NOP56 (NOP56 ribonucleoprotein)

Gene

• Entrez ID: 10528
• Gene name: NOP56 ribonucleoprotein
• Gene symbol: NOP56
• Synonyms (NCBI Gene): NOL5A, SCA36
• Disease Acronyms (UniProt): SCA36
• Chromosome: 20
• Chromosome location: 20p13
• Summary: Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is simi

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030362	hsa-miR-24-3p	Microarray	19748357
MIRT049889	hsa-miR-31-5p	CLASH	23622248
MIRT1189335	hsa-miR-1257	CLIP-seq
MIRT1189336	hsa-miR-1587	CLIP-seq
MIRT1189337	hsa-miR-2110	CLIP-seq
MIRT1189338	hsa-miR-3150a-3p	CLIP-seq
MIRT1189339	hsa-miR-3153	CLIP-seq
MIRT1189340	hsa-miR-3189-3p	CLIP-seq
MIRT1189341	hsa-miR-3611	CLIP-seq
MIRT1189342	hsa-miR-4271	CLIP-seq
MIRT1189343	hsa-miR-4668-5p	CLIP-seq
MIRT1189344	hsa-miR-4674	CLIP-seq
MIRT1189345	hsa-miR-4725-3p	CLIP-seq
MIRT1189346	hsa-miR-581	CLIP-seq
MIRT1189347	hsa-miR-635	CLIP-seq
MIRT2283857	hsa-miR-1224-3p	CLIP-seq
MIRT1189336	hsa-miR-1587	CLIP-seq
MIRT2283858	hsa-miR-3123	CLIP-seq
MIRT1189340	hsa-miR-3189-3p	CLIP-seq
MIRT2283859	hsa-miR-3189-5p	CLIP-seq
MIRT2283860	hsa-miR-3919	CLIP-seq
MIRT1189344	hsa-miR-4674	CLIP-seq
MIRT2283861	hsa-miR-4758-3p	CLIP-seq
MIRT1189347	hsa-miR-635	CLIP-seq
MIRT2283857	hsa-miR-1224-3p	CLIP-seq
MIRT1189336	hsa-miR-1587	CLIP-seq
MIRT2283858	hsa-miR-3123	CLIP-seq
MIRT1189340	hsa-miR-3189-3p	CLIP-seq
MIRT2283859	hsa-miR-3189-5p	CLIP-seq
MIRT2283860	hsa-miR-3919	CLIP-seq
MIRT1189344	hsa-miR-4674	CLIP-seq
MIRT2283861	hsa-miR-4758-3p	CLIP-seq
MIRT1189347	hsa-miR-635	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	17636026, 32296183
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	TAS	9372940
GO:0005732	Component	Sno(s)RNA-containing ribonucleoprotein complex	IDA	17636026
GO:0005737	Component	Cytoplasm	IEA
GO:0006364	Process	RRNA processing	TAS
GO:0016020	Component	Membrane	HDA	19946888
GO:0030515	Function	SnoRNA binding	IBA	21873635
GO:0030515	Function	SnoRNA binding	IDA	17636026
GO:0031428	Component	Box C/D RNP complex	IBA	21873635
GO:0031428	Component	Box C/D RNP complex	NAS	17636026
GO:0032040	Component	Small-subunit processome	IBA	21873635
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0070761	Component	Pre-snoRNP complex	IDA	17636026
GO:1990226	Function	Histone methyltransferase binding	IPI	17636026

Other IDs

• MIM: 614154
• HGNC: 15911
• e!Ensembl: ENSG00000101361

Protein

• UniProt ID: O00567
• Protein name: Nucleolar protein 56 (Nucleolar protein 5A)
• Protein function: Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs (PubMed:12777385, PubMed:15574333). Part of the small subunit (SSU) processome, first precurso
• PDB: 7MQ8, 7MQ9, 7MQA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08156	NOP5NT	5 → 70	NOP5NT (NUC127) domain	Domain
  PF01798	Nop	174 → 407	snoRNA binding domain, fibrillarin	Family

• Sequence:

  MVLLHVLFEHAVGYALLALKEVEEISLLQPQVEESVLNLGKFHSIVRLVAFCPFASSQVA
  LENANAVSEGVVHEDLRLLLETHLPSKKKKVLLGVGDPKIGAAIQEELGYNCQTGGVIAE
  ILRGVRLHFHNLVKGLTDLSACKAQLGLGHSYSRAKVKFNVNRVDNMIIQSISLLDQLDK
  DINTFSMRVREWYGYHFPELVKIINDNATYCRLAQFIGNRRELNEDKLEKLEELTMDGAK
  AKAILDASRSSMGMDISAIDLINIESFSSRVVSLSEYRQSLHTYLRSKMSQVAPSLSALI
  GEAVGARLIAHAGSLTNLAKYPASTVQILGAEKALFRALKTRGNTPKYGLIFHSTFIGRA
  AAKNKGRISRYLANKCSIASRIDCFSEVPTSVFGEKLREQVEERLSFYETGEIPRKNLDV
  MKEAMVQAEEAAAEITRKLEKQEKKRLKKEKKRLAALALASSENSSSTPEECEEMSEKPK
  KKKKQKPQEVPQENGMEDPSISFSKPKKKKSFSKEELMSSDLEETAGSTSIPKRKKSTPK
  EETVNDPEEAGHRSGSKKKRKFSKEEPVSSGPEEAVGKSSSKKKKKFHKASQED

• Sequence length: 594

Pathways

KEGG:

Ribosome biogenesis in eukaryotes
Spinocerebellar ataxia

Reactome:

Major pathway of rRNA processing in the nucleolus and cytosol

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Spinocerebellar ataxia	Ataxia, Spinocerebellar, Spinocerebellar Ataxia Type 1, Spinocerebellar Ataxia Type 2, Spinocerebellar Ataxia Type 4, Spinocerebellar Ataxia Type 5, Spinocerebellar Ataxia Type 6 (disorder), Spinocerebellar Ataxia Type 7, Spinocerebellar ataxia 36, Spinocerebellar ataxia type 36	rs80356538, rs80356539, rs56144125, rs28937887, rs80356544, rs80356540, rs80356542, rs1941485201, rs121918306, rs151344520, rs151344519, rs151344521, rs151344523, rs151344512, rs193922926, rs104894393, rs587776685, rs121908216, rs121908215, rs121908217, rs121909326, rs121918511, rs121918512, rs121918513, rs121918514, rs121918515, rs121918516, rs121918517, rs121918518, rs1555808841, rs104894699, rs104894700, rs121912425, rs121913123, rs267606939, rs201486601, rs387906679, rs151344514, rs151344515, rs151344517, rs387907033, rs387907089, rs794726680, rs761213683, rs794726681, rs1555779353, rs151344513, rs151344518, rs151344522, rs397514535, rs397514536, rs318240735, rs386134171, rs386134158, rs386134159, rs386134160, rs386134161, rs386134162, rs386134163, rs386134164, rs386134165, rs386134166, rs386134168, rs386134170, rs386134169, rs146859515, rs373728971, rs397515475, rs397515476, rs587777052, rs121908247, rs121908200, rs398122959, rs587777127, rs587777128, rs587777235, rs587777340, rs587777341, rs587777342, rs587777344, rs587777345, rs587777346, rs587777347, rs587780326, rs587777670, rs587777671, rs606231451, rs606231452, rs540331226, rs144272231, rs690016544, rs727502823, rs372250159, rs793888526, rs876657385, rs869320748, rs876657386, rs786205229, rs876657387, rs774694340, rs786205867, rs794727411, rs797044955, rs797044872, rs797045634, rs797045240, rs765592794, rs797045900, rs748445058, rs863223919, rs765987297, rs863224882, rs753611141, rs869025292, rs869025293, rs755221106, rs869312685, rs751181600, rs886037832, rs875989881, rs372245668, rs879255601, rs876657414, rs752281590, rs879253883, rs1114167316, rs879255651, rs879255653, rs879255654, rs886039392, rs540839115, rs886039762, rs201128942, rs886041279, rs531656357, rs1057519453, rs1057519454, rs573267388, rs1057519561, rs200277996, rs1064795856, rs749320057, rs750331613, rs1131692265, rs761564262, rs1555768154, rs1210764379, rs758937084, rs1555475283, rs1555475375, rs760424025, rs1555806333, rs1554308513, rs1554274719, rs1554317158, rs201920319, rs1553724533, rs1554985851, rs768831597, rs1554986345, rs1555755878, rs1554902760, rs368143665, rs1555370787, rs1322796318, rs1553756062, rs772345347, rs149905705, rs1555475794, rs760752847, rs1555781806, rs1555738369, rs1554986337, rs1184563885, rs1553758021, rs1559718601, rs1206950481, rs1568523843, rs748984540, rs1557539450, rs1557541619, rs771145682, rs1564808324, rs1567283195, rs752352896, rs1557794465, rs547792505, rs193922929, rs1571636501, rs1571636508, rs1571939827, rs1571939905, rs1559603328, rs1562374476, rs1599651549, rs1590020571, rs1598832526, rs1575415900, rs779142717, rs781016340, rs1366090807, rs1579319300, rs1311909367, rs1589625941, rs749656742, rs1317590341, rs1599943097, rs1590955348, rs749679347, rs1590911156, rs1395191127, rs1405576707, rs541484241, rs1598820860, rs1598832568, rs1589611043, rs758809498, rs754446573
Attention deficit hyperactivity disorder	Attention deficit hyperactivity disorder	rs786205019
Gastric cancer	Hereditary Diffuse Gastric Cancer	rs137854571, rs63751108, rs34612342, rs121908383, rs121909144, rs121909775, rs121909219, rs121909223, rs63750871, rs80359530, rs121964873, rs121913530, rs606231203, rs121918505, rs587776802, rs28933369, rs121912469, rs80358011, rs397507262, rs80359439, rs397507333, rs80359543, rs80358831, rs80359596, rs80358920, rs80358972, rs80359659, rs397507404, rs397514661, rs80359516, rs200495564, rs80358419, rs80359274, rs80359283, rs80358427, rs80358428, rs80358435, rs81002805, rs397507660, rs397507663, rs80359391, rs80359443, rs81002797, rs80359466, rs397507752, rs80359484, rs80359603, rs397507954, rs80359058, rs80359071, rs397507981, rs80359121, rs80357086, rs80357064, rs397508936, rs80357695, rs80357661, rs397509035, rs80357544, rs80357577, rs80357881, rs80357296, rs80356923, rs80356866, rs80357504, rs80357390, rs80357239, rs80358099, rs397509284, rs80357258, rs199474738, rs199474747, rs587779204, rs63750439, rs267608076, rs587779246, rs63749999, rs267608078, rs63751327, rs267607719, rs267607734, rs63750706, rs63751711, rs587779047, rs587779075, rs267607949, rs63750633, rs63750803, rs63751618, rs267608154, rs200640585, rs80358018, rs80357857, rs80357882, rs180177103, rs587779815, rs587779865, rs587779872, rs587780059, rs121912666, rs587780088, rs587780104, rs200432447, rs180177100, rs587780226, rs587780784, rs587776416, rs587781276, rs587781629, rs587781694, rs587781727, rs587781730, rs587781807, rs587781894, rs587781948, rs121913344, rs587782292, rs587782350, rs587782558, rs587782719, rs587782885, rs587783057, rs730881833, rs730881411, rs730881336, rs139770721, rs730881869, rs730881633, rs730882007, rs786203115, rs765123255, rs1553333738, rs762083530, rs786202800, rs17174393, rs55996097, rs750621215, rs786203451, rs747604569, rs764389018, rs786204433, rs786204862, rs772821016, rs779582317, rs863225406, rs193922343, rs759965045, rs63749919, rs760228510, rs746481984, rs762307622, rs876659736, rs876660933, rs747727055, rs1450394308, rs876658348, rs876658431, rs876659326, rs876660444, rs730881369, rs878853865, rs753862052, rs587780024, rs138941496, rs886040739, rs886040744, rs886040347, rs878854957, rs886040123, rs398122662, rs886040942, rs1057517104, rs1057516320, rs1057516683, rs879254046, rs1057517253, rs587781927, rs985033810, rs1057519989, rs775464903, rs374230313, rs758304323, rs1060501599, rs758081262, rs1060500126, rs1060502734, rs587776408, rs1060501695, rs1114167816, rs1114167596, rs1114167667, rs1555460315, rs1135402788, rs1554086196, rs730881919, rs773356478, rs769237459, rs1553653158, rs587782087, rs1555107263, rs1555119940, rs1403784434, rs1342519012, rs751710099, rs1553616361, rs1553619721, rs1270783041, rs775036118, rs1555288557, rs1555460548, rs1555461154, rs1298667185, rs1553622218, rs63751101, rs1349928568, rs771936821, rs1021662947, rs1555921011, rs81002831, rs1555124506, rs1555574803, rs1060502716, rs1555605362, rs747057367, rs1565385010, rs1567554500, rs1567516230, rs1558644995, rs1555591308, rs778306619, rs1566231194, rs1603328466, rs1570406302, rs1586108714, rs768362387, rs1597713777, rs1060502926, rs1597867185, rs1591517571, rs1591663236, rs1593903006, rs1555284779, rs1597096243, rs45459799, rs1597360340, rs587781905, rs864622481, rs1601753141, rs1966858562, rs1966967065, rs1967016153, rs1967113484, rs2080473458, rs1591387978, rs1224428422, rs1597747184, rs2082309297, rs2051929740, rs147542208	21364753
Lung adenocarcinoma	Adenocarcinoma of lung (disorder)	rs28934576, rs121913530, rs397516975, rs587776805, rs121913469, rs121913364, rs121913351, rs121913366, rs397516896, rs397516977, rs397516981, rs397517127, rs121913344, rs727504233, rs121913370, rs760043106, rs1057519788, rs1131692238, rs1131692237, rs1554350382	27602772
Migraine	Migraine Disorders	rs794727411
Nystagmus	Nystagmus	rs137852207, rs137852208, rs1928435502, rs137852209, rs137852210, rs1929191668, rs137852211, rs137852212, rs2124209414, rs387906720, rs387906721, rs1602791884, rs786205896

Unknown
Disease term	Disease name	Evidence	References	Source
Ptosis	Blepharoptosis, Ptosis			ClinVar

Associations from Text Mining
Disease Name	Relationship Type	References
Ataxia	Associate	22492559
Atherosclerosis	Associate	29685964
Carcinoma Hepatocellular	Associate	33750838, 34257558
Carcinoma Renal Cell	Associate	29099775
Colorectal Neoplasms	Associate	20473941
Macular Degeneration	Associate	30946360
Mandibulofacial Dysostosis	Associate	12777385
Neoplasms	Associate	34257558
Neuromuscular Diseases	Associate	24269018
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Associate	32011831
Spinocerebellar Ataxias	Stimulate	21683323, 40004498
Spinocerebellar Ataxias	Associate	22492559