ANP32B (acidic nuclear phosphoprotein 32 family member B)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 10541
Gene name Acidic nuclear phosphoprotein 32 family member B
Gene symbol ANP32B
Synonyms (NCBI Gene)
APRILPHAPI2SSP29
Chromosome 9
Chromosome location 9q22.33
miRNA miRNA information provided by mirtarbase database.
528
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (528)
miRTarBase ID miRNA Experiments Reference
MIRT001390 hsa-miR-1-3p pSILAC 18668040
MIRT001390 hsa-miR-1-3p Proteomics;Other 18668040
MIRT044574 hsa-miR-320a CLASH 23622248
MIRT041280 hsa-miR-193b-3p CLASH 23622248
MIRT037041 hsa-miR-877-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (22)
GO ID Ontology Definition Evidence Reference
GO:0001944 Process Vasculature development IEA
GO:0005515 Function Protein binding IPI 21988832, 25416956, 31515488, 32296183, 32814053, 35271311
GO:0005634 Component Nucleus HDA 16791210
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 9285060, 17178712
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
619823 16677 ENSG00000136938
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q92688
Protein name Acidic leucine-rich nuclear phosphoprotein 32 family member B (Acidic protein rich in leucines) (Putative HLA-DR-associated protein I-2) (PHAPI2) (Silver-stainable protein SSP29)
Protein function Multifunctional protein that is involved in the regulation of many processes including cell proliferation, apoptosis, cell cycle progression or transcription (PubMed:18039846, PubMed:20015864). Regulates the proliferation of neuronal stem cells,
PDB 2ELL , 2RR6 , 8R1J , 8R1L
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12799 LRR_4 88 → 133 Leucine Rich repeats (2 copies) Repeat
Tissue specificity TISSUE SPECIFICITY: Expressed in heart, lung, pancreas, prostate and in spleen, thymus and placenta. {ECO:0000269|PubMed:9473664}.
Sequence 
MDMKRRIHLELRNRTPAAVRELVLDNCKSNDGKIEGLTAEFVNLEFLSLINVGLISVSNL
PKLPKLKKLELSENRIFGGLDMLAEKLPNLTHLNLSGNKLKDISTLEPLKKLECLKSLDL
FNCEVTNLNDYRESVFKLLPQLTYLDGYDREDQEAPDSDAEVDGVDEEEEDEEGEDEEDE
DDEDGEEEEFDEEDDEDEDVEGDEDDDEVSEEEEEFGLDEEDEDEDEDEEEEEGGKGEKR
KRETDDEGEDD
Sequence length 251
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (5)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BILIARY LIVER CIRRHOSIS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PRIMARY BILIARY CIRRHOSIS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
THYROID CANCER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (6)
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acute Retroviral Syndrome Associate 31444273
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Associate 38401083
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 28486557
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Stimulate 35280441
★★★★★
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 28486557
★★★★★
★☆☆☆☆
Found in Text Mining only
Thyroid Neoplasms Associate 33903625
★★★★★
★☆☆☆☆
Found in Text Mining only