CARM1 (coactivator associated arginine methyltransferase 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 10498 |
| Gene name | Coactivator associated arginine methyltransferase 1 |
| Gene symbol | CARM1 |
| Synonyms (NCBI Gene) |
PRMT4
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| Chromosome | 19 |
| Chromosome location | 19p13.2 |
| Summary | This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts specifically on histones and other chromatin-associated protein |
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miRNA
miRNA information provided by mirtarbase database.
371
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Transcription factors
Transcription factors information provided by TRRUST V2 database.
3
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
48
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q86X55 | |||||||||||||||
| Protein name | Histone-arginine methyltransferase CARM1 (EC 2.1.1.319) (Coactivator-associated arginine methyltransferase 1) (Protein arginine N-methyltransferase 4) | |||||||||||||||
| Protein function | Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability (PubMed:12237300, PubMed:16497732, PubMed: | |||||||||||||||
| PDB | 2Y1W , 2Y1X , 4IKP , 5DWQ , 5DX0 , 5DX1 , 5DX8 , 5DXA , 5DXJ , 5U4X , 6ARJ , 6ARV , 6D2L , 6DVR , 6IZQ , 6S70 , 6S71 , 6S74 , 6S77 , 6S79 , 6S7A , 6S7B , 6S7C , 7FAI , 7FAJ , 7U9I , 8G2H , 8G2I , 8SIG , 8SIH | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Overexpressed in prostate adenocarcinomas and high-grade prostatic intraepithelial neoplasia. {ECO:0000269|PubMed:15221992}. | |||||||||||||||
| Sequence |
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| Sequence length | 608 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
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