Gene Gene information from NCBI Gene database.
Entrez ID 105
Gene name Adenosine deaminase RNA specific B2 (inactive)
Gene symbol ADARB2
Synonyms (NCBI Gene)
ADAR3RED2
Chromosome 10
Chromosome location 10p15.3
Summary This gene encodes a member of the double-stranded RNA adenosine deaminase family of RNA-editing enzymes and may play a regulatory role in RNA editing. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
305
miRTarBase ID miRNA Experiments Reference
MIRT616328 hsa-miR-2681-5p HITS-CLIP 23824327
MIRT616328 hsa-miR-2681-5p HITS-CLIP 23824327
MIRT539474 hsa-miR-497-3p PAR-CLIP 22012620
MIRT539473 hsa-miR-6768-3p PAR-CLIP 22012620
MIRT539471 hsa-miR-6776-3p PAR-CLIP 22012620
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
SFPQ Repression 24173718
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0003723 Function RNA binding IEA
GO:0003725 Function Double-stranded RNA binding IBA
GO:0003725 Function Double-stranded RNA binding TAS 10836796
GO:0003726 Function Double-stranded RNA adenosine deaminase activity IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602065 227 ENSG00000185736
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NS39
Protein name Double-stranded RNA-specific editase B2 (EC 3.5.-.-) (RNA-dependent adenosine deaminase 3) (RNA-editing deaminase 2) (RNA-editing enzyme 2) (dsRNA adenosine deaminase B2)
Protein function Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00035 dsrm 126 188 Double-stranded RNA binding motif Domain
PF00035 dsrm 282 339 Double-stranded RNA binding motif Domain
PF02137 A_deamin 408 729 Adenosine-deaminase (editase) domain Family
Tissue specificity TISSUE SPECIFICITY: Brain specific. Expressed at higher levels in astrocytomas as compared to the normal brain tissue. {ECO:0000269|PubMed:10836796, ECO:0000269|PubMed:18178553}.
Sequence
MASVLGSGRGSGGLSSQLKCKSKRRRRRRSKRKDKVSILSTFLAPFKHLSPGITNTEDDD
TLSTSSAEVKENRNVGNLAARPPPSGDRARGGAPGAKRKRPLEEGNGGHLCKLQLVWKKL
SWSVAPKNALVQLHELRPGLQYRTVSQTGPVHAPVFAVAVEVNGLTFEGTGPTKKKAKMR
AAELALRS
FVQFPNACQAHLAMGGGPGPGTDFTSDQADFPDTLFQEFEPPAPRPGLAGGR
PGDAALLSAAYGRRRLLCRALDLVGPTPATPAAPGERNPVVLLNRLRAGLRYVCLAEPAE
RRARSFVMAVSVDGRTFEGSGRSKKLARGQAAQAALQEL
FDIQMPGHAPGRARRTPMPQE
FADSISQLVTQKFREVTTDLTPMHARHKALAGIVMTKGLDARQAQVVALSSGTKCISGEH
LSDQGLVVNDCHAEVVARRAFLHFLYTQLELHLSKRREDSERSIFVRLKEGGYRLRENIL
FHLYVSTSPCGDARLHSPYEITTDLHSSKHLVRKFRGHLRTKIESGEGTVPVRGPSAVQT
WDGVLLGEQLITMSCTDKIARWNVLGLQGALLSHFVEPVYLQSIVVGSLHHTGHLARVMS
HRMEGVGQLPASYRHNRPLLSGVSDAEARQPGKSPPFSMNWVVGSADLEIINATTGRRSC
GGPSRLCKHVLSARWARLYGRLSTRTPSPGDTPSMYCEAKLGAHTYQSVKQQLFKAFQKA
GLGTWVRKP
PEQQQFLLTL
Sequence length 739
Interactions View interactions