3p	PAR-CLIP	21572407
MIRT529763	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT529762	hsa-miR-6750-3p	PAR-CLIP	22012620
MIRT529761	hsa-miR-6813-3p	PAR-CLIP	22012620
MIRT529760	hsa-miR-4714-3p	PAR-CLIP	22012620
MIRT529759	hsa-miR-4719	PAR-CLIP	22012620
MIRT529758	hsa-miR-432-5p	PAR-CLIP	22012620
MIRT529757	hsa-miR-1289	PAR-CLIP	22012620
MIRT529756	hsa-miR-4294	PAR-CLIP	22012620
MIRT529755	hsa-miR-3198	PAR-CLIP	22012620
MIRT529754	hsa-miR-4309	PAR-CLIP	22012620
MIRT243088	hsa-miR-1276	PAR-CLIP	22012620
MIRT243089	hsa-miR-5692a	PAR-CLIP	22012620
MIRT529753	hsa-miR-376c-3p	PAR-CLIP	22012620
MIRT529752	hsa-miR-6504-3p	PAR-CLIP	22012620
MIRT243087	hsa-miR-610	PAR-CLIP	22012620
MIRT509494	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT509493	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT509492	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT509494	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT509493	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT509492	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT509491	hsa-miR-3153	PAR-CLIP	23446348
MIRT509490	hsa-miR-6733-5p	PAR-CLIP	23446348
MIRT509489	hsa-miR-6739-5p	PAR-CLIP	23446348
MIRT509494	hsa-miR-411-5p	PAR-CLIP	21572407
MIRT509493	hsa-miR-187-3p	PAR-CLIP	21572407
MIRT529763	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT529762	hsa-miR-6750-3p	PAR-CLIP	22012620
MIRT529761	hsa-miR-6813-3p	PAR-CLIP	22012620
MIRT529760	hsa-miR-4714-3p	PAR-CLIP	22012620
MIRT529759	hsa-miR-4719	PAR-CLIP	22012620
MIRT529758	hsa-miR-432-5p	PAR-CLIP	22012620
MIRT529757	hsa-miR-1289	PAR-CLIP	22012620
MIRT529756	hsa-miR-4294	PAR-CLIP	22012620
MIRT529755	hsa-miR-3198	PAR-CLIP	22012620
MIRT529754	hsa-miR-4309	PAR-CLIP	22012620
MIRT243088	hsa-miR-1276	PAR-CLIP	22012620
MIRT243089	hsa-miR-5692a	PAR-CLIP	22012620
MIRT529753	hsa-miR-376c-3p	PAR-CLIP	22012620
MIRT529752	hsa-miR-6504-3p	PAR-CLIP	22012620
MIRT243087	hsa-miR-610	PAR-CLIP	22012620
MIRT509494	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT509493	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT509492	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT509494	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT509493	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT509492	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT509491	hsa-miR-3153	PAR-CLIP	23446348
MIRT509490	hsa-miR-6733-5p	PAR-CLIP	23446348
MIRT509489	hsa-miR-6739-5p	PAR-CLIP	23446348
MIRT884618	hsa-miR-1272	CLIP-seq
MIRT884619	hsa-miR-1322	CLIP-seq
MIRT884620	hsa-miR-219-5p	CLIP-seq
MIRT884621	hsa-miR-2467-3p	CLIP-seq
MIRT884622	hsa-miR-3125	CLIP-seq
MIRT884623	hsa-miR-3134	CLIP-seq
MIRT884624	hsa-miR-3545-5p	CLIP-seq
MIRT884625	hsa-miR-3614-3p	CLIP-seq
MIRT884626	hsa-miR-365	CLIP-seq
MIRT884627	hsa-miR-3688-3p	CLIP-seq
MIRT884628	hsa-miR-3916	CLIP-seq
MIRT884629	hsa-miR-3973	CLIP-seq
MIRT884630	hsa-miR-4257	CLIP-seq
MIRT884631	hsa-miR-4279	CLIP-seq
MIRT884632	hsa-miR-4297	CLIP-seq
MIRT884633	hsa-miR-4445	CLIP-seq
MIRT884634	hsa-miR-4534	CLIP-seq
MIRT884635	hsa-miR-4645-5p	CLIP-seq
MIRT884636	hsa-miR-4673	CLIP-seq
MIRT884637	hsa-miR-4742-5p	CLIP-seq
MIRT884638	hsa-miR-4777-3p	CLIP-seq
MIRT884639	hsa-miR-4782-3p	CLIP-seq
MIRT884640	hsa-miR-4796-3p	CLIP-seq
MIRT884641	hsa-miR-4796-5p	CLIP-seq
MIRT884642	hsa-miR-4797-5p	CLIP-seq
MIRT884643	hsa-miR-508-3p	CLIP-seq
MIRT884644	hsa-miR-520g	CLIP-seq
MIRT884645	hsa-miR-520h	CLIP-seq
MIRT884646	hsa-miR-556-3p	CLIP-seq
MIRT884647	hsa-miR-656	CLIP-seq
MIRT884648	hsa-miR-767-3p	CLIP-seq
MIRT884649	hsa-miR-942	CLIP-seq
MIRT884650	hsa-miR-4717-3p	CLIP-seq
MIRT884618	hsa-miR-1272	CLIP-seq
MIRT1962347	hsa-miR-1305	CLIP-seq
MIRT884619	hsa-miR-1322	CLIP-seq
MIRT1962348	hsa-miR-1324	CLIP-seq
MIRT1962349	hsa-miR-198	CLIP-seq
MIRT884621	hsa-miR-2467-3p	CLIP-seq
MIRT1962350	hsa-miR-2467-5p	CLIP-seq
MIRT1962351	hsa-miR-3120-3p	CLIP-seq
MIRT884623	hsa-miR-3134	CLIP-seq
MIRT1962352	hsa-miR-3179	CLIP-seq
MIRT1962353	hsa-miR-3188	CLIP-seq
MIRT884624	hsa-miR-3545-5p	CLIP-seq
MIRT884625	hsa-miR-3614-3p	CLIP-seq
MIRT884626	hsa-miR-365	CLIP-seq
MIRT1962354	hsa-miR-3664-5p	CLIP-seq
MIRT1962355	hsa-miR-3671	CLIP-seq
MIRT884627	hsa-miR-3688-3p	CLIP-seq
MIRT1962356	hsa-miR-3919	CLIP-seq
MIRT884629	hsa-miR-3973	CLIP-seq
MIRT1962357	hsa-miR-3975	CLIP-seq
MIRT1962358	hsa-miR-4252	CLIP-seq
MIRT884630	hsa-miR-4257	CLIP-seq
MIRT884632	hsa-miR-4297	CLIP-seq
MIRT1962359	hsa-miR-4307	CLIP-seq
MIRT1962360	hsa-miR-4316	CLIP-seq
MIRT1962361	hsa-miR-4436b-3p	CLIP-seq
MIRT884634	hsa-miR-4534	CLIP-seq
MIRT884635	hsa-miR-4645-5p	CLIP-seq
MIRT1962362	hsa-miR-4668-3p	CLIP-seq
MIRT884636	hsa-miR-4673	CLIP-seq
MIRT1962363	hsa-miR-4698	CLIP-seq
MIRT1962364	hsa-miR-4710	CLIP-seq
MIRT1962365	hsa-miR-4714-5p	CLIP-seq
MIRT884637	hsa-miR-4742-5p	CLIP-seq
MIRT1962366	hsa-miR-4756-3p	CLIP-seq
MIRT1962367	hsa-miR-4792	CLIP-seq
MIRT884640	hsa-miR-4796-3p	CLIP-seq
MIRT884641	hsa-miR-4796-5p	CLIP-seq
MIRT1962368	hsa-miR-485-5p	CLIP-seq
MIRT884644	hsa-miR-520g	CLIP-seq
MIRT884645	hsa-miR-520h	CLIP-seq
MIRT1962369	hsa-miR-545	CLIP-seq
MIRT1962370	hsa-miR-607	CLIP-seq
MIRT884648	hsa-miR-767-3p	CLIP-seq
MIRT2198769	hsa-miR-3064-5p	CLIP-seq
MIRT884626	hsa-miR-365	CLIP-seq
MIRT2198770	hsa-miR-4468	CLIP-seq
MIRT2198771	hsa-miR-4663	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000132	Process	Establishment of mitotic spindle orientation	IMP	19468067
GO:0000281	Process	Mitotic cytokinesis	IMP	27499292
GO:0000775	Component	Chromosome, centromeric region	IDA	11084331, 27499292
GO:0000775	Component	Chromosome, centromeric region	IEA
GO:0000775	Component	Chromosome, centromeric region	TAS	7962047
GO:0000779	Component	Condensed chromosome, centromeric region	IDA	11682612
GO:0000779	Component	Condensed chromosome, centromeric region	IEA
GO:0000786	Component	Nucleosome	IDA	27499292
GO:0000786	Component	Nucleosome	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	TAS	7962047
GO:0005515	Function	Protein binding	IPI	19410544, 19410545, 19503796, 19533040, 20080577, 20739937, 21478274, 26167883, 26496610, 32814053, 33961781, 35271311
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	27499292
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	7962047
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0005721	Component	Pericentric heterochromatin	IEA
GO:0005829	Component	Cytosol	TAS
GO:0030527	Function	Structural constituent of chromatin	IEA
GO:0034080	Process	CENP-A containing chromatin assembly	IDA	11682612
GO:0043505	Component	CENP-A containing nucleosome	IDA	18195732
GO:0043505	Component	CENP-A containing nucleosome	IPI	21743476
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0051301	Process	Cell division	IEA
GO:0051382	Process	Kinetochore assembly	IDA	11682612
GO:0061638	Component	CENP-A containing chromatin	IEA
GO:0061644	Process	Protein localization to CENP-A containing chromatin	NAS	21743476
GO:0071459	Process	Protein localization to chromosome, centromeric region	IDA	11682612
GO:0071459	Process	Protein localization to chromosome, centromeric region	IEA
GO:0071459	Process	Protein localization to chromosome, centromeric region	IEA

MIM	HGNC	e!Ensembl
117139	1851	ENSG00000115163

P49450

Protein name

Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)

Protein function

Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, P

PDB

3AN2 , 3NQJ , 3NQU , 3R45 , 3WTP , 5CVD , 5Z23 , 6BUZ , 6C0W , 6E0C , 6E0P , 6KDQ , 6KDS , 6L49 , 6MUO , 6MUP , 6O1D , 6SE0 , 6SE6 , 6SEE , 6SEF , 6SEG , 6TEM , 7D20 , 7PII , 7R5R , 7U46 , 7U47 , 7U4D , 7YWX , 7YYH , 9GXA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00125	Histone	2 → 133	Core histone H2A/H2B/H3/H4	Domain

Sequence

MGPRRRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRRQGWLKEIRKLQKSTHL
LIRKLPFSRLAREICVKFTRGVDFNWQAQALLALQEAAEAFLVHLFEDAYLLTLHAGRVT
LFPKDVQLARRIRGLEEGLG

Sequence length

140

Interactions

View interactions

	Reactome
			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation

CENPA (centromere protein A)