Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1058
Gene name Gene Name - the full gene name approved by the HGNC.	Centromere protein A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CENPA
Synonyms (NCBI Gene) Gene synonyms aliases	CENP-A, CenH3
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2p23.3
Summary Summary of gene provided in NCBI Entrez Gene.	Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centr

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024281	hsa-miR-215-5p	Microarray	19074876
MIRT026545	hsa-miR-192-5p	Microarray	19074876
MIRT509494	hsa-miR-411-5p	PAR-CLIP	21572407
MIRT509493	hsa-miR-187-3p	PAR-CLIP	21572407
MIRT529763	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT529762	hsa-miR-6750-3p	PAR-CLIP	22012620
MIRT529761	hsa-miR-6813-3p	PAR-CLIP	22012620
MIRT529760	hsa-miR-4714-3p	PAR-CLIP	22012620
MIRT529759	hsa-miR-4719	PAR-CLIP	22012620
MIRT529758	hsa-miR-432-5p	PAR-CLIP	22012620
MIRT529757	hsa-miR-1289	PAR-CLIP	22012620
MIRT529756	hsa-miR-4294	PAR-CLIP	22012620
MIRT529755	hsa-miR-3198	PAR-CLIP	22012620
MIRT529754	hsa-miR-4309	PAR-CLIP	22012620
MIRT243088	hsa-miR-1276	PAR-CLIP	22012620
MIRT243089	hsa-miR-5692a	PAR-CLIP	22012620
MIRT529753	hsa-miR-376c-3p	PAR-CLIP	22012620
MIRT529752	hsa-miR-6504-3p	PAR-CLIP	22012620
MIRT243087	hsa-miR-610	PAR-CLIP	22012620
MIRT509494	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT509493	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT509492	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT509494	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT509493	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT509492	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT509491	hsa-miR-3153	PAR-CLIP	23446348
MIRT509490	hsa-miR-6733-5p	PAR-CLIP	23446348
MIRT509489	hsa-miR-6739-5p	PAR-CLIP	23446348
MIRT509494	hsa-miR-411-5p	PAR-CLIP	21572407
MIRT509493	hsa-miR-187-3p	PAR-CLIP	21572407
MIRT529763	hsa-miR-6507-3p	PAR-CLIP	22012620
MIRT529762	hsa-miR-6750-3p	PAR-CLIP	22012620
MIRT529761	hsa-miR-6813-3p	PAR-CLIP	22012620
MIRT529760	hsa-miR-4714-3p	PAR-CLIP	22012620
MIRT529759	hsa-miR-4719	PAR-CLIP	22012620
MIRT529758	hsa-miR-432-5p	PAR-CLIP	22012620
MIRT529757	hsa-miR-1289	PAR-CLIP	22012620
MIRT529756	hsa-miR-4294	PAR-CLIP	22012620
MIRT529755	hsa-miR-3198	PAR-CLIP	22012620
MIRT529754	hsa-miR-4309	PAR-CLIP	22012620
MIRT243088	hsa-miR-1276	PAR-CLIP	22012620
MIRT243089	hsa-miR-5692a	PAR-CLIP	22012620
MIRT529753	hsa-miR-376c-3p	PAR-CLIP	22012620
MIRT529752	hsa-miR-6504-3p	PAR-CLIP	22012620
MIRT243087	hsa-miR-610	PAR-CLIP	22012620
MIRT509494	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT509493	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT509492	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT509494	hsa-miR-411-5p	PAR-CLIP	23446348
MIRT509493	hsa-miR-187-3p	PAR-CLIP	23446348
MIRT509492	hsa-miR-4668-5p	PAR-CLIP	23446348
MIRT509491	hsa-miR-3153	PAR-CLIP	23446348
MIRT509490	hsa-miR-6733-5p	PAR-CLIP	23446348
MIRT509489	hsa-miR-6739-5p	PAR-CLIP	23446348
MIRT884618	hsa-miR-1272	CLIP-seq
MIRT884619	hsa-miR-1322	CLIP-seq
MIRT884620	hsa-miR-219-5p	CLIP-seq
MIRT884621	hsa-miR-2467-3p	CLIP-seq
MIRT884622	hsa-miR-3125	CLIP-seq
MIRT884623	hsa-miR-3134	CLIP-seq
MIRT884624	hsa-miR-3545-5p	CLIP-seq
MIRT884625	hsa-miR-3614-3p	CLIP-seq
MIRT884626	hsa-miR-365	CLIP-seq
MIRT884627	hsa-miR-3688-3p	CLIP-seq
MIRT884628	hsa-miR-3916	CLIP-seq
MIRT884629	hsa-miR-3973	CLIP-seq
MIRT884630	hsa-miR-4257	CLIP-seq
MIRT884631	hsa-miR-4279	CLIP-seq
MIRT884632	hsa-miR-4297	CLIP-seq
MIRT884633	hsa-miR-4445	CLIP-seq
MIRT884634	hsa-miR-4534	CLIP-seq
MIRT884635	hsa-miR-4645-5p	CLIP-seq
MIRT884636	hsa-miR-4673	CLIP-seq
MIRT884637	hsa-miR-4742-5p	CLIP-seq
MIRT884638	hsa-miR-4777-3p	CLIP-seq
MIRT884639	hsa-miR-4782-3p	CLIP-seq
MIRT884640	hsa-miR-4796-3p	CLIP-seq
MIRT884641	hsa-miR-4796-5p	CLIP-seq
MIRT884642	hsa-miR-4797-5p	CLIP-seq
MIRT884643	hsa-miR-508-3p	CLIP-seq
MIRT884644	hsa-miR-520g	CLIP-seq
MIRT884645	hsa-miR-520h	CLIP-seq
MIRT884646	hsa-miR-556-3p	CLIP-seq
MIRT884647	hsa-miR-656	CLIP-seq
MIRT884648	hsa-miR-767-3p	CLIP-seq
MIRT884649	hsa-miR-942	CLIP-seq
MIRT884650	hsa-miR-4717-3p	CLIP-seq
MIRT884618	hsa-miR-1272	CLIP-seq
MIRT1962347	hsa-miR-1305	CLIP-seq
MIRT884619	hsa-miR-1322	CLIP-seq
MIRT1962348	hsa-miR-1324	CLIP-seq
MIRT1962349	hsa-miR-198	CLIP-seq
MIRT884621	hsa-miR-2467-3p	CLIP-seq
MIRT1962350	hsa-miR-2467-5p	CLIP-seq
MIRT1962351	hsa-miR-3120-3p	CLIP-seq
MIRT884623	hsa-miR-3134	CLIP-seq
MIRT1962352	hsa-miR-3179	CLIP-seq
MIRT1962353	hsa-miR-3188	CLIP-seq
MIRT884624	hsa-miR-3545-5p	CLIP-seq
MIRT884625	hsa-miR-3614-3p	CLIP-seq
MIRT884626	hsa-miR-365	CLIP-seq
MIRT1962354	hsa-miR-3664-5p	CLIP-seq
MIRT1962355	hsa-miR-3671	CLIP-seq
MIRT884627	hsa-miR-3688-3p	CLIP-seq
MIRT1962356	hsa-miR-3919	CLIP-seq
MIRT884629	hsa-miR-3973	CLIP-seq
MIRT1962357	hsa-miR-3975	CLIP-seq
MIRT1962358	hsa-miR-4252	CLIP-seq
MIRT884630	hsa-miR-4257	CLIP-seq
MIRT884632	hsa-miR-4297	CLIP-seq
MIRT1962359	hsa-miR-4307	CLIP-seq
MIRT1962360	hsa-miR-4316	CLIP-seq
MIRT1962361	hsa-miR-4436b-3p	CLIP-seq
MIRT884634	hsa-miR-4534	CLIP-seq
MIRT884635	hsa-miR-4645-5p	CLIP-seq
MIRT1962362	hsa-miR-4668-3p	CLIP-seq
MIRT884636	hsa-miR-4673	CLIP-seq
MIRT1962363	hsa-miR-4698	CLIP-seq
MIRT1962364	hsa-miR-4710	CLIP-seq
MIRT1962365	hsa-miR-4714-5p	CLIP-seq
MIRT884637	hsa-miR-4742-5p	CLIP-seq
MIRT1962366	hsa-miR-4756-3p	CLIP-seq
MIRT1962367	hsa-miR-4792	CLIP-seq
MIRT884640	hsa-miR-4796-3p	CLIP-seq
MIRT884641	hsa-miR-4796-5p	CLIP-seq
MIRT1962368	hsa-miR-485-5p	CLIP-seq
MIRT884644	hsa-miR-520g	CLIP-seq
MIRT884645	hsa-miR-520h	CLIP-seq
MIRT1962369	hsa-miR-545	CLIP-seq
MIRT1962370	hsa-miR-607	CLIP-seq
MIRT884648	hsa-miR-767-3p	CLIP-seq
MIRT2198769	hsa-miR-3064-5p	CLIP-seq
MIRT884626	hsa-miR-365	CLIP-seq
MIRT2198770	hsa-miR-4468	CLIP-seq
MIRT2198771	hsa-miR-4663	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000132	Process	Establishment of mitotic spindle orientation	IMP	19468067
GO:0000281	Process	Mitotic cytokinesis	IMP	27499292
GO:0000775	Component	Chromosome, centromeric region	IDA	11084331, 27499292
GO:0000778	Component	Condensed nuclear chromosome kinetochore	IDA	18195732
GO:0000779	Component	Condensed chromosome, centromeric region	IDA	11682612
GO:0000786	Component	Nucleosome	IDA	27499292
GO:0000939	Component	Condensed chromosome inner kinetochore	IEA
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	TAS	7962047
GO:0005515	Function	Protein binding	IPI	19410544, 19410545, 19503796, 19533040, 20080577, 21478274, 26167883, 26496610, 32814053
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA	21873635
GO:0005634	Component	Nucleus	IDA	27499292
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005721	Component	Pericentric heterochromatin	IEA
GO:0005829	Component	Cytosol	TAS
GO:0016032	Process	Viral process	IEA
GO:0034080	Process	CENP-A containing nucleosome assembly	TAS
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0051382	Process	Kinetochore assembly	IDA	11682612
GO:0071459	Process	Protein localization to chromosome, centromeric region	IDA	11682612

MIM	HGNC	e!Ensembl
117139	1851	ENSG00000115163

Protein

UniProt ID

P49450

Protein name

Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)

Protein function

Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:11756469, PubMed:14667408, PubMed:15282608, PubMed:15475964, PubMed:15702419, PubMed:17651496, PubMed:19114591, PubMed:20739937, PubMed:27499292, P

PDB

3AN2 , 3NQJ , 3NQU , 3R45 , 3WTP , 5CVD , 5Z23 , 6BUZ , 6C0W , 6E0C , 6E0P , 6KDQ , 6KDS , 6L49 , 6MUO , 6MUP , 6O1D , 6SE0 , 6SE6 , 6SEE , 6SEF , 6SEG , 6TEM , 7D20 , 7PII , 7R5R , 7U46 , 7U47 , 7U4D , 7YWX , 7YYH , 9GXA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00125	Histone	2 → 133	Core histone H2A/H2B/H3/H4	Domain

Sequence

MGPRRRSRKPEAPRRRSPSPTPTPGPSRRGPSLGASSHQHSRRRQGWLKEIRKLQKSTHL
LIRKLPFSRLAREICVKFTRGVDFNWQAQALLALQEAAEAFLVHLFEDAYLLTLHAGRVT
LFPKDVQLARRIRGLEEGLG

Sequence length

140

Interactions

View interactions

	Reactome
			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation

CENPA (centromere protein A)