Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10507
Gene name	Semaphorin 4D
Gene symbol	SEMA4D
Synonyms (NCBI Gene)	A8BB18C9orf164CD100COLL4GR3M-sema-GSEMAJcoll-4
Chromosome	9
Chromosome location	9q22.2

190

Show/Hide all (190)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004149	hsa-miR-192-5p	Microarray	16822819
MIRT017224	hsa-miR-335-5p	Microarray	18185580
MIRT024017	hsa-miR-1-3p	Microarray	18668037
MIRT024391	hsa-miR-215-5p	Microarray	19074876
MIRT004149	hsa-miR-192-5p	Microarray	19074876
MIRT050315	hsa-miR-25-3p	CLASH	23622248
MIRT042320	hsa-miR-484	CLASH	23622248
MIRT699785	hsa-miR-548ac	HITS-CLIP	23313552
MIRT699784	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT699783	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT699782	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT699781	hsa-miR-548z	HITS-CLIP	23313552
MIRT699780	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT699779	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT699778	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT699777	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT699776	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT699775	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT699774	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT699773	hsa-miR-7849-3p	HITS-CLIP	23313552
MIRT699772	hsa-miR-300	HITS-CLIP	23313552
MIRT699771	hsa-miR-381-3p	HITS-CLIP	23313552
MIRT699770	hsa-miR-4666a-3p	HITS-CLIP	23313552
MIRT699769	hsa-miR-3973	HITS-CLIP	23313552
MIRT699768	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT699767	hsa-miR-520h	HITS-CLIP	23313552
MIRT699766	hsa-let-7a-3p	HITS-CLIP	23313552
MIRT699765	hsa-let-7b-3p	HITS-CLIP	23313552
MIRT699764	hsa-let-7f-1-3p	HITS-CLIP	23313552
MIRT699763	hsa-miR-98-3p	HITS-CLIP	23313552
MIRT699762	hsa-miR-1225-5p	HITS-CLIP	23313552
MIRT526610	hsa-miR-3662	PAR-CLIP	22012620
MIRT526609	hsa-miR-7844-5p	PAR-CLIP	22012620
MIRT512536	hsa-miR-5088-5p	PAR-CLIP	23446348
MIRT512535	hsa-miR-4301	PAR-CLIP	23446348
MIRT512534	hsa-miR-4286	PAR-CLIP	23446348
MIRT512533	hsa-miR-361-3p	PAR-CLIP	23446348
MIRT512532	hsa-miR-5681a	PAR-CLIP	23446348
MIRT512531	hsa-miR-3679-3p	PAR-CLIP	23446348
MIRT439682	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439682	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT735709	sja-miR-71a	Luciferase reporter assayWestern blottingqRT-PCR	32944173
MIRT699785	hsa-miR-548ac	HITS-CLIP	23313552
MIRT699784	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT699783	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT699782	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT699781	hsa-miR-548z	HITS-CLIP	23313552
MIRT699780	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT699779	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT699778	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT699777	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT699776	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT699775	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT699774	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT699773	hsa-miR-7849-3p	HITS-CLIP	23313552
MIRT699772	hsa-miR-300	HITS-CLIP	23313552
MIRT699771	hsa-miR-381-3p	HITS-CLIP	23313552
MIRT699770	hsa-miR-4666a-3p	HITS-CLIP	23313552
MIRT699769	hsa-miR-3973	HITS-CLIP	23313552
MIRT699768	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT699767	hsa-miR-520h	HITS-CLIP	23313552
MIRT699766	hsa-let-7a-3p	HITS-CLIP	23313552
MIRT699765	hsa-let-7b-3p	HITS-CLIP	23313552
MIRT699764	hsa-let-7f-1-3p	HITS-CLIP	23313552
MIRT699763	hsa-miR-98-3p	HITS-CLIP	23313552
MIRT699762	hsa-miR-1225-5p	HITS-CLIP	23313552
MIRT526610	hsa-miR-3662	PAR-CLIP	22012620
MIRT526609	hsa-miR-7844-5p	PAR-CLIP	22012620
MIRT512536	hsa-miR-5088-5p	PAR-CLIP	23446348
MIRT512535	hsa-miR-4301	PAR-CLIP	23446348
MIRT512534	hsa-miR-4286	PAR-CLIP	23446348
MIRT512533	hsa-miR-361-3p	PAR-CLIP	23446348
MIRT512532	hsa-miR-5681a	PAR-CLIP	23446348
MIRT512531	hsa-miR-3679-3p	PAR-CLIP	23446348
MIRT1335178	hsa-miR-128	CLIP-seq
MIRT1335179	hsa-miR-140-3p	CLIP-seq
MIRT1335180	hsa-miR-3134	CLIP-seq
MIRT1335181	hsa-miR-3160-3p	CLIP-seq
MIRT1335182	hsa-miR-3201	CLIP-seq
MIRT1335183	hsa-miR-4487	CLIP-seq
MIRT1335184	hsa-miR-451b	CLIP-seq
MIRT1335185	hsa-miR-4534	CLIP-seq
MIRT1335186	hsa-miR-4791	CLIP-seq
MIRT1335187	hsa-miR-548b-3p	CLIP-seq
MIRT1335188	hsa-miR-558	CLIP-seq
MIRT1335189	hsa-miR-122	CLIP-seq
MIRT1335190	hsa-miR-125a-5p	CLIP-seq
MIRT1335191	hsa-miR-125b	CLIP-seq
MIRT1335192	hsa-miR-137	CLIP-seq
MIRT1335193	hsa-miR-186	CLIP-seq
MIRT1335194	hsa-miR-188-5p	CLIP-seq
MIRT1335195	hsa-miR-197	CLIP-seq
MIRT1335196	hsa-miR-224	CLIP-seq
MIRT1335197	hsa-miR-3121-3p	CLIP-seq
MIRT1335198	hsa-miR-3155	CLIP-seq
MIRT1335199	hsa-miR-3155b	CLIP-seq
MIRT739061	hsa-miR-326	CLIP-seq
MIRT739060	hsa-miR-330-5p	CLIP-seq
MIRT1335200	hsa-miR-3618	CLIP-seq
MIRT1335201	hsa-miR-3659	CLIP-seq
MIRT1335202	hsa-miR-3688-3p	CLIP-seq
MIRT1335203	hsa-miR-3691-3p	CLIP-seq
MIRT1335204	hsa-miR-3939	CLIP-seq
MIRT1335205	hsa-miR-412	CLIP-seq
MIRT1335206	hsa-miR-4251	CLIP-seq
MIRT1335207	hsa-miR-4257	CLIP-seq
MIRT1335208	hsa-miR-4263	CLIP-seq
MIRT1335209	hsa-miR-4311	CLIP-seq
MIRT1335210	hsa-miR-4319	CLIP-seq
MIRT1335211	hsa-miR-4324	CLIP-seq
MIRT1335212	hsa-miR-4432	CLIP-seq
MIRT1335213	hsa-miR-4438	CLIP-seq
MIRT1335214	hsa-miR-4503	CLIP-seq
MIRT1335215	hsa-miR-4691-3p	CLIP-seq
MIRT1335216	hsa-miR-4732-3p	CLIP-seq
MIRT1335217	hsa-miR-4766-3p	CLIP-seq
MIRT1335218	hsa-miR-499-5p	CLIP-seq
MIRT1335219	hsa-miR-513a-5p	CLIP-seq
MIRT1335220	hsa-miR-520a-5p	CLIP-seq
MIRT1335221	hsa-miR-525-5p	CLIP-seq
MIRT1335222	hsa-miR-548p	CLIP-seq
MIRT1335223	hsa-miR-576-5p	CLIP-seq
MIRT1335224	hsa-miR-580	CLIP-seq
MIRT1335225	hsa-miR-586	CLIP-seq
MIRT1335226	hsa-miR-616	CLIP-seq
MIRT1335227	hsa-miR-654-3p	CLIP-seq
MIRT1335228	hsa-miR-670	CLIP-seq
MIRT1335229	hsa-miR-934	CLIP-seq
MIRT739061	hsa-miR-326	CLIP-seq
MIRT739060	hsa-miR-330-5p	CLIP-seq
MIRT2099118	hsa-miR-1226	CLIP-seq
MIRT2099119	hsa-miR-1273f	CLIP-seq
MIRT1335195	hsa-miR-197	CLIP-seq
MIRT2099120	hsa-miR-3148	CLIP-seq
MIRT2099121	hsa-miR-3175	CLIP-seq
MIRT1335202	hsa-miR-3688-3p	CLIP-seq
MIRT1335205	hsa-miR-412	CLIP-seq
MIRT2099122	hsa-miR-4706	CLIP-seq
MIRT2099123	hsa-miR-4749-5p	CLIP-seq
MIRT2099124	hsa-miR-4781-5p	CLIP-seq
MIRT2099125	hsa-miR-542-5p	CLIP-seq
MIRT1335222	hsa-miR-548p	CLIP-seq
MIRT2323869	hsa-miR-1207-5p	CLIP-seq
MIRT1335189	hsa-miR-122	CLIP-seq
MIRT2323870	hsa-miR-1236	CLIP-seq
MIRT1335190	hsa-miR-125a-5p	CLIP-seq
MIRT1335191	hsa-miR-125b	CLIP-seq
MIRT2099119	hsa-miR-1273f	CLIP-seq
MIRT1335194	hsa-miR-188-5p	CLIP-seq
MIRT2099121	hsa-miR-3175	CLIP-seq
MIRT1335206	hsa-miR-4251	CLIP-seq
MIRT1335210	hsa-miR-4319	CLIP-seq
MIRT1335211	hsa-miR-4324	CLIP-seq
MIRT1335214	hsa-miR-4503	CLIP-seq
MIRT1335185	hsa-miR-4534	CLIP-seq
MIRT2323871	hsa-miR-4699-3p	CLIP-seq
MIRT2099122	hsa-miR-4706	CLIP-seq
MIRT1335216	hsa-miR-4732-3p	CLIP-seq
MIRT2323872	hsa-miR-4736	CLIP-seq
MIRT2099123	hsa-miR-4749-5p	CLIP-seq
MIRT2323873	hsa-miR-4763-3p	CLIP-seq
MIRT2099124	hsa-miR-4781-5p	CLIP-seq
MIRT2323874	hsa-miR-520d-5p	CLIP-seq
MIRT2323875	hsa-miR-524-5p	CLIP-seq
MIRT2323876	hsa-miR-574-5p	CLIP-seq
MIRT1335224	hsa-miR-580	CLIP-seq
MIRT1335228	hsa-miR-670	CLIP-seq
MIRT2323877	hsa-miR-873	CLIP-seq
MIRT2394202	hsa-miR-3910	CLIP-seq
MIRT2394203	hsa-miR-4708-3p	CLIP-seq
MIRT2394204	hsa-miR-4716-5p	CLIP-seq
MIRT2394205	hsa-miR-587	CLIP-seq
MIRT2619743	hsa-miR-1285	CLIP-seq
MIRT2619744	hsa-miR-149	CLIP-seq
MIRT2619745	hsa-miR-3187-5p	CLIP-seq
MIRT2619746	hsa-miR-3194-5p	CLIP-seq
MIRT739061	hsa-miR-326	CLIP-seq
MIRT739060	hsa-miR-330-5p	CLIP-seq
MIRT2619747	hsa-miR-378g	CLIP-seq
MIRT2619748	hsa-miR-4265	CLIP-seq
MIRT2619749	hsa-miR-4296	CLIP-seq
MIRT2619750	hsa-miR-4322	CLIP-seq
MIRT2619751	hsa-miR-4417	CLIP-seq
MIRT2619752	hsa-miR-4437	CLIP-seq
MIRT2619753	hsa-miR-4486	CLIP-seq
MIRT2619754	hsa-miR-4640-5p	CLIP-seq
MIRT2619755	hsa-miR-4674	CLIP-seq
MIRT2619756	hsa-miR-4726-5p	CLIP-seq
MIRT2619757	hsa-miR-508-3p	CLIP-seq
MIRT2619758	hsa-miR-612	CLIP-seq

Show/Hide all (74)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	22019888
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0001755	Process	Neural crest cell migration	IBA
GO:0001934	Process	Positive regulation of protein phosphorylation	IDA	16055703
GO:0002116	Component	Semaphorin receptor complex	IEA
GO:0002116	Component	Semaphorin receptor complex	ISS
GO:0004888	Function	Transmembrane signaling receptor activity	IMP	20877282
GO:0005102	Function	Signaling receptor binding	IDA	11254688, 20877282
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	20877282
GO:0005615	Component	Extracellular space	IBA
GO:0005615	Component	Extracellular space	IEA
GO:0005615	Component	Extracellular space	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005813	Component	Centrosome	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	8876214
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006955	Process	Immune response	TAS	8876214
GO:0007155	Process	Cell adhesion	TAS	8876214
GO:0007162	Process	Negative regulation of cell adhesion	IDA	15218527
GO:0007399	Process	Nervous system development	IEA
GO:0007409	Process	Axonogenesis	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0008360	Process	Regulation of cell shape	IMP	20877282
GO:0016020	Component	Membrane	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0030215	Function	Semaphorin receptor binding	IBA
GO:0030215	Function	Semaphorin receptor binding	IEA
GO:0030215	Function	Semaphorin receptor binding	IPI	15218527
GO:0030215	Function	Semaphorin receptor binding	ISS
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0030335	Process	Positive regulation of cell migration	IDA	16055703
GO:0030335	Process	Positive regulation of cell migration	IEA
GO:0030335	Process	Positive regulation of cell migration	ISS
GO:0031344	Process	Regulation of cell projection organization	IMP	20877282
GO:0035025	Process	Positive regulation of Rho protein signal transduction	IEA
GO:0035025	Process	Positive regulation of Rho protein signal transduction	ISS
GO:0036064	Component	Ciliary basal body	IDA
GO:0038023	Function	Signaling receptor activity	IDA	15613544
GO:0038191	Function	Neuropilin binding	IBA
GO:0042802	Function	Identical protein binding	IPI	20877282
GO:0043066	Process	Negative regulation of apoptotic process	TAS	8876214
GO:0043547	Process	Positive regulation of GTPase activity	IMP	19788569
GO:0043931	Process	Ossification involved in bone maturation	IEA
GO:0043931	Process	Ossification involved in bone maturation	IMP	22019888
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045499	Function	Chemorepellent activity	IBA
GO:0045668	Process	Negative regulation of osteoblast differentiation	IEA
GO:0045668	Process	Negative regulation of osteoblast differentiation	ISS
GO:0048018	Function	Receptor ligand activity	IEA
GO:0048018	Function	Receptor ligand activity	ISS
GO:0048672	Process	Positive regulation of collateral sprouting	IMP	19788569
GO:0048814	Process	Regulation of dendrite morphogenesis	IMP	19788569
GO:0050772	Process	Positive regulation of axonogenesis	IEA
GO:0050772	Process	Positive regulation of axonogenesis	IEA
GO:0050919	Process	Negative chemotaxis	IBA
GO:0051897	Process	Positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP	16055703
GO:0051963	Process	Regulation of synapse assembly	IEA
GO:0061430	Process	Bone trabecula morphogenesis	IEA
GO:0061430	Process	Bone trabecula morphogenesis	ISS
GO:0065008	Process	Regulation of biological quality	IEA
GO:0070486	Process	Leukocyte aggregation	IMP	8876214
GO:0071526	Process	Semaphorin-plexin signaling pathway	IBA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IDA	15218527
GO:0071526	Process	Semaphorin-plexin signaling pathway	IEA
GO:0071526	Process	Semaphorin-plexin signaling pathway	IMP	19788569, 20877282, 22019888
GO:0071526	Process	Semaphorin-plexin signaling pathway	ISS
GO:0098982	Component	GABA-ergic synapse	IEA
GO:1902533	Process	Positive regulation of intracellular signal transduction	IEA
GO:1905704	Process	Positive regulation of inhibitory synapse assembly	IEA
GO:1905704	Process	Positive regulation of inhibitory synapse assembly	ISS

MIM	HGNC	e!Ensembl
601866	10732	ENSG00000187764

Q92854

Protein name

Semaphorin-4D (A8) (BB18) (GR3) (CD antigen CD100)

Protein function

Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent man

PDB

1OLZ , 3OL2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01403	Sema	52 → 480	Sema domain	Family
PF01437	PSI	502 → 554	Plexin repeat	Family
PF00047	ig	561 → 639	Immunoglobulin domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and li

Sequence

MRMCTPIRGLLMALAVMFGTAMAFAPIPRITWEHREVHLVQFHEPDIYNYSALLLSEDKD
TLYIGAREAVFAVNALNISEKQHEVYWKVSEDKKAKCAEKGKSKQTECLNYIRVLQPLSA
TSLYVCGTNAFQPACDHLNLTSFKFLGKNEDGKGRCPFDPAHSYTSVMVDGELYSGTSYN
FLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIRKSPDSPDGEDDRVYFFFTEVSV
EYEFVFRVLIPRIARVCKGDQGGLRTLQKKWTSFLKARLICSRPDSGLVFNVLRDVFVLR
SPGLKVPVFYALFTPQLNNVGLSAVCAYNLSTAEEVFSHGKYMQSTTVEQSHTKWVRYNG
PVPKPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPRLIKKDVNY
TQIVVDRTQALDGTVYDVMFVSTDRGALHKAISLEHAVHIIEETQLFQDFEPVQTLLLSS
KKGNRFVYAGSNSGVVQAPLAFCGKHGTCEDCVLARDPYCAWSPPTATCVALHQTESPSR
GLIQEMSGDASVCPDKSKGSYRQHFFKHGGTAELKCSQKSNLARVFWKFQNGVLKAESPK
YGLMGRKNLLIFNLSEGDSGVYQCLSEERVKNKTVFQVVAKHVLEVKVVPKPVVAPTLSV
VQTEGSRIATKVLVASTQGSSPPTPAVQATSSGAITLPPKPAPTGTSCEPKIVINTVPQL
HSEKTMYLKSSDNRLLMSLFLFFFVLFLCLFFYNCYKGYLPRQCLKFRSALLIGKKKPKS
DFCDREQSLKETLVEPGSFSQQNGEHPKPALDTGYETEQDTITSKVPTDREDSQRIDDLS
ARDKPFDVKCELKFADSDADGD

Sequence length

862

Interactions

View interactions

	KEGG		Reactome
	Axon guidance		Sema4D mediated inhibition of cell attachment and migration Sema4D induced cell migration and growth-cone collapse Other semaphorin interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (22)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Anti-SEMA4D Monoclonal Antibody VX15/2503	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ESTROGEN-RECEPTOR NEGATIVE BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IGA GLOMERULONEPHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALIGNANT EPITHELIAL TUMOR OF OVARY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OCULAR HYPOTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OROFACIAL CLEFT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OTOSCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEMA4D-related disorder	Likely benign; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (65)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Abortion Spontaneous	Associate	22606231	★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of Lung	Associate	35710585	★★★★★ ★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm Thoracic	Associate	31035427	★★★★★ ★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Associate	30538782	★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Fibrillation	Associate	26417899	★★★★★ ★☆☆☆☆ Found in Text Mining only
Attention Deficit Disorder with Hyperactivity	Associate	30529763	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Associate	21244334, 33013906	★★★★★ ★☆☆☆☆ Found in Text Mining only
Benign non infected urachal cyst	Associate	33776991	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Associate	34854398	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Non Small Cell Lung	Associate	32149403	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Associate	23202951, 24289594, 29308068, 31105696	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Associate	21812859	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Renal Cell	Associate	33974462	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Associate	33381571	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Inhibit	39596507	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Associate	25717256, 27456345, 34337054, 35730423	★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Associate	31651222	★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Associate	24114199	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heart Diseases	Associate	28760660	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemorrhagic Fever with Renal Syndrome	Associate	26378166	★★★★★ ★☆☆☆☆ Found in Text Mining only
Heterotaxy Syndrome	Associate	26417899	★★★★★ ★☆☆☆☆ Found in Text Mining only
HIV Infections	Inhibit	22134167	★★★★★ ★☆☆☆☆ Found in Text Mining only
HIV Infections	Associate	30161254	★★★★★ ★☆☆☆☆ Found in Text Mining only
Huntington Disease	Associate	35941373	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypogonadism	Associate	30098700	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	21244334, 26740106, 28296344, 30141208, 33013906, 33381571	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Associate	33649851, 35401878	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Biphenotypic Acute	Stimulate	35401878	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Lymphocytic Chronic B Cell	Associate	15613544	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Associate	33649851, 35401878	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lichen Planus Oral	Associate	28760660	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Stimulate	21812859, 23202951	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Associate	25717256, 27456345, 29434448	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma Non Hodgkin	Associate	9665486	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma T Cell Peripheral	Associate	9665486	★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanoma	Associate	22189792, 33974462, 34659201	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mucocutaneous Lymph Node Syndrome	Associate	33381571	★★★★★ ★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Associate	33593275	★★★★★ ★☆☆☆☆ Found in Text Mining only
Necrosis	Stimulate	17520683	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Invasiveness	Associate	27456345	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Stimulate	21812859	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasm Metastasis	Associate	24289594	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	16754882, 17520683, 21812859, 22476930, 23202951, 24289594, 25549701, 25717256, 26718213, 26740106, 27456345, 28225892, 29308068, 31651222, 33776991 View all (4 more)	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Inhibit	22189792, 34659201, 38006346	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Stimulate	24114199, 29434448	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Stimulate	28296344	★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Associate	28296344	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Associate	34854398	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Associate	24289594	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Stimulate	26718213, 28225892, 39972314	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Associate	21812859	★★★★★ ★☆☆☆☆ Found in Text Mining only
Plaque Atherosclerotic	Associate	24098722	★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Stimulate	35401878	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms Castration Resistant	Associate	30141208	★★★★★ ★☆☆☆☆ Found in Text Mining only
Purpura Thrombocytopenic Idiopathic	Associate	22111667	★★★★★ ★☆☆☆☆ Found in Text Mining only
Reperfusion Injury	Inhibit	32977749	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Associate	17520683	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Scleroderma Systemic	Associate	21244334	★★★★★ ★☆☆☆☆ Found in Text Mining only
Spondylitis Ankylosing	Associate	33013906	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Associate	16754882, 26740106, 33776991	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Inhibit	38006346	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Associate	29434448	★★★★★ ★☆☆☆☆ Found in Text Mining only
Thymoma	Associate	33974462	★★★★★ ★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Associate	33974462	★★★★★ ★☆☆☆☆ Found in Text Mining only
Virus Diseases	Associate	26378166	★★★★★ ★☆☆☆☆ Found in Text Mining only

SEMA4D (semaphorin 4D)