Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10579
Gene name	Transforming acidic coiled-coil containing protein 2
Gene symbol	TACC2
Synonyms (NCBI Gene)	AZU-1ECTACC
Chromosome	10
Chromosome location	10q26.13
Summary	Transforming acidic coiled-coil proteins are a conserved family of centrosome- and microtubule-interacting proteins that are implicated in cancer. This gene encodes a protein that concentrates at centrosomes throughout the cell cycle. This gene lies withi

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018988	hsa-miR-335-5p	Microarray	18185580
MIRT486351	hsa-miR-4753-5p	PAR-CLIP	20371350
MIRT486350	hsa-miR-3922-5p	PAR-CLIP	20371350
MIRT486349	hsa-miR-581	PAR-CLIP	20371350
MIRT486348	hsa-miR-4708-3p	PAR-CLIP	20371350
MIRT486347	hsa-miR-6809-5p	PAR-CLIP	20371350
MIRT486344	hsa-miR-3177-5p	PAR-CLIP	20371350
MIRT486343	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT486342	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT486341	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT486351	hsa-miR-4753-5p	PAR-CLIP	20371350
MIRT486350	hsa-miR-3922-5p	PAR-CLIP	20371350
MIRT486349	hsa-miR-581	PAR-CLIP	20371350
MIRT486348	hsa-miR-4708-3p	PAR-CLIP	20371350
MIRT486347	hsa-miR-6809-5p	PAR-CLIP	20371350
MIRT486345	hsa-miR-4471	PAR-CLIP	20371350
MIRT486346	hsa-miR-8059	PAR-CLIP	20371350
MIRT486344	hsa-miR-3177-5p	PAR-CLIP	20371350
MIRT486343	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT486342	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT486341	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT486351	hsa-miR-4753-5p	PAR-CLIP	22012620
MIRT486350	hsa-miR-3922-5p	PAR-CLIP	22012620
MIRT486349	hsa-miR-581	PAR-CLIP	22012620
MIRT486348	hsa-miR-4708-3p	PAR-CLIP	22012620
MIRT486347	hsa-miR-6809-5p	PAR-CLIP	22012620
MIRT486345	hsa-miR-4471	PAR-CLIP	22012620
MIRT486346	hsa-miR-8059	PAR-CLIP	22012620
MIRT486344	hsa-miR-3177-5p	PAR-CLIP	22012620
MIRT486343	hsa-miR-520d-5p	PAR-CLIP	22012620
MIRT486342	hsa-miR-524-5p	PAR-CLIP	22012620
MIRT486341	hsa-let-7c-3p	PAR-CLIP	22012620
MIRT486351	hsa-miR-4753-5p	PAR-CLIP	23446348
MIRT486350	hsa-miR-3922-5p	PAR-CLIP	23446348
MIRT486349	hsa-miR-581	PAR-CLIP	23446348
MIRT486348	hsa-miR-4708-3p	PAR-CLIP	23446348
MIRT486347	hsa-miR-6809-5p	PAR-CLIP	23446348
MIRT486344	hsa-miR-3177-5p	PAR-CLIP	23446348
MIRT486343	hsa-miR-520d-5p	PAR-CLIP	23446348
MIRT486342	hsa-miR-524-5p	PAR-CLIP	23446348
MIRT486341	hsa-let-7c-3p	PAR-CLIP	23446348
MIRT486351	hsa-miR-4753-5p	PAR-CLIP	23592263
MIRT486350	hsa-miR-3922-5p	PAR-CLIP	23592263
MIRT486349	hsa-miR-581	PAR-CLIP	23592263
MIRT486348	hsa-miR-4708-3p	PAR-CLIP	23592263
MIRT486347	hsa-miR-6809-5p	PAR-CLIP	23592263
MIRT486345	hsa-miR-4471	PAR-CLIP	23592263
MIRT486346	hsa-miR-8059	PAR-CLIP	23592263
MIRT486344	hsa-miR-3177-5p	PAR-CLIP	23592263
MIRT486343	hsa-miR-520d-5p	PAR-CLIP	23592263
MIRT486342	hsa-miR-524-5p	PAR-CLIP	23592263
MIRT486341	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT486351	hsa-miR-4753-5p	PAR-CLIP	20371350
MIRT486350	hsa-miR-3922-5p	PAR-CLIP	20371350
MIRT486349	hsa-miR-581	PAR-CLIP	20371350
MIRT486348	hsa-miR-4708-3p	PAR-CLIP	20371350
MIRT486347	hsa-miR-6809-5p	PAR-CLIP	20371350
MIRT486344	hsa-miR-3177-5p	PAR-CLIP	20371350
MIRT486343	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT486342	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT486341	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT486351	hsa-miR-4753-5p	PAR-CLIP	20371350
MIRT486350	hsa-miR-3922-5p	PAR-CLIP	20371350
MIRT486349	hsa-miR-581	PAR-CLIP	20371350
MIRT486348	hsa-miR-4708-3p	PAR-CLIP	20371350
MIRT486347	hsa-miR-6809-5p	PAR-CLIP	20371350
MIRT486345	hsa-miR-4471	PAR-CLIP	20371350
MIRT486346	hsa-miR-8059	PAR-CLIP	20371350
MIRT486344	hsa-miR-3177-5p	PAR-CLIP	20371350
MIRT486343	hsa-miR-520d-5p	PAR-CLIP	20371350
MIRT486342	hsa-miR-524-5p	PAR-CLIP	20371350
MIRT486341	hsa-let-7c-3p	PAR-CLIP	20371350
MIRT486351	hsa-miR-4753-5p	PAR-CLIP	22012620
MIRT486350	hsa-miR-3922-5p	PAR-CLIP	22012620
MIRT486349	hsa-miR-581	PAR-CLIP	22012620
MIRT486348	hsa-miR-4708-3p	PAR-CLIP	22012620
MIRT486347	hsa-miR-6809-5p	PAR-CLIP	22012620
MIRT486345	hsa-miR-4471	PAR-CLIP	22012620
MIRT486346	hsa-miR-8059	PAR-CLIP	22012620
MIRT486344	hsa-miR-3177-5p	PAR-CLIP	22012620
MIRT486343	hsa-miR-520d-5p	PAR-CLIP	22012620
MIRT486342	hsa-miR-524-5p	PAR-CLIP	22012620
MIRT486341	hsa-let-7c-3p	PAR-CLIP	22012620
MIRT486351	hsa-miR-4753-5p	PAR-CLIP	23446348
MIRT486350	hsa-miR-3922-5p	PAR-CLIP	23446348
MIRT486349	hsa-miR-581	PAR-CLIP	23446348
MIRT486348	hsa-miR-4708-3p	PAR-CLIP	23446348
MIRT486347	hsa-miR-6809-5p	PAR-CLIP	23446348
MIRT486344	hsa-miR-3177-5p	PAR-CLIP	23446348
MIRT486343	hsa-miR-520d-5p	PAR-CLIP	23446348
MIRT486342	hsa-miR-524-5p	PAR-CLIP	23446348
MIRT486341	hsa-let-7c-3p	PAR-CLIP	23446348
MIRT486351	hsa-miR-4753-5p	PAR-CLIP	23592263
MIRT486350	hsa-miR-3922-5p	PAR-CLIP	23592263
MIRT486349	hsa-miR-581	PAR-CLIP	23592263
MIRT486348	hsa-miR-4708-3p	PAR-CLIP	23592263
MIRT486347	hsa-miR-6809-5p	PAR-CLIP	23592263
MIRT486345	hsa-miR-4471	PAR-CLIP	23592263
MIRT486346	hsa-miR-8059	PAR-CLIP	23592263
MIRT486344	hsa-miR-3177-5p	PAR-CLIP	23592263
MIRT486343	hsa-miR-520d-5p	PAR-CLIP	23592263
MIRT486342	hsa-miR-524-5p	PAR-CLIP	23592263
MIRT486341	hsa-let-7c-3p	PAR-CLIP	23592263
MIRT1408432	hsa-miR-125b	CLIP-seq
MIRT1408433	hsa-miR-4649-3p	CLIP-seq
MIRT1408434	hsa-miR-670	CLIP-seq
MIRT1408435	hsa-miR-873	CLIP-seq
MIRT1408436	hsa-miR-105	CLIP-seq
MIRT1408437	hsa-miR-124	CLIP-seq
MIRT1408438	hsa-miR-31	CLIP-seq
MIRT1408439	hsa-miR-3714	CLIP-seq
MIRT1408440	hsa-miR-3910	CLIP-seq
MIRT1408441	hsa-miR-483-3p	CLIP-seq
MIRT1408442	hsa-miR-506	CLIP-seq
MIRT1408443	hsa-miR-545	CLIP-seq
MIRT1408444	hsa-miR-548ac	CLIP-seq
MIRT1408445	hsa-miR-548ae	CLIP-seq
MIRT1408446	hsa-miR-548aj	CLIP-seq
MIRT1408447	hsa-miR-548am	CLIP-seq
MIRT1408448	hsa-miR-548d-3p	CLIP-seq
MIRT1408449	hsa-miR-548x	CLIP-seq
MIRT1408450	hsa-miR-548z	CLIP-seq
MIRT2122541	hsa-miR-1279	CLIP-seq
MIRT2344938	hsa-miR-1206	CLIP-seq
MIRT1408437	hsa-miR-124	CLIP-seq
MIRT2122541	hsa-miR-1279	CLIP-seq
MIRT2344939	hsa-miR-2114	CLIP-seq
MIRT2344940	hsa-miR-25	CLIP-seq
MIRT1408438	hsa-miR-31	CLIP-seq
MIRT2344941	hsa-miR-32	CLIP-seq
MIRT2344942	hsa-miR-363	CLIP-seq
MIRT2344943	hsa-miR-367	CLIP-seq
MIRT1408439	hsa-miR-3714	CLIP-seq
MIRT1408440	hsa-miR-3910	CLIP-seq
MIRT2344944	hsa-miR-3928	CLIP-seq
MIRT2344945	hsa-miR-4302	CLIP-seq
MIRT2344946	hsa-miR-4519	CLIP-seq
MIRT1408433	hsa-miR-4649-3p	CLIP-seq
MIRT2344947	hsa-miR-4666-5p	CLIP-seq
MIRT2344948	hsa-miR-4709-5p	CLIP-seq
MIRT2344949	hsa-miR-4718	CLIP-seq
MIRT1408441	hsa-miR-483-3p	CLIP-seq
MIRT2344950	hsa-miR-501-3p	CLIP-seq
MIRT2344951	hsa-miR-502-3p	CLIP-seq
MIRT1408442	hsa-miR-506	CLIP-seq
MIRT2344952	hsa-miR-648	CLIP-seq
MIRT2344953	hsa-miR-765	CLIP-seq
MIRT1408435	hsa-miR-873	CLIP-seq
MIRT2344954	hsa-miR-92a	CLIP-seq
MIRT2344955	hsa-miR-92b	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000226	Process	Microtubule cytoskeleton organization	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA
GO:0007052	Process	Mitotic spindle organization	IEA
GO:0007097	Process	Nuclear migration	IBA
GO:0016922	Function	Nuclear receptor binding	IDA	15207008
GO:0021987	Process	Cerebral cortex development	IBA

MIM	HGNC	e!Ensembl
605302	11523	ENSG00000138162

O95359

Protein name

Transforming acidic coiled-coil-containing protein 2 (Anti-Zuai-1) (AZU-1)

Protein function

Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in orga

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05010	TACC_C	2742 → 2942	Transforming acidic coiled-coil-containing protein (TACC), C-terminal	Coiled-coil

Tissue specificity

TISSUE SPECIFICITY: Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea. {ECO:0000269|PubMed:11161455, ECO:0000269|PubMed:12620397}.

Sequence

MGNENSTSDNQRTLSAQTPRSAQPPGNSQNIKRKQQDTPGSPDHRDASSIGSVGLGGFCT
ASESSASLDPCLVSPEVTEPRKDPQGARGPEGSLLPSPPPSQEREHPSSSMPFAECPPEG
CLASPAAAPEDGPQTQSPRREPAPNAPGDIAAAFPAERDSSTPYQEIAAVPSAGRERQPK
EEGQKSSFSFSSGIDQSPGMSPVPLREPMKAPLCGEGDQPGGFESQEKEAAGGFPPAESR
QGVASVQVTPEAPAAAQQGTESSAVLEKSPLKPMAPIPQDPAPRASDRERGQGEAPPQYL
TDDLEFLRACHLPRSNSGAAPEAEVNAASQESCQQPVGAYLPHAELPWGLPSPALVPEAG
GSGKEALDTIDVQGHPQTGMRGTKPNQVVCVAAGGQPEGGLPVSPEPSLLTPTEEAHPAS
SLASFPAAQIPIAVEEPGSSSRESVSKAGMPVSADAAKEVVDAGLVGLERQVSDLGSKGE
HPEGDPGEVPAPSPQERGEHLNTEQSHEVQPGVPPPPLPKEQSHEVQPGAPPPPLPKAPS
ESARGPPGPTDGAKVHEDSTSPAVAKEGSRSPGDSPGGKEEAPEPPDGGDPGNLQGEDSQ
AFSSKRDPEVGKDELSKPSSDAESRDHPSSHSAQPPRKGGAGHTDGPHSQTAEADASGLP
HKLGEEDPVLPPVPDGAGEPTVPEGAIWEGSGLQPKCPDTLQSREGLGRMESFLTLESEK
SDFPPTPVAEVAPKAQEGESTLEIRKMGSCDGEGLLTSPDQPRGPACDASRQEFHAGVPH
PPQGENLAADLGLTALILDQDQQGIPSCPGEGWIRGAASEWPLLSSEKHLQPSQAQPETS
IFDVLKEQAQPPENGKETSPSHPGFKDQGADSSQIHVPVEPQEDNNLPTHGGQEQALGSE
LQSQLPKGTLSDTPTSSPTDMVWESSLTEESELSAPTRQKLPALGEKRPEGACGDGQSSR
VSPPAADVLKDFSLAGNFSRKETCCTGQGPNKSQQALADALEEGSQHEEACQRHPGASEA
ADGCSPLWGLSKREMASGNTGEAPPCQPDSVALLDAVPCLPALAPASPGVTPTQDAPETE
ACDETQEGRQQPVPAPQQKMECWATSDAESPKLLASFPSAGEQGGEAGAAETGGSAGAGD
PGKQQAPEKPGEATLSCGLLQTEHCLTSGEEASTSALRESCQAEHPMASCQDALLPAREL
GGIPRSTMDFSTHQAVPDPKELLLSGPPEVAAPDTPYLHVDSAAQRGAEDSGVKAVSSAD
PRAPGESPCPVGEPPLALENAASLKLFAGSLAPLLQPGAAGGEIPAVQASSGSPKARTTE
GPVDSMPCLDRMPLLAKGKQATGEEKAATAPGAGAKASGEGMAGDAAGETEGSMERMGEP
SQDPKQGTSGGVDTSSEQIATLTGFPDFREHIAKIFEKPVLGALATPGEKAGAGRSAVGK
DLTRPLGPEKLLDGPPGVDVTLLPAPPARLQVEKKQQLAGEAEISHLALQDPASDKLLGP
AGLTWERNLPGAGVGKEMAGVPPTLREDERPEGPGAAWPGLEGQAYSQLERSRQELASGL
PSPAATQELPVERAAAFQVAPHSHGEEAVAQDRIPSGKQHQETSACDSPHGEDGPGDFAH
TGVPGHVPRSTCAPSPQREVLTVPEANSEPWTLDTLGGERRPGVTAGILEMRNALGNQST
PAPPTGEVADTPLEPGKVAGAAGEAEGDITLSTAETQACASGDLPEAGTTRTFSVVAGDL
VLPGSCQDPACSDKAPGMEGTAALHGDSPARPQQAKEQPGPERPIPAGDGKVCVSSPPEP
DETHDPKLQHLAPEELHTDRESPRPGPSMLPSVPKKDAPRVMDKVTSDETRGAEGTESSP
VADDIIQPAAPADLESPTLAASSYHGDVVGQVSTDLIAQSISPAAAHAGLPPSAAEHIVS
PSAPAGDRVEASTPSCPDPAKDLSRSSDSEEAFETPESTTPVKAPPAPPPPPPEVIPEPE
VSTQPPPEEPGCGSETVPVPDGPRSDSVEGSPFRPPSHSFSAVFDEDKPIASSGTYNLDF
DNIELVDTFQTLEPRASDAKNQEGKVNTRRKSTDSVPISKSTLSRSLSLQASDFDGASSS
GNPEAVALAPDAYSTGSSSASSTLKRTKKPRPPSLKKKQTTKKPTETPPVKETQQEPDEE
SLVPSGENLASETKTESAKTEGPSPALLEETPLEPAVGPKAACPLDSESAEGVVPPASGG
GRVQNSPPVGRKTLPLTTAPEAGEVTPSDSGGQEDSPAKGLSVRLEFDYSEDKSSWDNQQ
ENPPPTKKIGKKPVAKMPLRRPKMKKTPEKLDNTPASPPRSPAEPNDIPIAKGTYTFDID
KWDDPNFNPFSSTSKMQESPKLPQQSYNFDPDTCDESVDPFKTSSKTPSSPSKSPASFEI
PASAMEANGVDGDGLNKPAKKKKTPLKTDTFRVKKSPKRSPLSDPPSQDPTPAATPETPP
VISAVVHATDEEKLAVTNQKWTCMTVDLEADKQDYPQPSDLSTFVNETKFSSPTEELDYR
NSYEIEYMEKIGSSLPQDDDAPKKQALYLMFDTSQESPVKSSPVRMSESPTPCSGSSFEE
TEALVNTAAKNQHPVPRGLAPNQESHLQVPEKSSQKELEAMGLGTPSEAIEITAPEGSFA
SADALLSRLAHPVSLCGALDYLEPDLAEKNPPLFAQKLQEELEFAIMRIEALKLARQIAL
ASRSHQDAKREAAHPTDVSISKTALYSRIGTAEVEKPAGLLFQQPDLDSALQIARAEIIT
KEREVSEWKDKYEESRREVMEMRKIVAEYEKTIAQMIEDEQREKSVSHQTVQQLVLEKEQ
ALADLNSVEKSLADLFRRYEKMKEVLEGFRKNEEVLKRCAQEYLSRVKKEEQRYQALKVH
AEEKLDRANAEIAQVRGKAQQEQAAHQASLRKEQLRVDALERTLEQKNKEIEELTKICDE
LIAKMGKS

Sequence length

2948

Interactions

View interactions

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Uterine corpus endometrial carcinoma	Uncertain significance	rs375973608	RCV005939239

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	24927736
Carcinoma Embryonal	Associate	36713456
Carcinoma Hepatocellular	Associate	29843208
Colonic Diseases	Associate	35170141
Drug Related Side Effects and Adverse Reactions	Associate	26744305
Endometrial Neoplasms	Associate	33931666
Gastrointestinal Stromal Tumors	Associate	35170141
Glioblastoma	Associate	33853673
Leukemia Lymphocytic Chronic B Cell	Associate	33510140
Lymphatic Metastasis	Associate	33931666
Mpox (monkeypox)	Associate	37992435
Myopia	Associate	29383007
Neoplasms	Associate	29074988, 29843208, 33853673, 33931666, 34511423, 35170141, 37382632
Neuroblastoma	Associate	18980998
Pancreatic Neoplasms	Associate	34511423
Prostatic Neoplasms	Associate	21880074, 30271587
Pulmonary Disease Chronic Obstructive	Associate	26744305
Stomach Neoplasms	Associate	34551773
Triple Negative Breast Neoplasms	Associate	32504034

TACC2 (transforming acidic coiled-coil containing protein 2)