Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10509
Gene name Gene Name - the full gene name approved by the HGNC.	Semaphorin 4B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SEMA4B
Synonyms (NCBI Gene) Gene synonyms aliases	SEMAC, SemC
Chromosome Chromosome number	15
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	15q26.1

Show/Hide all(158)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017490	hsa-miR-335-5p	Microarray	18185580
MIRT051498	hsa-let-7e-5p	CLASH	23622248
MIRT073414	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT073407	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT073414	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT073406	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT073418	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT073408	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT073423	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT073407	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT1335046	hsa-miR-106a	CLIP-seq
MIRT1335047	hsa-miR-106b	CLIP-seq
MIRT1335048	hsa-miR-1236	CLIP-seq
MIRT1335049	hsa-miR-1238	CLIP-seq
MIRT1335050	hsa-miR-125b	CLIP-seq
MIRT1335051	hsa-miR-142-5p	CLIP-seq
MIRT1335052	hsa-miR-145	CLIP-seq
MIRT1335053	hsa-miR-17	CLIP-seq
MIRT1335054	hsa-miR-20a	CLIP-seq
MIRT1335055	hsa-miR-20b	CLIP-seq
MIRT1335056	hsa-miR-216b	CLIP-seq
MIRT1335057	hsa-miR-3126-5p	CLIP-seq
MIRT1335058	hsa-miR-3140-5p	CLIP-seq
MIRT1335059	hsa-miR-3150a-3p	CLIP-seq
MIRT1335060	hsa-miR-3153	CLIP-seq
MIRT1335061	hsa-miR-3165	CLIP-seq
MIRT1335062	hsa-miR-3175	CLIP-seq
MIRT1335063	hsa-miR-3201	CLIP-seq
MIRT1335064	hsa-miR-3609	CLIP-seq
MIRT1335065	hsa-miR-3676	CLIP-seq
MIRT1335066	hsa-miR-4303	CLIP-seq
MIRT1335067	hsa-miR-4326	CLIP-seq
MIRT1335068	hsa-miR-4419a	CLIP-seq
MIRT1335069	hsa-miR-4426	CLIP-seq
MIRT1335070	hsa-miR-4452	CLIP-seq
MIRT1335071	hsa-miR-4477a	CLIP-seq
MIRT1335072	hsa-miR-4484	CLIP-seq
MIRT1335073	hsa-miR-4510	CLIP-seq
MIRT1335074	hsa-miR-4534	CLIP-seq
MIRT1335075	hsa-miR-4647	CLIP-seq
MIRT1335076	hsa-miR-4649-3p	CLIP-seq
MIRT1335077	hsa-miR-4662b	CLIP-seq
MIRT1335078	hsa-miR-4680-3p	CLIP-seq
MIRT1335079	hsa-miR-4725-5p	CLIP-seq
MIRT1335080	hsa-miR-4747-5p	CLIP-seq
MIRT1335081	hsa-miR-4751	CLIP-seq
MIRT1335082	hsa-miR-4791	CLIP-seq
MIRT1335083	hsa-miR-4796-3p	CLIP-seq
MIRT1335084	hsa-miR-504	CLIP-seq
MIRT1335085	hsa-miR-519a	CLIP-seq
MIRT1335086	hsa-miR-519b-3p	CLIP-seq
MIRT1335087	hsa-miR-519c-3p	CLIP-seq
MIRT1335088	hsa-miR-519d	CLIP-seq
MIRT1335089	hsa-miR-541	CLIP-seq
MIRT1335090	hsa-miR-548ah	CLIP-seq
MIRT1335091	hsa-miR-654-5p	CLIP-seq
MIRT1335092	hsa-miR-658	CLIP-seq
MIRT1335093	hsa-miR-670	CLIP-seq
MIRT1335094	hsa-miR-93	CLIP-seq
MIRT1335095	hsa-miR-939	CLIP-seq
MIRT2099065	hsa-miR-615-3p	CLIP-seq
MIRT1335050	hsa-miR-125b	CLIP-seq
MIRT1335057	hsa-miR-3126-5p	CLIP-seq
MIRT2099066	hsa-miR-3909	CLIP-seq
MIRT1335068	hsa-miR-4419a	CLIP-seq
MIRT2099067	hsa-miR-4436b-3p	CLIP-seq
MIRT1335073	hsa-miR-4510	CLIP-seq
MIRT2099068	hsa-miR-4685-5p	CLIP-seq
MIRT2099069	hsa-miR-4701-5p	CLIP-seq
MIRT2099070	hsa-miR-4710	CLIP-seq
MIRT2099071	hsa-miR-4786-3p	CLIP-seq
MIRT2099072	hsa-miR-544b	CLIP-seq
MIRT2099073	hsa-miR-588	CLIP-seq
MIRT1335093	hsa-miR-670	CLIP-seq
MIRT2099074	hsa-miR-885-3p	CLIP-seq
MIRT2323847	hsa-miR-1229	CLIP-seq
MIRT1335048	hsa-miR-1236	CLIP-seq
MIRT1335050	hsa-miR-125b	CLIP-seq
MIRT2323848	hsa-miR-1273	CLIP-seq
MIRT1335057	hsa-miR-3126-5p	CLIP-seq
MIRT1335058	hsa-miR-3140-5p	CLIP-seq
MIRT2323849	hsa-miR-3144-5p	CLIP-seq
MIRT1335059	hsa-miR-3150a-3p	CLIP-seq
MIRT1335062	hsa-miR-3175	CLIP-seq
MIRT2323850	hsa-miR-3179	CLIP-seq
MIRT2323851	hsa-miR-3191	CLIP-seq
MIRT2323852	hsa-miR-3199	CLIP-seq
MIRT2323853	hsa-miR-3202	CLIP-seq
MIRT2323854	hsa-miR-3545-3p	CLIP-seq
MIRT1335066	hsa-miR-4303	CLIP-seq
MIRT1335068	hsa-miR-4419a	CLIP-seq
MIRT1335070	hsa-miR-4452	CLIP-seq
MIRT2323855	hsa-miR-4476	CLIP-seq
MIRT1335073	hsa-miR-4510	CLIP-seq
MIRT2323856	hsa-miR-4515	CLIP-seq
MIRT1335074	hsa-miR-4534	CLIP-seq
MIRT1335076	hsa-miR-4649-3p	CLIP-seq
MIRT2323857	hsa-miR-4652-5p	CLIP-seq
MIRT2323858	hsa-miR-4667-5p	CLIP-seq
MIRT1335078	hsa-miR-4680-3p	CLIP-seq
MIRT2323859	hsa-miR-4688	CLIP-seq
MIRT2323860	hsa-miR-4700-5p	CLIP-seq
MIRT2099070	hsa-miR-4710	CLIP-seq
MIRT1335080	hsa-miR-4747-5p	CLIP-seq
MIRT1335081	hsa-miR-4751	CLIP-seq
MIRT2323861	hsa-miR-4802-5p	CLIP-seq
MIRT1335089	hsa-miR-541	CLIP-seq
MIRT2099072	hsa-miR-544b	CLIP-seq
MIRT2323862	hsa-miR-602	CLIP-seq
MIRT1335091	hsa-miR-654-5p	CLIP-seq
MIRT1335093	hsa-miR-670	CLIP-seq
MIRT1335095	hsa-miR-939	CLIP-seq
MIRT2099066	hsa-miR-3909	CLIP-seq
MIRT2099067	hsa-miR-4436b-3p	CLIP-seq
MIRT2099068	hsa-miR-4685-5p	CLIP-seq
MIRT2099071	hsa-miR-4786-3p	CLIP-seq
MIRT2099074	hsa-miR-885-3p	CLIP-seq
MIRT2440113	hsa-miR-31	CLIP-seq
MIRT2440114	hsa-miR-320e	CLIP-seq
MIRT2440115	hsa-miR-4438	CLIP-seq
MIRT2440116	hsa-miR-4690-3p	CLIP-seq
MIRT2440117	hsa-miR-4708-3p	CLIP-seq
MIRT2440118	hsa-miR-5095	CLIP-seq
MIRT2442612	hsa-miR-1184	CLIP-seq
MIRT2442613	hsa-miR-1205	CLIP-seq
MIRT2440113	hsa-miR-31	CLIP-seq
MIRT1335058	hsa-miR-3140-5p	CLIP-seq
MIRT2442614	hsa-miR-3158-5p	CLIP-seq
MIRT2440114	hsa-miR-320e	CLIP-seq
MIRT2440116	hsa-miR-4690-3p	CLIP-seq
MIRT2440117	hsa-miR-4708-3p	CLIP-seq
MIRT2442612	hsa-miR-1184	CLIP-seq
MIRT2442613	hsa-miR-1205	CLIP-seq
MIRT2440113	hsa-miR-31	CLIP-seq
MIRT1335058	hsa-miR-3140-5p	CLIP-seq
MIRT2442614	hsa-miR-3158-5p	CLIP-seq
MIRT2619730	hsa-miR-3190	CLIP-seq
MIRT2323853	hsa-miR-3202	CLIP-seq
MIRT2440114	hsa-miR-320e	CLIP-seq
MIRT2619731	hsa-miR-3652	CLIP-seq
MIRT2619732	hsa-miR-3978	CLIP-seq
MIRT2619733	hsa-miR-4259	CLIP-seq
MIRT2619734	hsa-miR-4430	CLIP-seq
MIRT2619735	hsa-miR-4433	CLIP-seq
MIRT2099067	hsa-miR-4436b-3p	CLIP-seq
MIRT2440115	hsa-miR-4438	CLIP-seq
MIRT2619736	hsa-miR-4491	CLIP-seq
MIRT2619737	hsa-miR-4533	CLIP-seq
MIRT2619738	hsa-miR-4657	CLIP-seq
MIRT2440116	hsa-miR-4690-3p	CLIP-seq
MIRT2440117	hsa-miR-4708-3p	CLIP-seq
MIRT2099070	hsa-miR-4710	CLIP-seq
MIRT2619739	hsa-miR-4792	CLIP-seq
MIRT2440118	hsa-miR-5095	CLIP-seq
MIRT2619740	hsa-miR-571	CLIP-seq
MIRT2619741	hsa-miR-665	CLIP-seq
MIRT2619742	hsa-miR-875-3p	CLIP-seq
MIRT2099074	hsa-miR-885-3p	CLIP-seq

Show/Hide all(18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001755	Process	Neural crest cell migration	IBA
GO:0005515	Function	Protein binding	IPI	33845483, 34232536, 36217030
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0016020	Component	Membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030215	Function	Semaphorin receptor binding	IBA
GO:0030215	Function	Semaphorin receptor binding	IEA
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0038191	Function	Neuropilin binding	IBA
GO:0045202	Component	Synapse	IEA
GO:0045499	Function	Chemorepellent activity	IBA
GO:0050919	Process	Negative chemotaxis	IBA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

MIM	HGNC	e!Ensembl
617029	10730	ENSG00000185033

Protein

UniProt ID

Q9NPR2

Protein name

Semaphorin-4B (Semaphorin-C)

Protein function

Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01403	Sema	72 → 505	Sema domain	Family
PF01437	PSI	525 → 579	Plexin repeat	Family

Sequence

MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL
RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC
SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED
GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF
VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW
TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV
FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL
NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG
PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD
PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ
FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE
EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV
MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST
PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV

Sequence length

837

Interactions

View interactions

	KEGG
	Axon guidance

Show/Hide Unknown Diseases (2)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Acne	acne vulgaris	N/A	N/A	GWAS
Frontal Fibrosing Alopecia	Frontal fibrosing alopecia	N/A	N/A	GWAS

Show/Hide Text Mining Associations (19)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Breast Neoplasms	Inhibit	36115854
Carcinoma Non Small Cell Lung	Associate	24474252, 25095981
Carcinoma Renal Cell	Associate	29968393
Cholangiocarcinoma	Associate	36817485
Colorectal Neoplasms	Associate	29197895
Crohn Disease	Associate	36817485
Hypoxia	Inhibit	24474252
Inflammation	Associate	37173738
Lung Neoplasms	Associate	24474252
Lymphatic Metastasis	Inhibit	36115854
Myasthenia Gravis	Associate	35802752
Neonatal Sepsis	Associate	37471663
Neoplasm Metastasis	Associate	25095981
Neoplasm Metastasis	Inhibit	36115854
Neoplasms	Inhibit	33110154, 36115854
Neoplasms	Associate	36817485
Schizophrenia Spectrum and Other Psychotic Disorders	Associate	28850114
Stomach Neoplasms	Associate	30097497, 32481437
Thymoma	Associate	35802752

SEMA4B (semaphorin 4B)