Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10526
Gene name Gene Name - the full gene name approved by the HGNC.	Importin 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	IPO8
Synonyms (NCBI Gene) Gene synonyms aliases	RANBP8, VISS
Chromosome Chromosome number	12
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	12p11.21
Summary Summary of gene provided in NCBI Entrez Gene.	The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence mot

Show/Hide all(203)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020599	hsa-miR-155-5p	Proteomics	18668040
MIRT023609	hsa-miR-1-3p	Proteomics	18668040
MIRT032284	hsa-let-7b-5p	Proteomics	18668040
MIRT041468	hsa-miR-193b-3p	CLASH	23622248
MIRT440435	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440435	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1069045	hsa-miR-1	CLIP-seq
MIRT1069046	hsa-miR-1343	CLIP-seq
MIRT1069047	hsa-miR-138	CLIP-seq
MIRT1069048	hsa-miR-140-3p	CLIP-seq
MIRT1069049	hsa-miR-148a	CLIP-seq
MIRT1069050	hsa-miR-148b	CLIP-seq
MIRT1069051	hsa-miR-152	CLIP-seq
MIRT1069052	hsa-miR-181a	CLIP-seq
MIRT1069053	hsa-miR-181b	CLIP-seq
MIRT1069054	hsa-miR-181c	CLIP-seq
MIRT1069055	hsa-miR-181d	CLIP-seq
MIRT1069056	hsa-miR-1825	CLIP-seq
MIRT1069057	hsa-miR-1910	CLIP-seq
MIRT1069058	hsa-miR-200b	CLIP-seq
MIRT1069059	hsa-miR-200c	CLIP-seq
MIRT1069060	hsa-miR-204	CLIP-seq
MIRT1069061	hsa-miR-206	CLIP-seq
MIRT1069062	hsa-miR-211	CLIP-seq
MIRT1069063	hsa-miR-217	CLIP-seq
MIRT1069064	hsa-miR-27a	CLIP-seq
MIRT1069065	hsa-miR-27b	CLIP-seq
MIRT1069066	hsa-miR-298	CLIP-seq
MIRT1069067	hsa-miR-3074-5p	CLIP-seq
MIRT1069068	hsa-miR-3124-3p	CLIP-seq
MIRT1069069	hsa-miR-3158-5p	CLIP-seq
MIRT1069070	hsa-miR-3164	CLIP-seq
MIRT1069071	hsa-miR-3662	CLIP-seq
MIRT1069072	hsa-miR-3673	CLIP-seq
MIRT1069073	hsa-miR-3675-3p	CLIP-seq
MIRT1069074	hsa-miR-369-3p	CLIP-seq
MIRT1069075	hsa-miR-374a	CLIP-seq
MIRT1069076	hsa-miR-374b	CLIP-seq
MIRT1069077	hsa-miR-374c	CLIP-seq
MIRT1069078	hsa-miR-4262	CLIP-seq
MIRT1069079	hsa-miR-429	CLIP-seq
MIRT1069080	hsa-miR-4418	CLIP-seq
MIRT1069081	hsa-miR-4446-5p	CLIP-seq
MIRT1069082	hsa-miR-448	CLIP-seq
MIRT1069083	hsa-miR-4490	CLIP-seq
MIRT1069084	hsa-miR-455-3p	CLIP-seq
MIRT1069085	hsa-miR-4646-5p	CLIP-seq
MIRT1069086	hsa-miR-4676-5p	CLIP-seq
MIRT1069087	hsa-miR-4712-5p	CLIP-seq
MIRT1069088	hsa-miR-4742-3p	CLIP-seq
MIRT1069089	hsa-miR-4753-3p	CLIP-seq
MIRT1069090	hsa-miR-4755-5p	CLIP-seq
MIRT1069091	hsa-miR-4797-5p	CLIP-seq
MIRT1069092	hsa-miR-495	CLIP-seq
MIRT1069093	hsa-miR-509-3-5p	CLIP-seq
MIRT1069094	hsa-miR-509-5p	CLIP-seq
MIRT1069095	hsa-miR-513a-5p	CLIP-seq
MIRT1069096	hsa-miR-548aa	CLIP-seq
MIRT1069097	hsa-miR-548ac	CLIP-seq
MIRT1069098	hsa-miR-548d-3p	CLIP-seq
MIRT1069099	hsa-miR-548p	CLIP-seq
MIRT1069100	hsa-miR-548u	CLIP-seq
MIRT1069101	hsa-miR-548z	CLIP-seq
MIRT1069102	hsa-miR-554	CLIP-seq
MIRT1069103	hsa-miR-575	CLIP-seq
MIRT1069104	hsa-miR-610	CLIP-seq
MIRT1069105	hsa-miR-613	CLIP-seq
MIRT1069106	hsa-miR-623	CLIP-seq
MIRT1069107	hsa-miR-655	CLIP-seq
MIRT1069108	hsa-miR-759	CLIP-seq
MIRT1069109	hsa-miR-770-5p	CLIP-seq
MIRT1069110	hsa-miR-889	CLIP-seq
MIRT1069052	hsa-miR-181a	CLIP-seq
MIRT1069053	hsa-miR-181b	CLIP-seq
MIRT1069054	hsa-miR-181c	CLIP-seq
MIRT1069055	hsa-miR-181d	CLIP-seq
MIRT1069057	hsa-miR-1910	CLIP-seq
MIRT1069078	hsa-miR-4262	CLIP-seq
MIRT1069084	hsa-miR-455-3p	CLIP-seq
MIRT2016840	hsa-miR-1271	CLIP-seq
MIRT2016841	hsa-miR-136	CLIP-seq
MIRT1069052	hsa-miR-181a	CLIP-seq
MIRT1069053	hsa-miR-181b	CLIP-seq
MIRT1069054	hsa-miR-181c	CLIP-seq
MIRT1069055	hsa-miR-181d	CLIP-seq
MIRT2016842	hsa-miR-216a	CLIP-seq
MIRT2016843	hsa-miR-216b	CLIP-seq
MIRT1069066	hsa-miR-298	CLIP-seq
MIRT2016844	hsa-miR-3157-5p	CLIP-seq
MIRT2016845	hsa-miR-3189-3p	CLIP-seq
MIRT2016846	hsa-miR-3913-3p	CLIP-seq
MIRT2016847	hsa-miR-3945	CLIP-seq
MIRT2016848	hsa-miR-4253	CLIP-seq
MIRT1069078	hsa-miR-4262	CLIP-seq
MIRT2016849	hsa-miR-4517	CLIP-seq
MIRT2016850	hsa-miR-4699-5p	CLIP-seq
MIRT2016851	hsa-miR-4715-5p	CLIP-seq
MIRT2016852	hsa-miR-4790-5p	CLIP-seq
MIRT2016853	hsa-miR-499-3p	CLIP-seq
MIRT2016854	hsa-miR-499a-3p	CLIP-seq
MIRT2016855	hsa-miR-532-5p	CLIP-seq
MIRT2016856	hsa-miR-579	CLIP-seq
MIRT2016857	hsa-miR-635	CLIP-seq
MIRT1069110	hsa-miR-889	CLIP-seq
MIRT2016858	hsa-miR-96	CLIP-seq
MIRT1069052	hsa-miR-181a	CLIP-seq
MIRT1069053	hsa-miR-181b	CLIP-seq
MIRT1069054	hsa-miR-181c	CLIP-seq
MIRT1069055	hsa-miR-181d	CLIP-seq
MIRT2248899	hsa-miR-199a-5p	CLIP-seq
MIRT2248900	hsa-miR-199b-5p	CLIP-seq
MIRT1069078	hsa-miR-4262	CLIP-seq
MIRT2248901	hsa-miR-4503	CLIP-seq
MIRT2016853	hsa-miR-499-3p	CLIP-seq
MIRT2016854	hsa-miR-499a-3p	CLIP-seq
MIRT1069052	hsa-miR-181a	CLIP-seq
MIRT1069053	hsa-miR-181b	CLIP-seq
MIRT1069054	hsa-miR-181c	CLIP-seq
MIRT1069055	hsa-miR-181d	CLIP-seq
MIRT2016845	hsa-miR-3189-3p	CLIP-seq
MIRT1069071	hsa-miR-3662	CLIP-seq
MIRT1069078	hsa-miR-4262	CLIP-seq
MIRT1069097	hsa-miR-548ac	CLIP-seq
MIRT1069098	hsa-miR-548d-3p	CLIP-seq
MIRT1069101	hsa-miR-548z	CLIP-seq
MIRT2437905	hsa-miR-139-3p	CLIP-seq
MIRT2437906	hsa-miR-3115	CLIP-seq
MIRT2016844	hsa-miR-3157-5p	CLIP-seq
MIRT2016845	hsa-miR-3189-3p	CLIP-seq
MIRT2016847	hsa-miR-3945	CLIP-seq
MIRT2016848	hsa-miR-4253	CLIP-seq
MIRT2016857	hsa-miR-635	CLIP-seq
MIRT2552613	hsa-miR-1305	CLIP-seq
MIRT2437905	hsa-miR-139-3p	CLIP-seq
MIRT2552614	hsa-miR-190	CLIP-seq
MIRT2552615	hsa-miR-190b	CLIP-seq
MIRT2552616	hsa-miR-214	CLIP-seq
MIRT2552617	hsa-miR-219-5p	CLIP-seq
MIRT2552618	hsa-miR-2355-3p	CLIP-seq
MIRT2437906	hsa-miR-3115	CLIP-seq
MIRT2016844	hsa-miR-3157-5p	CLIP-seq
MIRT2016845	hsa-miR-3189-3p	CLIP-seq
MIRT2552619	hsa-miR-323b-5p	CLIP-seq
MIRT2552620	hsa-miR-3619-5p	CLIP-seq
MIRT1069071	hsa-miR-3662	CLIP-seq
MIRT2552621	hsa-miR-3922-5p	CLIP-seq
MIRT2552622	hsa-miR-3940-5p	CLIP-seq
MIRT2016847	hsa-miR-3945	CLIP-seq
MIRT2016848	hsa-miR-4253	CLIP-seq
MIRT2552623	hsa-miR-4445	CLIP-seq
MIRT2552624	hsa-miR-4459	CLIP-seq
MIRT2552625	hsa-miR-4480	CLIP-seq
MIRT2552626	hsa-miR-4507	CLIP-seq
MIRT2552627	hsa-miR-4722-5p	CLIP-seq
MIRT2552628	hsa-miR-4738-3p	CLIP-seq
MIRT2552629	hsa-miR-4749-3p	CLIP-seq
MIRT2552630	hsa-miR-4779	CLIP-seq
MIRT2552631	hsa-miR-4782-3p	CLIP-seq
MIRT2552632	hsa-miR-485-3p	CLIP-seq
MIRT2552633	hsa-miR-498	CLIP-seq
MIRT2552634	hsa-miR-508-3p	CLIP-seq
MIRT2016856	hsa-miR-579	CLIP-seq
MIRT2016857	hsa-miR-635	CLIP-seq
MIRT2552635	hsa-miR-653	CLIP-seq
MIRT2552636	hsa-miR-676	CLIP-seq
MIRT2552637	hsa-miR-761	CLIP-seq
MIRT2437905	hsa-miR-139-3p	CLIP-seq
MIRT2552614	hsa-miR-190	CLIP-seq
MIRT2552615	hsa-miR-190b	CLIP-seq
MIRT2552616	hsa-miR-214	CLIP-seq
MIRT2552617	hsa-miR-219-5p	CLIP-seq
MIRT2552618	hsa-miR-2355-3p	CLIP-seq
MIRT2437906	hsa-miR-3115	CLIP-seq
MIRT2682876	hsa-miR-3127-3p	CLIP-seq
MIRT2016844	hsa-miR-3157-5p	CLIP-seq
MIRT2682877	hsa-miR-3163	CLIP-seq
MIRT2016845	hsa-miR-3189-3p	CLIP-seq
MIRT2552619	hsa-miR-323b-5p	CLIP-seq
MIRT2682878	hsa-miR-342-3p	CLIP-seq
MIRT2682879	hsa-miR-3611	CLIP-seq
MIRT2552620	hsa-miR-3619-5p	CLIP-seq
MIRT1069071	hsa-miR-3662	CLIP-seq
MIRT2552622	hsa-miR-3940-5p	CLIP-seq
MIRT2016847	hsa-miR-3945	CLIP-seq
MIRT2016848	hsa-miR-4253	CLIP-seq
MIRT2552623	hsa-miR-4445	CLIP-seq
MIRT2552624	hsa-miR-4459	CLIP-seq
MIRT2552626	hsa-miR-4507	CLIP-seq
MIRT2552627	hsa-miR-4722-5p	CLIP-seq
MIRT2682880	hsa-miR-4725-5p	CLIP-seq
MIRT2552628	hsa-miR-4738-3p	CLIP-seq
MIRT2552629	hsa-miR-4749-3p	CLIP-seq
MIRT2552630	hsa-miR-4779	CLIP-seq
MIRT2682881	hsa-miR-4780	CLIP-seq
MIRT2552631	hsa-miR-4782-3p	CLIP-seq
MIRT2682882	hsa-miR-483-3p	CLIP-seq
MIRT2682883	hsa-miR-504	CLIP-seq
MIRT2552634	hsa-miR-508-3p	CLIP-seq
MIRT2682884	hsa-miR-581	CLIP-seq
MIRT2016857	hsa-miR-635	CLIP-seq
MIRT2552635	hsa-miR-653	CLIP-seq
MIRT2552636	hsa-miR-676	CLIP-seq
MIRT2552637	hsa-miR-761	CLIP-seq

Show/Hide all(13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	17785517, 17932509, 19167051, 26168401, 26496610, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IBA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006606	Process	Protein import into nucleus	IBA
GO:0006886	Process	Intracellular protein transport	IEA
GO:0007165	Process	Signal transduction	TAS	9214382
GO:0015031	Process	Protein transport	IEA
GO:0031267	Function	Small GTPase binding	IEA
GO:0031267	Function	Small GTPase binding	TAS	9214382

MIM	HGNC	e!Ensembl
605600	9853	ENSG00000133704

Protein

UniProt ID

O15397

Protein name

Importin-8 (Imp8) (Ran-binding protein 8) (RanBP8)

Protein function

Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03810	IBN_N	22 → 102	Importin-beta N-terminal domain	Family
PF08506	Cse1	173 → 449	Cse1	Family

Sequence

MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYL
KNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRAIIK
HDFPGHWPGVVDKIDYYLQSQSSASWLGSLLCLYQLVKTYEYKKAEEREPLIIAMQIFLP
RIQQQIVQLLPDSSYYSVLLQKQILKIFYALVQYALPLQLVNNQTMTTWMEIFRTIIDRT
VPPETLHIDEDDRPELVWWKCKKWALHIVARLFERYGSPGNVTKEYFEFSEFFLKTYAVG
IQQVLLKILDQYRQKEYVAPRVLQQAFNYLNQGVVHSITWKQMKPHIQNISEDVIFSVMC
YKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTLLYTAAKKRKEVLPKMMAFCYQIL
TDPNFDPRKKDGALHVIGSLAEILLKKSLFKDQMELFLQNHVFPLLLSNLGYLRARSCWV
LHAFSSLKFHNELNLRNAVELAKKSLIEDKEMPVKVEAALALQSLISNQIQAKEYMKPHV
RPIMQELLHIVRETENDDVTNVIQKMICEYSQEVASIAVDMTQHLAEIFGKVLQSDEYEE
VEDKTVMAMGILHTIDTILTVVEDHKEITQQLENICLRIIDLVLQKHVIEFYEEILSLAY
SLTCHSISPQMWQLLGILYEVFQQDCFEYFTDMMPLLHNYVTIDTDTLLSNAKHLEILFT
MCRKVLCGDAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVQLVLERLTRGVKTSELRT
MCLQVAIAALYYNPDLLLHTLERIQLPHNPGPITVQFINQWMNDTDCFLGHHDRKMCIIG
LSILLELQNRPPAVDAVVGQIVPSILFLFLGLKQVCATRQLVNREDRSKAEKADMEENEE
ISSDEEETNVTAQAMQSNNGRGEDEEEEDDDWDEEVLEETALEGFSTPLDLDNSVDEYQF
FTQALITVQSRDAAWYQLLMAPLSEDQRTALQEVYTLAEHRRTVAEAKKKIEQQGGFTFE
NKGVLSAFNFGTVPSNN

Sequence length

1037

Interactions

View interactions

	KEGG		Reactome
	Nucleocytoplasmic transport		Transcriptional regulation by small RNAs

Show/Hide Unknown Diseases (1)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast Cancer	Breast cancer	N/A	N/A	GWAS

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Astrocytoma	Associate	20511187
Carcinoma Non Small Cell Lung	Associate	28262749
Colorectal Neoplasms	Associate	21059236
Endometrial Neoplasms	Associate	32439920
Lung Neoplasms	Associate	19014639
Osteoarthritis	Associate	24080205
Psychotic Disorders	Associate	29064472

IPO8 (importin 8)