Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	10475
Gene name	Tripartite motif containing 38
Gene symbol	TRIM38
Synonyms (NCBI Gene)	RNF15RORET
Chromosome	6
Chromosome location	6p22.2
Summary	This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on t

235

Show/Hide all (235)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022126	hsa-miR-124-3p	Microarray	18668037
MIRT030670	hsa-miR-21-5p	Microarray	18591254
MIRT646583	hsa-miR-1827	HITS-CLIP	23824327
MIRT646581	hsa-miR-4775	HITS-CLIP	23824327
MIRT646582	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT646579	hsa-miR-6765-5p	HITS-CLIP	23824327
MIRT646580	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT560613	hsa-miR-34b-3p	PAR-CLIP	20371350
MIRT560612	hsa-miR-4705	PAR-CLIP	20371350
MIRT560611	hsa-miR-600	PAR-CLIP	20371350
MIRT560610	hsa-miR-6077	PAR-CLIP	20371350
MIRT560609	hsa-miR-323a-5p	PAR-CLIP	20371350
MIRT560608	hsa-miR-876-3p	PAR-CLIP	20371350
MIRT560607	hsa-miR-6079	PAR-CLIP	20371350
MIRT560606	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT449809	hsa-miR-586	PAR-CLIP	22100165
MIRT449808	hsa-miR-3913-3p	PAR-CLIP	22100165
MIRT449807	hsa-miR-489-3p	PAR-CLIP	22100165
MIRT449806	hsa-miR-448	PAR-CLIP	22100165
MIRT449805	hsa-miR-1273e	PAR-CLIP	22100165
MIRT734139	hsa-miR-30e-5p	Luciferase reporter assayImmunoprecipitaion (IP)ELISA	32688283
MIRT646583	hsa-miR-1827	HITS-CLIP	23824327
MIRT646581	hsa-miR-4775	HITS-CLIP	23824327
MIRT646582	hsa-miR-502-5p	HITS-CLIP	23824327
MIRT646579	hsa-miR-6765-5p	HITS-CLIP	23824327
MIRT646580	hsa-miR-1304-5p	HITS-CLIP	23824327
MIRT560613	hsa-miR-34b-3p	PAR-CLIP	20371350
MIRT560612	hsa-miR-4705	PAR-CLIP	20371350
MIRT560611	hsa-miR-600	PAR-CLIP	20371350
MIRT560610	hsa-miR-6077	PAR-CLIP	20371350
MIRT560609	hsa-miR-323a-5p	PAR-CLIP	20371350
MIRT560608	hsa-miR-876-3p	PAR-CLIP	20371350
MIRT560607	hsa-miR-6079	PAR-CLIP	20371350
MIRT560606	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT449809	hsa-miR-586	PAR-CLIP	22100165
MIRT449808	hsa-miR-3913-3p	PAR-CLIP	22100165
MIRT449807	hsa-miR-489-3p	PAR-CLIP	22100165
MIRT449806	hsa-miR-448	PAR-CLIP	22100165
MIRT449805	hsa-miR-1273e	PAR-CLIP	22100165
MIRT1454626	hsa-miR-1273f	CLIP-seq
MIRT1454627	hsa-miR-138	CLIP-seq
MIRT1454628	hsa-miR-197	CLIP-seq
MIRT1454629	hsa-miR-2682	CLIP-seq
MIRT1454630	hsa-miR-3162-3p	CLIP-seq
MIRT1454631	hsa-miR-3187-3p	CLIP-seq
MIRT1454632	hsa-miR-3545-3p	CLIP-seq
MIRT1454633	hsa-miR-3612	CLIP-seq
MIRT1454634	hsa-miR-421	CLIP-seq
MIRT1454635	hsa-miR-4272	CLIP-seq
MIRT1454636	hsa-miR-4275	CLIP-seq
MIRT1454637	hsa-miR-4423-3p	CLIP-seq
MIRT1454638	hsa-miR-4435	CLIP-seq
MIRT1454639	hsa-miR-4438	CLIP-seq
MIRT1454640	hsa-miR-4443	CLIP-seq
MIRT1454641	hsa-miR-449c	CLIP-seq
MIRT1454642	hsa-miR-4534	CLIP-seq
MIRT1454643	hsa-miR-4680-5p	CLIP-seq
MIRT1454644	hsa-miR-4694-5p	CLIP-seq
MIRT1454645	hsa-miR-4701-5p	CLIP-seq
MIRT1454646	hsa-miR-4716-5p	CLIP-seq
MIRT1454647	hsa-miR-4755-3p	CLIP-seq
MIRT1454648	hsa-miR-4756-3p	CLIP-seq
MIRT1454649	hsa-miR-4781-3p	CLIP-seq
MIRT1454650	hsa-miR-4802-5p	CLIP-seq
MIRT1454651	hsa-miR-4803	CLIP-seq
MIRT1454652	hsa-miR-5095	CLIP-seq
MIRT1454653	hsa-miR-5096	CLIP-seq
MIRT1454654	hsa-miR-548s	CLIP-seq
MIRT1454655	hsa-miR-588	CLIP-seq
MIRT1454656	hsa-miR-650	CLIP-seq
MIRT1454657	hsa-miR-653	CLIP-seq
MIRT1454658	hsa-miR-940	CLIP-seq
MIRT2136187	hsa-miR-1301	CLIP-seq
MIRT2136188	hsa-miR-1305	CLIP-seq
MIRT2136189	hsa-miR-3646	CLIP-seq
MIRT2136190	hsa-miR-3662	CLIP-seq
MIRT2136191	hsa-miR-3680	CLIP-seq
MIRT2136192	hsa-miR-3974	CLIP-seq
MIRT2136193	hsa-miR-4660	CLIP-seq
MIRT2136194	hsa-miR-4670-3p	CLIP-seq
MIRT2136195	hsa-miR-4698	CLIP-seq
MIRT2136196	hsa-miR-4798-3p	CLIP-seq
MIRT2136197	hsa-miR-5047	CLIP-seq
MIRT2136198	hsa-miR-590-3p	CLIP-seq
MIRT2136199	hsa-miR-607	CLIP-seq
MIRT2357195	hsa-miR-2277-3p	CLIP-seq
MIRT1454632	hsa-miR-3545-3p	CLIP-seq
MIRT2357196	hsa-miR-3921	CLIP-seq
MIRT2357197	hsa-miR-4427	CLIP-seq
MIRT2357198	hsa-miR-4653-5p	CLIP-seq
MIRT2357199	hsa-miR-4680-3p	CLIP-seq
MIRT1454643	hsa-miR-4680-5p	CLIP-seq
MIRT2136198	hsa-miR-590-3p	CLIP-seq
MIRT1454657	hsa-miR-653	CLIP-seq
MIRT2357200	hsa-miR-942	CLIP-seq
MIRT1454630	hsa-miR-3162-3p	CLIP-seq
MIRT1454628	hsa-miR-197	CLIP-seq
MIRT2462349	hsa-miR-3149	CLIP-seq
MIRT2462350	hsa-miR-411	CLIP-seq
MIRT1454646	hsa-miR-4716-5p	CLIP-seq
MIRT2462351	hsa-miR-4735-5p	CLIP-seq
MIRT1454649	hsa-miR-4781-3p	CLIP-seq
MIRT1454653	hsa-miR-5096	CLIP-seq
MIRT2136198	hsa-miR-590-3p	CLIP-seq
MIRT2462349	hsa-miR-3149	CLIP-seq
MIRT2462350	hsa-miR-411	CLIP-seq
MIRT2462351	hsa-miR-4735-5p	CLIP-seq
MIRT2136198	hsa-miR-590-3p	CLIP-seq
MIRT2650819	hsa-miR-1266	CLIP-seq
MIRT2650820	hsa-miR-1273g	CLIP-seq
MIRT2650821	hsa-miR-127-5p	CLIP-seq
MIRT1454627	hsa-miR-138	CLIP-seq
MIRT2650822	hsa-miR-140-5p	CLIP-seq
MIRT1454628	hsa-miR-197	CLIP-seq
MIRT2650823	hsa-miR-204	CLIP-seq
MIRT2650824	hsa-miR-211	CLIP-seq
MIRT2650825	hsa-miR-2110	CLIP-seq
MIRT2650826	hsa-miR-223	CLIP-seq
MIRT1454629	hsa-miR-2682	CLIP-seq
MIRT2650827	hsa-miR-3120-3p	CLIP-seq
MIRT2462349	hsa-miR-3149	CLIP-seq
MIRT1454630	hsa-miR-3162-3p	CLIP-seq
MIRT1454631	hsa-miR-3187-3p	CLIP-seq
MIRT2650828	hsa-miR-3189-5p	CLIP-seq
MIRT2650829	hsa-miR-342-3p	CLIP-seq
MIRT2650830	hsa-miR-34c-3p	CLIP-seq
MIRT1454632	hsa-miR-3545-3p	CLIP-seq
MIRT2650831	hsa-miR-361-3p	CLIP-seq
MIRT2650832	hsa-miR-3664-3p	CLIP-seq
MIRT2357196	hsa-miR-3921	CLIP-seq
MIRT2650833	hsa-miR-3927	CLIP-seq
MIRT2650834	hsa-miR-3938	CLIP-seq
MIRT2650835	hsa-miR-3973	CLIP-seq
MIRT2462350	hsa-miR-411	CLIP-seq
MIRT2650836	hsa-miR-4271	CLIP-seq
MIRT2650837	hsa-miR-4287	CLIP-seq
MIRT2650838	hsa-miR-4292	CLIP-seq
MIRT1454637	hsa-miR-4423-3p	CLIP-seq
MIRT2357197	hsa-miR-4427	CLIP-seq
MIRT1454638	hsa-miR-4435	CLIP-seq
MIRT2650839	hsa-miR-4469	CLIP-seq
MIRT2650840	hsa-miR-4477a	CLIP-seq
MIRT1454641	hsa-miR-449c	CLIP-seq
MIRT2650841	hsa-miR-4518	CLIP-seq
MIRT1454642	hsa-miR-4534	CLIP-seq
MIRT2650842	hsa-miR-4536	CLIP-seq
MIRT2650843	hsa-miR-455-3p	CLIP-seq
MIRT2650844	hsa-miR-4639-5p	CLIP-seq
MIRT2650845	hsa-miR-4650-3p	CLIP-seq
MIRT2357198	hsa-miR-4653-5p	CLIP-seq
MIRT2650846	hsa-miR-4667-5p	CLIP-seq
MIRT2357199	hsa-miR-4680-3p	CLIP-seq
MIRT1454643	hsa-miR-4680-5p	CLIP-seq
MIRT2650847	hsa-miR-4685-3p	CLIP-seq
MIRT2650848	hsa-miR-4687-3p	CLIP-seq
MIRT2650849	hsa-miR-4697-3p	CLIP-seq
MIRT2650850	hsa-miR-4700-5p	CLIP-seq
MIRT1454645	hsa-miR-4701-5p	CLIP-seq
MIRT1454646	hsa-miR-4716-5p	CLIP-seq
MIRT2650851	hsa-miR-4725-3p	CLIP-seq
MIRT2650852	hsa-miR-4725-5p	CLIP-seq
MIRT2462351	hsa-miR-4735-5p	CLIP-seq
MIRT1454647	hsa-miR-4755-3p	CLIP-seq
MIRT2650853	hsa-miR-4755-5p	CLIP-seq
MIRT2650854	hsa-miR-4758-3p	CLIP-seq
MIRT2650855	hsa-miR-4760-5p	CLIP-seq
MIRT1454649	hsa-miR-4781-3p	CLIP-seq
MIRT2650856	hsa-miR-504	CLIP-seq
MIRT1454653	hsa-miR-5096	CLIP-seq
MIRT2650857	hsa-miR-520g	CLIP-seq
MIRT2650858	hsa-miR-520h	CLIP-seq
MIRT1454654	hsa-miR-548s	CLIP-seq
MIRT2650859	hsa-miR-548u	CLIP-seq
MIRT2650860	hsa-miR-579	CLIP-seq
MIRT1454655	hsa-miR-588	CLIP-seq
MIRT2136198	hsa-miR-590-3p	CLIP-seq
MIRT2650861	hsa-miR-623	CLIP-seq
MIRT2650862	hsa-miR-647	CLIP-seq
MIRT2650863	hsa-miR-660	CLIP-seq
MIRT2650864	hsa-miR-7	CLIP-seq
MIRT1454658	hsa-miR-940	CLIP-seq
MIRT2357200	hsa-miR-942	CLIP-seq
MIRT2650819	hsa-miR-1266	CLIP-seq
MIRT1454628	hsa-miR-197	CLIP-seq
MIRT2650825	hsa-miR-2110	CLIP-seq
MIRT2650826	hsa-miR-223	CLIP-seq
MIRT1454629	hsa-miR-2682	CLIP-seq
MIRT2650827	hsa-miR-3120-3p	CLIP-seq
MIRT2462349	hsa-miR-3149	CLIP-seq
MIRT1454630	hsa-miR-3162-3p	CLIP-seq
MIRT1454631	hsa-miR-3187-3p	CLIP-seq
MIRT2650828	hsa-miR-3189-5p	CLIP-seq
MIRT2650830	hsa-miR-34c-3p	CLIP-seq
MIRT1454632	hsa-miR-3545-3p	CLIP-seq
MIRT2650832	hsa-miR-3664-3p	CLIP-seq
MIRT2650833	hsa-miR-3927	CLIP-seq
MIRT2462350	hsa-miR-411	CLIP-seq
MIRT2650836	hsa-miR-4271	CLIP-seq
MIRT2650837	hsa-miR-4287	CLIP-seq
MIRT2650838	hsa-miR-4292	CLIP-seq
MIRT1454637	hsa-miR-4423-3p	CLIP-seq
MIRT1454638	hsa-miR-4435	CLIP-seq
MIRT2650839	hsa-miR-4469	CLIP-seq
MIRT2650840	hsa-miR-4477a	CLIP-seq
MIRT1454641	hsa-miR-449c	CLIP-seq
MIRT2650841	hsa-miR-4518	CLIP-seq
MIRT1454642	hsa-miR-4534	CLIP-seq
MIRT2650842	hsa-miR-4536	CLIP-seq
MIRT2650843	hsa-miR-455-3p	CLIP-seq
MIRT2650845	hsa-miR-4650-3p	CLIP-seq
MIRT2650846	hsa-miR-4667-5p	CLIP-seq
MIRT1454643	hsa-miR-4680-5p	CLIP-seq
MIRT2650847	hsa-miR-4685-3p	CLIP-seq
MIRT2650848	hsa-miR-4687-3p	CLIP-seq
MIRT2650849	hsa-miR-4697-3p	CLIP-seq
MIRT2650850	hsa-miR-4700-5p	CLIP-seq
MIRT1454645	hsa-miR-4701-5p	CLIP-seq
MIRT1454646	hsa-miR-4716-5p	CLIP-seq
MIRT2650851	hsa-miR-4725-3p	CLIP-seq
MIRT2650852	hsa-miR-4725-5p	CLIP-seq
MIRT2462351	hsa-miR-4735-5p	CLIP-seq
MIRT1454647	hsa-miR-4755-3p	CLIP-seq
MIRT2650854	hsa-miR-4758-3p	CLIP-seq
MIRT2650855	hsa-miR-4760-5p	CLIP-seq
MIRT1454649	hsa-miR-4781-3p	CLIP-seq
MIRT2694179	hsa-miR-4797-3p	CLIP-seq
MIRT2650856	hsa-miR-504	CLIP-seq
MIRT1454653	hsa-miR-5096	CLIP-seq
MIRT1454654	hsa-miR-548s	CLIP-seq
MIRT2650859	hsa-miR-548u	CLIP-seq
MIRT1454655	hsa-miR-588	CLIP-seq
MIRT2136198	hsa-miR-590-3p	CLIP-seq
MIRT2650862	hsa-miR-647	CLIP-seq
MIRT2650863	hsa-miR-660	CLIP-seq
MIRT1454658	hsa-miR-940	CLIP-seq

Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0003713	Function	Transcription coactivator activity	IDA	23077300
GO:0005515	Function	Protein binding	IPI	23275563, 25416956, 25910212, 29892012, 31515488, 32296183, 32814053
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0010468	Process	Regulation of gene expression	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016925	Process	Protein sumoylation	IEA
GO:0032648	Process	Regulation of interferon-beta production	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	HMP	12761501
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IDA	23077300
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IEA
GO:0045070	Process	Positive regulation of viral genome replication	IEA
GO:0045087	Process	Innate immune response	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046596	Process	Regulation of viral entry into host cell	IBA
GO:0046598	Process	Positive regulation of viral entry into host cell	IDA	18248090
GO:0046872	Function	Metal ion binding	IEA
GO:0048524	Process	Positive regulation of viral process	IEA
GO:0050687	Process	Negative regulation of defense response to virus	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	ISS
GO:0070936	Process	Protein K48-linked ubiquitination	IEA
GO:1903900	Process	Regulation of viral life cycle	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

O00635

Protein name

E3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet)

Protein function

E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, l

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15227	zf-C3HC4_4	16 → 62		Domain
PF00643	zf-B_box	88 → 129	B-box zinc finger	Domain
PF13765	PRY	294 → 342	SPRY-associated domain	Family
PF00622	SPRY	346 → 458	SPRY domain	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9149941}.

Sequence

MASTTSTKKMMEEATCSICLSLMTNPVSINCGHSYCHLCITDFFKNPSQKQLRQETFCCP
QCRAPFHMDSLRPNKQLGSLIEALKETDQEMSCEEHGEQFHLFCEDEGQLICWRCERAPQ
HKGHTTALVEDVCQGYKEKLQKAVTKLKQLEDRCTEQKLSTAMRITKWKEKVQIQRQKIR
SDFKNLQCFLHEEEKSYLWRLEKEEQQTLSRLRDYEAGLGLKSNELKSHILELEEKCQGS
AQKLLQNVNDTLSRSWAVKLETSEAVSLELHTMCNVSKLYFDVKKMLRSHQVSVTLDPDT
AHHELILSEDRRQVTRGYTQENQDTSSRRFTAFPCVLGCEGFTSGRRYFEVDVGEGTGWD
LGVCMENVQRGTGMKQEPQSGFWTLRLCKKKGYVALTSPPTSLHLHEQPLLVGIFLDYEA
GVVSFYNGNTGCHIFTFPKASFSDTLRPYFQVYQYSPLFLPPPGD

Sequence length

465

Interactions

View interactions

	Reactome
			Interferon gamma signaling

TRIM38 (tripartite motif containing 38)