SEMA4B (semaphorin 4B)

Gene

• Entrez ID: 10509
• Gene name: Semaphorin 4B
• Gene symbol: SEMA4B
• Synonyms (NCBI Gene): SEMAC, SemC
• Chromosome: 15
• Chromosome location: 15q26.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017490	hsa-miR-335-5p	Microarray	18185580
MIRT051498	hsa-let-7e-5p	CLASH	23622248
MIRT073414	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT073407	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT073414	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT073406	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT073418	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT073408	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT073423	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT073407	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT1335046	hsa-miR-106a	CLIP-seq
MIRT1335047	hsa-miR-106b	CLIP-seq
MIRT1335048	hsa-miR-1236	CLIP-seq
MIRT1335049	hsa-miR-1238	CLIP-seq
MIRT1335050	hsa-miR-125b	CLIP-seq
MIRT1335051	hsa-miR-142-5p	CLIP-seq
MIRT1335052	hsa-miR-145	CLIP-seq
MIRT1335053	hsa-miR-17	CLIP-seq
MIRT1335054	hsa-miR-20a	CLIP-seq
MIRT1335055	hsa-miR-20b	CLIP-seq
MIRT1335056	hsa-miR-216b	CLIP-seq
MIRT1335057	hsa-miR-3126-5p	CLIP-seq
MIRT1335058	hsa-miR-3140-5p	CLIP-seq
MIRT1335059	hsa-miR-3150a-3p	CLIP-seq
MIRT1335060	hsa-miR-3153	CLIP-seq
MIRT1335061	hsa-miR-3165	CLIP-seq
MIRT1335062	hsa-miR-3175	CLIP-seq
MIRT1335063	hsa-miR-3201	CLIP-seq
MIRT1335064	hsa-miR-3609	CLIP-seq
MIRT1335065	hsa-miR-3676	CLIP-seq
MIRT1335066	hsa-miR-4303	CLIP-seq
MIRT1335067	hsa-miR-4326	CLIP-seq
MIRT1335068	hsa-miR-4419a	CLIP-seq
MIRT1335069	hsa-miR-4426	CLIP-seq
MIRT1335070	hsa-miR-4452	CLIP-seq
MIRT1335071	hsa-miR-4477a	CLIP-seq
MIRT1335072	hsa-miR-4484	CLIP-seq
MIRT1335073	hsa-miR-4510	CLIP-seq
MIRT1335074	hsa-miR-4534	CLIP-seq
MIRT1335075	hsa-miR-4647	CLIP-seq
MIRT1335076	hsa-miR-4649-3p	CLIP-seq
MIRT1335077	hsa-miR-4662b	CLIP-seq
MIRT1335078	hsa-miR-4680-3p	CLIP-seq
MIRT1335079	hsa-miR-4725-5p	CLIP-seq
MIRT1335080	hsa-miR-4747-5p	CLIP-seq
MIRT1335081	hsa-miR-4751	CLIP-seq
MIRT1335082	hsa-miR-4791	CLIP-seq
MIRT1335083	hsa-miR-4796-3p	CLIP-seq
MIRT1335084	hsa-miR-504	CLIP-seq
MIRT1335085	hsa-miR-519a	CLIP-seq
MIRT1335086	hsa-miR-519b-3p	CLIP-seq
MIRT1335087	hsa-miR-519c-3p	CLIP-seq
MIRT1335088	hsa-miR-519d	CLIP-seq
MIRT1335089	hsa-miR-541	CLIP-seq
MIRT1335090	hsa-miR-548ah	CLIP-seq
MIRT1335091	hsa-miR-654-5p	CLIP-seq
MIRT1335092	hsa-miR-658	CLIP-seq
MIRT1335093	hsa-miR-670	CLIP-seq
MIRT1335094	hsa-miR-93	CLIP-seq
MIRT1335095	hsa-miR-939	CLIP-seq
MIRT2099065	hsa-miR-615-3p	CLIP-seq
MIRT1335050	hsa-miR-125b	CLIP-seq
MIRT1335057	hsa-miR-3126-5p	CLIP-seq
MIRT2099066	hsa-miR-3909	CLIP-seq
MIRT1335068	hsa-miR-4419a	CLIP-seq
MIRT2099067	hsa-miR-4436b-3p	CLIP-seq
MIRT1335073	hsa-miR-4510	CLIP-seq
MIRT2099068	hsa-miR-4685-5p	CLIP-seq
MIRT2099069	hsa-miR-4701-5p	CLIP-seq
MIRT2099070	hsa-miR-4710	CLIP-seq
MIRT2099071	hsa-miR-4786-3p	CLIP-seq
MIRT2099072	hsa-miR-544b	CLIP-seq
MIRT2099073	hsa-miR-588	CLIP-seq
MIRT1335093	hsa-miR-670	CLIP-seq
MIRT2099074	hsa-miR-885-3p	CLIP-seq
MIRT2323847	hsa-miR-1229	CLIP-seq
MIRT1335048	hsa-miR-1236	CLIP-seq
MIRT1335050	hsa-miR-125b	CLIP-seq
MIRT2323848	hsa-miR-1273	CLIP-seq
MIRT1335057	hsa-miR-3126-5p	CLIP-seq
MIRT1335058	hsa-miR-3140-5p	CLIP-seq
MIRT2323849	hsa-miR-3144-5p	CLIP-seq
MIRT1335059	hsa-miR-3150a-3p	CLIP-seq
MIRT1335062	hsa-miR-3175	CLIP-seq
MIRT2323850	hsa-miR-3179	CLIP-seq
MIRT2323851	hsa-miR-3191	CLIP-seq
MIRT2323852	hsa-miR-3199	CLIP-seq
MIRT2323853	hsa-miR-3202	CLIP-seq
MIRT2323854	hsa-miR-3545-3p	CLIP-seq
MIRT1335066	hsa-miR-4303	CLIP-seq
MIRT1335068	hsa-miR-4419a	CLIP-seq
MIRT1335070	hsa-miR-4452	CLIP-seq
MIRT2323855	hsa-miR-4476	CLIP-seq
MIRT1335073	hsa-miR-4510	CLIP-seq
MIRT2323856	hsa-miR-4515	CLIP-seq
MIRT1335074	hsa-miR-4534	CLIP-seq
MIRT1335076	hsa-miR-4649-3p	CLIP-seq
MIRT2323857	hsa-miR-4652-5p	CLIP-seq
MIRT2323858	hsa-miR-4667-5p	CLIP-seq
MIRT1335078	hsa-miR-4680-3p	CLIP-seq
MIRT2323859	hsa-miR-4688	CLIP-seq
MIRT2323860	hsa-miR-4700-5p	CLIP-seq
MIRT2099070	hsa-miR-4710	CLIP-seq
MIRT1335080	hsa-miR-4747-5p	CLIP-seq
MIRT1335081	hsa-miR-4751	CLIP-seq
MIRT2323861	hsa-miR-4802-5p	CLIP-seq
MIRT1335089	hsa-miR-541	CLIP-seq
MIRT2099072	hsa-miR-544b	CLIP-seq
MIRT2323862	hsa-miR-602	CLIP-seq
MIRT1335091	hsa-miR-654-5p	CLIP-seq
MIRT1335093	hsa-miR-670	CLIP-seq
MIRT1335095	hsa-miR-939	CLIP-seq
MIRT2099066	hsa-miR-3909	CLIP-seq
MIRT2099067	hsa-miR-4436b-3p	CLIP-seq
MIRT2099068	hsa-miR-4685-5p	CLIP-seq
MIRT2099071	hsa-miR-4786-3p	CLIP-seq
MIRT2099074	hsa-miR-885-3p	CLIP-seq
MIRT2440113	hsa-miR-31	CLIP-seq
MIRT2440114	hsa-miR-320e	CLIP-seq
MIRT2440115	hsa-miR-4438	CLIP-seq
MIRT2440116	hsa-miR-4690-3p	CLIP-seq
MIRT2440117	hsa-miR-4708-3p	CLIP-seq
MIRT2440118	hsa-miR-5095	CLIP-seq
MIRT2442612	hsa-miR-1184	CLIP-seq
MIRT2442613	hsa-miR-1205	CLIP-seq
MIRT2440113	hsa-miR-31	CLIP-seq
MIRT1335058	hsa-miR-3140-5p	CLIP-seq
MIRT2442614	hsa-miR-3158-5p	CLIP-seq
MIRT2440114	hsa-miR-320e	CLIP-seq
MIRT2440116	hsa-miR-4690-3p	CLIP-seq
MIRT2440117	hsa-miR-4708-3p	CLIP-seq
MIRT2442612	hsa-miR-1184	CLIP-seq
MIRT2442613	hsa-miR-1205	CLIP-seq
MIRT2440113	hsa-miR-31	CLIP-seq
MIRT1335058	hsa-miR-3140-5p	CLIP-seq
MIRT2442614	hsa-miR-3158-5p	CLIP-seq
MIRT2619730	hsa-miR-3190	CLIP-seq
MIRT2323853	hsa-miR-3202	CLIP-seq
MIRT2440114	hsa-miR-320e	CLIP-seq
MIRT2619731	hsa-miR-3652	CLIP-seq
MIRT2619732	hsa-miR-3978	CLIP-seq
MIRT2619733	hsa-miR-4259	CLIP-seq
MIRT2619734	hsa-miR-4430	CLIP-seq
MIRT2619735	hsa-miR-4433	CLIP-seq
MIRT2099067	hsa-miR-4436b-3p	CLIP-seq
MIRT2440115	hsa-miR-4438	CLIP-seq
MIRT2619736	hsa-miR-4491	CLIP-seq
MIRT2619737	hsa-miR-4533	CLIP-seq
MIRT2619738	hsa-miR-4657	CLIP-seq
MIRT2440116	hsa-miR-4690-3p	CLIP-seq
MIRT2440117	hsa-miR-4708-3p	CLIP-seq
MIRT2099070	hsa-miR-4710	CLIP-seq
MIRT2619739	hsa-miR-4792	CLIP-seq
MIRT2440118	hsa-miR-5095	CLIP-seq
MIRT2619740	hsa-miR-571	CLIP-seq
MIRT2619741	hsa-miR-665	CLIP-seq
MIRT2619742	hsa-miR-875-3p	CLIP-seq
MIRT2099074	hsa-miR-885-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001755	Process	Neural crest cell migration	IBA
GO:0005515	Function	Protein binding	IPI	33845483, 34232536, 36217030
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0016020	Component	Membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030215	Function	Semaphorin receptor binding	IBA
GO:0030215	Function	Semaphorin receptor binding	IEA
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0038191	Function	Neuropilin binding	IBA
GO:0045202	Component	Synapse	IEA
GO:0045499	Function	Chemorepellent activity	IBA
GO:0050919	Process	Negative chemotaxis	IBA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA
GO:0098839	Component	Postsynaptic density membrane	IEA
GO:0098978	Component	Glutamatergic synapse	IEA

Other IDs

• MIM: 617029
• HGNC: 10730
• e!Ensembl: ENSG00000185033

Protein

• UniProt ID: Q9NPR2
• Protein name: Semaphorin-4B (Semaphorin-C)
• Protein function: Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01403	Sema	72 → 505	Sema domain	Family
  PF01437	PSI	525 → 579	Plexin repeat	Family

• Sequence:

  MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLGSEERPFL
  RFEAEHISNYTALLLSRDGRTLYVGAREALFALSSNLSFLPGGEYQELLWGADAEKKQQC
  SFKGKDPQRDCQNYIKILLPLSGSHLFTCGTAAFSPMCTYINMENFTLARDEKGNVLLED
  GKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSLRPTKTESSLNWLQDPAF
  VASAYIPESLGSLQGDDDKIYFFFSETGQEFEFFENTIVSRIARICKGDEGGERVLQQRW
  TSFLKAQLLCSRPDDGFPFNVLQDVFTLSPSPQDWRDTLFYGVFTSQWHRGTTEGSAVCV
  FTMKDVQRVFSGLYKEVNRETQQWYTVTHPVPTPRPGACITNSARERKINSSLQLPDRVL
  NFLKDHFLMDGQVRSRMLLLQPQARYQRVAVHRVPGLHHTYDVLFLGTGDGRLHKAVSVG
  PRVHIIEELQIFSSGQPVQNLLLDTHRGLLYAASHSGVVQVPMANCSLYRSCGDCLLARD
  PYCAWSGSSCKHVSLYQPQLATRPWIQDIEGASAKDLCSASSVVSPSFVPTGEKPCEQVQ
  FQPNTVNTLACPLLSNLATRLWLRNGAPVNASASCHVLPTGDLLLVGTQQLGEFQCWSLE
  EGFQQLVASYCPEVVEDGVADQTDEGGSVPVIISTSRVSAPAGGKASWGADRSYWKEFLV
  MCTLFVLAVLLPVLFLLYRHRNSMKVFLKQGECASVHPKTCPVVLPPETRPLNGLGPPST
  PLDHRGYQSLSDSPPGSRVFTESEKRPLSIQDSFVEVSPVCPRPRVRLGSEIRDSVV

• Sequence length: 837

Pathways

KEGG:

Axon guidance