Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	10537
Gene name	Ubiquitin like modifier D
Gene symbol	UBD
Synonyms (NCBI Gene)	FAT10UBD-3
Chromosome	6
Chromosome location	6p22.1
Summary	This gene encodes a protein which contains two ubiquitin-like domains and appears to have similar function to ubiquitin. Through covalent attachment, the encoded protein targets other proteins for 26S proteasome degradation. This protein has been implicat

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017438	hsa-miR-335-5p	Microarray	18185580
MIRT030468	hsa-miR-24-3p	qRT-PCR;Microarray	19748357
MIRT713487	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT713485	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT713484	hsa-miR-3162-3p	HITS-CLIP	19536157
MIRT713483	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT713481	hsa-miR-6784-3p	HITS-CLIP	19536157
MIRT713482	hsa-miR-6862-3p	HITS-CLIP	19536157
MIRT713480	hsa-miR-214-5p	HITS-CLIP	19536157
MIRT713479	hsa-miR-6735-3p	HITS-CLIP	19536157
MIRT713478	hsa-miR-3909	HITS-CLIP	19536157
MIRT713477	hsa-miR-6852-3p	HITS-CLIP	19536157
MIRT713475	hsa-miR-7848-3p	HITS-CLIP	19536157
MIRT713476	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT709758	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT709757	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT709756	hsa-miR-6801-3p	HITS-CLIP	19536157
MIRT709755	hsa-miR-6810-3p	HITS-CLIP	19536157
MIRT709754	hsa-miR-331-3p	HITS-CLIP	19536157
MIRT709753	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT709752	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT709751	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT709750	hsa-miR-4469	HITS-CLIP	19536157
MIRT709749	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT709748	hsa-miR-4287	HITS-CLIP	19536157
MIRT709747	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT709746	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT709745	hsa-miR-938	HITS-CLIP	19536157
MIRT709744	hsa-miR-6886-3p	HITS-CLIP	19536157
MIRT709743	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT709742	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT713487	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT713485	hsa-miR-3620-3p	HITS-CLIP	19536157
MIRT713484	hsa-miR-3162-3p	HITS-CLIP	19536157
MIRT713483	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT713481	hsa-miR-6784-3p	HITS-CLIP	19536157
MIRT713482	hsa-miR-6862-3p	HITS-CLIP	19536157
MIRT713480	hsa-miR-214-5p	HITS-CLIP	19536157
MIRT713479	hsa-miR-6735-3p	HITS-CLIP	19536157
MIRT713478	hsa-miR-3909	HITS-CLIP	19536157
MIRT713477	hsa-miR-6852-3p	HITS-CLIP	19536157
MIRT713475	hsa-miR-7848-3p	HITS-CLIP	19536157
MIRT713476	hsa-miR-6749-3p	HITS-CLIP	19536157
MIRT709758	hsa-miR-6887-3p	HITS-CLIP	19536157
MIRT709757	hsa-miR-6795-3p	HITS-CLIP	19536157
MIRT709756	hsa-miR-6801-3p	HITS-CLIP	19536157
MIRT709755	hsa-miR-6810-3p	HITS-CLIP	19536157
MIRT709754	hsa-miR-331-3p	HITS-CLIP	19536157
MIRT709753	hsa-miR-6892-3p	HITS-CLIP	19536157
MIRT709752	hsa-miR-6752-3p	HITS-CLIP	19536157
MIRT709751	hsa-miR-6734-3p	HITS-CLIP	19536157
MIRT709750	hsa-miR-4469	HITS-CLIP	19536157
MIRT709749	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT709748	hsa-miR-4287	HITS-CLIP	19536157
MIRT709747	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT709746	hsa-miR-18a-3p	HITS-CLIP	19536157
MIRT709745	hsa-miR-938	HITS-CLIP	19536157
MIRT709744	hsa-miR-6886-3p	HITS-CLIP	19536157
MIRT709743	hsa-miR-6826-3p	HITS-CLIP	19536157
MIRT709742	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT1466923	hsa-miR-3152-5p	CLIP-seq
MIRT1466924	hsa-miR-4774-3p	CLIP-seq
MIRT1466925	hsa-miR-548c-3p	CLIP-seq
MIRT2140326	hsa-miR-3122	CLIP-seq
MIRT2140327	hsa-miR-3153	CLIP-seq
MIRT2140328	hsa-miR-3913-5p	CLIP-seq
MIRT2140329	hsa-miR-4668-5p	CLIP-seq
MIRT2140330	hsa-miR-4775	CLIP-seq
MIRT2140331	hsa-miR-590-3p	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0005515	Function	Protein binding	IPI	10200259, 14757770, 16495226, 16707496, 17889673, 19033385, 24528925, 25422469, 25814554, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA	12730673
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	NAS	9368598
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IBA
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	17889673
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IEA
GO:0006950	Process	Response to stress	IEA
GO:0016235	Component	Aggresome	IDA	19033385
GO:0016567	Process	Protein ubiquitination	IBA
GO:0016567	Process	Protein ubiquitination	IDA	15831455, 17889673
GO:0016567	Process	Protein ubiquitination	IEA
GO:0032446	Process	Protein modification by small protein conjugation	NAS	9368598
GO:0034341	Process	Response to type II interferon	IBA
GO:0034341	Process	Response to type II interferon	IEA
GO:0034341	Process	Response to type II interferon	IEP	17889673
GO:0034612	Process	Response to tumor necrosis factor	IBA
GO:0034612	Process	Response to tumor necrosis factor	IEA
GO:0034612	Process	Response to tumor necrosis factor	IEP	17889673
GO:0043011	Process	Myeloid dendritic cell differentiation	IMP	19028597
GO:0043065	Process	Positive regulation of apoptotic process	IBA
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043065	Process	Positive regulation of apoptotic process	IMP	16495380
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IMP	19959714
GO:0070628	Function	Proteasome binding	IBA
GO:0070628	Function	Proteasome binding	IDA	16707496
GO:0070628	Function	Proteasome binding	IEA
GO:0070842	Process	Aggresome assembly	IDA	19033385
GO:1901990	Process	Regulation of mitotic cell cycle phase transition	IMP	16495226

MIM	HGNC	e!Ensembl
606050	18795	ENSG00000213886

O15205

Protein name

Ubiquitin D (Diubiquitin) (Ubiquitin-like protein FAT10)

Protein function

Ubiquitin-like protein modifier which can be covalently attached to target proteins and subsequently leads to their degradation by the 26S proteasome, in a NUB1-dependent manner (PubMed:15831455, PubMed:16707496, PubMed:19166848). Conjugation to

PDB

2MBE , 6GF1 , 6GF2 , 7PYV , 9E8O

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00240	ubiquitin	10 → 81	Ubiquitin family	Domain
PF00240	ubiquitin	91 → 161	Ubiquitin family	Domain

Tissue specificity

TISSUE SPECIFICITY: Constitutively expressed in mature dendritic cells and B-cells. Mostly expressed in the reticuloendothelial system (e.g. thymus, spleen), the gastrointestinal system, kidney, lung and prostate gland. {ECO:0000269|PubMed:12730673, ECO:0

Sequence

MAPNASCLCVHVRSEEWDLMTFDANPYDSVKKIKEHVRSKTKVPVQDQVLLLGSKILKPR
RSLSSYGIDKEKTIHLTLKVVKPSDEELPLFLVESGDEAKRHLLQVRRSSSVAQVKAMIE
TKTGIIPETQIVTCNGKRLEDGKMMADYGIRKGNLLFLACYCIGG

Sequence length

165

Interactions

View interactions

	Reactome
			Neddylation

UBD (ubiquitin like modifier D)