AGPAT1 (1-acylglycerol-3-phosphate O-acyltransferase 1)

Gene

• Entrez ID: 10554
• Gene name: 1-acylglycerol-3-phosphate O-acyltransferase 1
• Gene symbol: AGPAT1
• Synonyms (NCBI Gene): 1-AGPAT1, G15, LPAAT-alpha, LPAATA, LPLAT1
• Chromosome: 6
• Chromosome location: 6p21.32
• Summary: This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. Thi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016494	hsa-miR-193b-3p	Microarray	20304954
MIRT025835	hsa-miR-7-5p	Microarray	19073608
MIRT618407	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618406	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618405	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT618404	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618403	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT618407	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618406	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618405	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT618404	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618403	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT618407	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618406	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618405	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT618404	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618403	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT618407	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618406	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618405	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT618404	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618403	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT618407	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618406	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618405	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT618404	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618403	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT618407	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT618406	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT618405	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT618404	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT618403	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT756173	hsa-miR-122-5p	Luciferase reporter assay, Western blotting, qRT-PCR, RNA pull down assay	36674813
MIRT772225	hsa-miR-1285	CLIP-seq
MIRT772226	hsa-miR-3187-5p	CLIP-seq
MIRT772227	hsa-miR-3545-3p	CLIP-seq
MIRT772228	hsa-miR-3945	CLIP-seq
MIRT772229	hsa-miR-4253	CLIP-seq
MIRT772230	hsa-miR-4292	CLIP-seq
MIRT772231	hsa-miR-4693-3p	CLIP-seq
MIRT772232	hsa-miR-4725-5p	CLIP-seq
MIRT772233	hsa-miR-4733-5p	CLIP-seq
MIRT772234	hsa-miR-4774-5p	CLIP-seq
MIRT772235	hsa-miR-504	CLIP-seq
MIRT772236	hsa-miR-582-3p	CLIP-seq
MIRT772237	hsa-miR-612	CLIP-seq
MIRT772238	hsa-miR-1272	CLIP-seq
MIRT772225	hsa-miR-1285	CLIP-seq
MIRT772239	hsa-miR-129-5p	CLIP-seq
MIRT772240	hsa-miR-188-3p	CLIP-seq
MIRT772241	hsa-miR-18a	CLIP-seq
MIRT772242	hsa-miR-18b	CLIP-seq
MIRT772243	hsa-miR-3154	CLIP-seq
MIRT772226	hsa-miR-3187-5p	CLIP-seq
MIRT772244	hsa-miR-3192	CLIP-seq
MIRT772245	hsa-miR-335	CLIP-seq
MIRT772227	hsa-miR-3545-3p	CLIP-seq
MIRT772246	hsa-miR-3646	CLIP-seq
MIRT772247	hsa-miR-365	CLIP-seq
MIRT772248	hsa-miR-3660	CLIP-seq
MIRT772249	hsa-miR-3689a-3p	CLIP-seq
MIRT772250	hsa-miR-3689c	CLIP-seq
MIRT772251	hsa-miR-3689d	CLIP-seq
MIRT772252	hsa-miR-378g	CLIP-seq
MIRT772253	hsa-miR-3915	CLIP-seq
MIRT772254	hsa-miR-3928	CLIP-seq
MIRT772228	hsa-miR-3945	CLIP-seq
MIRT772255	hsa-miR-3975	CLIP-seq
MIRT772229	hsa-miR-4253	CLIP-seq
MIRT772256	hsa-miR-4266	CLIP-seq
MIRT772230	hsa-miR-4292	CLIP-seq
MIRT772257	hsa-miR-4328	CLIP-seq
MIRT772258	hsa-miR-4427	CLIP-seq
MIRT772259	hsa-miR-4436b-3p	CLIP-seq
MIRT772260	hsa-miR-4447	CLIP-seq
MIRT772261	hsa-miR-4459	CLIP-seq
MIRT772262	hsa-miR-4472	CLIP-seq
MIRT772263	hsa-miR-4486	CLIP-seq
MIRT772264	hsa-miR-4526	CLIP-seq
MIRT772265	hsa-miR-4645-3p	CLIP-seq
MIRT772266	hsa-miR-4663	CLIP-seq
MIRT772267	hsa-miR-4680-3p	CLIP-seq
MIRT772231	hsa-miR-4693-3p	CLIP-seq
MIRT772268	hsa-miR-4695-5p	CLIP-seq
MIRT772269	hsa-miR-4715-3p	CLIP-seq
MIRT772232	hsa-miR-4725-5p	CLIP-seq
MIRT772270	hsa-miR-4728-5p	CLIP-seq
MIRT772271	hsa-miR-4733-3p	CLIP-seq
MIRT772233	hsa-miR-4733-5p	CLIP-seq
MIRT772272	hsa-miR-4735-3p	CLIP-seq
MIRT772273	hsa-miR-4747-5p	CLIP-seq
MIRT772234	hsa-miR-4774-5p	CLIP-seq
MIRT772274	hsa-miR-4779	CLIP-seq
MIRT772275	hsa-miR-4786-5p	CLIP-seq
MIRT772276	hsa-miR-493	CLIP-seq
MIRT772235	hsa-miR-504	CLIP-seq
MIRT772236	hsa-miR-582-3p	CLIP-seq
MIRT772237	hsa-miR-612	CLIP-seq
MIRT772277	hsa-miR-769-5p	CLIP-seq
MIRT1927870	hsa-miR-1255a	CLIP-seq
MIRT1927871	hsa-miR-1255b	CLIP-seq
MIRT1927872	hsa-miR-1270	CLIP-seq
MIRT1927873	hsa-miR-143	CLIP-seq
MIRT772240	hsa-miR-188-3p	CLIP-seq
MIRT1927874	hsa-miR-3132	CLIP-seq
MIRT1927875	hsa-miR-3151	CLIP-seq
MIRT1927876	hsa-miR-3184	CLIP-seq
MIRT772245	hsa-miR-335	CLIP-seq
MIRT1927877	hsa-miR-3612	CLIP-seq
MIRT772251	hsa-miR-3689d	CLIP-seq
MIRT1927878	hsa-miR-423-5p	CLIP-seq
MIRT772256	hsa-miR-4266	CLIP-seq
MIRT772260	hsa-miR-4447	CLIP-seq
MIRT772262	hsa-miR-4472	CLIP-seq
MIRT772265	hsa-miR-4645-3p	CLIP-seq
MIRT1927879	hsa-miR-4683	CLIP-seq
MIRT772268	hsa-miR-4695-5p	CLIP-seq
MIRT1927880	hsa-miR-4716-3p	CLIP-seq
MIRT1927881	hsa-miR-4723-5p	CLIP-seq
MIRT1927882	hsa-miR-4770	CLIP-seq
MIRT772274	hsa-miR-4779	CLIP-seq
MIRT1927883	hsa-miR-491-5p	CLIP-seq
MIRT1927884	hsa-miR-620	CLIP-seq
MIRT1927885	hsa-miR-650	CLIP-seq
MIRT1927870	hsa-miR-1255a	CLIP-seq
MIRT1927871	hsa-miR-1255b	CLIP-seq
MIRT2168736	hsa-miR-4724-5p	CLIP-seq
MIRT2168737	hsa-miR-548aa	CLIP-seq
MIRT2471248	hsa-miR-1	CLIP-seq
MIRT2471249	hsa-miR-1193	CLIP-seq
MIRT1927870	hsa-miR-1255a	CLIP-seq
MIRT1927871	hsa-miR-1255b	CLIP-seq
MIRT772238	hsa-miR-1272	CLIP-seq
MIRT2471250	hsa-miR-181a	CLIP-seq
MIRT2471251	hsa-miR-181b	CLIP-seq
MIRT2471252	hsa-miR-181c	CLIP-seq
MIRT2471253	hsa-miR-181d	CLIP-seq
MIRT772241	hsa-miR-18a	CLIP-seq
MIRT772242	hsa-miR-18b	CLIP-seq
MIRT2471254	hsa-miR-206	CLIP-seq
MIRT2471255	hsa-miR-2115	CLIP-seq
MIRT2471256	hsa-miR-31	CLIP-seq
MIRT2471257	hsa-miR-3130-3p	CLIP-seq
MIRT772244	hsa-miR-3192	CLIP-seq
MIRT772245	hsa-miR-335	CLIP-seq
MIRT2471258	hsa-miR-3673	CLIP-seq
MIRT2471259	hsa-miR-3675-5p	CLIP-seq
MIRT772249	hsa-miR-3689a-3p	CLIP-seq
MIRT772250	hsa-miR-3689c	CLIP-seq
MIRT772251	hsa-miR-3689d	CLIP-seq
MIRT2471260	hsa-miR-3713	CLIP-seq
MIRT772253	hsa-miR-3915	CLIP-seq
MIRT772254	hsa-miR-3928	CLIP-seq
MIRT772255	hsa-miR-3975	CLIP-seq
MIRT2471261	hsa-miR-3977	CLIP-seq
MIRT2471262	hsa-miR-421	CLIP-seq
MIRT2471263	hsa-miR-4262	CLIP-seq
MIRT772256	hsa-miR-4266	CLIP-seq
MIRT2471264	hsa-miR-4287	CLIP-seq
MIRT2471265	hsa-miR-4433	CLIP-seq
MIRT772260	hsa-miR-4447	CLIP-seq
MIRT2471266	hsa-miR-4450	CLIP-seq
MIRT772261	hsa-miR-4459	CLIP-seq
MIRT772262	hsa-miR-4472	CLIP-seq
MIRT772265	hsa-miR-4645-3p	CLIP-seq
MIRT2471267	hsa-miR-4649-5p	CLIP-seq
MIRT772266	hsa-miR-4663	CLIP-seq
MIRT2471268	hsa-miR-4667-5p	CLIP-seq
MIRT2471269	hsa-miR-4685-3p	CLIP-seq
MIRT2471270	hsa-miR-4694-3p	CLIP-seq
MIRT772268	hsa-miR-4695-5p	CLIP-seq
MIRT2471271	hsa-miR-4699-5p	CLIP-seq
MIRT2471272	hsa-miR-4700-5p	CLIP-seq
MIRT2471273	hsa-miR-4709-3p	CLIP-seq
MIRT2471274	hsa-miR-4709-5p	CLIP-seq
MIRT2471275	hsa-miR-4719	CLIP-seq
MIRT2471276	hsa-miR-4722-5p	CLIP-seq
MIRT772270	hsa-miR-4728-5p	CLIP-seq
MIRT772272	hsa-miR-4735-3p	CLIP-seq
MIRT772273	hsa-miR-4747-5p	CLIP-seq
MIRT772274	hsa-miR-4779	CLIP-seq
MIRT2471277	hsa-miR-4780	CLIP-seq
MIRT2471278	hsa-miR-486-3p	CLIP-seq
MIRT2471279	hsa-miR-490-5p	CLIP-seq
MIRT772276	hsa-miR-493	CLIP-seq
MIRT2471280	hsa-miR-520f	CLIP-seq
MIRT2471281	hsa-miR-581	CLIP-seq
MIRT2471282	hsa-miR-613	CLIP-seq
MIRT2471283	hsa-miR-623	CLIP-seq
MIRT2471284	hsa-miR-661	CLIP-seq
MIRT2471248	hsa-miR-1	CLIP-seq
MIRT1927870	hsa-miR-1255a	CLIP-seq
MIRT1927871	hsa-miR-1255b	CLIP-seq
MIRT772238	hsa-miR-1272	CLIP-seq
MIRT772241	hsa-miR-18a	CLIP-seq
MIRT772242	hsa-miR-18b	CLIP-seq
MIRT2471254	hsa-miR-206	CLIP-seq
MIRT2471255	hsa-miR-2115	CLIP-seq
MIRT2471256	hsa-miR-31	CLIP-seq
MIRT2471257	hsa-miR-3130-3p	CLIP-seq
MIRT772244	hsa-miR-3192	CLIP-seq
MIRT772245	hsa-miR-335	CLIP-seq
MIRT2471258	hsa-miR-3673	CLIP-seq
MIRT772249	hsa-miR-3689a-3p	CLIP-seq
MIRT772250	hsa-miR-3689c	CLIP-seq
MIRT772251	hsa-miR-3689d	CLIP-seq
MIRT772253	hsa-miR-3915	CLIP-seq
MIRT772254	hsa-miR-3928	CLIP-seq
MIRT2674722	hsa-miR-3929	CLIP-seq
MIRT772255	hsa-miR-3975	CLIP-seq
MIRT2471261	hsa-miR-3977	CLIP-seq
MIRT772256	hsa-miR-4266	CLIP-seq
MIRT2471264	hsa-miR-4287	CLIP-seq
MIRT2674723	hsa-miR-4419b	CLIP-seq
MIRT772260	hsa-miR-4447	CLIP-seq
MIRT2471266	hsa-miR-4450	CLIP-seq
MIRT772261	hsa-miR-4459	CLIP-seq
MIRT772262	hsa-miR-4472	CLIP-seq
MIRT2674724	hsa-miR-4478	CLIP-seq
MIRT772265	hsa-miR-4645-3p	CLIP-seq
MIRT2471267	hsa-miR-4649-5p	CLIP-seq
MIRT772266	hsa-miR-4663	CLIP-seq
MIRT2471268	hsa-miR-4667-5p	CLIP-seq
MIRT2471269	hsa-miR-4685-3p	CLIP-seq
MIRT2471270	hsa-miR-4694-3p	CLIP-seq
MIRT772268	hsa-miR-4695-5p	CLIP-seq
MIRT2471272	hsa-miR-4700-5p	CLIP-seq
MIRT2471275	hsa-miR-4719	CLIP-seq
MIRT772270	hsa-miR-4728-5p	CLIP-seq
MIRT772272	hsa-miR-4735-3p	CLIP-seq
MIRT772273	hsa-miR-4747-5p	CLIP-seq
MIRT772274	hsa-miR-4779	CLIP-seq
MIRT2471277	hsa-miR-4780	CLIP-seq
MIRT772276	hsa-miR-493	CLIP-seq
MIRT2471280	hsa-miR-520f	CLIP-seq
MIRT2471281	hsa-miR-581	CLIP-seq
MIRT2471282	hsa-miR-613	CLIP-seq
MIRT2471283	hsa-miR-623	CLIP-seq
MIRT2471284	hsa-miR-661	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001819	Process	Positive regulation of cytokine production	IMP	9212163
GO:0001961	Process	Positive regulation of cytokine-mediated signaling pathway	IC	9212163
GO:0003841	Function	1-acylglycerol-3-phosphate O-acyltransferase activity	IBA
GO:0003841	Function	1-acylglycerol-3-phosphate O-acyltransferase activity	IDA	9461603, 21873652
GO:0003841	Function	1-acylglycerol-3-phosphate O-acyltransferase activity	IEA
GO:0003841	Function	1-acylglycerol-3-phosphate O-acyltransferase activity	IGI	9212163
GO:0003841	Function	1-acylglycerol-3-phosphate O-acyltransferase activity	TAS
GO:0005515	Function	Protein binding	IPI	25416956, 28514442, 33961781
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	9461603, 21873652
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	9461603
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006644	Process	Phospholipid metabolic process	TAS	9212163
GO:0006654	Process	Phosphatidic acid biosynthetic process	IBA
GO:0006654	Process	Phosphatidic acid biosynthetic process	IGI	9212163
GO:0006654	Process	Phosphatidic acid biosynthetic process	TAS
GO:0008654	Process	Phospholipid biosynthetic process	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016024	Process	CDP-diacylglycerol biosynthetic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA

Other IDs

• MIM: 603099
• HGNC: 324
• e!Ensembl: ENSG00000204310

Protein

• UniProt ID: Q99943
• Protein name: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC 2.3.1.51) (1-acylglycerol-3-phosphate O-acyltransferase 1) (1-AGP acyltransferase 1) (1-AGPAT 1) (Lysophosphatidic acid acyltransferase alpha) (LPAAT-alpha) (Protein G15)
• Protein function: Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. {ECO:0000269|PubMed:21873652,
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01553	Acyltransferase	83 → 211	Acyltransferase	Family

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas. Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate, ovary, intestine, colon, leukocyte an
• Sequence:

  MDLWPGAWMLLLLLFLLLLFLLPTLWFCSPSAKYFFKMAFYNGWILFLAVLAIPVCAVRG
  RNVENMKILRLMLLHIKYLYGIRVEVRGAHHFPPSQPYVVVSNHQSSLDLLGMMEVLPGR
  CVPIAKRELLWAGSAGLACWLAGVIFIDRKRTGDAISVMSEVAQTLLTQDVRVWVFPEGT
  RNHNGSMLPFKRGAFHLAVQAQVPIVPIVMSSYQDFYCKKERRFTSGQCQVRVLPPVPTE
  GLTPDDVPALADRVRHSMLTVFREISTDGRGGGDYLKKPGGGG

• Sequence length: 283

Pathways

KEGG:

Glycerolipid metabolism
Glycerophospholipid metabolism
Metabolic pathways
Phospholipase D signaling pathway
Fat digestion and absorption

Reactome:

Synthesis of PA
ChREBP activates metabolic gene expression