LAMTOR5 (late endosomal/lysosomal adaptor, MAPK and MTOR activator 5)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10542
Gene name Gene Name - the full gene name approved by the HGNC.
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LAMTOR5
Synonyms (NCBI Gene) Gene synonyms aliases
HBXIP, XIP
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p13.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by R
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(11)
miRTarBase ID miRNA Experiments Reference
MIRT001458 hsa-miR-16-5p pSILAC 18668040
MIRT006082 hsa-miR-520b ChIP-seq, ELISA, Immunohistochemistry, Microarray, qRT-PCR, Western blot 21343296
MIRT006082 hsa-miR-520b ChIP-seq, ELISA, Immunohistochemistry, Microarray, qRT-PCR, Western blot 21343296
MIRT006082 hsa-miR-520b ChIP-seq, ELISA, Immunohistochemistry, Microarray, qRT-PCR, Western blot 21343296
MIRT007340 hsa-miR-501-5p Luciferase reporter assay, qRT-PCR, Western blot 23266610
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
ERCC2 Repression 22387547
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(28)
GO ID Ontology Definition Evidence Reference
GO:0005085 Function Guanyl-nucleotide exchange factor activity IBA 21873635
GO:0005085 Function Guanyl-nucleotide exchange factor activity IDA 22980980
GO:0005515 Function Protein binding IPI 12773388, 22740693, 23414517, 24169621, 25561175, 25567906, 29123114
GO:0005764 Component Lysosome IBA 21873635
GO:0005764 Component Lysosome IDA 22980980
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
608521 17955 ENSG00000134248
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID O43504
Protein name Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5)
Protein function As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:29158492, PubMed:301
PDB 3MS6 , 3MSH , 5VOK , 5X6U , 5X6V , 5Y38 , 5Y39 , 5Y3A , 5YK3 , 5YK5 , 6B9X , 6EHP , 6EHR , 6NZD , 6U62 , 6ULG , 6WJ2 , 6WJ3 , 7T3A , 7T3B , 7T3C , 7UX2 , 7UXC , 7UXH , 8DHB
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16672 LAMTOR5 1 → 88 Ragulator complex protein LAMTOR5 Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in skeletal and cardiac muscle, followed by pancreas, kidney, liver, brain, placenta and lung (PubMed:9499022). Elevated levels in both cancerous and non-cancerous liver tissue of patients with chronic HBV infection co
Sequence
Sequence length 91
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  mTOR signaling pathway   Macroautophagy
mTOR signalling
mTORC1-mediated signalling
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of PTEN gene transcription
Amino acids regulate mTORC1
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)		 26229107
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)		 26229107
Marfan syndrome Mammary Carcinoma, Human rs137854456, rs137854457, rs267606796, rs137854458, rs137854459, rs137854460, rs137854470, rs137854471, rs267606797, rs137854461, rs137854462, rs137854463, rs869025419, rs137854464, rs137854465
View all (942 more)		 26229107
Show/Hide Text Mining Associations (16)
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 21343296, 22740693, 24098497, 26229107, 30273966, 30381907, 35093383
Carcinogenesis Associate 12773388
Carcinoma Hepatocellular Associate 21239735, 36109580
Carcinoma Non Small Cell Lung Associate 28718367, 34588094
Lymphatic Metastasis Associate 28388957, 28718367
Neoplasm Metastasis Stimulate 34588094
Neoplasm Metastasis Associate 36109580
Neoplasms Associate 26229107, 28388957, 28718367, 34588094, 34730200, 35093383
Neoplasms Basal Cell Associate 34730200
Neurodegenerative Diseases Associate 11925594